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1 March 2020
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The cover shows a trans-iliac bone marrow biopsy of a patient with hormone-naïve metastatic prostate cancer. The hematoxylin and eosin stained section reveals bony trabecula lined by osteoblasts and foci of prostatic adenocarcinoma in an edematous stromal background, lacking hematopoiesis. For details, see the article by Corn and colleagues on page 990 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Clinical Trials: Targeted Therapy
A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer
Paul G. Corn; Miao Zhang; Graciela M. Nogueras-Gonzalez; Lianchun Xiao; Amado J. Zurita; Sumit K. Subudhi; Shi-Ming Tu; Ana M. Aparicio; Cristian Coarfa; Kimal Rajapakshe; Shixia Huang; Nora M. Navone; Sue-Hwa Lin; Guocan Wang; Sumankalai Ramachandran; Mark A. Titus; Theocharis Panaretakis; Gary E. Gallick; Eleni Efstathiou; Patricia Troncoso; Christopher Logothetis
Romidepsin Plus Liposomal Doxorubicin Is Safe and Effective in Patients with Relapsed or Refractory T-Cell Lymphoma: Results of a Phase I Dose-Escalation Study
Khoan Vu; Chi-Heng Wu; Chen-Yen Yang; Aaron Zhan; Erika Cavallone; Wade Berry; Pamela Heeter; Laura Pincus; Matthew J. Wieduwilt; Basem M. William; Charalambos Andreadis; Lawrence K. Kaplan; Frank McCormick; Pierluigi Porcu; Jonathan E. Brammer; Weiyun Z. Ai
A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer
Amit M. Oza; Ursula A. Matulonis; Angeles Alvarez Secord; John Nemunaitis; Lynda D. Roman; Sarah P. Blagden; Susana Banerjee; William P. McGuire; Sharad Ghamande; Michael J. Birrer; Gini F. Fleming; Merry Jennifer Markham; Hal W. Hirte; Diane M. Provencher; Bristi Basu; Rebecca Kristeleit; Deborah K. Armstrong; Benjamin Schwartz; Patricia Braly; Geoff D. Hall; Kenneth P. Nephew; Simone Jueliger; Aram Oganesian; Sue Naim; Yong Hao; Harold Keer; Mohammad Azab; Daniela Matei
Author Choice
Capecitabine and Temozolomide versus FOLFIRI in RAS-Mutated, MGMT-Methylated Metastatic Colorectal Cancer
Filippo Pietrantonio; Riccardo Lobefaro; Maria Antista; Sara Lonardi; Alessandra Raimondi; Federica Morano; Stefania Mosconi; Lorenza Rimassa; Sabina Murgioni; Andrea Sartore-Bianchi; Gianluca Tomasello; Raffaella Longarini; Gabriella Farina; Fausto Petrelli; Stefania Gori; Giovanni Randon; Salvatore Corallo; Filippo Pagani; Vincenzo Guarini; Federica Palermo; Antonia Martinetti; Marco Macagno; Ludovic Barault; Federica Perrone; Elena Tamborini; Massimo Milione; Federica Di Nicolantonio; Massimo Di Maio; Giovanni Fucà; Maria Di Bartolomeo; Filippo de Braud
Clinical Trials: Immunotherapy
Author Choice
First-In-Human Study of Cemiplimab Alone or In Combination with Radiotherapy and/or Low-dose Cyclophosphamide in Patients with Advanced Malignancies
Kyriakos P. Papadopoulos; Melissa L. Johnson; Albert C. Lockhart; Kathleen Moore; Gerald S. Falchook; Silvia C. Formenti; Aung Naing; Richard D. Carvajal; Lee S. Rosen; Glen J. Weiss; Rom S. Leidner; Jingjin Li; Anne Paccaly; Minjie Feng; Elizabeth Stankevich; Israel Lowy; Matthew G. Fury; Marka R. Crittenden
Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma
Robert Chen; Alex F. Herrera; Jessie Hou; Lu Chen; Jun Wu; Yuming Guo; Timothy W. Synold; Vu N. Ngo; Sandrine Puverel; Matthew Mei; Leslie Popplewell; Shuhua Yi; Joo Y. Song; Shu Tao; Xiwei Wu; Wing C. Chan; Stephen J. Forman; Larry W. Kwak; Steven T. Rosen; Edward M. Newman
Rapid Generation of Sustainable HER2-specific T-cell Immunity in Patients with HER2 Breast Cancer using a Degenerate HLA Class II Epitope Vaccine
Keith L. Knutson; Matthew S. Block; Nadine Norton; Courtney L. Erskine; Timothy J. Hobday; Allan B. Dietz; Douglas Padley; Michael P. Gustafson; Danell Puglisi-Knutson; Toni Kay Mangskau; Saranya Chumsri; Amylou C. Dueck; Lavakumar Karyampudi; Glynn Wilson; Amy C. Degnim
Precision Medicine and Imaging
Author Choice
The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response
Henry C.-H. Law; Dragana Lagundžin; Emalie J. Clement; Fangfang Qiao; Zachary S. Wagner; Kimiko L. Krieger; Diane Costanzo-Garvey; Thomas C. Caffrey; Jean L. Grem; Dominick J. DiMaio; Paul M. Grandgenett; Leah M. Cook; Kurt W. Fisher; Fang Yu; Michael A. Hollingsworth; Nicholas T. Woods
Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer
Jashodeep Datta; J. Joshua Smith; Walid K. Chatila; John C. McAuliffe; Cyriac Kandoth; Efsevia Vakiani; Timothy L. Frankel; Karuna Ganesh; Isaac Wasserman; Marla Lipsyc-Sharf; Jose Guillem; Garrett M. Nash; Philip B. Paty; Martin R. Weiser; Leonard B. Saltz; Michael F. Berger; William R. Jarnagin; Vinod Balachandran; T. Peter Kingham; Nancy E. Kemeny; Andrea Cercek; Julio Garcia-Aguilar; Barry S. Taylor; Agnes Viale; Rona Yaeger; David B. Solit; Nikolaus Schultz; Michael I. D'Angelica
Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer
Emma H. Allott; Ericka M. Ebot; Konrad H. Stopsack; Amparo G. Gonzalez-Feliciano; Sarah C. Markt; Kathryn M. Wilson; Thomas U. Ahearn; Travis A. Gerke; Mary K. Downer; Jennifer R. Rider; Stephen J. Freedland; Tamara L. Lotan; Philip W. Kantoff; Elizabeth A. Platz; Massimo Loda; Meir J. Stampfer; Edward Giovannucci; Christopher J. Sweeney; Stephen P. Finn; Lorelei A. Mucci
Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma
Rachael A. Vaubel; Shulan Tian; Dioval Remonde; Mark A. Schroeder; Ann C. Mladek; Gaspar J. Kitange; Alissa Caron; Thomas M. Kollmeyer; Rebecca Grove; Sen Peng; Brett L. Carlson; Daniel J. Ma; Gobinda Sarkar; Lisa Evers; Paul A. Decker; Huihuang Yan; Harshil D. Dhruv; Michael E. Berens; Qianghu Wang; Bianca M. Marin; Eric W. Klee; Andrea Califano; Daniel H. LaChance; Jeanette E. Eckel-Passow; Roel G. Verhaak; Erik P. Sulman; Terry C. Burns; Fredrick B. Meyer; Brian P. O'Neill; Nhan L. Tran; Caterina Giannini; Robert B. Jenkins; Ian F. Parney; Jann N. Sarkaria
Author Choice
Baseline Characteristics, Treatment Patterns, and Outcomes in Patients with HER2-Positive Metastatic Breast Cancer by Hormone Receptor Status from SystHERs
Melody Cobleigh; Denise A. Yardley; Adam M. Brufsky; Hope S. Rugo; Sandra M. Swain; Peter A. Kaufman; Debu Tripathy; Sara A. Hurvitz; Joyce O'Shaughnessy; Ginny Mason; Vincent Antao; Haocheng Li; Laura Chu; Mohammad Jahanzeb
Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer
Elie Ritch; Simon Y.F. Fu; Cameron Herberts; Gang Wang; Evan W. Warner; Elena Schönlau; Sinja Taavitsainen; Andrew J. Murtha; Gillian Vandekerkhove; Kevin Beja; Yulia Loktionova; Daniel Khalaf; Ladan Fazli; Igal Kushnir; Cristiano Ferrario; Sebastien Hotte; Matti Annala; Kim N. Chi; Alexander W. Wyatt
Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death
Prathamesh M. Kulkarni; Eric J. Robinson; Jaya Sarin Pradhan; Robyn D. Gartrell-Corrado; Bethany R. Rohr; Megan H. Trager; Larisa J. Geskin; Harriet M. Kluger; Pok Fai Wong; Balazs Acs; Emanuelle M. Rizk; Chen Yang; Manas Mondal; Michael R. Moore; Iman Osman; Robert Phelps; Basil A. Horst; Zhe S. Chen; Tammie Ferringer; David L. Rimm; Jing Wang; Yvonne M. Saenger
Translational Cancer Mechanisms and Therapy
Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease
Hanna R. Kemeny; Aladine A. Elsamadicy; S. Harrison Farber; Cosette D. Champion; Selena J. Lorrey; Pakawat Chongsathidkiet; Karolina I. Woroniecka; Xiuyu Cui; Steven H. Shen; Kristen E. Rhodin; Vadim Tsvankin; Jeffrey Everitt; Luis Sanchez-Perez; Patrick Healy; Roger E. McLendon; Patrick J. Codd; Ian F. Dunn; Peter E. Fecci
High-Intensity Focused Ultrasound (HIFU) Triggers Immune Sensitization of Refractory Murine Neuroblastoma to Checkpoint Inhibitor Therapy
Avinash Eranki; Priya Srinivasan; Mario Ries; AeRang Kim; Christopher A. Lazarski; Christopher T. Rossi; Tatiana D. Khokhlova; Emmanuel Wilson; Susan M. Knoblach; Karun V. Sharma; Bradford J. Wood; Chrit Moonen; Anthony D. Sandler; Peter C.W. Kim
Organoid Cultures as Preclinical Models of Non–Small Cell Lung Cancer
Ruoshi Shi; Nikolina Radulovich; Christine Ng; Ni Liu; Hirotsugu Notsuda; Michael Cabanero; Sebastiao N. Martins-Filho; Vibha Raghavan; Quan Li; Arvind Singh Mer; Joshua C. Rosen; Ming Li; Yu-Hui Wang; Laura Tamblyn; Nhu-An Pham; Benjamin Haibe-Kains; Geoffrey Liu; Nadeem Moghal; Ming-Sound Tsao
Letter to the Editor
Correction
Correction: Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas
Roberta Frapolli; Ezia Bello; Marianna Ponzo; Ilaria Craparotta; Laura Mannarino; Sara Ballabio; Sergio Marchini; Laura Carrassa; Paolo Ubezio; Luca Porcu; Silvia Brich; Roberta Sanfilippo; Paolo Giovanni Casali; Alessandro Gronchi; Silvana Pilotti; Maurizio D'Incalci
Editor’s Note
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