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1 January 2021
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The cover shows a tissue section from a patient with pancreatic ductal adenocarcinoma. Multiplex fluorescent immunohistochemistry of FAP (fibroblast activation protein alpha, green) and ACTA2 (alpha smooth muscle action, magenta) visualizes mutually exclusive fibroblast subpopulations. For details, see the article by Ogawa and colleagues on page 107 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Issue Sections
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Review
Perspectives
Special Report
Clinical Trial Brief Report
Author Choice
Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
Ezra Y. Rosen; Melissa L. Johnson; Sarah E. Clifford; Romel Somwar; Jennifer F. Kherani; Jieun Son; Arrien A. Bertram; Monika A. Davare; Eric Gladstone; Elena V. Ivanova; Dahlia N. Henry; Elaine M. Kelley; Mika Lin; Marina S.D. Milan; Binoj C. Nair; Elizabeth A. Olek; Jenna E. Scanlon; Morana Vojnic; Kevin Ebata; Jaclyn F. Hechtman; Bob T. Li; Lynette M. Sholl; Barry S. Taylor; Marc Ladanyi; Pasi A. Jänne; S. Michael Rothenberg; Alexander Drilon; Geoffrey R. Oxnard
Clinical Trials: Targeted Therapy
Author Choice
Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody–Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma
Xinan Sheng; Xieqiao Yan; Lin Wang; Yanxia Shi; Xin Yao; Hong Luo; Benkang Shi; Jiyan Liu; Zhisong He; Guohua Yu; Jianming Ying; Weiqing Han; Changlu Hu; Yun Ling; Zhihong Chi; Chuanliang Cui; Lu Si; Jianmin Fang; Aiping Zhou; Jun Guo
Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
Jonathan M. Loree; Anthony Dowers; Dongsheng Tu; Derek J. Jonker; Daniel L. Edelstein; Hannah Quinn; Frank Holtrup; Timothy Price; John R. Zalcberg; Malcolm J. Moore; Christos S. Karapetis; Chris J. O'Callaghan; Paul Waring; Hagen F. Kennecke; Stanley R. Hamilton; Scott Kopetz
Flumatinib versus Imatinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia: A Phase III, Randomized, Open-label, Multi-center FESTnd Study
Li Zhang; Li Meng; Bingcheng Liu; Yanli Zhang; Huanling Zhu; Jiuwei Cui; Aining Sun; Yu Hu; Jie Jin; Hao Jiang; Xi Zhang; Yan Li; Li Liu; Wanggang Zhang; Xiaoli Liu; Jian Gu; Jianhui Qiao; Guifang Ouyang; Xin Liu; Jianmin Luo; Ming Jiang; Xiaobao Xie; Jianyong Li; Chunting Zhao; Mei Zhang; Tonghua Yang; Jianxiang Wang
Clinical Trials: Immunotherapy
Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma
Nizar M. Tannir; Sabina Signoretti; Toni K. Choueiri; David F. McDermott; Robert J. Motzer; Abdallah Flaifel; Jean-Christophe Pignon; Miriam Ficial; Osvaldo Arén Frontera; Saby George; Thomas Powles; Frede Donskov; Michael R. Harrison; Philippe Barthélémy; Scott S. Tykodi; Judit Kocsis; Alain Ravaud; Jeronimo R. Rodriguez-Cid; Sumanta K. Pal; Andre M. Murad; Yuko Ishii; Shruti Shally Saggi; M. Brent McHenry; Brian I. Rini
Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity
Shipra Gandhi; Manu R. Pandey; Kristopher Attwood; Wenyan Ji; Agnieszka K. Witkiewicz; Erik S. Knudsen; Cheryl Allen; Joseph D. Tario; Paul K. Wallace; Carlos D. Cedeno; Maria Levis; Suzanne Stack; Pauline Funchain; Joseph J. Drabick; Mark J. Bucsek; Igor Puzanov; Hemn Mohammadpour; Elizabeth A. Repasky; Marc S. Ernstoff
Intratumoral Injection of Clostridium novyi-NT Spores in Patients with Treatment-refractory Advanced Solid Tumors
Filip Janku; Halle Huihong Zhang; Abdulmohammad Pezeshki; Sanjay Goel; Ravi Murthy; Andrea Wang-Gillam; Dale R. Shepard; Thorunn Helgason; Tyler Masters; David S. Hong; Sarina A. Piha-Paul; Daniel D. Karp; Mark Klang; Steven Y. Huang; Divya Sakamuri; Anjali Raina; Jean Torrisi; Stephen B. Solomon; Alice Weissfeld; Ernest Trevino; Gary DeCrescenzo; Amanda Collins; Maria Miller; Jennifer L. Salstrom; Ronald L. Korn; Linping Zhang; Saurabh Saha; Alexey A. Leontovich; David Tung; Brent Kreider; Mary Varterasian; Khashayarsha Khazaie; Mrinal M. Gounder
Precision Medicine and Imaging
Author Choice
Development and Validation of a Gene Signature Classifier for Consensus Molecular Subtyping of Colorectal Carcinoma in a CLIA-Certified Setting
Jeffrey S. Morris; Rajyalakshmi Luthra; Yusha Liu; Dzifa Y. Duose; Wonyul Lee; Neelima G. Reddy; Justin Windham; Huiqin Chen; Zhimin Tong; Baili Zhang; Wei Wei; Manyam Ganiraju; Bradley M. Broom; Hector A. Alvarez; Alicia Mejia; Omkara Veeranki; Mark J. Routbort; Van K. Morris; Michael J. Overman; David Menter; Riham Katkhuda; Ignacio I. Wistuba; Jennifer S. Davis; Scott Kopetz; Dipen M. Maru
Author Choice
Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma
Paul Johannet; Nicolas Coudray; Douglas M. Donnelly; George Jour; Irineu Illa-Bochaca; Yuhe Xia; Douglas B. Johnson; Lee Wheless; James R. Patrinely; Sofia Nomikou; David L. Rimm; Anna C. Pavlick; Jeffrey S. Weber; Judy Zhong; Aristotelis Tsirigos; Iman Osman
Author Choice
Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence
Hao Xie; Douglas W. Mahoney; Patrick H. Foote; Kelli N. Burger; Karen A. Doering; William R. Taylor; Sara S. Then; Xiaoming Cao; Maria McGlinch; Calise K. Berger; Tsung-Teh Wu; Joleen M. Hubbard; Hatim T. Allawi; Michael W. Kaiser; Graham P. Lidgard; David A. Ahlquist; John B. Kisiel
Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics
James T. Topham; Joanna M. Karasinska; Michael K.C. Lee; Veronika Csizmok; Laura M. Williamson; Gun Ho Jang; Robert E. Denroche; Erica S. Tsang; Steve E. Kalloger; Hui-li Wong; Grainne M. O'Kane; Richard A. Moore; Andrew J. Mungall; Faiyaz Notta; Jonathan M. Loree; Julie M. Wilson; Oliver Bathe; Patricia A. Tang; Rachel Goodwin; Jennifer J. Knox; Steven Gallinger; Janessa Laskin; Marco A. Marra; Steven J.M. Jones; Daniel J. Renouf; David F. Schaeffer
International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia
Maximilian Schönung; Julia Meyer; Peter Nöllke; Adam B. Olshen; Mark Hartmann; Norihiro Murakami; Manabu Wakamatsu; Yusuke Okuno; Christoph Plass; Mignon L. Loh; Charlotte M. Niemeyer; Hideki Muramatsu; Christian Flotho; Elliot Stieglitz; Daniel B. Lipka
TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Koushik Muralidharan; Anudeep Yekula; Julia L. Small; Zachary S. Rosh; Keiko M. Kang; Lan Wang; Spencer Lau; Hui Zhang; Hakho Lee; Chetan Bettegowda; Michael R. Chicoine; Steven N. Kalkanis; Ganesh M. Shankar; Brian V. Nahed; William T. Curry; Pamela S. Jones; Daniel P. Cahill; Leonora Balaj; Bob S. Carter
MRI and 18FET-PET Predict Survival Benefit from Bevacizumab Plus Radiotherapy in Patients with Isocitrate Dehydrogenase Wild-type Glioblastoma: Results from the Randomized ARTE Trial
Hans-Georg Wirsching; Ulrich Roelcke; Jonathan Weller; Thomas Hundsberger; Andreas F. Hottinger; Roger von Moos; Francesca Caparrotti; Katrin Conen; Luca Remonda; Patrick Roth; Adrian Ochsenbein; Ghazaleh Tabatabai; Michael Weller
Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs
Nicola Colclough; Kan Chen; Peter Johnström; Nicole Strittmatter; Yumei Yan; Gail L. Wrigley; Magnus Schou; Richard Goodwin; Katarina Varnäs; Sally J. Adua; Minghui Zhao; Don X. Nguyen; Gareth Maglennon; Peter Barton; James Atkinson; Lin Zhang; Annika Janefeldt; Joanne Wilson; Aaron Smith; Akihiro Takano; Ryosuke Arakawa; Mikhail Kondrashov; Jonas Malmquist; Evgeny Revunov; Ana Vazquez-Romero; Mohammad Mahdi Moein; Albert D. Windhorst; Natasha A. Karp; M. Raymond V. Finlay; Richard A. Ward; James W.T. Yates; Paul D. Smith; Lars Farde; Zack Cheng; Darren A.E. Cross
Author Choice
Genome and Transcriptome Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors
Alexandra Pender; Emma Titmuss; Erin D. Pleasance; Kevin Y. Fan; Hillary Pearson; Scott D. Brown; Cameron J. Grisdale; James T. Topham; Yaoqing Shen; Melika Bonakdar; Gregory A. Taylor; Laura M. Williamson; Karen L. Mungall; Eric Chuah; Andrew J. Mungall; Richard A. Moore; Jean-Michel Lavoie; Stephen Yip; Howard Lim; Daniel J. Renouf; Sophie Sun; Robert A. Holt; Steven J.M. Jones; Marco A. Marra; Janessa Laskin
A Cyclin D1–Dependent Transcriptional Program Predicts Clinical Outcome in Mantle Cell Lymphoma
Santiago Demajo; Robert Albero; Guillem Clot; Giancarlo Castellano; Alba Navarro; Cristina Capdevila; Anna Enjuanes; Ferran Nadeu; Eva Giné; Magda Pinyol; Elaine S. Jaffe; German Ott; Louis M. Staudt; Andreas Rosenwald; David W. Scott; Lisa M. Rimsza; Armando López-Guillermo; Sílvia Beà; Elias Campo; Pedro Jares
Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA
ChongFeng Gao; Luke Wisniewski; Ying Liu; Ben Staal; Ian Beddows; Dennis Plenker; Mohammed Aldakkak; Johnathan Hall; Daniel Barnett; Mirna Kheir Gouda; Peter Allen; Richard Drake; Amer Zureikat; Ying Huang; Douglas Evans; Aatur Singhi; Randall E. Brand; David A. Tuveson; Susan Tsai; Brian B. Haab
Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
Erica S. Tsang; James T. Topham; Joanna M. Karasinska; Michael K.C. Lee; Laura M. Williamson; Shehara Mendis; Robert E. Denroche; Gun Ho Jang; Steve E. Kalloger; Richard A. Moore; Andrew J. Mungall; Oliver F. Bathe; Patricia A. Tang; Faiyaz Notta; Julie M. Wilson; Janessa Laskin; Grainne M. O'Kane; Jennifer J. Knox; Rachel A. Goodwin; Jonathan M. Loree; Steven J.M. Jones; Marco A. Marra; Steven Gallinger; David F. Schaeffer; Daniel J. Renouf
An Immune Risk Score Predicts Survival of Patients with Acute Myeloid Leukemia Receiving Chemotherapy
Yun Wang; Yan-yu Cai; Tobias Herold; Run-cong Nie; Yu Zhang; Robert Peter Gale; Klaus H. Metzeler; Yun Zeng; Shun-qing Wang; Xue-yi Pan; Tong-hua Yang; Yuan-bin Wu; Qing Zhang; Zhi-jun Wuxiao; Xin Du; Zhi-wei Liang; Yong-zhong Su; Jing-bo Xu; Yong-qing Wang; Ze-lin Liu; Jian-wei Wu; Xiong Zhang; Bing-yi Wu; Ruo-zhi Xiao; San-bin Wang; Jin-yuan Li; Pei-dong Chi; Qian-yi Zhang; Si-liang Chen; Zhe-yuan Qin; Xin-mei Zhang; Na Zhong; Wolfgang Hiddemann; Qi-fa Liu; Bei Zhang; Yang Liang
Translational Cancer Mechanisms and Therapy
Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance)
Federico Innocenti; Alexander B. Sibley; Sushant A. Patil; Amy S. Etheridge; Chen Jiang; Fang-Shu Ou; Stefanie D. Howell; Sarah J. Plummer; Graham Casey; Monica M. Bertagnolli; Howard L. McLeod; James T. Auman; Charles D. Blanke; Yoichi Furukawa; Alan P. Venook; Michiaki Kubo; Heinz-Josef Lenz; Joel S. Parker; Mark J. Ratain; Kouros Owzar
Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma
J. Bryan Iorgulescu; Prafulla C. Gokhale; Maria C. Speranza; Benjamin K. Eschle; Michael J. Poitras; Margaret K. Wilkens; Kara M. Soroko; Chhayheng Chhoeu; Aine Knott; Yan Gao; Mary Jane Lim-Fat; Gregory J. Baker; Dennis M. Bonal; Quang-Dé Nguyen; Gareth R. L. Grant; Keith L. Ligon; Peter K. Sorger; E. Antonio Chiocca; Ana C. Anderson; Paul T. Kirschmeier; Arlene H. Sharpe; Gordon J. Freeman; David A. Reardon
Author Choice
In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer
Sudhir B. Malla; David J. Fisher; Enric Domingo; Andrew Blake; Sylvana Hassanieh; Keara L. Redmond; Susan D. Richman; Michael Youdell; Steven M. Walker; Gemma E. Logan; Aikaterina Chatzipli; Raheleh Amirkhah; Matthew P. Humphries; Stephanie G. Craig; Ultan McDermott; Matthew T. Seymour; Dion G. Morton; Philip Quirke; Nicholas P. West; Manuel Salto-Tellez; Richard D. Kennedy; Patrick G. Johnston; Ian Tomlinson; Viktor H. Koelzer; Letitia Campo; Richard S. Kaplan; Daniel B. Longley; Mark Lawler; Timothy S. Maughan; Louise C. Brown; Philip D. Dunne; on behalf of the S:CORT consortium
Author Choice
Serial Circulating Tumor DNA in Predicting and Monitoring the Effect of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer: A Prospective Multicenter Study
Jiaolin Zhou; Changxi Wang; Guole Lin; Yi Xiao; Wenzhuo Jia; Gang Xiao; Qian Liu; Bin Wu; Aiwen Wu; Huizhong Qiu; Fuquan Zhang; Ke Hu; Huadan Xue; Zhanlong Shen; Zhenjun Wang; Jiagang Han; Beizhan Niu; Yaping Xu; Zicheng Yu; Ling Yang
Author Choice
Breast Cancer Index Predicts Extended Endocrine Benefit to Individualize Selection of Patients with HR+ Early-stage Breast Cancer for 10 Years of Endocrine Therapy
Iris Noordhoek; Kai Treuner; Hein Putter; Yi Zhang; Jenna Wong; Elma Meershoek-Klein Kranenbarg; Marjolijn Duijm-de Carpentier; Cornelis J.H. van de Velde; Catherine A. Schnabel; Gerrit-Jan Liefers
Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer
Shivanshu Awasthi; Anders Berglund; Julieta Abraham-Miranda; Robert J. Rounbehler; Kevin Kensler; Amparo Serna; Adriana Vidal; Sungyong You; Michael R. Freeman; Elai Davicioni; Yang Liu; R. Jeffrey Karnes; Eric A. Klein; Robert B. Den; Bruce J. Trock; Joshua D. Campbell; David J. Einstein; Raavi Gupta; Steven Balk; Priti Lal; Jong Y. Park; John L. Cleveland; Timothy R. Rebbeck; Stephen J. Freedland; Kosj Yamoah
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling
Chen Liu; Hengyu Lu; Hongyun Wang; Alice Loo; Xiamei Zhang; Guizhi Yang; Colleen Kowal; Scott Delach; Ye Wang; Silvia Goldoni; William D. Hastings; Karrie Wong; Hui Gao; Matthew J. Meyer; Susan E. Moody; Matthew J. LaMarche; Jeffrey A. Engelman; Juliet A. Williams; Peter S. Hammerman; Tinya J. Abrams; Morvarid Mohseni; Giordano Caponigro; Huai-Xiang Hao
Letters to the Editor
Corrections
Correction: Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus–unrelated Head and Neck Cancer: A Multicenter, Phase II Trial
Ravindra Uppaluri; Katie M. Campbell; Ann Marie Egloff; Paul Zolkind; Zachary L. Skidmore; Brian Nussenbaum; Randal C. Paniello; Jason T. Rich; Ryan Jackson; Patrik Pipkorn; Loren S. Michel; Jessica Ley; Peter Oppelt; Gavin P. Dunn; Erica K. Barnell; Nicholas C. Spies; Tianxiang Lin; Tiantian Li; David T. Mulder; Youstina Hanna; Iulia Cirlan; Trevor J. Pugh; Tenny Mudianto; Rachel Riley; Liye Zhou; Vickie Y. Jo; Matthew D. Stachler; Glenn J. Hanna; Jason Kass; Robert Haddad; Jonathan D. Schoenfeld; Evisa Gjini; Ana Lako; Wade Thorstad; Hiram A. Gay; Mackenzie Daly; Scott J. Rodig; Ian S. Hagemann; Dorina Kallogjeri; Jay F. Piccirillo; Rebecca D. Chernock; Malachi Griffith; Obi L. Griffith; Douglas R. Adkins
Correction: Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Changqing Xie; Austin G. Duffy; Gagandeep Brar; Suzanne Fioravanti; Donna Mabry-Hrones; Melissa Walker; Cecilia Monge Bonilla; Bradford J. Wood; Deborah E. Citrin; Elizabeth M. Gil Ramirez; Freddy E. Escorcia; Bernadette Redd; Jonathan M. Hernandez; Jeremy L. Davis; Billel Gasmi; David Kleiner; Seth M. Steinberg; Jennifer C. Jones; Tim F. Greten
Acknowledgment to Reviewers
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