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1 December 2020
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Cover Image
Cover Image
The image shows EGFR (pink) and DAPI (nuclei in blue) of EGFR-expressing A431 xenografts obtained from mice administered with lovastatin. Lovastatin enhances temporary EGFR availability at the cell membrane of tumor cells. For details, see the article by Pereira and colleagues on page 6215 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I–Related Plexiform Neurofibromas
Lauren H. Boal; John Glod; Melissa Spencer; Miki Kasai; Joanne Derdak; Eva Dombi; Mark Ahlman; Daniel W. Beury; Melinda S. Merchant; Christianne Persenaire; David J. Liewehr; Seth M. Steinberg; Brigitte C. Widemann; Rosandra N. Kaplan
Dual Blockade of c-MET and the Androgen Receptor in Metastatic Castration-resistant Prostate Cancer: A Phase I Study of Concurrent Enzalutamide and Crizotinib
Abhishek Tripathi; Jeffrey G. Supko; Kathryn P. Gray; Zachary J. Melnick; Meredith M. Regan; Mary-Ellen Taplin; Atish D. Choudhury; Mark M. Pomerantz; Joaquim Bellmunt; Channing Yu; Zijie Sun; Sandy Srinivas; Philip W. Kantoff; Christopher J. Sweeney; Lauren C. Harshman
Author Choice
A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia
Amer M. Zeidan; Maya Ridinger; Tara L. Lin; Pamela S. Becker; Gary J. Schiller; Prapti A. Patel; Alexander I. Spira; Michaela L. Tsai; Errin Samuëlsz; Sandra L. Silberman; Mark Erlander; Eunice S. Wang
A Prognostic Model Based on PAM50 and Clinical Variables (PAM50MET) for Metastatic Hormone Receptor–positive HER2-negative Breast Cancer
Aleix Prat; Yi-Hsuan Tsai; Tomás Pascual; Laia Paré; Barbara Adamo; Maria Vidal; Fara Brasó-Maristany; Patricia Galván; Jan Christoph Brase; Vanessa Rodrik-Outmezguine; Stephen Johnston; Eva Ciruelos; Joel S. Parker
Author Choice
A Randomized Placebo Controlled Phase II Trial Evaluating Exemestane with or without Enzalutamide in Patients with Hormone Receptor–Positive Breast Cancer
Ian Krop; Vandana Abramson; Marco Colleoni; Tiffany Traina; Frankie Holmes; Laura Garcia-Estevez; Lowell Hart; Ahmad Awada; Claudio Zamagni; Patrick G. Morris; Lee Schwartzberg; Stephen Chan; Ayca Gucalp; Laura Biganzoli; Joyce Steinberg; Lorenzo Sica; Maureen Trudeau; Denka Markova; Jamal Tarazi; Zhou Zhu; Thomas O'Brien; Catherine M. Kelly; Eric Winer; Denise A. Yardley
Author Choice
Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer
Lipika Goyal; Cynthia Sirard; Michael Schrag; Michael H. Kagey; Jennifer R. Eads; Stacey Stein; Anthony B. El-Khoueiry; Gulam A. Manji; Thomas A. Abrams; Alok A. Khorana; Rebecca Miksad; Devalingam Mahalingam; Andrew X. Zhu; Dan G. Duda
Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M–positive Non–Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study
Ligang Xing; Yueyin Pan; Yuankai Shi; Yongqian Shu; Jifeng Feng; Wei Li; Lejie Cao; Lifeng Wang; Wei Gu; Yong Song; Puyuan Xing; Yutao Liu; Wen Gao; Jiuwei Cui; Nana Hu; Rutian Li; Hua Bao; Yang Shao; Jinming Yu
Clinical Trials: Immunotherapy
Molecular and Immunologic Signatures are Related to Clinical Benefit from Treatment with Vocimagene Amiretrorepvec (Toca 511) and 5-Fluorocytosine (Toca FC) in Patients with Glioma
William P. Accomando; Aliz R. Rao; Daniel J. Hogan; Aaron M. Newman; Aki Nakao; Ash A. Alizadeh; Maximilian Diehn; Oscar R. Diago; Dawn Gammon; Ali Haghighi; Harry E. Gruber; Douglas J. Jolly; Derek Ostertag
Early Intervention with Lenalidomide in Patients with High-risk Chronic Lymphocytic Leukemia
Shanmugapriya Thangavadivel; Qiuhong Zhao; Narendranath Epperla; Lindsey Rike; Xiaokui Mo; Mohamed Badawi; Darlene M. Bystry; Mitch A. Phelps; Leslie A. Andritsos; Kerry A. Rogers; Jeffrey Jones; Jennifer A. Woyach; John C. Byrd; Farrukh T. Awan
Author Choice
Safety and Clinical Activity of MEDI1873, a Novel GITR Agonist, in Advanced Solid Tumors
Ani S. Balmanoukian; Jeffrey R. Infante; Raid Aljumaily; Aung Naing; Ashish V. Chintakuntlawar; Naiyer A. Rizvi; Helen J. Ross; Michael Gordon; Philip R. Mallinder; Nairouz Elgeioushi; Ignacio González-García; Nathan Standifer; Jennifer Cann; Nicholas Durham; Shahram Rahimian; Rakesh Kumar; Crystal S. Denlinger
Precision Medicine and Imaging
Autoantibody Landscape in Patients with Advanced Prostate Cancer
William S. Chen; Winston A. Haynes; Rebecca Waitz; Kathy Kamath; Agustin Vega-Crespo; Raunak Shrestha; Minlu Zhang; Adam Foye; Ignacio Baselga Carretero; Ivan Perez Garcilazo; Meng Zhang; Shuang G. Zhao; Martin Sjöström; David A. Quigley; Jonathan Chou; Tomasz M. Beer; Matthew Rettig; Martin Gleave; Christopher P. Evans; Primo Lara; Kim N. Chi; Robert E. Reiter; Joshi J. Alumkal; Alan Ashworth; Rahul Aggarwal; Eric J. Small; Patrick S. Daugherty; Antoni Ribas; David Y. Oh; John C. Shon; Felix Y. Feng
Circulating Tumor DNA Genomics Reveal Potential Mechanisms of Resistance to BRAF-Targeted Therapies in Patients with BRAF-Mutant Metastatic Non–Small Cell Lung Cancer
Sandra Ortiz-Cuaran; Laura Mezquita; Aurélie Swalduz; Mihalea Aldea; Julien Mazieres; Camille Leonce; Cecile Jovelet; Anne Pradines; Virginie Avrillon; Washington R. Chumbi Flores; Ludovic Lacroix; Yohann Loriot; Virginie Westeel; Maud Ngo-Camus; Claire Tissot; Christine Raynaud; Radj Gervais; Etienne Brain; Isabelle Monnet; Etienne Giroux Leprieur; Caroline Caramella; Celine Mahier-Aït Oukhatar; Natalie Hoog-Labouret; Frank de Kievit; Karen Howarth; Clive Morris; Emma Green; Luc Friboulet; Sylvie Chabaud; Jean-François Guichou; Maurice Perol; Benjamin Besse; Jean-Yves Blay; Pierre Saintigny; David Planchard
Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer
François Richard; Samira Majjaj; David Venet; Françoise Rothé; Julien Pingitore; Bram Boeckx; Caterina Marchio; Florian Clatot; François Bertucci; Odette Mariani; Christine Galant; Gert van den Eynden; Roberto Salgado; Elia Biganzoli; Diether Lambrechts; Anne Vincent-Salomon; Giancarlo Pruneri; Denis Larsimont; Christos Sotiriou; Christine Desmedt
Electronic DNA Analysis of CSF Cell-free Tumor DNA to Quantify Multi-gene Molecular Response in Pediatric High-grade Glioma
Amy K. Bruzek; Karthik Ravi; Ashwath Muruganand; Jack Wadden; Clarissa May Babila; Evan Cantor; Leo Tunkle; Kyle Wierzbicki; Stefanie Stallard; Robert P. Dickson; Ian Wolfe; Rajen Mody; Jonathan Schwartz; Andrea Franson; Patricia L. Robertson; Karin M. Muraszko; Cormac O. Maher; Hugh J.L. Garton; Tingtin Qin; Carl Koschmann
Author Choice
Long-term Outcomes of Oral Vinorelbine in Advanced, Progressive Desmoid Fibromatosis and Influence of CTNNB1 Mutational Status
Olivier Mir; Charles Honoré; Ali N. Chamseddine; Julien Dômont; Sarah N. Dumont; Andrea Cavalcanti; Matthieu Faron; Françoise Rimareix; Leila Haddag-Miliani; Cécile Le Péchoux; Antonin Levy; Charles Court; Sylvain Briand; Elie Fadel; Olaf Mercier; Arnaud Bayle; Anaïs Brunet; Carine Ngo; Etienne Rouleau; Julien Adam; Axel Le Cesne
Translational Cancer Mechanisms and Therapy
Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment
Susannah L. Hewitt; Dyane Bailey; John Zielinski; Ameya Apte; Faith Musenge; Russell Karp; Shannon Burke; Fabien Garcon; Ankita Mishra; Sushma Gurumurthy; Amanda Watkins; Kristen Arnold; James Moynihan; Eleanor Clancy-Thompson; Kathy Mulgrew; Grace Adjei; Katharina Deschler; Darren Potz; Gordon Moody; David A. Leinster; Steve Novick; Michal Sulikowski; Chris Bagnall; Philip Martin; Jean-Martin Lapointe; Han Si; Chris Morehouse; Maja Sedic; Robert W. Wilkinson; Ronald Herbst; Joshua P. Frederick; Nadia Luheshi
Author Choice
Itacitinib (INCB039110), a JAK1 Inhibitor, Reduces Cytokines Associated with Cytokine Release Syndrome Induced by CAR T-cell Therapy
Eduardo Huarte; Roddy S. O'Connor; Michael T. Peel; Selene Nunez-Cruz; John Leferovich; Ashish Juvekar; Yan-ou Yang; Lisa Truong; Taisheng Huang; Ahmad Naim; Michael C. Milone; Paul A. Smith
Author Choice
CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes
Valeria Leuci; Chiara Donini; Giovanni Grignani; Ramona Rotolo; Giulia Mesiano; Erika Fiorino; Loretta Gammaitoni; Lorenzo D'Ambrosio; Alessandra Merlini; Elisa Landoni; Enzo Medico; Sonia Capellero; Lidia Giraudo; Giulia Cattaneo; Ilenia Iaia; Ymera Pignochino; Marco Basiricò; Elisa Vigna; Alberto Pisacane; Franca Fagioli; Soldano Ferrone; Massimo Aglietta; Gianpietro Dotti; Dario Sangiolo
STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1
Theresa A. Proia; Maneesh Singh; Richard Woessner; Larissa Carnevalli; Gayathri Bommakanti; Lukasz Magiera; Srimathi Srinivasan; Shaun Grosskurth; Mike Collins; Chris Womack; Matthew Griffin; Minwei Ye; Susan Cantin; Deanna Russell; Mingchao Xie; Adina Hughes; Nanhua Deng; Deanna A. Mele; Stephen Fawell; Simon Barry; Corinne Reimer; J. Carl Barrett; Patricia McCoon
Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma
Laia Bassaganyas; Roser Pinyol; Roger Esteban-Fabró; Laura Torrens; Sara Torrecilla; Catherine E. Willoughby; Sebastià Franch-Expósito; Maria Vila-Casadesús; Itziar Salaverria; Robert Montal; Vincenzo Mazzaferro; Jordi Camps; Daniela Sia; Josep M. Llovet
The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval
Kimberly R. Jordan; Matthew J. Sikora; Jill E. Slansky; Angela Minic; Jennifer K. Richer; Marisa R. Moroney; Junxiao Hu; Rebecca J. Wolsky; Zachary L. Watson; Tomomi M. Yamamoto; James C. Costello; Aaron Clauset; Kian Behbakht; T. Rajendra Kumar; Benjamin G. Bitler
Chloroquine Sensitizes GNAQ/11-mutated Melanoma to MEK1/2 Inhibition
Amanda Truong; Jae Hyuk Yoo; Michael T. Scherzer; John Michael S. Sanchez; Kali J. Dale; Conan G. Kinsey; Jackson R. Richards; Donghan Shin; Phaedra C. Ghazi; Michael D. Onken; Kendall J. Blumer; Shannon J. Odelberg; Martin McMahon
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