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1 April 2020
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The cover shows a section of a tissue resected from a patient with early-stage breast cancer undergoing a novel cytokine-based immunotherapy treatment (IRX-2). Multispectral immunohistochemical staining (mIHC) shows upregulation of PD-L1 (red) and increased immune cell infiltration after treatment. For details, see the article by Page and colleagues on page 1595 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Clinical Trials: Targeted Therapy
Author Choice
Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER+ Invasive Breast Cancer (STAKT)
John F.R. Robertson; Robert E. Coleman; Kwok-Leung Cheung; Abigail Evans; Chris Holcombe; Anthony Skene; Daniel Rea; Samreen Ahmed; Ali Jahan; Kieran Horgan; Petra Rauchhaus; Roberta Littleford; S.Y. Amy Cheung; Marie Cullberg; Elza C. de Bruin; Loumpiana Koulai; Justin P.O. Lindemann; Martin Pass; Paul Rugman; Gaia Schiavon; Rahul Deb; Pauline Finlay; Andrew Foxley; Julia M.W. Gee
Clinical Trials: Immunotherapy
Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial
David A. Reardon; Annick Desjardins; James J. Vredenburgh; Donald M. O'Rourke; David D. Tran; Karen L. Fink; Louis B. Nabors; Gordon Li; Daniela A. Bota; Rimas V. Lukas; Lynn S. Ashby; J. Paul Duic; Maciej M. Mrugala; Scott Cruickshank; Laura Vitale; Yi He; Jennifer A. Green; Michael J. Yellin; Christopher D. Turner; Tibor Keler; Thomas A. Davis; John H. Sampson; for the ReACT trial investigators
A Phase Ib Study of Preoperative, Locoregional IRX-2 Cytokine Immunotherapy to Prime Immune Responses in Patients with Early-Stage Breast Cancer
David B. Page; Joanna Pucilowska; Katherine G. Sanchez; Valerie K. Conrad; Alison K. Conlin; Anupama K. Acheson; Kelly S. Perlewitz; James H. Imatani; Shaghayegh Aliabadi-Wahle; Nicole Moxon; Staci L. Mellinger; Amanda Y. Seino; Martiza Martel; Yaping Wu; Zhaoyu Sun; William L. Redmond; Venkatesh Rajamanickam; Dottie Waddell; Deborah Laxague; Monil Shah; Shu-Ching Chang; Walter J. Urba
Author Choice
Sustained Therapeutic Efficacy of Humanized Anti-CD19 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Acute Lymphoblastic Leukemia
Gang Heng; Jiankun Jia; Shiqi Li; Gang Fu; Meiling Wang; Dabing Qin; Yunyan Li; Li Pei; Xiaobo Tian; Jiasi Zhang; Yi Wu; Shali Xiang; Jia Wan; Wei Zhu; Pei Zhang; Qianzhen Zhang; Xi Peng; Linling Wang; Ping Wang; Zhihao Wei; Yingzi Zhang; Guiqin Wang; Xue Chen; Chengcheng Zhang; Yanni Sun; Wenxu Zhao; Yahan Fan; Zhi Yang; Jieping Chen; Cheng Qian
Author Choice
A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3
Youn Jin Choi; Soo Young Hur; Tae-Jin Kim; Sung Ran Hong; Jae Kwan Lee; Chi-Heum Cho; Ki Seok Park; Jung Won Woo; Young Chul Sung; You Suk Suh; Jong Sup Park
Precision Medicine and Imaging
Author Choice
TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
Ezra Y. Rosen; Debra A. Goldman; Jaclyn F. Hechtman; Ryma Benayed; Alison M. Schram; Emiliano Cocco; Sophie Shifman; Yixiao Gong; Ritika Kundra; James P. Solomon; Alberto Bardelli; Maurizio Scaltriti; Alexander Drilon; Alexia Iasonos; Barry S. Taylor; David M. Hyman
Translational Cancer Mechanisms and Therapy
PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors
Minsuk Kwon; Chang Gon Kim; Hoyoung Lee; Hyunsoo Cho; Youngun Kim; Eung Chang Lee; Seong Jin Choi; Junsik Park; In-Ho Seo; Bjarne Bogen; Ik-Chan Song; Deog-Yeon Jo; Jin Seok Kim; Su-Hyung Park; Inhak Choi; Yoon Seok Choi; Eui-Cheol Shin
Analysis of Released Circulating Tumor Cells During Surgery for Non-Small Cell Lung Cancer
Menno Tamminga; Sanne de Wit; Caroline van de Wauwer; Hilda van den Bos; Joost F. Swennenhuis; Theo J. Klinkenberg; T. Jeroen N. Hiltermann; Kiki C. Andree; Diana C.J. Spierings; Peter M. Lansdorp; Anke van den Berg; Wim Timens; Leon W.M.M. Terstappen; Harry J.M. Groen
Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer
Alexandra N. Corella; Ma Victoria Andrea Cabiliza Ordonio; Ilsa Coleman; Jared M. Lucas; Arja Kaipainen; Holly M. Nguyen; Daniel Sondheim; Lisha G. Brown; Lawrence D. True; John K. Lee; David MacPherson; Paul Nghiem; Roman Gulati; Colm Morrissey; Eva Corey; Peter S. Nelson
Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer
Mannan Nouri; Shabnam Massah; Josselin Caradec; Amy A. Lubik; Na Li; Sarah Truong; Ahn R. Lee; Ladan Fazli; Varune R. Ramnarine; Jessica M. Lovnicki; Jackson Moore; Mike Wang; Jane Foo; Martin E. Gleave; Brett G. Hollier; Colleen Nelson; Colin Collins; Xuesen Dong; Ralph Buttyan
Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Elizabeth A. Lemm; Beatriz Valle-Argos; Lindsay D. Smith; Johanna Richter; Yohannes Gebreselassie; Matthew J. Carter; Jana Karolova; Michael Svaton; Karel Helman; Nicola J. Weston-Bell; Laura Karydis; Chris T. Williamson; Georg Lenz; Jeremy Pettigrew; Curtis Harwig; Freda K. Stevenson; Mark Cragg; Francesco Forconi; Andrew J. Steele; Jennifer Cross; Lloyd Mackenzie; Pavel Klener; Graham Packham
Author Choice
A Th1/IFNγ Gene Signature Is Prognostic in the Adjuvant Setting of Resectable High-Risk Melanoma but Not in Non–Small Cell Lung Cancer
Benjamin Dizier; Andrea Callegaro; Muriel Debois; Brigitte Dreno; Peter Hersey; Helen J. Gogas; John M. Kirkwood; Johan F. Vansteenkiste; Lecia V. Sequist; Djordje Atanackovic; Jelle Goeman; Hans van Houwelingen; Susana Salceda; Fawn Wang; Patrick Therasse; Channa Debruyne; Bart Spiessens; Vincent G. Brichard; Jamila Louahed; Fernando Ulloa-Montoya
Author Choice
lncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP
Nan Li; Guohua Yang; Liyun Luo; Li Ling; Xiaorong Wang; Lejuan Shi; Junsong Lan; Xiaoting Jia; Qiong Zhang; Ze Long; Jinbao Liu; Weimin Hu; Zhimin He; Haiying Liu; Wanqing Liu; Guopei Zheng
Letters to the Editor
Editor’s Note
Retraction
Retraction: UM-164: A Potent c-Src/p38 Kinase Inhibitor with In Vivo Activity against Triple-Negative Breast Cancer
Rabia A. Gilani; Sameer Phadke; Li Wei Bao; Eric J. Lachacz; Michele L. Dziubinski; Kristoffer R. Brandvold; Michael E. Steffey; Frank E. Kwarcinski; Carrie R. Graveel; Kelley M. Kidwell; Sofia D. Merajver; Matthew B. Soellner
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