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15 September 2020
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Cover Image
Cover Image
The cover shows a liver biopsy image from a patient with metastatic pancreatic ductal adenocarcinoma. Dual immunohistochemistry reveals expression of GATA6 (brown) or CK5 (magenta) in distinct cells within the same neoplastic glands. For details, see the article by O'Kane and colleagues on page 4901 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Review
Perspectives
Clinical Trials: Targeted Therapy
Ganetespib in Combination with Pemetrexed–Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial
Dean A. Fennell; Sarah Danson; Penella J. Woll; Martin Forster; Denis Talbot; Jennifer Child; Laura Farrelly; Annabel Sharkey; Sara Busacca; Yenting Ngai; Allan Hackshaw; Graham M. Wheeler
Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome
Manish A. Shah; Peter Enzinger; Andrew H. Ko; Allyson J. Ocean; Philip Agop Philip; Prashant V. Thakkar; Kyle Cleveland; Yao Lu; Jeremy Kortmansky; Paul J. Christos; Chao Zhang; Navjot Kaur; Dina Elmonshed; Giuseppe Galletti; Sandipto Sarkar; Bhavneet Bhinder; Meredith E. Pittman; Olga Mikhaylovna Plotnikova; Nikita Kotlov; Felix Frenkel; Aleksander Bagaev; Olivier Elemento; Doron Betel; Paraskevi Giannakakou; Heinz-Josef Lenz
A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive TP53-mutant Ovarian Cancer
Amit M. Oza; Maria Estevez-Diz; Eva-Maria Grischke; Marcia Hall; Frederik Marmé; Diane Provencher; Denise Uyar; Johanne I. Weberpals; Robert M. Wenham; Naomi Laing; Michael Tracy; Tomoko Freshwater; Mark A. Lee; Ji Liu; Jingjun Qiu; Shelonitda Rose; Eric H. Rubin; Kathleen Moore
Author Choice
First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors
Robert McLeod; Rajiv Kumar; Dionysis Papadatos-Pastos; Joaquin Mateo; Jessica S. Brown; Alvaro H. Ingles Garces; Ruth Ruddle; Shaun Decordova; Simone Jueliger; Roberta Ferraldeschi; Oscar Maiques; Victoria Sanz-Moreno; Paul Jones; Stephanie Traub; Gavin Halbert; Sarah Mellor; Karen E. Swales; Florence I. Raynaud; Michelle D. Garrett; Udai Banerji
Author Choice
U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
Kyriakos P. Papadopoulos; Erkut Borazanci; Alice T. Shaw; Ryohei Katayama; Yuki Shimizu; Viola W. Zhu; Thomas Yang Sun; Heather A. Wakelee; Russell Madison; Alexa B. Schrock; Giorgio Senaldi; Naoki Nakao; Hiroyuki Hanzawa; Masaya Tachibana; Takeshi Isoyama; Kenji Nakamaru; Chenhui Deng; Meijing Li; Frank Fan; Qinying Zhao; Yanfei Gao; Takashi Seto; Pasi A. Jänne; Sai-Hong Ignatius Ou
Author Choice
Serum Alpha-fetoprotein Levels and Clinical Outcomes in the Phase III CELESTIAL Study of Cabozantinib versus Placebo in Patients with Advanced Hepatocellular Carcinoma
Robin Kate Kelley; Tim Meyer; Lorenza Rimassa; Philippe Merle; Joong-Won Park; Thomas Yau; Stephen L. Chan; Jean-Frederic Blanc; Vincent C. Tam; Albert Tran; Vincenzo Dadduzio; David W. Markby; Rajesh Kaldate; Ann-Lii Cheng; Anthony B. El-Khoueiry; Ghassan K. Abou-Alfa
Radiological Patterns of Drug-induced Interstitial Lung Disease (DILD) in Early-phase Oncology Clinical Trials
Angelika Terbuch; Crescens Tiu; Irene Moreno Candilejo; Mariana Scaranti; Andra Curcean; Dan Bar; Miriam Estevez Timon; Malaka Ameratunga; Joo Ern Ang; Jonathan Ratoff; Anna R. Minchom; Udai Banerji; Johann S. de Bono; Nina Tunariu; Juanita S. Lopez
Clinical Trials: Immunotherapy
Author Choice
Open-label, Phase I Study of Nivolumab Combined with nab-Paclitaxel Plus Gemcitabine in Advanced Pancreatic Cancer
Zev A. Wainberg; Howard S. Hochster; Edward J. Kim; Ben George; Aparna Kaylan; E. Gabriela Chiorean; David M. Waterhouse; Martin Guiterrez; Aparna Parikh; Rishi Jain; Daniel Ricardo Carrizosa; Hatem H. Soliman; Thomas Lila; David J. Reiss; Daniel W. Pierce; Rafia Bhore; Sibabrata Banerjee; Larry Lyons; Chrystal U. Louis; Teng Jin Ong; Peter J. O'Dwyer
Precision Medicine and Imaging
Author Choice
Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma Treated with Axicabtagene Ciloleucel
Rawan Faramand; Michael Jain; Verena Staedtke; Hiroshi Kotani; Renyuan Bai; Kayla Reid; Sae Bom Lee; Kristen Spitler; Xuefeng Wang; Biwei Cao; Javier Pinilla; Aleksander Lazaryan; Farhad Khimani; Bijal Shah; Julio C. Chavez; Taiga Nishihori; Asmita Mishra; John Mullinax; Ricardo Gonzalez; Mohammad Hussaini; Marian Dam; Brigett D. Brandjes; Christina A. Bachmeier; Claudio Anasetti; Frederick L. Locke; Marco L. Davila
Early Relapse Risk in Patients with Newly Diagnosed Multiple Myeloma Characterized by Next-generation Sequencing
Mattia D'Agostino; Gian Maria Zaccaria; Bachisio Ziccheddu; Even H. Rustad; Elisa Genuardi; Andrea Capra; Stefania Oliva; Daniel Auclair; Jennifer Yesil; Paola Colucci; Jonathan J. Keats; Manuela Gambella; Sara Bringhen; Alessandra Larocca; Mario Boccadoro; Niccolò Bolli; Francesco Maura; Francesca Gay
Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer
Neelima Vidula; Taronish Dubash; Michael S. Lawrence; Antoine Simoneau; Andrzej Niemierko; Erica Blouch; Becky Nagy; Whijae Roh; Brian Chirn; Brittany A. Reeves; Giuliana Malvarosa; Jochen Lennerz; Steven J. Isakoff; Dejan Juric; Douglas Micalizzi; Seth Wander; Laura Spring; Beverly Moy; Kristen Shannon; Jerry Younger; Richard Lanman; Mehmet Toner; A. John Iafrate; Gad Getz; Lee Zou; Leif W. Ellisen; Shyamala Maheswaran; Daniel A. Haber; Aditya Bardia
Author Choice
Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor of Disease-free Survival in Postnephrectomy High-risk Locoregional Renal Cell Carcinoma: Analysis of the S-TRAC Trial
Anup Patel; Alain Ravaud; Robert J. Motzer; Allan J. Pantuck; Michael Staehler; Bernard Escudier; Jean-François Martini; Mariajose Lechuga; Xun Lin; Daniel J. George
Genomic and Clinicopathologic Characterization of ATM-deficient Prostate Cancer
Harsimar Kaur; Daniela C. Salles; Sanjana Murali; Jessica L. Hicks; Minh Nguyen; Colin C. Pritchard; Angelo M. De Marzo; Jerry S. Lanchbury; Bruce J. Trock; William B. Isaacs; Kirsten M. Timms; Emmanuel S. Antonarakis; Tamara L. Lotan
Translational Cancer Mechanisms and Therapy
GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer
Grainne M. O’Kane; Barbara T. Grünwald; Gun-Ho Jang; Mehdi Masoomian; Sarah Picardo; Robert C. Grant; Robert E. Denroche; Amy Zhang; Yifan Wang; Jessica K. Miller; Bernard Lam; Paul M. Krzyzanowski; Ilinca M. Lungu; John M.S. Bartlett; Melanie Peralta; Foram Vyas; Rama Khokha; James Biagi; Dianne Chadwick; Stephanie Ramotar; Shawn Hutchinson; Anna Dodd; Julie M. Wilson; Faiyaz Notta; George Zogopoulos; Steven Gallinger; Jennifer J. Knox; Sandra E. Fischer
Clinical Significance of Circulating Tumor Cells in Hormone Receptor–positive Metastatic Breast Cancer Patients who Received Letrozole with or Without Bevacizumab
Mark Jesus M. Magbanua; Oleksandr Savenkov; Erik J. Asmus; Karla V. Ballman; Janet H. Scott; John W. Park; Maura Dickler; Ann Partridge; Lisa A. Carey; Eric P. Winer; Hope S. Rugo
Author Choice
The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development
Nallasivam Palanisamy; Jun Yang; Peter D.A. Shepherd; Elsa M. Li-Ning-Tapia; Estefania Labanca; Ganiraju C. Manyam; Murali K. Ravoori; Vikas Kundra; John C. Araujo; Eleni Efstathiou; Louis L. Pisters; Xinhai Wan; Xuemei Wang; Elba S. Vazquez; Ana M. Aparicio; Shannon L. Carskadon; Scott A. Tomlins; Lakshmi P. Kunju; Arul M. Chinnaiyan; Bradley M. Broom; Christopher J. Logothetis; Patricia Troncoso; Nora M. Navone
The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas
Manling Huang; Minghui He; Yu Guo; Heping Li; Shunli Shen; Yubin Xie; Xiaoxing Li; Han Xiao; Lujing Fang; Dongming Li; Baogang Peng; Lijian Liang; Jun Yu; Ming Kuang; Lixia Xu; Sui Peng
T-Cell Dynamics in Chronic Lymphocytic Leukemia under Different Treatment Modalities
Anna Vardi; Elisavet Vlachonikola; Despoina Papazoglou; Fotis Psomopoulos; Kostantia Kotta; Nikolaos Ioannou; Chrysi Galigalidou; Katerina Gemenetzi; Kostantinos Pasentsis; Maria Kotouza; Evdoxia Koravou; Lydia Scarfó; Michail Iskas; Niki Stavroyianni; Paolo Ghia; Achilles Anagnostopoulos; Anastasia Kouvatsi; Alan G. Ramsay; Kostas Stamatopoulos; Anastasia Chatzidimitriou
Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer
Sophie J. Cowman; Daniel G. Fuja; Xian-De Liu; Rebecca S. Slack Tidwell; Neelima Kandula; Deepika Sirohi; Archana M. Agarwal; Lyska L. Emerson; Sheryl R. Tripp; Jeffrey S. Mohlman; Miekan Stonhill; Guillermina Garcia; Christopher J. Conley; Adam A. Olalde; Timothy Sargis; Adela Ramirez-Torres; Jose A. Karam; Christopher G. Wood; Kanishka Sircar; Pheroze Tamboli; Kenneth Boucher; Benjamin Maughan; Benjamin T. Spike; Thai H. Ho; Neeraj Agarwal; Eric Jonasch; Mei Yee Koh
Author Choice
Radiation with STAT3 Blockade Triggers Dendritic Cell–T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy
Martina Ott; Cynthia Kassab; Anantha Marisetty; Yuuri Hashimoto; Jun Wei; Daniel Zamler; Jia-Shiun Leu; Karl-Heinz Tomaszowski; Aria Sabbagh; Dexing Fang; Pravesh Gupta; Waldemar Priebe; Rafal J. Zielinski; Jared K. Burks; James P. Long; Ling-Yuan Kong; Gregory N. Fuller; John DeGroot; Erik P. Sulman; Amy B. Heimberger
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine
Thomas P. Howard; Elaine M. Oberlick; Matthew G. Rees; Taylor E. Arnoff; Minh-Tam Pham; Lisa Brenan; Mariana DoCarmo; Andrew L. Hong; Guillaume Kugener; Hsien-Chao Chou; Yiannis Drosos; Kaeli M. Mathias; Pilar Ramos; Brinton Seashore-Ludlow; Andrew O. Giacomelli; Xiaofeng Wang; Burgess B. Freeman, III; Kaley Blankenship; Lauren Hoffmann; Hong L. Tiv; Prafulla C. Gokhale; Cory M. Johannessen; Elizabeth A. Stewart; Stuart L. Schreiber; William C. Hahn; Charles W.M. Roberts
Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI
Derek J. Erstad; Mozhdeh Sojoodi; Martin S. Taylor; Veronica Clavijo Jordan; Christian T. Farrar; Andrea L. Axtell; Nicholas J. Rotile; Chloe Jones; Katherine A. Graham-O'Regan; Diego S. Ferreira; Theodoros Michelakos; Filippos Kontos; Akhil Chawla; Shen Li; Sarani Ghoshal; Yin-Ching Iris Chen; Gunisha Arora; Valerie Humblet; Vikram Deshpande; Motaz Qadan; Nabeel Bardeesy; Cristina R. Ferrone; Michael Lanuti; Kenneth K. Tanabe; Peter Caravan; Bryan C. Fuchs
Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle–based Chemotherapy in Pten-deleted Mouse Models of Sarcoma
Rebecca D. Dodd; Amanda Scherer; Wesley Huang; Gavin R. McGivney; Wade R. Gutierrez; Emily A. Laverty; Kathleen A. Ashcraft; Victoria R. Stephens; Parisa Yousefpour; Soumen Saha; Vickie Knepper-Adrian; Warren Floyd; Mark Chen; Yan Ma; Eric M. Mastria; Diana M. Cardona; William C. Eward; Ashutosh Chilkoti; David G. Kirsch
Corrections
Correction: Safety, Efficacy, and Biomarker Analysis of Toripalimab in Previously Treated Advanced Melanoma: Results of the POLARIS-01 Multicenter Phase II Trial
Bixia Tang; Zhihong Chi; Yingbo Chen; Xiufeng Liu; Di Wu; Jing Chen; Xin Song; Weifeng Wang; Lihou Dong; Haifeng Song; Hai Wu; Hui Feng; Sheng Yao; Shuikui Qin; Xiaoshi Zhang; Jun Guo
Correction: Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability
Hailing Yang; Weiqun Mao; Cristian Rodriguez-Aguayo; Lingegowda S. Mangala; Geoffrey Bartholomeusz; Lakesla R. Iles; Nicholas B. Jennings; Ahmed Ashour Ahmed; Anil K. Sood; Gabriel Lopez-Berestein; Zhen Lu; Robert C. Bast, Jr
Correction: Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases
Nancy Chan; Amy Willis; Naomi Kornhauser; Maureen M. Ward; Sharrell B. Lee; Eleni Nackos; Bo Ri Seo; Ellen Chuang; Tessa Cigler; Anne Moore; Diana Donovan; Marta Vallee Cobham; Veronica Fitzpatrick; Sarah Schneider; Alysia Wiener; Jessica Guillaume-Abraham; Elnaz Aljom; Richard Zelkowitz; J. David Warren; Maureen E. Lane; Claudia Fischbach; Vivek Mittal; Linda Vahdat
Editor’s Note
Editor's Note: The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma
Dongsheng Wang; Susan Müller; A.R.M. Ruhul Amin; Donghai Huang; Ling Su; Zhongliang Hu; Mohammad Aminur Rahman; Sreenivas Nannapaneni; Lydia Koenig; Zhengjia Chen; Mourad Tighiouart; Dong M. Shin; Zhuo G. Chen
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