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15 February 2020
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Cover Image
Cover Image
The cover shows a section of a colonic neuroendocrine carcinoma marked with synaptophysin. The immunohistochemical staining shows strong cytoplasmic positivity with typical granular pattern. For details, see the article by Capdevila and colleagues on page 902 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Clinical Trials: Targeted Therapy
HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma
Kevin D. Courtney; Yuanqing Ma; Alberto Diaz de Leon; Alana Christie; Zhiqun Xie; Layton Woolford; Nirmish Singla; Allison Joyce; Haley Hill; Ananth J. Madhuranthakam; Qing Yuan; Yin Xi; Yue Zhang; Jenny Chang; Oluwatomilade Fatunde; Yull Arriaga; Arthur E. Frankel; Sanjeeva Kalva; Song Zhang; Tiffani McKenzie; Oscar Reig Torras; Robert A. Figlin; Brian I. Rini; Renée M. McKay; Payal Kapur; Tao Wang; Ivan Pedrosa; James Brugarolas
Randomized Phase II Trial and Tumor Mutational Spectrum Analysis from Cabozantinib versus Chemotherapy in Metastatic Uveal Melanoma (Alliance A091201)
Jason J. Luke; Daniel J. Olson; Jacob B. Allred; Carrie A. Strand; Riyue Bao; Yuanyuan Zha; Timothy Carll; Brian W. Labadie; Bruno R. Bastos; Marcus O. Butler; David Hogg; Pamela N. Munster; Gary K. Schwartz
Author Choice
Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome–Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia
Nobuko Hijiya; C. Michel Zwaan; Carmelo Rizzari; Robin Foà; Floor Abbink; Donna Lancaster; Judith Landman-Parker; Frédéric Millot; John Moppett; Brigitte Nelken; Maria Caterina Putti; Xianbin Tian; Karen Sinclair; Helene Santanastasio; Aby Buchbinder; Pamela Kearns
TBCRC023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 versus 24 Weeks in Patients with HER2-Positive Breast Cancer
Mothaffar F. Rimawi; Polly Niravath; Tao Wang; Brent N. Rexer; Andres Forero; Antonio C. Wolff; Rita Nanda; Anna M. Storniolo; Ian Krop; Matthew P. Goetz; Julie R. Nangia; Sao Jiralerspong; Anne Pavlick; Jamunarani Veeraraghavan; Carmine De Angelis; Carolina Gutierrez; Rachel Schiff; Susan G. Hilsenbeck; C. Kent Osborne; on behalf of the Translational Breast Cancer Research Consortium
Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma
Christine Alewine; Mehwish Ahmad; Cody J. Peer; Zishuo I. Hu; Min-Jung Lee; Akira Yuno; Jessica D. Kindrick; Anish Thomas; Seth M. Steinberg; Jane B. Trepel; William D. Figg; Raffit Hassan; Ira Pastan
Clinical Trials: Immunotherapy
A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer
Cristina P. Rodriguez; Qian (Vicky) Wu; Jenna Voutsinas; Jonathan R. Fromm; Xiuyun Jiang; Venu G. Pillarisetty; Sylvia M. Lee; Rafael Santana-Davila; Bernardo Goulart; Christina S. Baik; Laura Q.M. Chow; Keith Eaton; Renato Martins
Author Choice
Safety and Efficacy of Durvalumab and Tremelimumab Alone or in Combination in Patients with Advanced Gastric and Gastroesophageal Junction Adenocarcinoma
Ronan J. Kelly; Jeeyun Lee; Yung-Jue Bang; Khaldoun Almhanna; Mariela Blum-Murphy; Daniel V.T. Catenacci; Hyun Cheol Chung; Zev A. Wainberg; Michael K. Gibson; Keun-Wook Lee; Johanna C. Bendell; Crystal S. Denlinger; Cheng Ean Chee; Takeshi Omori; Rom Leidner; Heinz-Josef Lenz; Yee Chao; Marlon C. Rebelatto; Philip Z. Brohawn; Peng He; Jennifer McDevitt; Siddharth Sheth; Judson M. Englert; Geoffrey Y. Ku
Precision Medicine and Imaging
The Nanocind Signature Is an Independent Prognosticator of Recurrence and Death in Uterine Leiomyosarcomas
Sabrina Croce; Tom Lesluyes; Carine Valle; Loubna M'Hamdi; Noémie Thébault; Gaëlle Pérot; Eberhard Stoeckle; Jean-Christophe Noël; Quitterie Fontanges; Mojgan Devouassoux-Shisheboran; Denis Querleu; Frédéric Guyon; Anne Floquet; Camille Chakiba; Laetitia Mayeur; Flora Rebier; Gaëtan Marie MacGrogan; Isabelle Soubeyran; Sophie Le Guellec; Frédéric Chibon
Imaging Phenotypes of Breast Cancer Heterogeneity in Preoperative Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) Scans Predict 10-Year Recurrence
Rhea D. Chitalia; Jennifer Rowland; Elizabeth S. McDonald; Lauren Pantalone; Eric A. Cohen; Aimilia Gastounioti; Michael Feldman; Mitchell Schnall; Emily Conant; Despina Kontos
Whole-Slide Image Analysis Reveals Quantitative Landscape of Tumor–Immune Microenvironment in Colorectal Cancers
Seung-Yeon Yoo; Hye Eun Park; Jung Ho Kim; Xianyu Wen; Seorin Jeong; Nam-Yun Cho; Hwang Gwan Gwon; Kwangsoo Kim; Hye Seung Lee; Seung-Yong Jeong; Kyu Joo Park; Sae-Won Han; Tae-You Kim; Jeong Mo Bae; Gyeong Hoon Kang
Adaptive Immune Resistance to Intravesical BCG in Non–Muscle Invasive Bladder Cancer: Implications for Prospective BCG-Unresponsive Trials
Max Kates; Andres Matoso; Woonyoung Choi; Alexander S. Baras; Marcus J. Daniels; Kara Lombardo; Aaron Brant; Nina Mikkilineni; David J. McConkey; Ashish M. Kamat; Robert S. Svatek; Sima P. Porten; Joshua J. Meeks; Seth P. Lerner; Colin P. Dinney; Peter C. Black; James M. McKiernan; Chris Anderson; Charles G. Drake; Trinity J. Bivalacqua
The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma
Minglei Zhuo; Yanfang Guan; Xue Yang; Lingzhi Hong; Yuqi Wang; Zhongwu Li; Runzhe Chen; Hussein A. Abbas; Lianpeng Chang; Yuhua Gong; Nan Wu; Jia Zhong; Wenting Chen; Hanxiao Chen; Zhi Dong; Xiang Zhu; Jianjie Li; Yuyan Wang; Tongtong An; Meina Wu; Ziping Wang; Jiayin Wang; Emily B. Roarty; Waree Rinsurongkawong; Jeff Lewis; Jack A. Roth; Stephen G. Swisher; J. Jack Lee; John V. Heymach; Ignacio I. Wistuba; Neda Kalhor; Ling Yang; Xin Yi; P. Andrew Futreal; Bonnie S. Glisson; Xuefeng Xia; Jianjun Zhang; Jun Zhao
Translational Cancer Mechanisms and Therapy
Author Choice
Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas
Jaume Capdevila; Oriol Arqués; Jose Ramón Hernández Mora; Judit Matito; Ginevra Caratù; Francesco M. Mancuso; Stefania Landolfi; Jorge Barriuso; Paula Jimenez-Fonseca; Carlos Lopez Lopez; Rocio Garcia-Carbonero; Jorge Hernando; Ignacio Matos; Nuciforo Paolo; Javier Hernández-Losa; Manel Esteller; Anna Martínez-Cardús; Josep Tabernero; Ana Vivancos; Héctor G. Palmer
Author Choice
AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells
Justin Cidado; Scott Boiko; Theresa Proia; Douglas Ferguson; Steven W. Criscione; Maryann San Martin; Petar Pop-Damkov; Nancy Su; Valar Nila Roamio Franklin; Chandra Sekhar Reddy Chilamakuri; Clive S. D'Santos; Wenlin Shao; Jamal C. Saeh; Raphael Koch; David M. Weinstock; Michael Zinda; Stephen E. Fawell; Lisa Drew
A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors
Mari C. Vázquez-Borrego; Vandana Gupta; Alejandro Ibáñez-Costa; Manuel D. Gahete; Eva Venegas-Moreno; Álvaro Toledano-Delgado; David A. Cano; Cristóbal Blanco-Acevedo; Rosa Ortega-Salas; Miguel A. Japón; Ana Barrera-Martín; Alexandre Vasiljevic; Jason Hill; Shengwen Zhang; Heather Halem; Juan Solivera; Gérald Raverot; María A. Gálvez; Alfonso Soto-Moreno; Marcelo Paez-Pereda; Michael D. Culler; Justo P. Castaño; Raúl M. Luque
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