Skip Nav Destination
Issues
1 April 2020
-
Cover Image
Cover Image
The cover shows a section of a tissue resected from a patient with early-stage breast cancer undergoing a novel cytokine-based immunotherapy treatment (IRX-2). Multispectral immunohistochemical staining (mIHC) shows upregulation of PD-L1 (red) and increased immune cell infiltration after treatment. For details, see the article by Page and colleagues on page 1595 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Clinical Trials: Targeted Therapy
Author Choice
Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER+ Invasive Breast Cancer (STAKT)
John F.R. Robertson; Robert E. Coleman; Kwok-Leung Cheung; Abigail Evans; Chris Holcombe; Anthony Skene; Daniel Rea; Samreen Ahmed; Ali Jahan; Kieran Horgan; Petra Rauchhaus; Roberta Littleford; S.Y. Amy Cheung; Marie Cullberg; Elza C. de Bruin; Loumpiana Koulai; Justin P.O. Lindemann; Martin Pass; Paul Rugman; Gaia Schiavon; Rahul Deb; Pauline Finlay; Andrew Foxley; Julia M.W. Gee
Clinical Trials: Immunotherapy
Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial
David A. Reardon; Annick Desjardins; James J. Vredenburgh; Donald M. O'Rourke; David D. Tran; Karen L. Fink; Louis B. Nabors; Gordon Li; Daniela A. Bota; Rimas V. Lukas; Lynn S. Ashby; J. Paul Duic; Maciej M. Mrugala; Scott Cruickshank; Laura Vitale; Yi He; Jennifer A. Green; Michael J. Yellin; Christopher D. Turner; Tibor Keler; Thomas A. Davis; John H. Sampson; for the ReACT trial investigators
A Phase Ib Study of Preoperative, Locoregional IRX-2 Cytokine Immunotherapy to Prime Immune Responses in Patients with Early-Stage Breast Cancer
David B. Page; Joanna Pucilowska; Katherine G. Sanchez; Valerie K. Conrad; Alison K. Conlin; Anupama K. Acheson; Kelly S. Perlewitz; James H. Imatani; Shaghayegh Aliabadi-Wahle; Nicole Moxon; Staci L. Mellinger; Amanda Y. Seino; Martiza Martel; Yaping Wu; Zhaoyu Sun; William L. Redmond; Venkatesh Rajamanickam; Dottie Waddell; Deborah Laxague; Monil Shah; Shu-Ching Chang; Walter J. Urba
Author Choice
Sustained Therapeutic Efficacy of Humanized Anti-CD19 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Acute Lymphoblastic Leukemia
Gang Heng; Jiankun Jia; Shiqi Li; Gang Fu; Meiling Wang; Dabing Qin; Yunyan Li; Li Pei; Xiaobo Tian; Jiasi Zhang; Yi Wu; Shali Xiang; Jia Wan; Wei Zhu; Pei Zhang; Qianzhen Zhang; Xi Peng; Linling Wang; Ping Wang; Zhihao Wei; Yingzi Zhang; Guiqin Wang; Xue Chen; Chengcheng Zhang; Yanni Sun; Wenxu Zhao; Yahan Fan; Zhi Yang; Jieping Chen; Cheng Qian
Author Choice
A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3
Youn Jin Choi; Soo Young Hur; Tae-Jin Kim; Sung Ran Hong; Jae Kwan Lee; Chi-Heum Cho; Ki Seok Park; Jung Won Woo; Young Chul Sung; You Suk Suh; Jong Sup Park
Precision Medicine and Imaging
Author Choice
TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
Ezra Y. Rosen; Debra A. Goldman; Jaclyn F. Hechtman; Ryma Benayed; Alison M. Schram; Emiliano Cocco; Sophie Shifman; Yixiao Gong; Ritika Kundra; James P. Solomon; Alberto Bardelli; Maurizio Scaltriti; Alexander Drilon; Alexia Iasonos; Barry S. Taylor; David M. Hyman
Translational Cancer Mechanisms and Therapy
PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors
Minsuk Kwon; Chang Gon Kim; Hoyoung Lee; Hyunsoo Cho; Youngun Kim; Eung Chang Lee; Seong Jin Choi; Junsik Park; In-Ho Seo; Bjarne Bogen; Ik-Chan Song; Deog-Yeon Jo; Jin Seok Kim; Su-Hyung Park; Inhak Choi; Yoon Seok Choi; Eui-Cheol Shin
Analysis of Released Circulating Tumor Cells During Surgery for Non-Small Cell Lung Cancer
Menno Tamminga; Sanne de Wit; Caroline van de Wauwer; Hilda van den Bos; Joost F. Swennenhuis; Theo J. Klinkenberg; T. Jeroen N. Hiltermann; Kiki C. Andree; Diana C.J. Spierings; Peter M. Lansdorp; Anke van den Berg; Wim Timens; Leon W.M.M. Terstappen; Harry J.M. Groen
Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer
Alexandra N. Corella; Ma Victoria Andrea Cabiliza Ordonio; Ilsa Coleman; Jared M. Lucas; Arja Kaipainen; Holly M. Nguyen; Daniel Sondheim; Lisha G. Brown; Lawrence D. True; John K. Lee; David MacPherson; Paul Nghiem; Roman Gulati; Colm Morrissey; Eva Corey; Peter S. Nelson
Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer
Mannan Nouri; Shabnam Massah; Josselin Caradec; Amy A. Lubik; Na Li; Sarah Truong; Ahn R. Lee; Ladan Fazli; Varune R. Ramnarine; Jessica M. Lovnicki; Jackson Moore; Mike Wang; Jane Foo; Martin E. Gleave; Brett G. Hollier; Colleen Nelson; Colin Collins; Xuesen Dong; Ralph Buttyan
Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Elizabeth A. Lemm; Beatriz Valle-Argos; Lindsay D. Smith; Johanna Richter; Yohannes Gebreselassie; Matthew J. Carter; Jana Karolova; Michael Svaton; Karel Helman; Nicola J. Weston-Bell; Laura Karydis; Chris T. Williamson; Georg Lenz; Jeremy Pettigrew; Curtis Harwig; Freda K. Stevenson; Mark Cragg; Francesco Forconi; Andrew J. Steele; Jennifer Cross; Lloyd Mackenzie; Pavel Klener; Graham Packham
Author Choice
A Th1/IFNγ Gene Signature Is Prognostic in the Adjuvant Setting of Resectable High-Risk Melanoma but Not in Non–Small Cell Lung Cancer
Benjamin Dizier; Andrea Callegaro; Muriel Debois; Brigitte Dreno; Peter Hersey; Helen J. Gogas; John M. Kirkwood; Johan F. Vansteenkiste; Lecia V. Sequist; Djordje Atanackovic; Jelle Goeman; Hans van Houwelingen; Susana Salceda; Fawn Wang; Patrick Therasse; Channa Debruyne; Bart Spiessens; Vincent G. Brichard; Jamila Louahed; Fernando Ulloa-Montoya
Author Choice
lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP
Nan Li; Guohua Yang; Liyun Luo; Li Ling; Xiaorong Wang; Lejuan Shi; Junsong Lan; Xiaoting Jia; Qiong Zhang; Ze Long; Jinbao Liu; Weimin Hu; Zhimin He; Haiying Liu; Wanqing Liu; Guopei Zheng
Letters to the Editor
Editor’s Note
Retraction
Retraction: UM-164: A Potent c-Src/p38 Kinase Inhibitor with In Vivo Activity against Triple-Negative Breast Cancer
Rabia A. Gilani; Sameer Phadke; Li Wei Bao; Eric J. Lachacz; Michele L. Dziubinski; Kristoffer R. Brandvold; Michael E. Steffey; Frank E. Kwarcinski; Carrie R. Graveel; Kelley M. Kidwell; Sofia D. Merajver; Matthew B. Soellner
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.