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15 August 2020
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Cover Image
Cover Image
The cover shows multiplex immunofluorescence staining of a human NSCLC case (cytokeratin in green, CD3 in red, and CD56 in white). There is abundant CD56 expression in the stroma, including CD56+/CD3− cells (NK cells) and CD56+/CD3+ cells (NKT cells). For details, see the article by Zugazagoitia and colleagues on page 4360 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Ado-Trastuzumab Emtansine for the Adjuvant Treatment of HER2-positive Early Breast Cancer
Suparna Wedam; Lola Fashoyin-Aje; Xin Gao; Erik Bloomquist; Shenghui Tang; Rajeshwari Sridhara; Kirsten B. Goldberg; Bellinda L. King-Kallimanis; Marc R. Theoret; Amna Ibrahim; Laleh Amiri-Kordestani; Richard Pazdur; Julia A. Beaver
Review
Perspectives
Clinical Trials: Targeted Therapy
EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression
Stephanie Lheureux; Ana Oaknin; Swati Garg; Jeffrey P. Bruce; Ainhoa Madariaga; Neesha C. Dhani; Valerie Bowering; Justin White; Sarah Accardi; Qian Tan; Marsela Braunstein; Katherine Karakasis; Iulia Cirlan; Stephanie Pedersen; Tiantiam Li; Lorena Fariñas-Madrid; Yeh Chen Lee; Zhihui (Amy) Liu; Trevor J. Pugh; Amit M. Oza
Author Choice
Treatment of Patients with Relapsed or Refractory Mantle–Cell Lymphoma with Zanubrutinib, a Selective Inhibitor of Bruton's Tyrosine Kinase
Yuqin Song; Keshu Zhou; Dehui Zou; Jianfeng Zhou; Jianda Hu; Haiyan Yang; Huilai Zhang; Jie Ji; Wei Xu; Jie Jin; Fangfang Lv; Ru Feng; Sujun Gao; Haiyi Guo; Lei Zhou; Rebecca Elstrom; Jane Huang; William Novotny; Rachel Wei; Jun Zhu
A Phase 1b Dose Escalation Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft-tissue Sarcoma
Sant P. Chawla; Sanjay Goel; Warren Chow; Fadi Braiteh; Arun S. Singh; Juneko E. Grilley Olson; Atsushi Osada; Iulian Bobe; Richard F. Riedel
Author Choice
NSABP B-41, a Randomized Neoadjuvant Trial: Genes and Signatures Associated with Pathologic Complete Response
Sandra M. Swain; Gong Tang; Heather Ann Brauer; David S. Goerlitz; Peter C. Lucas; André Robidoux; Brent T. Harris; Hanna Bandos; Yuqi Ren; Charles E. Geyer, Jr; Priya Rastogi; Eleftherios P. Mamounas; Norman Wolmark
Author Choice
A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2− Primary Breast Cancer
John F.R. Robertson; Abigail Evans; Stephan Henschen; Cliona C. Kirwan; Ali Jahan; Laura M. Kenny; J. Michael Dixon; Peter Schmid; Ashutosh Kothari; Omar Mohamed; Peter A. Fasching; Kwok-Leung Cheung; Rachel Wuerstlein; Danielle Carroll; Teresa Klinowska; Justin P.O. Lindemann; Alexander MacDonald; Richard Mather; Rhiannon Maudsley; Michele Moschetta; Myria Nikolaou; Martine P. Roudier; Tinnu Sarvotham; Gaia Schiavon; Diansong Zhou; Li Zhou; Nadia Harbeck
Clinical Trials: Immunotherapy
Safety, Efficacy, and Biomarker Analysis of Toripalimab in Previously Treated Advanced Melanoma: Results of the POLARIS-01 Multicenter Phase II Trial
Bixia Tang; Zhihong Chi; Yingbo Chen; Xiufeng Liu; Di Wu; Jing Chen; Xin Song; Weifeng Wang; Lihou Dong; Haifeng Song; Hai Wu; Hui Feng; Sheng Yao; Shuikui Qin; Xiaoshi Zhang; Jun Guo
Concurrent Definitive Immunoradiotherapy for Patients with Stage III–IV Head and Neck Cancer and Cisplatin Contraindication
Jared Weiss; Siddharth Sheth; Allison M. Deal; Juneko E. Grilley Olson; Samip Patel; Trevor G. Hackman; Jeffrey M. Blumberg; Thomas J. Galloway; Shetal Patel; Adam M. Zanation; Colette J. Shen; D. Neil Hayes; Christopher Hilliard; Ranee Mehra; Karen P. McKinnon; Hsing-Hui Wang; Mark Christian Weissler; Jessica R. Bauman; Bhishamjit S. Chera; Benjamin G. Vincent
Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study
Erika J. Lampert; Alexandra Zimmer; Michelle Padget; Ashley Cimino-Mathews; Jayakumar R. Nair; Yingmiao Liu; Elizabeth M. Swisher; James W. Hodge; Andrew B. Nixon; Erin Nichols; Mohammad H. Bagheri; Elliott Levy; Marc R. Radke; Stanley Lipkowitz; Christina M. Annunziata; Janis M. Taube; Seth M. Steinberg; Jung-Min Lee
Precision Medicine and Imaging
Differentiation Syndrome with Ivosidenib and Enasidenib Treatment in Patients with Relapsed or Refractory IDH-Mutated AML: A U.S. Food and Drug Administration Systematic Analysis
Kelly J. Norsworthy; Flora Mulkey; Emma C. Scott; Ashley F. Ward; Donna Przepiorka; Rosane Charlab; Sarah E. Dorff; Albert Deisseroth; Dickran Kazandjian; Rajeshwari Sridhara; Julia A. Beaver; Ann T. Farrell; R. Angelo de Claro; Richard Pazdur
The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones
Isabel C. Poschke; Jessica C. Hassel; Aaron Rodriguez-Ehrenfried; Katharina A.M. Lindner; Ignacio Heras-Murillo; Lena M. Appel; Johanna Lehmann; Tanja Lövgren; Stina L. Wickström; Claudia Lauenstein; Jasmin Roth; Anna-Katharina König; John B.A.G. Haanen; Joost van den Berg; Rolf Kiessling; Frank Bergmann; Michael Flossdorf; Oliver Strobel; Rienk Offringa
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer
Sarah McCuaig; David Barras; Elizabeth H. Mann; Matthias Friedrich; Samuel J. Bullers; Alina Janney; Lucy C. Garner; Enric Domingo; Viktor Hendrik Koelzer; Mauro Delorenzi; Sabine Tejpar; Timothy S. Maughan; Nathaniel R. West; Fiona Powrie
Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin–Stained Sections
Juha P. Väyrynen; Mai Chan Lau; Koichiro Haruki; Sara A. Väyrynen; Andressa Dias Costa; Jennifer Borowsky; Melissa Zhao; Kenji Fujiyoshi; Kota Arima; Tyler S. Twombly; Junko Kishikawa; Simeng Gu; Saina Aminmozaffari; Shanshan Shi; Yoshifumi Baba; Naohiko Akimoto; Tomotaka Ugai; Annacarolina Da Silva; Mingyang Song; Kana Wu; Andrew T. Chan; Reiko Nishihara; Charles S. Fuchs; Jeffrey A. Meyerhardt; Marios Giannakis; Shuji Ogino; Jonathan A. Nowak
Detection of Promoter DNA Methylation in Urine and Plasma Aids the Detection of Non–Small Cell Lung Cancer
Bin Liu; Julio Ricarte Filho; Apurva Mallisetty; Cassandra Villani; Anastasia Kottorou; Kristen Rodgers; Chen Chen; Tomoaki Ito; Kyla Holmes; Nicole Gastala; Klara Valyi-Nagy; Odile David; Ron C. Gaba; Christian Ascoli; Mary Pasquinelli; Lawrence E. Feldman; Malek G. Massad; Tza-Huei Wang; Ignacio Jusue-Torres; Enrico Benedetti; Robert A. Winn; Malcolm V. Brock; James G. Herman; Alicia Hulbert
Translational Cancer Mechanisms and Therapy
AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer
Nellie K. McDaniel; Mari Iida; Kwangok P. Nickel; Colin A. Longhurst; Samantha R. Fischbach; Tamara S. Rodems; Carlene A. Kranjac; Amber Y. Bo; Qianyun Luo; Meghan M. Gallagher; Noah B. Welke; Kaitlyn R. Mitchell; Alison E. Schulz; Jaimee C. Eckers; Rong Hu; Ravi Salgia; Seungpyo Hong; Justine Y. Bruce; Randall J. Kimple; Deric L. Wheeler
Early Hepatic Lesions Display Immature Tertiary Lymphoid Structures and Show Elevated Expression of Immune Inhibitory and Immunosuppressive Molecules
Maxime Meylan; Florent Petitprez; Laetitia Lacroix; Luca Di Tommaso; Massimo Roncalli; Antoine Bougoüin; Alexis Laurent; Giuliana Amaddeo; Daniele Sommacale; Hélène Regnault; Jonathan Derman; Cécile Charpy; Fouad Lafdil; Jean-Michel Pawlotsky; Catherine Sautès-Fridman; Wolf H. Fridman; Julien Calderaro
CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas
Joshua R. Kane; Junfei Zhao; Takashi Tsujiuchi; Brice Laffleur; Víctor A. Arrieta; Aayushi Mahajan; Ganesh Rao; Angeliki Mela; Crismita Dmello; Li Chen; Daniel Y. Zhang; Edgar González-Buendia; Catalina Lee-Chang; Ting Xiao; Gerson Rothschild; Uttiya Basu; Craig Horbinski; Maciej S. Lesniak; Amy B. Heimberger; Raul Rabadan; Peter Canoll; Adam M. Sonabend
Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type
Jennifer X. Ji; Dawn R. Cochrane; Basile Tessier-Cloutier; Shary Yutin Chen; Germain Ho; Khyatiben V. Pathak; Isabel N. Alcazar; David Farnell; Samuel Leung; Angela Cheng; Christine Chow; Shane Colborne; Gian Luca Negri; Friedrich Kommoss; Anthony Karnezis; Gregg B. Morin; Jessica N. McAlpine; C. Blake Gilks; Bernard E. Weissman; Jeffrey M. Trent; Lynn Hoang; Patrick Pirrotte; Yemin Wang; David G. Huntsman
Radiomics, Tumor Volume, and Blood Biomarkers for Early Prediction of Pseudoprogression in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibition
Lucas Basler; Hubert S. Gabryś; Sabrina A. Hogan; Matea Pavic; Marta Bogowicz; Diem Vuong; Stephanie Tanadini-Lang; Robert Förster; Ken Kudura; Martin W. Huellner; Reinhard Dummer; Matthias Guckenberger; Mitchell P. Levesque
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