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1 November 2020
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Cover Image
Cover Image
Density heatmap of CD8-positive lymphocytes in a case of pleomorphic dermal sarcoma, where high density is indicated in red. For further details, please see the article by Klein and colleagues on page 5638 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma
Filip Janku; Haeseong Park; S. Greg Call; Kiran Madwani; Yasuhiro Oki; Vivek Subbiah; David S. Hong; Aung Naing; Vivianne M. Velez-Bravo; Tamara G. Barnes; Fredrick B. Hagemeister; Gerald S. Falchook; Daniel D. Karp; Jennifer J. Wheler; Sarina A. Piha-Paul; Ignacio Garrido-Laguna; Elizabeth J. Shpall; Luis E. Fayad; Sattva S. Neelapu; Funda Meric-Bernstam; Razelle Kurzrock; Michelle A. Fanale
Author Choice
A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors
Sara M. Tolaney; Khanh T. Do; Joseph P. Eder; Patricia M. LoRusso; Colin D. Weekes; Sarat Chandarlapaty; Ching-Wei Chang; Shang-Chiung Chen; Denise Nazzal; Eva Schuth; Flavia Brunstein; Montserrat Carrasco-Triguero; Walter C. Darbonne; Jennifer M. Giltnane; William M. Flanagan; S. Renee Commerford; Alexander Ungewickell; Geoffrey I. Shapiro; Shanu Modi
Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma
Jean-François Martini; Elizabeth R. Plimack; Toni K. Choueiri; David F. McDermott; Igor Puzanov; Mayer N. Fishman; Daniel C. Cho; Ulka Vaishampayan; Bradley Rosbrook; Kathrine C. Fernandez; Jamal C. Tarazi; Saby George; Michael B. Atkins
Clinical Trials: Immunotherapy
Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study
Karen A. Autio; Christopher A. Klebanoff; David Schaer; John Sae Wook Kauh; Susan F. Slovin; Matthew Adamow; Victoria S. Blinder; Manisha Brahmachary; Michelle Carlsen; Elizabeth Comen; Daniel C. Danila; Thompson N. Doman; Jeremy C. Durack; Josef J. Fox; Jill S. Gluskin; David M. Hoffman; Suhyun Kang; Praneet Kang; Jonathan Landa; Philomena F. McAndrew; Shanu Modi; Michael J. Morris; Ruslan Novosiadly; Dana E. Rathkopf; Rachel Sanford; Sonya C. Chapman; Courtney M. Tate; Danni Yu; Phillip Wong; Heather L. McArthur
Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929)
Diane M. Da Silva; Danielle M. Enserro; Jyoti S. Mayadev; Joseph G. Skeate; Koji Matsuo; Huyen Q. Pham; Heather A. Lankes; Katherine M. Moxley; Sharad A. Ghamande; Yvonne G. Lin; Russell J. Schilder; Michael J. Birrer; W. Martin Kast
Safety and Clinical Activity of Atezolizumab Plus Bevacizumab in Patients with Ovarian Cancer: A Phase Ib Study
John W. Moroney; John Powderly; Christopher H. Lieu; Johanna C. Bendell; S. Gail Eckhardt; Ching-Wei Chang; Luciana Molinero; Jessica Spahn; Patrick Williams; Yvonne G. Lin; F. Stephen Hodi
Precision Medicine and Imaging
Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy
Sebastian Klein; Alexander Quaas; Ka-Won Noh; Maria Cartolano; Nima Abedpour; Cornelia Mauch; Jennifer Quantius; Hans Christian Reinhardt; Reinhard Buettner; Martin Peifer; Doris Helbig
Noninvasive Detection of Urothelial Carcinoma by Cost-effective Low-coverage Whole-genome Sequencing from Urine-Exfoliated Cell DNA
Shuxiong Zeng; Yidie Ying; Naidong Xing; Baiyun Wang; Ziliang Qian; Zunlin Zhou; Zhensheng Zhang; Weidong Xu; Huiqing Wang; Lihe Dai; Li Gao; Tie Zhou; Jiatao Ji; Chuanliang Xu
Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers
Dan Høgdall; Colm J. O'Rourke; Christian Dehlendorff; Ole F. Larsen; Lars H. Jensen; Astrid Z. Johansen; Hien Dang; Valentina M. Factor; Mie Grunnet; Morten Mau-Sørensen; Douglas V.N.P. Oliveira; Dorte Linnemann; Mogens K. Boisen; Xin W. Wang; Julia S. Johansen; Jesper B. Andersen
Translational Cancer Mechanisms and Therapy
Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer
Margaret L. Axelrod; Mellissa J. Nixon; Paula I. Gonzalez-Ericsson; Riley E. Bergman; Mark A. Pilkinton; Wyatt J. McDonnell; Violeta Sanchez; Susan R. Opalenik; Sherene Loi; Jing Zhou; Sean Mackay; Brent N. Rexer; Vandana G. Abramson; Valerie M. Jansen; Simon Mallal; Joshua Donaldson; Sara M. Tolaney; Ian E. Krop; Ana C. Garrido-Castro; Jonathan D. Marotti; Kevin Shee; Todd W. Miller; Melinda E. Sanders; Ingrid A. Mayer; Roberto Salgado; Justin M. Balko
Predictive Value of Molecular Subtypes in Premenopausal Women with Hormone Receptor–positive Early Breast Cancer: Results from the ABCSG Trial 5
Zsuzsanna Bago-Horvath; Margaretha Rudas; Christian F. Singer; Richard Greil; Marija Balic; Sigurd F. Lax; Werner Kwasny; Wolfgang Hulla; Michael Gnant; Martin Filipits
Author Choice
Immune Escape After Adoptive T-cell Therapy for Malignant Gliomas
Tyler J. Wildes; Kyle A. Dyson; Connor Francis; Brandon Wummer; Changlin Yang; Oleg Yegorov; David Shin; Adam Grippin; Bayli DiVita Dean; Rebecca Abraham; Christina Pham; Ginger Moore; Carmelle Kuizon; Duane A. Mitchell; Catherine T. Flores
The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer
Adam J. Schoenfeld; Chai Bandlamudi; Jessica A. Lavery; Joseph Montecalvo; Azadeh Namakydoust; Hira Rizvi; Jacklynn Egger; Carla P. Concepcion; Sonal Paul; Maria E. Arcila; Yahya Daneshbod; Jason Chang; Jennifer L. Sauter; Amanda Beras; Marc Ladanyi; Tyler Jacks; Charles M. Rudin; Barry S. Taylor; Mark T.A. Donoghue; Glenn Heller; Matthew D. Hellmann; Natasha Rekhtman; Gregory J. Riely
sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients
Mitchell E. Fane; Brett L. Ecker; Amanpreet Kaur; Gloria E. Marino; Gretchen M. Alicea; Stephen M. Douglass; Yash Chhabra; Marie R. Webster; Andrea Marshall; Richard Colling; Olivia Espinosa; Nicholas Coupe; Neera Maroo; Leticia Campo; Mark R. Middleton; Pippa Corrie; Xiaowei Xu; Giorgos C. Karakousis; Ashani T. Weeraratna
Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling
Sakthivel Muniyan; Satyanarayana Rachagani; Seema Parte; Sushanta Halder; Parthasarathy Seshacharyulu; Prakash Kshirsagar; Jawed A. Siddiqui; Raghupathy Vengoji; Sanchita Rauth; Ridwan Islam; Kavita Mallya; Kaustubh Datta; Lei Xi; Anindita Das; Benjamin A. Teply; Rakesh C. Kukreja; Surinder K. Batra
The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia
Delphine Verbeke; Sofie Demeyer; Cristina Prieto; Charles E. de Bock; Jolien De Bie; Olga Gielen; Kris Jacobs; Nicole Mentens; Bronte Manouk Verhoeven; Anne Uyttebroeck; Nancy Boeckx; Kim De Keersmaecker; Johan Maertens; Heidi Segers; Jan Cools
Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells
Fatma Aboulnasr; Ashton Krogman; Rondell P. Graham; Nathan W. Cummins; Anisha Misra; Enrique Garcia-Rivera; Jeff R. Anderson; Sekar Natesampillai; Nicole Kogan; Murali Aravamudan; Zilin Nie; Thomas D.Y. Chung; Richard Buick; Andrew L. Feldman; Rebecca L. King; Anne J. Novak; Stephen M. Ansell; Saad Kenderian; Andrew D. Badley
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