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15 November 2020
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Cover Image
Cover Image
Multiplex immunofluorescence for PI3K pathway activation on a single cell-level, using formalin-fixed paraffin-embedded (FFPE) prostate cancer tissue on tissue microarrays (TMA). The merged image shows the following markers: PTEN (orange), stathmin (aqua), phosphoS6 (green), p63 (red), AMACR (yellow), and DAPI counterstain (blue) in a TMA core with both normal tissue (center) and invasive tumor tissue. For details, see the article by Stopsack and colleagues on page 5903 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Clinical Trial Brief Report
Clinical Trials: Targeted Therapy
Palbociclib and Trastuzumab in HER2-Positive Advanced Breast Cancer: Results from the Phase II SOLTI-1303 PATRICIA Trial
Eva Ciruelos; Patricia Villagrasa; Tomás Pascual; Mafalda Oliveira; Sonia Pernas; Laia Paré; Santiago Escrivá-de-Romaní; Luis Manso; Barbara Adamo; Eduardo Martínez; Javier Cortés; Silvia Vazquez; Antonia Perelló; Isabel Garau; Mireia Melé; Noelia Martínez; Alvaro Montaño; Begoña Bermejo; Serafin Morales; María J. Echarri; Estela Vega; Blanca González-Farré; Débora Martínez; Patricia Galván; Jordi Canes; Paolo Nuciforo; Xavier Gonzalez; Aleix Prat
Author Choice
Phase I Study of P-cadherin–targeted Radioimmunotherapy with 90Y-FF-21101 Monoclonal Antibody in Solid Tumors
Vivek Subbiah; William Erwin; Osama Mawlawi; Asa McCoy; David Wages; Catherine Wheeler; Carlos Gonzalez-Lepera; Holly Liu; Homer Macapinlac; Funda Meric-Bernstam; David S. Hong; Shubham Pant; Dao Le; Elmer Santos; Jose Gonzalez; Jason Roszik; Takeaki Suzuki; Ruth Ann Subach; Timothy Madden; Mary Johansen; Fumiko Nomura; Hirokazu Satoh; Tadashi Matsuura; Masamichi Kajita; Eri Nakamura; Yuichi Funase; Satoshi Matsushima; Gregory Ravizzini
Author Choice
PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2+ Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype
Valentina Guarneri; Maria Vittoria Dieci; Giancarlo Bisagni; Alba A. Brandes; Antonio Frassoldati; Luigi Cavanna; Antonino Musolino; Francesco Giotta; Anita Rimanti; Ornella Garrone; Elena Bertone; Katia Cagossi; Oriana Nanni; Federico Piacentini; Enrico Orvieto; Gaia Griguolo; Matteo Curtarello; Loredana Urso; Laia Paré; Nuria Chic; Roberto D'Amico; Aleix Prat; Pierfranco Conte
Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression
Alison R. Walker; John C. Byrd; James S. Blachly; Bhavana Bhatnagar; Alice S. Mims; Shelley Orwick; Tara L. Lin; Howland E. Crosswell; Danjie Zhang; Mark D. Minden; Veerendra Munugalavadla; Lauren Long; Jinfeng Liu; Yang Pan; Thomas Oellerich; Hubert Serve; Arati V. Rao; William G. Blum
Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck
Dong M. Shin; Sreenivas Nannapaneni; Mihir R. Patel; Qiuying Shi; Yuan Liu; Zhengjia Chen; Amy Y. Chen; Mark W. El-Deiry; Jonathan J. Beitler; Conor E. Steuer; Steven M. Roser; Adam M. Klein; Taofeek K. Owonikoko; Suresh S. Ramalingam; Fadlo R. Khuri; Zhuo G. Chen; Nabil F. Saba
Clinical Trials: Immunotherapy
Author Choice
Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma
Mark R. Middleton; Cheryl McAlpine; Victoria K. Woodcock; Pippa Corrie; Jeffrey R. Infante; Neil M. Steven; Thomas R. Jeffry Evans; Alan Anthoney; Alexander N. Shoushtari; Omid Hamid; Avinash Gupta; Antonella Vardeu; Emma Leach; Revashnee Naidoo; Sarah Stanhope; Sion Lewis; Jacob Hurst; Ita O’Kelly; Mario Sznol
Author Choice
Efficacy and Tolerability of High- versus Low-dose Lenalidomide Maintenance Therapy of Multiple Myeloma after Autologous Blood Stem Cell Transplantation
Roland Fenk; Aristoteles Giagounidis; Hartmut Goldschmidt; Michael Heinsch; Mathias Rummel; Nicolaus Kroger; Amelie Boquoi; David Lopez; Celina Gerrlich; Julia Baier; Svenja Liesenjohann; Katarzyna Hauck; Ingrida Savickaite; Elias K. Mai; Carlo Aul; Judith Strapatsas; Ariane Dienst; Mustafa Kondakci; Rainer Haas; Guido Kobbe
Author Choice
Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)
Akihito Kawazoe; Yasutoshi Kuboki; Eiji Shinozaki; Hiroki Hara; Tomohiro Nishina; Yoshito Komatsu; Satoshi Yuki; Masashi Wakabayashi; Shogo Nomura; Akihiro Sato; Takeshi Kuwata; Masahito Kawazu; Hiroyuki Mano; Yosuke Togashi; Hiroyoshi Nishikawa; Takayuki Yoshino
Author Choice
Immunomodulation in Pomalidomide, Dexamethasone, and Daratumumab-Treated Patients with Relapsed/Refractory Multiple Myeloma
William E. Pierceall; Michael D. Amatangelo; Nizar J. Bahlis; David S. Siegel; Adeeb Rahman; Oliver Van Oekelen; Paola Neri; Mary Young; Weiyuan Chung; Natalya Serbina; Samir Parekh; Amit Agarwal; Anjan Thakurta
Precision Medicine and Imaging
Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
Konrad H. Stopsack; Ying Huang; Svitlana Tyekucheva; Travis A. Gerke; Clyde Bango; Habiba Elfandy; Michaela Bowden; Kathryn L. Penney; Thomas M. Roberts; Giovanni Parmigiani; Philip W. Kantoff; Lorelei A. Mucci; Massimo Loda
TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions
Allison S. Cohen; Jun Li; Matthew R. Hight; Eliot McKinley; Allie Fu; Adria Payne; Yang Liu; Dawei Zhang; Qing Xie; Mingfeng Bai; Gregory D. Ayers; Mohammed Noor Tantawy; Jarrod A. Smith; Frank Revetta; M. Kay Washington; Chanjuan Shi; Nipun Merchant; H. Charles Manning
Author Choice
Circulating Tumor DNA Predicts Outcome from First-, but not Second-line Treatment and Identifies Melanoma Patients Who May Benefit from Combination Immunotherapy
Gabriela Marsavela; Jenny Lee; Leslie Calapre; Stephen Q. Wong; Michelle R. Pereira; Ashleigh C. McEvoy; Anna L. Reid; Cleo Robinson; Lydia Warburton; Afaf Abed; Muhammad A. Khattak; Tarek M. Meniawy; Sarah-Jane Dawson; Shahneen Sandhu; Matteo S. Carlino; Alexander M. Menzies; Richard A. Scolyer; Georgina V. Long; Benhur Amanuel; Michael Millward; Melanie R. Ziman; Helen Rizos; Elin S. Gray
Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
Alberto Puccini; Kelsey Poorman; Mohamed E. Salem; Davide Soldato; Andreas Seeber; Richard M. Goldberg; Anthony F. Shields; Joanne Xiu; Francesca Battaglin; Martin D. Berger; Ryuma Tokunaga; Madiha Naseem; Afsaneh Barzi; Syma Iqbal; Wu Zhang; Shivani Soni; Jimmy J. Hwang; Philip A. Philip; Stefania Sciallero; W. Michael Korn; John L. Marshall; Heinz-Josef Lenz
Translational Cancer Mechanisms and Therapy
Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer
Pingping Mao; Ofir Cohen; Kailey J. Kowalski; Justin G. Kusiel; Jorge E. Buendia-Buendia; Michael S. Cuoco; Pedro Exman; Seth A. Wander; Adrienne G. Waks; Utthara Nayar; Jon Chung; Samuel Freeman; Orit Rozenblatt-Rosen; Vincent A. Miller; Federica Piccioni; David E. Root; Aviv Regev; Eric P. Winer; Nancy U. Lin; Nikhil Wagle
PD1 Blockade Enhances ICAM1-Directed CAR T Therapeutic Efficacy in Advanced Thyroid Cancer
Katherine D. Gray; Jaclyn E. McCloskey; Yogindra Vedvyas; Olivia R. Kalloo; Steve El Eshaky; Yanping Yang; Enda Shevlin; Marjan Zaman; Timothy M. Ullmann; Heng Liang; Dessislava Stefanova; Paul J. Christos; Theresa Scognamiglio; Andrew B. Tassler; Rasa Zarnegar; Thomas J. Fahey, III; Moonsoo M. Jin; Irene M. Min
Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non–Small Cell Lung Cancer
David E. Gerber; William C. Putnam; Farjana J. Fattah; Kemp H. Kernstine; Rolf A. Brekken; Ivan Pedrosa; Rachael Skelton; Jessica M. Saltarski; Robert E. Lenkinski; Richard D. Leff; Chul Ahn; Chyndhri Padmanabhan; Vaidehi Chembukar; Sahba Kasiri; Raja Reddy Kallem; Indhumathy Subramaniyan; Qing Yuan; Quyen N. Do; Yin Xi; Scott I. Reznik; Lorraine Pelosof; Brandon Faubert; Ralph J. DeBerardinis; James Kim
Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma
Charles Marusak; Varsha Thakur; Yuan Li; Juliano T. Freitas; Patrick M. Zmina; Vijay S. Thakur; Mayland Chang; Ming Gao; Jiufeng Tan; Min Xiao; Yiling Lu; Gordon B. Mills; Keith Flaherty; Dennie T. Frederick; Benchun Miao; Ryan J. Sullivan; Tabea Moll; Genevieve M. Boland; Meenhard Herlyn; Gao Zhang; Barbara Bedogni
Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer
Cameron M. Armstrong; Chengfei Liu; Liangren Liu; Joy C. Yang; Wei Lou; Ruining Zhao; Shu Ning; Alan P. Lombard; Jinge Zhao; Leandro S. D'Abronzo; Christopher P. Evans; Pui-Kai Li; Allen C. Gao
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