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15 December 2020
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The cover shows a section of a primary tumor from a Luminal B early-stage breast cancer patient with a high Tumor Inflammation Signature (TIS) score. Immunohistochemical staining shows strong stromal lymphocyte infiltration at several sites. For details, see the article by Schroth and colleagues on page 6523 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Regulatory Considerations for Contribution of Effect of Drugs Used in Combination Regimens: Renal Cell Cancer Case Studies
Jamie R. Brewer; Elaine Chang; Sundeep Agrawal; Harpreet Singh; Daniel L. Suzman; James Xu; Chana Weinstock; Laura L. Fernandes; Joyce Cheng; Lijun Zhang; Diqiong Xie; Kirsten B. Goldberg; Erik W. Bloomquist; Shenghui Tang; Rajeshwari Sridhara; Marc R. Theoret; Richard Pazdur; Amna Ibrahim; Julia A. Beaver
Project Orbis: Global Collaborative Review Program
R. Angelo de Claro; Dianne Spillman; Lauren Tesh Hotaki; Michael Shum; Laila Sofia Mouawad; Gustavo Mendes Lima Santos; Kelly Robinson; Melissa Hunt; Caroline Healy; Agnes Chan; Yee Hoo Looi; Clare Rodrigues; Ulrich-Peter Rohr; Chantal Walther; Richard Pazdur
Clinical Trials: Targeted Therapy
Phase Ib Dose-escalation/Expansion Trial of Ribociclib in Combination With Everolimus and Exemestane in Postmenopausal Women with HR+, HER2− Advanced Breast Cancer
Aditya Bardia; Shanu Modi; Mafalda Oliveira; Javier Cortes; Mario Campone; Brigette Ma; Luc Dirix; Amy Weise; Becker Hewes; Ivan Diaz-Padilla; Yu Han; Priya Deshpande; Tanay S. Samant; Karen Rodriguez Lorenc; Wei He; Fei Su; Mariana Chavez-MacGregor
Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Christophe Le Tourneau; Yungan Tao; Carlos Gomez-Roca; Valerie Cristina; Edith Borcoman; Eric Deutsch; Rastislav Bahleda; Valentin Calugaru; Anouchka Modesto; Elisabeth Rouits; Kathrin Gollmer; Gregoire Vuagniaux; Philippa Crompton; Claudio Zanna; Sergio Szyldergemajn; Jean-Pierre Delord; Jean Bourhis
Clinical Trials: Immunotherapy
Improved Survival Associated with Local Tumor Response Following Multisite Radiotherapy and Pembrolizumab: Secondary Analysis of a Phase I Trial
Jason J. Luke; Benjamin E. Onderdonk; Sandeep R. Bhave; Theodore Karrison; Jeffrey M. Lemons; Paul Chang; Yuanyuan Zha; Tim Carll; Thomas Krausz; Lei Huang; Carlos Martinez; Linda A. Janisch; Robyn D. Hseu; John W. Moroney; Jyoti D. Patel; Nikolai N. Khodarev; Joseph K. Salama; Patrick A. Ott; Gini F. Fleming; Thomas F. Gajewski; Ralph R. Weichselbaum; Sean P. Pitroda; Steven J. Chmura
Author Choice
Activity and Safety of Geptanolimab (GB226) for Patients with Unresectable, Recurrent, or Metastatic Alveolar Soft Part Sarcoma: A Phase II, Single-arm Study
Yuankai Shi; Qiqing Cai; Yu Jiang; Gang Huang; Minghong Bi; Baocheng Wang; Yuhong Zhou; Guowen Wang; Hongyan Ying; Zhiwei Tao; Chunmei Shi; Qian Guo; Chao Gao
Precision Medicine and Imaging
Author Choice
Spatial and Temporal Heterogeneity of PD-L1 Expression and Tumor Mutational Burden in Gastroesophageal Adenocarcinoma at Baseline Diagnosis and after Chemotherapy
Katherine I. Zhou; Bryan Peterson; Anthony Serritella; Joseph Thomas; Natalie Reizine; Stephanie Moya; Carol Tan; Yan Wang; Daniel V.T. Catenacci
Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation
Michael L. Maitland; Julia Wilkerson; Sanja Karovic; Binsheng Zhao; Jessica Flynn; Mengxi Zhou; Patrick Hilden; Firas S. Ahmed; Laurent Dercle; Chaya S. Moskowitz; Ying Tang; Dana E. Connors; Stacey J. Adam; Gary Kelloff; Mithat Gonen; Tito Fojo; Lawrence H. Schwartz; Geoffrey R. Oxnard
Evaluation of Trends and Prognosis Over Time in Patients with AML Relapsing After Allogeneic Hematopoietic Cell Transplant Reveals Improved Survival for Young Patients in Recent Years
Ali Bazarbachi; Christoph Schmid; Myriam Labopin; Dietrich Beelen; Igor Wolfgang Blau; Victoria Potter; Riitta Niittyvuopio; Gerard Socié; Didier Blaise; Jaime Sanz; Fabio Ciceri; Iman Abou Dalle; Alexandros Spyridonidis; Gesine Bug; Jordi Esteve; Bipin N. Savani; Arnon Nagler; Mohamad Mohty
Effects of Acute and Chronic Graft-versus-myelodysplastic Syndrome on Long-term Outcomes Following Allogeneic Hematopoietic Cell Transplantation
Takaaki Konuma; Ken Ishiyama; Aiko Igarashi; Naoyuki Uchida; Yukiyasu Ozawa; Takahiro Fukuda; Yasunori Ueda; Ken-ichi Matsuoka; Takehiko Mori; Yuta Katayama; Makoto Onizuka; Tatsuo Ichinohe; Yoshiko Atsuta; for the Adult Myelodysplastic Syndrome Working Group of the Japan Society for Hematopoietic Cell Transplantation
Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma
Siddhartha Yadav; Pashtoon M. Kasi; William R. Bamlet; Thanh P. Ho; Eric C. Polley; Chunling Hu; Steven N. Hart; Kari G. Rabe; Nicholas J. Boddicker; Rohan D. Gnanaolivu; Kun Y. Lee; Tricia H. Lindstrom; Gloria M. Petersen; Fergus J. Couch; Robert R. McWilliams
Development and Validation of a Next-Generation Sequencing–Based Multigene Assay to Predict the Prognosis of Estrogen Receptor–Positive, HER2-Negative Breast Cancer
Han-Byoel Lee; Sae Byul Lee; Minsu Kim; Sunyoung Kwon; Jeonghee Jo; Jinkyoung Kim; Hee Jin Lee; Han-Suk Ryu; Jong Won Lee; Chungyeul Kim; Jaehwan Jeong; Hyoki Kim; Dong-Young Noh; In-Ae Park; Sei-Hyun Ahn; Sun Kim; Sungroh Yoon; Aeree Kim; Wonshik Han
Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor–Positive Breast Cancer Patients
Werner Schroth; Florian A. Büttner; Siarhei Kandabarau; Reiner Hoppe; Peter Fritz; Jörg Kumbrink; Thomas Kirchner; Heather A. Brauer; Yuqi Ren; David Henderson; Stephen F. Madden; Georg Sauer; Tanja Fehm; Diethelm Wallwiener; Peter A. Fasching; Thomas Mürdter; Matthias Schwab; Hiltrud Brauch; for The German Tamoxifen and AI Clinicians Group
Translational Cancer Mechanisms and Therapy
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
Srividya B. Balachander; Steven W. Criscione; Kate F. Byth; Justin Cidado; Ammar Adam; Paula Lewis; Terry Macintyre; Shenghua Wen; Deborah Lawson; Kathleen Burke; Tristan Lubinski; Jeffrey W. Tyner; Stephen E. Kurtz; Shannon K. McWeeney; Jeffrey Varnes; R. Bruce Diebold; Thomas Gero; Stephanos Ioannidis; Edward J. Hennessy; William McCoull; Jamal C. Saeh; Areya Tabatabai; Omid Tavana; Nancy Su; Alwin Schuller; Mathew J. Garnett; Patricia Jaaks; Elizabeth A. Coker; Gareth P. Gregory; Andrea Newbold; Ricky W. Johnstone; Eric Gangl; Martin Wild; Michael Zinda; J. Paul Secrist; Barry R. Davies; Stephen E. Fawell; Francis D. Gibbons
Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors
Matthew R. Trendowski; Heather E. Wheeler; Omar El-Charif; Darren R. Feldman; Robert J. Hamilton; David J. Vaughn; Chunkit Fung; Christian Kollmannsberger; Lawrence H. Einhorn; Lois B. Travis; M. Eileen Dolan
Amphiregulin Expression Is a Predictive Biomarker for EGFR Inhibition in Metastatic Colorectal Cancer: Combined Analysis of Three Randomized Trials
Arndt Stahler; Sebastian Stintzing; Dominik P. Modest; Ingrid Ricard; Clemens Giessen-Jung; Christine Kapaun; Boryana Ivanova; Florian Kaiser; Ludwig Fischer von Weikersthal; Nicolas Moosmann; Andreas Schalhorn; Martina Stauch; Alexander Kiani; Swantje Held; Thomas Decker; Markus Moehler; Jens Neumann; Thomas Kirchner; Andreas Jung; Volker Heinemann
Short-term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor–Positive Breast Cancers
Andrea M. Pesch; Nicole H. Hirsh; Benjamin C. Chandler; Anna R. Michmerhuizen; Cassandra L. Ritter; Marlie P. Androsiglio; Kari Wilder-Romans; Meilan Liu; Christina L. Gersch; José M. Larios; Lori J. Pierce; James M. Rae; Corey W. Speers
Implications of MYC Rearrangements in Newly Diagnosed Multiple Myeloma
Nadine Abdallah; Linda B. Baughn; S. Vincent Rajkumar; Prashant Kapoor; Morie A. Gertz; Angela Dispenzieri; Martha Q. Lacy; Suzanne R. Hayman; Francis K. Buadi; David Dingli; Ronald S. Go; Yi L. Hwa; Amie Fonder; Miriam Hobbs; Yi Lin; Nelson Leung; Taxiarchis Kourelis; Rahma Warsame; Mustaqeem Siddiqui; John Lust; Robert A. Kyle; Rhett Ketterling; Leif Bergsagel; Patricia Greipp; Shaji K. Kumar
Preclinical Activity of SAR408701: A Novel Anti-CEACAM5–maytansinoid Antibody–drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors
Stéphanie Decary; Pierre-François Berne; Céline Nicolazzi; Anne-Marie Lefebvre; Tarik Dabdoubi; Béatrice Cameron; Pierrick Rival; Catherine Devaud; Catherine Prades; Hervé Bouchard; Alhassan Cassé; Christophe Henry; Céline Amara; Claire Brillac; Paul Ferrari; Laetitia Maçon; Eric Lacoste; Cecile Combeau; Eric Beys; Souad Naimi; Carlos García-Echeverría; Jean-François Mayaux; Véronique Blanc
Glioblastoma TCGA Mesenchymal and IGS 23 Tumors are Identifiable by IHC and have an Immune-phenotype Indicating a Potential Benefit from Immunotherapy
Cristina Carrato; Francesc Alameda; Anna Esteve-Codina; Estela Pineda; Oriol Arpí; Maria Martinez-García; Mar Mallo; Marta Gut; Raquel Lopez-Martos; Sonia Del Barco; Teresa Ribalta; Jaume Capellades; Josep Puig; Oscar Gallego; Carlos Mesia; Ana M Muñoz-Marmol; Ivan Archilla; Montserrat Arumí; Julie Marie Blanc; Beatriz Bellosillo; Silvia Menendez; Anna Esteve; Silvia Bagué; Ainhoa Hernandez; Jordi Craven-Bartle; Rafael Fuentes; Noemí Vidal; Iban Aldecoa; Nuria de la Iglesia; Carmen Balana
Correction
Correction: The First-week Proliferative Response of Peripheral Blood PD-1+CD8+ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid Tumors
Kyung Hwan Kim; Jinhyun Cho; Bo Mi Ku; Jiae Koh; Jong-Mu Sun; Se-Hoon Lee; Jin Seok Ahn; Jaekyung Cheon; Young Joo Min; Su-Hyung Park; Keunchil Park; Myung-Ju Ahn; Eui-Cheol Shin
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