Issues

The cover shows aggregates of immune cells detected in rhabdomyosarcomas, termed tertiary lymphoid structures (TLS). The image depicts fused single chromogenic stains of immune markers clustering in TLS. TIGIT: purple, CD31: red, CD163: white, CSF-1R: yellow, IDO-1: green, CD8: orange, CD4: light blue, CD3: pink. Stem-like T cells reside in these dense antigen-presenting-cell niches within the tumor TLS. TLS are a major player in antitumor immune responses and are organized structures where intratumoral T and B cells are educated to become effector and memory cells capable of recognizing the tumor. For details, see the article by Chen and colleagues on page 4018 of this issue.