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15 April 2020
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Cover Image
Cover Image
The cover shows a section of primary tumor from a patient with breast cancer who was treated with the beta-blocker propranolol. Immunohistochemical staining shows infiltration by CD8-positive T cells. For details, see the article by Hiller and colleagues on page 1803 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Research Briefs: Clinical Trial Brief Report
A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
Paul K. Paik; Rachel K. Kim; Linda Ahn; Andrew J. Plodkowski; Ai Ni; Mark T.A. Donoghue; Philip Jonsson; Miguel Villalona-Calero; Kenneth Ng; Daniel McFarland; John J. Fiore; Afsheen Iqbal; Juliana Eng; Mark G. Kris; Charles M. Rudin
Clinical Trials: Targeted Therapy
Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial
Jonathan G. Hiller; Steven W. Cole; Elizabeth M. Crone; David J. Byrne; David M. Shackleford; Jia-Min B. Pang; Michael A. Henderson; Sophie S. Nightingale; Kwok M. Ho; Paul S. Myles; Stephen Fox; Bernhard Riedel; Erica K. Sloan
Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131)
Douglas B. Johnson; Fengmin Zhao; Marcus Noel; Gregory J. Riely; Edith P. Mitchell; John J. Wright; Helen X. Chen; Robert J. Gray; Shuli Li; Lisa M. McShane; Larry V. Rubinstein; David Patton; P. Mickey Williams; Stanly R. Hamilton; Barbara A. Conley; Carlos L. Arteaga; Lyndsay N. Harris; Peter J. O'Dwyer; Alice P. Chen; Keith T. Flaherty
First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma
Patrick Y. Wen; Timothy F. Cloughesy; Alan G. Olivero; Kari M. Morrissey; Timothy R. Wilson; Xuyang Lu; Lars U. Mueller; Alexandre F. Coimbra; Benjamin M. Ellingson; Elizabeth Gerstner; Eudocia Q. Lee; Jordi Rodon
A Phase II Trial of 5-Day Neoadjuvant Radiotherapy for Patients with High-Risk Primary Soft Tissue Sarcoma
Anusha Kalbasi; Mitchell Kamrava; Fang-I Chu; Donatello Telesca; Ritchell Van Dams; Yingli Yang; Dan Ruan; Scott D. Nelson; Sarah M. Dry; Jackie Hernandez; Bartosz Chmielowski; Arun S. Singh; Susan V. Bukata; Nicholas M. Bernthal; Michael L. Steinberg; Joanne B. Weidhaas; Fritz C. Eilber
Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study
Margaret von Mehren; Suzanne George; Michael C. Heinrich; Scott M. Schuetze; Jeffrey T. Yap; Jain Q. Yu; Amanda Abbott; Samuel Litwin; John Crowley; Martin Belinsky; Katherine A. Janeway; Jason L. Hornick; Douglas B. Flieder; Rashmi Chugh; Lori Rink; Annick D. Van den Abbeele
Clinical Trials: Immunotherapy
Author Choice
Capturing Hyperprogressive Disease with Immune-Checkpoint Inhibitors Using RECIST 1.1 Criteria
Ignacio Matos; Juan Martin-Liberal; Alonso García-Ruiz; Cinta Hierro; Maria Ochoa de Olza; Cristina Viaplana; Analia Azaro; Maria Vieito; Irene Braña; Gemma Mur; Javier Ros; Jose Mateos; Guillermo Villacampa; Roger Berché; Mafalda Oliveira; Maria Alsina; Elena Elez; Ana Oaknin; Eva Muñoz-Couselo; Joan Carles; Enriqueta Felip; Jordi Rodón; Josep Tabernero; Rodrigo Dienstmann; Raquel Perez-Lopez; Elena Garralda
Precision Medicine and Imaging
Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial
Daniel Rodriguez Gutierrez; Chris Jones; Pascale Varlet; Alan Mackay; Daniel Warren; Monika Warmuth-Metz; Esther Sánchez Aliaga; Raphael Calmon; Darren R. Hargrave; Adela Cañete; Maura Massimino; Amedeo A. Azizi; Marie-Cécile Le Deley; Frank Saran; Raphael F. Rousseau; Gudrun Zahlmann; Josep Garcia; Gilles Vassal; Jacques Grill; Paul S. Morgan; Tim Jaspan
Radiogenomic-Based Survival Risk Stratification of Tumor Habitat on Gd-T1w MRI Is Associated with Biological Processes in Glioblastoma
Niha Beig; Kaustav Bera; Prateek Prasanna; Jacob Antunes; Ramon Correa; Salendra Singh; Anas Saeed Bamashmos; Marwa Ismail; Nathaniel Braman; Ruchika Verma; Virginia B. Hill; Volodymyr Statsevych; Manmeet S. Ahluwalia; Vinay Varadan; Anant Madabhushi; Pallavi Tiwari
Author Choice
Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers
Aparna R. Parikh; Amikasra Mojtahed; Jaime L. Schneider; Katie Kanter; Emily E. Van Seventer; Isobel J. Fetter; Ashraf Thabet; Madeleine G. Fish; Bezaye Teshome; Kathryn Fosbenner; Brandon Nadres; Heather A. Shahzade; Jill N. Allen; Lawrence S. Blaszkowsky; David P. Ryan; Bruce Giantonio; Lipika Goyal; Ryan D. Nipp; Eric Roeland; Colin D. Weekes; Jennifer Y. Wo; Andrew X. Zhu; Dora Dias-Santagata; A. John Iafrate; Jochen K. Lennerz; Theodore S. Hong; Giulia Siravegna; Nora Horick; Jeffrey W. Clark; Ryan B. Corcoran
Circulating Tumor Cells and Early Relapse in Node-positive Melanoma
Anthony Lucci; Carolyn S. Hall; Sapna P. Patel; Boomadevi Narendran; Jessica B. Bauldry; Richard E. Royal; Mandar Karhade; Joshua R. Upshaw; Jennifer A. Wargo; Isabella C. Glitza; Michael K.K. Wong; Rodabe N. Amaria; Hussein A. Tawbi; Adi Diab; Michael A. Davies; Jeffrey E. Gershenwald; Jeffrey E. Lee; Patrick Hwu; Merrick I. Ross
A Small Hypoxia Signature Predicted pCR Response to Bevacizumab in the Neoadjuvant GeparQuinto Breast Cancer Trial
Thomas Karn; Tobias Meissner; Karsten E. Weber; Christine Solbach; Carsten Denkert; Knut Engels; Peter A. Fasching; Bruno V. Sinn; Iris Schrader; Jan Budczies; Frederik Marmé; Volkmar Müller; Uwe Holtrich; Bernd Gerber; Christian Schem; Brandon M. Young; Claus Hanusch; Elmar Stickeler; Jens Huober; Marion van Mackelenbergh; Brian Leyland-Jones; Tanja Fehm; Valentina Nekljudova; Michael Untch; Sibylle Loibl
Author Choice
Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival
Jung S. Byun; Sandeep K. Singhal; Samson Park; Dae Ik Yi; Tingfen Yan; Ambar Caban; Alana Jones; Partha Mukhopadhyay; Sara M. Gil; Stephen M. Hewitt; Lisa Newman; Melissa B. Davis; Brittany D. Jenkins; Jorge L. Sepulveda; Adriana De Siervi; Anna María Nápoles; Nasreen A. Vohra; Kevin Gardner
Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients
Hersh K. Bhargava; Patrick Leo; Robin Elliott; Andrew Janowczyk; Jon Whitney; Sanjay Gupta; Pingfu Fu; Kosj Yamoah; Francesca Khani; Brian D. Robinson; Timothy R. Rebbeck; Michael Feldman; Priti Lal; Anant Madabhushi
Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer
Seyed Pairawan; Kenneth R. Hess; Filip Janku; Nora S. Sanchez; Kenna R. Mills Shaw; Cathy Eng; Senthilkumar Damodaran; Milind Javle; Ahmed O. Kaseb; David S. Hong; Vivek Subbiah; Siqing Fu; David R. Fogelman; Victoria M. Raymond; Richard B. Lanman; Funda Meric-Bernstam
Author Choice
Metabolic Imaging Using Hyperpolarized Pyruvate–Lactate Exchange Assesses Response or Resistance to the EGFR Inhibitor Cetuximab in Patient-Derived HNSCC Xenografts
Lionel Mignion; Stefania Acciardo; Florian Gourgue; Nicolas Joudiou; Xavier Caignet; Rose-Marie Goebbels; Cyril Corbet; Olivier Feron; Caroline Bouzin; Patrice D. Cani; Jean-Pascal Machiels; Sandra Schmitz; Bénédicte F. Jordan
Deep Learning to Distinguish Benign from Malignant Renal Lesions Based on Routine MR Imaging
Ianto Lin Xi; Yijun Zhao; Robin Wang; Marcello Chang; Subhanik Purkayastha; Ken Chang; Raymond Y. Huang; Alvin C. Silva; Martin Vallières; Peiman Habibollahi; Yong Fan; Beiji Zou; Terence P. Gade; Paul J. Zhang; Michael C. Soulen; Zishu Zhang; Harrison X. Bai; S. William Stavropoulos
Translational Cancer Mechanisms and Therapy
Author Choice
CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies
Steven N. Quayle; Natasha Girgis; Dharma R. Thapa; Zohra Merazga; Melissa M. Kemp; Alex Histed; Fan Zhao; Miguel Moreta; Paige Ruthardt; Sandrine Hulot; Alyssa Nelson; Lauren D. Kraemer; Dominic R. Beal; Luke Witt; Jessica Ryabin; Jonathan Soriano; Mark Haydock; Emily Spaulding; John F. Ross; Peter A. Kiener; Steven Almo; Rodolfo Chaparro; Ronald Seidel; Anish Suri; Saso Cemerski; Kenneth J. Pienta; Mary Ellen Simcox
Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer
Yingming Li; Rendong Yang; Christine M. Henzler; Yeung Ho; Courtney Passow; Benjamin Auch; Suzanne Carreira; Daniel Nava Rodrigues; Claudia Bertan; Tae Hyun Hwang; David A. Quigley; Ha X. Dang; Colm Morrissey; Michael Fraser; Stephen R. Plymate; Christopher A. Maher; Felix Y. Feng; Johann S. de Bono; Scott M. Dehm
Author Choice
Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer
Stefanie Hammer; Urs B. Hagemann; Sabine Zitzmann-Kolbe; Aasmund Larsen; Christine Ellingsen; Solene Geraudie; Derek Grant; Baard Indrevoll; Roger Smeets; Oliver von Ahsen; Alexander Kristian; Pascale Lejeune; Hartwig Hennekes; Jenny Karlsson; Roger M. Bjerke; Olav B. Ryan; Alan S. Cuthbertson; Dominik Mumberg
A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer
Joan M. Romero; Barbara Grünwald; Gun-Ho Jang; Prashant P. Bavi; Aaditeya Jhaveri; Mehdi Masoomian; Sandra E. Fischer; Amy Zhang; Robert E. Denroche; Ilinca M. Lungu; Angela De Luca; John M.S. Bartlett; Jing Xu; Niandong Li; Sharon Dhaliwal; Sheng-Ben Liang; Dianne Chadwick; Foram Vyas; Peter Bronsert; Rama Khokha; Tracy L. McGaha; Faiyaz Notta; Pamela S. Ohashi; Susan J. Done; Grainne M. O'Kane; Julie M. Wilson; Jennifer J. Knox; Ashton Connor; Yifan Wang; George Zogopoulos; Steven Gallinger
Gene Expression Signatures Identify Novel Therapeutics for Metastatic Pancreatic Neuroendocrine Tumors
Aaron T. Scott; Michelle Weitz; Patrick J. Breheny; Po Hien Ear; Benjamin Darbro; Bart J. Brown; Terry A. Braun; Guiying Li; Shaikamjad Umesalma; Courtney A. Kaemmer; Chandra K. Maharjan; Dawn E. Quelle; Andrew M. Bellizzi; Chandrikha Chandrasekharan; Joseph S. Dillon; Thomas M. O'Dorisio; James R. Howe
Author Choice
A Combinatorial Strategy for Targeting BRAFV600E-Mutant Cancers with BRAFV600E Inhibitor (PLX4720) and Tyrosine Kinase Inhibitor (Ponatinib)
Chandrayee Ghosh; Suresh Kumar; Yevgeniya Kushchayeva; Kelli Gaskins; Myriem Boufraqech; Darmood Wei; Sudheer Kumar Gara; Lisa Zhang; Ya-qin Zhang; Min Shen; Sanjit Mukherjee; Electron Kebebew
Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation–Positive Non–Small Cell Lung Cancer
Kohsuke Isomoto; Koji Haratani; Hidetoshi Hayashi; Shigeki Shimizu; Shuta Tomida; Takashi Niwa; Toshihide Yokoyama; Yasushi Fukuda; Yasutaka Chiba; Ryoji Kato; Junko Tanizaki; Kaoru Tanaka; Masayuki Takeda; Takashi Ogura; Tadashi Ishida; Akihiko Ito; Kazuhiko Nakagawa
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression
Goutam Chakraborty; Joshua Armenia; Ying Z. Mazzu; Subhiksha Nandakumar; Konrad H. Stopsack; Mohammad O. Atiq; Kazumasa Komura; Lina Jehane; Rahim Hirani; Kalyani Chadalavada; Yuki Yoshikawa; Nabeela A. Khan; Yu Chen; Wassim Abida; Lorelei A. Mucci; Gwo-Shu Mary Lee; Gouri J. Nanjangud; Philip W. Kantoff
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction
Kohei Kobatake; Ken-ichiro Ikeda; Yuichiro Nakata; Norimasa Yamasaki; Takeshi Ueda; Akinori Kanai; Kazuhiro Sentani; Yasuyuki Sera; Tetsutaro Hayashi; Miho Koizumi; Yoshihiko Miyakawa; Toshiya Inaba; Yusuke Sotomaru; Osamu Kaminuma; Tatsuo Ichinohe; Zen-ichiro Honda; Wataru Yasui; Shigeo Horie; Peter C. Black; Akio Matsubara; Hiroaki Honda
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