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15 July 2020
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Cover Image
Cover Image
The cover shows a high magnification microscopic image of the tumor bed from a patient with resected non-small cell lung cancer treated with neoadjuvant nintedanib plus chemotherapy. The image demonstrates approximately 40% residual viable tumor with a mixed inflammatory infiltrate and marked fibroelastotic changes following treatment. For details, see the article by Cascone and colleagues on page 3525 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Perspectives
Clinical Trials: Targeted Therapy
Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase Ib Study
Edwin M. Posadas; Kim N. Chi; Ronald de Wit; Maja J.A. de Jonge; Gerhardt Attard; Terence W. Friedlander; Margaret K. Yu; Peter Hellemans; Caly Chien; Charlene Abrams; Juhui J. Jiao; Fred Saad
Author Choice
A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel, and Nintedanib for Resectable Non–Small Cell Lung Cancer
Tina Cascone; Boris Sepesi; Heather Y. Lin; Neda Kalhor; Edwin R. Parra; Mei Jiang; Myrna C.B. Godoy; Jianjun Zhang; Frank V. Fossella; Anne S. Tsao; Vincent K. Lam; Charles Lu; Frank E. Mott; George R. Simon; Mara B. Antonoff; Reza J. Mehran; David C. Rice; Carmen Behrens; Annikka Weissferdt; Cesar Moran; Ara A. Vaporciyan; J. Jack Lee; Stephen G. Swisher; Don L. Gibbons; Ignacio I. Wistuba; William N. William, Jr.; John V. Heymach
Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors
Florence Atrafi; Ruben A.G. van Eerden; Marte A.M van Hylckama Vlieg; Esther Oomen-de Hoop; Peter de Bruijn; Martijn P. Lolkema; Adriaan Moelker; Cristianne J. Rijcken; Rob Hanssen; Alex Sparreboom; Ferry A.L.M. Eskens; Ron H.J. Mathijssen; Stijn L.W. Koolen
Author Choice
Phase I Study of TAK-659, an Investigational, Dual SYK/FLT3 Inhibitor, in Patients with B-Cell Lymphoma
Leo I. Gordon; Jason B. Kaplan; Rakesh Popat; Howard A. Burris, III; Silvia Ferrari; Sumit Madan; Manish R. Patel; Giuseppe Gritti; Dima El-Sharkawi; Ian Chau; John A. Radford; Jaime Pérez de Oteyza; Pier Luigi Zinzani; Swaminathan Iyer; William Townsend; Reem Karmali; Harry Miao; Igor Proscurshim; Shining Wang; Yujun Wu; Kate Stumpo; Yaping Shou; Cecilia Carpio; Francesc Bosch
Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer
Richard D. Kim; Nilofer S. Azad; Michael A. Morse; Elizabeth Poplin; Amit Mahipal; Benjamin Tan, Jr; Sharon A. Mavroukakis; Massimo Fantini; Kwong Y. Tsang; Anjum Zaki; Jose Torrealba; Philip M. Arlen; Muhammad S. Beg
Clinical Trials: Immunotherapy
Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial
Shiao-Pei Weathers; Marta Penas-Prado; Be-Lian Pei; Xiaoyang Ling; Cynthia Kassab; Pinaki Banerjee; Mustafa Bdiwi; Hila Shaim; Abdullah Alsuliman; Mayra Shanley; John F. de Groot; Barbara J. O'Brien; Rebecca Harrison; Nazanin Majd; Carlos Kamiya-Matsuoka; Gregory N. Fuller; Jason T. Huse; Linda Chi; Ganesh Rao; Jeffrey S. Weinberg; Frederick F. Lang; Raymond Sawaya; Elizabeth J. Shpall; Katayoun Rezvani; Amy B. Heimberger
Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer
Takahiro Tsujikawa; Todd Crocenzi; Jennifer N. Durham; Elizabeth A. Sugar; Annie A. Wu; Beth Onners; Julie M. Nauroth; Robert A. Anders; Elana J. Fertig; Daniel A. Laheru; Kim Reiss; Robert H. Vonderheide; Andrew H. Ko; Margaret A. Tempero; George A. Fisher; Michael Considine; Ludmila Danilova; Dirk G. Brockstedt; Lisa M. Coussens; Elizabeth M. Jaffee; Dung T. Le
Precision Medicine and Imaging
Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK Inhibition as an Effective Strategy
Anthony R. Mato; Lindsey E. Roeker; Ryan Jacobs; Brian T. Hill; Nicole Lamanna; Danielle Brander; Mazyar Shadman; Chaitra S. Ujjani; Maryam Sarraf Yazdy; Guilherme Fleury Perini; Javier A. Pinilla-Ibarz; Jacqueline Barrientos; Alan P. Skarbnik; Pallawi Torka; Jeffrey J. Pu; John M. Pagel; Satyen Gohil; Bita Fakhri; Michael Choi; Catherine C. Coombs; Joanna Rhodes; Paul M. Barr; Craig A. Portell; Helen Parry; Christine A. Garcia; Kate J. Whitaker; Allison M. Winter; Andrea Sitlinger; Sirin Khajavian; Ariel F. Grajales-Cruz; Krista M. Isaac; Pratik Shah; Othman S. Akhtar; Rachael Pocock; Kentson Lam; Timothy J. Voorhees; Stephen J. Schuster; Thomas D. Rodgers; Christopher P. Fox; Nicolas Martinez-Calle; Talha Munir; Erica B. Bhavsar; Neil Bailey; Jason C. Lee; Hanna B. Weissbrot; Chadi Nabhan; Julie M. Goodfriend; Amber C. King; Andrew D. Zelenetz; Colleen Dorsey; Kayla Bigelow; Bruce D. Cheson; John N. Allan; Toby A. Eyre
RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia
Govardhan Anande; Nandan P. Deshpande; Sylvain Mareschal; Aarif M.N. Batcha; Henry R. Hampton; Tobias Herold; Soren Lehmann; Marc R. Wilkins; Jason W.H. Wong; Ashwin Unnikrishnan; John E. Pimanda
Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer
Anna Moroz; Yung-Hua Wang; Jeremy M. Sharib; Junnian Wei; Ning Zhao; Yangjie Huang; Zhuo Chen; Alexander J. Martinko; Jie Zhuo; Shion A. Lim; Lydia H. Zhang; Youngho Seo; Sean Carlin; Kevin K. Leung; Eric A. Collisson; Kimberly S. Kirkwood; James A. Wells; Michael J. Evans
Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer
Bohai Feng; Ying Shen; Xavier Pastor Hostench; Matthias Bieg; Michaela Plath; Naveed Ishaque; Roland Eils; Kolja Freier; Wilko Weichert; Karim Zaoui; Jochen Hess
Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression
Julian Marcon; Renzo G. DiNatale; Alejandro Sanchez; Ritesh R. Kotecha; Sounak Gupta; Fengshen Kuo; Vladimir Makarov; Amar Sandhu; Roy Mano; Andrew W. Silagy; Kyle A. Blum; Daniel E. Nassau; Nicole E. Benfante; Michael V. Ortiz; Maria I. Carlo; Timothy A. Chan; Robert J. Motzer; Martin H. Voss; Jonathan Coleman; Paul Russo; Victor Reuter; A. Ari Hakimi; Ed Reznik
Author Choice
Identification of Deleterious NOTCH Mutation as Novel Predictor to Efficacious Immunotherapy in NSCLC
Kai Zhang; Xiaohua Hong; Zhengbo Song; Yu Xu; Chengcheng Li; Guoqiang Wang; Yuzi Zhang; Xiaochen Zhao; Zhengyi Zhao; Jing Zhao; Mengli Huang; Depei Huang; Chuang Qi; Chan Gao; Shangli Cai; Feifei Gu; Yue Hu; Chunwei Xu; Wenxian Wang; Zhenkun Lou; Yong Zhang; Li Liu
Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy
Vignesh Narasimhan; Josephine A. Wright; Michael Churchill; Tongtong Wang; Rachele Rosati; Tamsin R.M. Lannagan; Laura Vrbanac; Anne B. Richardson; Hiroki Kobayashi; Timothy Price; Gayle X.Y. Tye; Julie Marker; Peter J. Hewett; Michael P. Flood; Shalini Pereira; G. Adam Whitney; Michael Michael; Jeanne Tie; Siddhartha Mukherjee; Carla Grandori; Alexander G. Heriot; Daniel L. Worthley; Robert G. Ramsay; Susan L. Woods
Translational Cancer Mechanisms and Therapy
Tumor CD155 Expression Is Associated with Resistance to Anti-PD1 Immunotherapy in Metastatic Melanoma
Ailin Lepletier; Jason Madore; Jake S. O'Donnell; Rebecca L. Johnston; Xian-Yang Li; Elizabeth McDonald; Elizabeth Ahern; Anna Kuchel; Melissa Eastgate; Sally-Ann Pearson; Domenico Mallardo; Paolo A. Ascierto; Daniela Massi; Barbara Merelli; Mario Mandala; James S. Wilmott; Alexander M. Menzies; Charles Leduc; John Stagg; Bertrand Routy; Georgina V. Long; Richard A. Scolyer; Tobias Bald; Nicola Waddell; William C. Dougall; Michele W.L. Teng; Mark J. Smyth
Whole-Exome Sequencing Analysis of the Progression from Non–Low-Grade Ductal Carcinoma In Situ to Invasive Ductal Carcinoma
Fresia Pareja; David N. Brown; Ju Youn Lee; Arnaud Da Cruz Paula; Pier Selenica; Rui Bi; Felipe C. Geyer; Andrea Gazzo; Edaise M. da Silva; Mahsa Vahdatinia; Anthe A. Stylianou; Lorenzo Ferrando; Hannah Y. Wen; James B. Hicks; Britta Weigelt; Jorge S. Reis-Filho
AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells
Riley A. Hampsch; Jason D. Wells; Nicole A. Traphagen; Charlotte F. McCleery; Jennifer L. Fields; Kevin Shee; Lloye M. Dillon; Darcy B. Pooler; Lionel D. Lewis; Eugene Demidenko; Yina H. Huang; Jonathan D. Marotti; Abigail E. Goen; William B. Kinlaw; Todd W. Miller
Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts
Albert Gris-Oliver; Marta Palafox; Laia Monserrat; Fara Brasó-Maristany; Andreu Òdena; Mònica Sánchez-Guixé; Yasir H. Ibrahim; Guillermo Villacampa; Judit Grueso; Mireia Parés; Marta Guzmán; Olga Rodríguez; Alejandra Bruna; Caroline S. Hirst; Alan Barnicle; Elza C. de Bruin; Avinash Reddy; Gaia Schiavon; Joaquín Arribas; Gordon B. Mills; Carlos Caldas; Rodrigo Dienstmann; Aleix Prat; Paolo Nuciforo; Pedram Razavi; Maurizio Scaltriti; Nicholas C. Turner; Cristina Saura; Barry R. Davies; Mafalda Oliveira; Violeta Serra
TP53 Mutations Predict Sensitivity to Adjuvant Gemcitabine in Patients with Pancreatic Ductal Adenocarcinoma: Next-Generation Sequencing Results from the CONKO-001 Trial
Marianne Sinn; Bruno V. Sinn; Denise Treue; Ulrich Keilholz; Frederik Damm; Rosa Schmuck; Philipp Lohneis; Frederick Klauschen; Jana K. Striefler; Marcus Bahra; Hendrik Bläker; Sven Bischoff; Uwe Pelzer; Helmut Oettle; Hanno Riess; Jan Budczies; Carsten Denkert
Author Choice
The Pharmacokinetic–Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST
Venkatesh Pilla Reddy; Rana Anjum; Michael Grondine; Aaron Smith; Deepa Bhavsar; Evan Barry; Sylvie M. Guichard; Wenlin Shao; Jason G. Kettle; Crystal Brown; Erica Banks; Rhys D.O. Jones
Author Choice
A CpG Methylation Classifier to Predict Relapse in Adults with T-Cell Lymphoblastic Lymphoma
Xiao-Peng Tian; Ning Su; Liang Wang; Wei-Juan Huang; Yan-Hui Liu; Xi Zhang; Hui-Qiang Huang; Tong-Yu Lin; Shu-Yun Ma; Hui-Lan Rao; Mei Li; Fang Liu; Fen Zhang; Li-Ye Zhong; Li Liang; Xiao-Liang Lan; Juan Li; Bing Liao; Zhi-Hua Li; Qiong-Lan Tang; Qiong Liang; Chun-Kui Shao; Qiong-Li Zhai; Run-Fen Cheng; Qi Sun; Kun Ru; Xia Gu; Xi-Na Lin; Kun Yi; Yue-Rong Shuang; Xiao-Dong Chen; Wei Dong; Cai Sun; Wei Sang; Hui Liu; Zhi-Gang Zhu; Jun Rao; Qiao-Nan Guo; Ying Zhou; Xiang-Ling Meng; Yong Zhu; Chang-Lu Hu; Yi-Rong Jiang; Ying Zhang; Hong-Yi Gao; Wen-Jun He; Zhong-Jun Xia; Xue-Yi Pan; Lan Hai; Guo-Wei Li; Li-Yan Song; Tie-Bang Kang; Dan Xie; Qing-Qing Cai
The Impact of Molecular Subtype on Efficacy of Chemotherapy and Checkpoint Inhibition in Advanced Gastric Cancer
Yohei Kubota; Akihito Kawazoe; Akinori Sasaki; Saori Mishima; Kentaro Sawada; Yoshiaki Nakamura; Daisuke Kotani; Yasutoshi Kuboki; Hiroya Taniguchi; Takashi Kojima; Toshihiko Doi; Takayuki Yoshino; Genichiro Ishii; Takeshi Kuwata; Kohei Shitara
Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma
Jossie Rotman; A. Marijne Heeren; Awa A. Gassama; Sinead M. Lougheed; Noëlle Pocorni; Anita G.M. Stam; Maaike C.G. Bleeker; Henry J.M.A.A Zijlmans; Constantijne H. Mom; Gemma G. Kenter; Ekaterina S. Jordanova; Tanja D. de Gruijl
Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition
Rebecca L. Shattuck-Brandt; Sheau-Chiann Chen; Emily Murray; Christopher Andrew Johnson; Holly Crandall; Jamye F. O'Neal; Rami Nayef Al-Rohil; Caroline A. Nebhan; Vijaya Bharti; Kimberly B. Dahlman; Gregory D. Ayers; Chi Yan; Mark C. Kelley; Rondi M. Kauffmann; Mary Hooks; Ana Grau; Douglas B. Johnson; Anna E. Vilgelm; Ann Richmond
Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup
Christine Pirker; Agnes Bilecz; Michael Grusch; Thomas Mohr; Barbara Heidenreich; Viktoria Laszlo; Paul Stockhammer; Daniela Lötsch-Gojo; Johannes Gojo; Lisa Gabler; Sabine Spiegl-Kreinecker; Balazs Dome; Ariane Steindl; Thomas Klikovits; Mir Alireza Hoda; Marko Jakopovic; Miroslav Samarzija; Katja Mohorcic; Izidor Kern; Barbara Kiesel; Luka Brcic; Felicitas Oberndorfer; Leonhard Müllauer; Walter Klepetko; Wolfgang M. Schmidt; Rajiv Kumar; Balazs Hegedus; Walter Berger
Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy
Mark J.A. Schoonderwoerd; Maaike F.M. Koops; Ricardo A. Angela; Bryan Koolmoes; Melpomeni Toitou; Madelon Paauwe; Marieke C. Barnhoorn; Yingmiao Liu; Cornelis F.M. Sier; James C.H. Hardwick; Andrew B. Nixon; Charles P. Theuer; Marieke F. Fransen; Lukas J.A.C. Hawinkels
Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing
Martee L. Hensley; Shweta S. Chavan; David B. Solit; Rajmohan Murali; Robert Soslow; Sarah Chiang; Achim A. Jungbluth; Chaitanya Bandlamudi; Preethi Srinivasan; William D. Tap; Evan Rosenbaum; Barry S. Taylor; Mark T.A. Donoghue; David M. Hyman
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