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15 January 2020
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Cover Image
Cover Image
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The cover shows multiplexing immunohistochemistry of a murine triple-negative breast tumor treated with anti-PD1 and anti-CTLA4 in the context of CXCR3 blockade. The image demonstrates near total absence of CD3 positive cells (white) and outgrowth of CK8 positive tumor cells (green). For details, see the article by House and colleagues on page 487 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Calaspargase Pegol-mknl For Treatment of Acute Lymphoblastic Leukemia in Children and Young Adults
Ruo-Jing Li; Runyan Jin; Chao Liu; Xianhua Cao; Michael L. Manning; Xu Michael Di; Donna Przepiorka; Frances Namuswe; Albert Deisseroth; Kirsten B. Goldberg; Gideon M. Blumenthal; Richard Pazdur
Review
Perspectives
Clinical Trials: Targeted Therapy
A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma
Irene M. Ghobrial; Chia-Jen Liu; Robert A. Redd; Raymond P. Perez; Rachid Baz; Oksana Zavidij; Romanos Sklavenitis-Pistofidis; Paul G. Richardson; Kenneth C. Anderson; Jacob Laubach; Patrick Henrick; Alexandra Savell; Kaitlen Reyes; Kalvis Hornburg; Stacey Chuma; Peter Sabbatini; Michael D. Robbins; Pamela S. Becker
Lucitanib for the Treatment of HR+/HER2− Metastatic Breast Cancer: Results from the Multicohort Phase II FINESSE Study
Rina Hui; Alex Pearson; Javier Cortes; Christine Campbell; Camille Poirot; Hatem A. Azim, Jr; Debora Fumagalli; Matteo Lambertini; Fergus Daly; Amal Arahmani; José Perez-Garcia; Philippe Aftimos; Philippe L. Bedard; Laura Xuereb; Elsemieke D. Scheepers; Malou Vicente; Theodora Goulioti; Sibylle Loibl; Sherene Loi; Marie-Jeanne Pierrat; Nicholas C. Turner; Fabrice Andre; Giuseppe Curigliano
Phase Ia Study of Anti-NaPi2b Antibody–Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non–Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer
David E. Gerber; Jeffrey R. Infante; Michael S. Gordon; Sarah B. Goldberg; Miguel Martín; Enriqueta Felip; Maria Martinez Garcia; Joan H. Schiller; David R. Spigel; Julie Cordova; Valerie Westcott; Yulei Wang; David S. Shames; YounJeong Choi; Robert Kahn; Randall C. Dere; Divya Samineni; Jian Xu; Kedan Lin; Katie Wood; Stephanie Royer-Joo; Vanessa Lemahieu; Eva Schuth; Anjali Vaze; Daniel Maslyar; Eric W. Humke; Howard A. Burris, III
Precision Medicine and Imaging
A Gene Expression–based Model to Predict Metabolic Response After Two Courses of ABVD in Hodgkin Lymphoma Patients
Stefano Luminari; Benedetta Donati; Massimiliano Casali; Riccardo Valli; Raffaella Santi; Benedetta Puccini; Sofya Kovalchuk; Alessia Ruffini; Angelo Fama; Valentina Berti; Valentina Fragliasso; Magda Zanelli; Federica Vergoni; Annibale Versari; Luigi Rigacci; Francesco Merli; Alessia Ciarrocchi
Author Choice
Submucosal Saline Injection Followed by Endoscopic Ultrasound versus Endoscopic Ultrasound Only for Distinguishing between T1a and T1b Esophageal Cancer
Long-Jun He; Chuanbo Xie; Zi-Xian Wang; Yin Li; Yi-Tai Xiao; Xiao-Yan Gao; Hong-Bo Shan; Lin-Na Luo; Li-Ming Chen; Guang-Yu Luo; Ping Yang; Shuo-Chun Zeng; Guo-Liang Xu; Jian-Jun Li
Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study
Stephen J. Bagley; S. Ali Nabavizadeh; Jazmine J. Mays; Jacob E. Till; Jeffrey B. Ware; Scott Levy; Whitney Sarchiapone; Jasmin Hussain; Timothy Prior; Samantha Guiry; Theresa Christensen; Stephanie S. Yee; MacLean P. Nasrallah; Jennifer J.D. Morrissette; Zev A. Binder; Donald M. O'Rourke; Andrew J. Cucchiara; Steven Brem; Arati S. Desai; Erica L. Carpenter
Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides
John T. O'Malley; Adele de Masson; Elizabeth L. Lowry; Anita Giobbie-Hurder; Nicole R. LeBoeuf; Cecilia Larocca; Ahmed Gehad; Edward Seger; Jessica E. Teague; David C. Fisher; Thomas S. Kupper; Phillip M. Devlin; Rachael A. Clark
Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma
Guo Gord Zhu; Khedoudja Nafa; Narasimhan Agaram; Ahmet Zehir; Ryma Benayed; Justyna Sadowska; Laetitia Borsu; Ciara Kelly; William D. Tap; Nicola Fabbri; Edward Athanasian; Patrick J. Boland; John H. Healey; Michael F. Berger; Marc Ladanyi; Meera Hameed
Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment
Lynn Jeanette Savic; Isabel Theresa Schobert; Dana Peters; John J. Walsh; Fabian Max Laage-Gaupp; Charlie Alexander Hamm; Nina Tritz; Luzie A. Doemel; MingDe Lin; Albert Sinusas; Todd Schlachter; James S. Duncan; Fahmeed Hyder; Daniel Coman; Julius Chapiro
Translational Cancer Mechanisms and Therapy
Co-occurring Alterations in the RAS–MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer
Julia K. Rotow; Philippe Gui; Wei Wu; Victoria M. Raymond; Richard B. Lanman; Frederic J. Kaye; Nir Peled; Ferran Fece de la Cruz; Brandon Nadres; Ryan B. Corcoran; Iwei Yeh; Boris C. Bastian; Petr Starostik; Kimberly Newsom; Victor R. Olivas; Alexander M. Wolff; James S. Fraser; Eric A. Collisson; Caroline E. McCoach; D. Ross Camidge; Jose Pacheco; Lyudmila Bazhenova; Tianhong Li; Trever G. Bivona; Collin M. Blakely
Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma
Deepak Perumal; Naoko Imai; Alessandro Laganà; John Finnigan; David Melnekoff; Violetta V. Leshchenko; Alexander Solovyov; Deepu Madduri; Ajai Chari; Hearn Jay Cho; Joel T. Dudley; Joshua D. Brody; Sundar Jagannath; Benjamin Greenbaum; Sacha Gnjatic; Nina Bhardwaj; Samir Parekh
Author Choice
A Virus-Infected, Reprogrammed Somatic Cell–Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer
Shuangshuang Lu; Zhe Zhang; Pan Du; Louisa S. Chard; Wenli Yan; Margueritte El Khouri; Zhizhong Wang; Zhongxian Zhang; Yongchao Chu; Dongling Gao; Qinxian Zhang; Lirong Zhang; Ai Nagano; Jun Wang; Claude Chelala; Jing Liu; Jiekai Chen; Pentao Liu; Yunshu Dong; Shengdian Wang; Xiaozhu Li; Jianzeng Dong; Nick R. Lemoine; Duanqing Pei; Yaohe Wang
Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations
Daniel Y. Zhang; Crismita Dmello; Li Chen; Victor A. Arrieta; Edgar Gonzalez-Buendia; J. Robert Kane; Lisa P. Magnusson; Aneta Baran; C. David James; Craig Horbinski; Alexandre Carpentier; Carole Desseaux; Michael Canney; Miguel Muzzio; Roger Stupp; Adam M. Sonabend
Author Choice
Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade
Imran G. House; Peter Savas; Junyun Lai; Amanda X.Y. Chen; Amanda J. Oliver; Zhi L. Teo; Kirsten L. Todd; Melissa A. Henderson; Lauren Giuffrida; Emma V. Petley; Kevin Sek; Sherly Mardiana; Tuba N. Gide; Camelia Quek; Richard A. Scolyer; Georgina V. Long; James S. Wilmott; Sherene Loi; Phillip K. Darcy; Paul A. Beavis
Letter to the Editor
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