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1 July 2020
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Cover Image
Cover Image
Immunofluorescent staining of histone 3 mutant protein (H3K27M, green) and the receptor tyrosine kinase AXL (red) in a needle biopsy sample taken from the brainstem of a patient suffering from diffuse intrinsic pontine glioma. Co-staining reveals a high expression of AXL specifically in tumor cells, which can be exploited therapeutically. For details, see the article by Meel and colleagues on page 3319 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Research Briefs: Clinical Trial Brief Report
Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer
Heiko Schöder; Paula Demétrio De Souza França; Reiko Nakajima; Eva Burnazi; Sheryl Roberts; Christian Brand; Milan Grkovski; Audrey Mauguen; Mark P. Dunphy; Ronald A. Ghossein; Serge K. Lyashchenko; Jason S. Lewis; Joseph A. O'Donoghue; Ian Ganly; Snehal G. Patel; Nancy Y. Lee; Thomas Reiner
Clinical Trials: Targeted Therapy
Phase I Trial of Trametinib with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer
Christina Wu; Terence M. Williams; Ryan Robb; Amy Webb; Lai Wei; Wei Chen; Sameh Mikhail; Kristen K. Ciombor; Dana B. Cardin; Cynthia Timmers; Somashekar G. Krishna; Mark Arnold; Alan Harzman; Sherif Abdel-Misih; Sameek Roychowdhury; Tanios Bekaii-Saab; Evan Wuthrick
Author Choice
A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients
Herbert J. Zeh; Nathan Bahary; Brian A. Boone; Aatur D. Singhi; Jennifer Lee Miller-Ocuin; Daniel P. Normolle; Amer H. Zureikat; Melissa E. Hogg; David L. Bartlett; Kenneth K. Lee; Allan Tsung; J. Wallis Marsh; Pranav Murthy; Daolin Tang; Natalie Seiser; Ravi K. Amaravadi; Virginia Espina; Lance Liotta; Michael T. Lotze
Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma
Benjamin M. Ellingson; Jingwen Yao; Catalina Raymond; David A. Nathanson; Ararat Chakhoyan; Jeremy Simpson; James S. Garner; Alan G. Olivero; Lars U. Mueller; Jordi Rodon; Elizabeth Gerstner; Timothy F. Cloughesy; Patrick Y. Wen
A LYSA Phase Ib Study of Tazemetostat (EPZ-6438) plus R-CHOP in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) with Poor Prognosis Features
Clémentine Sarkozy; Franck Morschhauser; Sydney Dubois; Thierry Molina; Jean Marie Michot; Peggy Cullières-Dartigues; Benjamin Suttle; Lionel Karlin; Steven Le Gouill; Jean-Michel Picquenot; Romain Dubois; Hervé Tilly; Charles Herbaux; Fabrice Jardin; Gilles Salles; Vincent Ribrag
Randomized Trial of Intermediate-dose Cytarabine in Induction and Consolidation Therapy in Adults with Acute Myeloid Leukemia
Hui Wei; Ying Wang; Robert Peter Gale; Dong Lin; Chunlin Zhou; Bingcheng Liu; Shaowei Qiu; Runxia Gu; Yan Li; Xingli Zhao; Shuning Wei; Benfa Gong; Kaiqi Liu; Xiaoyuan Gong; Yuntao Liu; Guangji Zhang; Zhen Song; Yang Wang; Wei Li; Yingchang Mi; Jianxiang Wang
Author Choice
Routine-Dose and High-Dose Icotinib in Patients with Advanced Non–Small Cell Lung Cancer Harboring EGFR Exon 21-L858R Mutation: the Randomized, Phase II, INCREASE Trial
Xi Li; Li Zhang; Da Jiang; Yan Wang; Aimin Zang; Cuimin Ding; Min Zhao; Wuyun Su; Yan Zhang; Diansheng Zhong; Jin Wu; Cuiying Zhang; Guangyu An; Xingsheng Hu; Gang Cheng; Huaqing Wang; Yongqun Li; Xiaohui He; Junli Liu; Li Liang; Lieming Ding; Li Mao; Shucai Zhang
Randomized Phase II Trial Evaluating Treatment with EGFR-TKI Associated with Antiestrogen in Women with Nonsquamous Advanced-Stage NSCLC: IFCT-1003 LADIE Trial
Julien Mazieres; Fabrice Barlesi; Isabelle Rouquette; Olivier Molinier; Benjamin Besse; Isabelle Monnet; Clarisse Audigier-Valette; Anne-Claire Toffart; Patrick Aldo Renault; Séverine Fraboulet; Sandrine Hiret; Bertrand Mennecier; Didier Debieuvre; Virginie Westeel; Philippe Masson; Anne Madroszyk-Flandin; Eric Pichon; Alexis B. Cortot; Elodie Amour; Franck Morin; Gérard Zalcman; Denis Moro-Sibilot; Pierre-Jean Souquet
Clinical Trials: Immunotherapy
T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer
Aleksandar Z. Obradovic; Matthew C. Dallos; Marianna L. Zahurak; Alan W. Partin; Edward M. Schaeffer; Ashley E. Ross; Mohamad E. Allaf; Thomas R. Nirschl; David Liu; Carolyn G. Chapman; Tanya O'Neal; Haiyi Cao; Jennifer N. Durham; Gunes Guner; Javier A. Baena-Del Valle; Onur Ertunc; Angelo M. De Marzo; Emmanuel S. Antonarakis; Charles G. Drake
A Prospective, Phase 1 Trial of Nivolumab, Ipilimumab, and Radiotherapy in Patients with Advanced Melanoma
Michael A. Postow; Susan J. Knox; Debra A. Goldman; Yuval Elhanati; Vikram Mavinkurve; Phillip Wong; Darragh Halpenny; Sunil K. Reddy; Kenya Vado; Danielle McCabe; Kristen Aufiero Ramirez; Mary Macri; Paul Schwarzenberger; Toni Ricciardi; Aileen Ryan; Ralph Venhaus; Parisa Momtaz; Alexander N. Shoushtari; Margaret K. Callahan; Paul B. Chapman; Jedd D. Wolchok; Priyanka B. Subrahmanyam; Holden T. Maecker; Katherine S. Panageas; Christopher A. Barker
Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer
Yoon-Koo Kang; Yung-Jue Bang; Shunsuke Kondo; Hyun Cheol Chung; Kei Muro; Isabelle Dussault; Christoph Helwig; Motonobu Osada; Toshihiko Doi
Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results
Renata Ferrarotto; Diana Bell; Maria L. Rubin; Katherine A. Hutcheson; Jason M. Johnson; Ryan P. Goepfert; Jack Phan; Yasir Y. Elamin; Danice K. Torman; Carla L. Warneke; Amy C. Hessel; Adam S. Garden; Jeffrey N. Myers; Faye M. Johnson; J. Jack Lee; Andrew G. Sikora; Maura L. Gillison; Bonnie S. Glisson; Neil D. Gross
Precision Medicine and Imaging
Integrative Omics Analysis Reveals Soluble Cadherin-3 as a Survival Predictor and an Early Monitoring Marker of EGFR Tyrosine Kinase Inhibitor Therapy in Lung Cancer
Ting-Feng Hsiao; Chih-Liang Wang; Yi-Cheng Wu; Hsiang-Pu Feng; Yen-Chuan Chiu; Hao-Yu Lin; Ko-Jiunn Liu; Gee-Chen Chang; Kun-Yi Chien; Jau-Song Yu; Chia-Jung Yu
Oncogenic Genomic Alterations, Clinical Phenotypes, and Outcomes in Metastatic Castration-Sensitive Prostate Cancer
Konrad H. Stopsack; Subhiksha Nandakumar; Andreas G. Wibmer; Samuel Haywood; Emily S. Weg; Ethan S. Barnett; Chloe J. Kim; Emily A. Carbone; Samantha E. Vasselman; Bastien Nguyen; Melanie A. Hullings; Howard I. Scher; Michael J. Morris; David B. Solit; Nikolaus Schultz; Philip W. Kantoff; Wassim Abida
Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection
Wungki Park; Jiapeng Chen; Joanne F. Chou; Anna M. Varghese; Kenneth H. Yu; Winston Wong; Marinela Capanu; Vinod Balachandran; Caitlin A. McIntyre; Imane El Dika; Danny N. Khalil; James J. Harding; Nima Ghalehsari; Zoe McKinnell; Sree B. Chalasani; Vladimir Makarov; Pier Selenica; Xin Pei; Nicolas Lecomte; David P. Kelsen; Ghassan K. Abou-Alfa; Mark E. Robson; Liying Zhang; Michael F. Berger; Nikolaus Schultz; Timothy A. Chan; Simon N. Powell; Jorge S. Reis-Filho; Christine A. Iacobuzio-Donahue; Nadeem Riaz; Eileen M. O'Reilly
A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma
Zijian Yang; Michael J. LaRiviere; Jina Ko; Jacob E. Till; Theresa Christensen; Stephanie S. Yee; Taylor A. Black; Kyle Tien; Andrew Lin; Hanfei Shen; Neha Bhagwat; Daniel Herman; Andrew Adallah; Mark H. O'Hara; Charles M. Vollmer; Bryson W. Katona; Ben Z. Stanger; David Issadore; Erica L. Carpenter
Early Mortality of Brain Cancer Patients and its Connection to Cytomegalovirus Reactivation During Radiochemotherapy
Nicole L. Goerig; Benjamin Frey; Klaus Korn; Bernhard Fleckenstein; Klaus Überla; Manuel A. Schmidt; Arnd Dörfler; Tobias Engelhorn; Ilker Eyüpoglu; Paul F. Rühle; Florian Putz; Sabine Semrau; Udo S. Gaipl; Rainer Fietkau
Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Andrea Cercek; Gustavo Dos Santos Fernandes; Campbell S. Roxburgh; Karuna Ganesh; Shu Ng; Francisco Sanchez-Vega; Rona Yaeger; Neil H. Segal; Diane L. Reidy-Lagunes; Anna M. Varghese; Arnold Markowitz; Chao Wu; Bryan Szeglin; Charles-Etienne Gabriel Sauvé; Erin Salo-Mullen; Christina Tran; Zalak Patel; Asha Krishnan; Kaitlyn Tkachuk; Garrett M. Nash; Jose Guillem; Philip B. Paty; Jinru Shia; Nikolaus Schultz; Julio Garcia-Aguilar; Luis A. Diaz; Karyn Goodman; Leonard B. Saltz; Martin R. Weiser; J. Joshua Smith; Zsofia K. Stadler
Translational Cancer Mechanisms and Therapy
Author Choice
Repotrectinib Exhibits Potent Antitumor Activity in Treatment-Naïve and Solvent-Front–Mutant ROS1-Rearranged Non–Small Cell Lung Cancer
Mi Ran Yun; Dong Hwi Kim; Seok-Young Kim; Hyeong-Seok Joo; You Won Lee; Hun Mi Choi; Chae Won Park; Seong Gu Heo; Han Na Kang; Sung Sook Lee; Adam J. Schoenfeld; Alexander Drilon; Seok-Gu Kang; Hyo Sup Shim; Min Hee Hong; J. Jean Cui; Hye Ryun Kim; Byoung Chul Cho
Author Choice
Outcome-Related Signatures Identified by Whole Transcriptome Sequencing of Resectable Stage III/IV Melanoma Evaluated after Starting Hu14.18-IL2
Richard K. Yang; Igor B. Kuznetsov; Erik A. Ranheim; Jun S. Wei; Sivasish Sindiri; Berkley E. Gryder; Vineela Gangalapudi; Young K. Song; Viharkumar Patel; Jacquelyn A. Hank; Cindy Zuleger; Amy K. Erbe; Zachary S. Morris; Renae Quale; KyungMann Kim; Mark R. Albertini; Javed Khan; Paul M. Sondel
Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia
Anouchka P. Laurent; Aurélie Siret; Cathy Ignacimouttou; Kunjal Panchal; M'Boyba Diop; Silvia Jenni; Yi-Chien Tsai; Damien Roos-Weil; Zakia Aid; Nais Prade; Stephanie Lagarde; Damien Plassard; Gaelle Pierron; Estelle Daudigeos; Yann Lecluse; Nathalie Droin; Beat C. Bornhauser; Laurence C. Cheung; John D. Crispino; Muriel Gaudry; Olivier A. Bernard; Elizabeth Macintyre; Carole Barin Bonnigal; Rishi S. Kotecha; Birgit Geoerger; Paola Ballerini; Jean-Pierre Bourquin; Eric Delabesse; Thomas Mercher; Sebastien Malinge
Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma
Michaël H. Meel; Mark C. de Gooijer; Dennis S. Metselaar; A. Charlotte P. Sewing; Kenn Zwaan; Piotr Waranecki; Marjolein Breur; Levi C.M. Buil; Tonny Lagerweij; Laurine E. Wedekind; Jos W.R. Twisk; Jan Koster; Rintaro Hashizume; Eric H. Raabe; Ángel Montero Carcaboso; Marianna Bugiani; Timothy N. Phoenix; Olaf van Tellingen; Dannis G. van Vuurden; Gertjan J.L. Kaspers; Esther Hulleman
Author Choice
FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity
Matthew Kraman; Mustapha Faroudi; Natalie L. Allen; Katarzyna Kmiecik; Daniel Gliddon; Claire Seal; Alexander Koers; Mateusz M. Wydro; Sarah Batey; Julia Winnewisser; Lesley Young; Mihriban Tuna; Jacqueline Doody; Michelle Morrow; Neil Brewis
Author Choice
Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells
Martin J. Scurr; Alex Greenshields-Watson; Emma Campbell; Michelle S. Somerville; Yuan Chen; Sarah L. Hulin-Curtis; Stephanie E.A. Burnell; James A. Davies; Michael M. Davies; Rachel Hargest; Simon Phillips; Adam D. Christian; Kevin E. Ashelford; Robert Andrews; Alan L. Parker; Richard J. Stanton; Awen Gallimore; Andrew Godkin
Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells
Junya Ichikawa; Tatsuya Yoshida; Ariel Isser; Andressa S. Laino; Melinda Vassallo; David Woods; Sojung Kim; Mathias Oelke; Kristi Jones; Jonathan P. Schneck; Jeffrey S. Weber
The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer
Artur A. Serebrenik; Prokopios P. Argyris; Matthew C. Jarvis; William L. Brown; Martina Bazzaro; Rachel I. Vogel; Britt K. Erickson; Sun-Hee Lee; Krista M. Goergen; Matthew J. Maurer; Ethan P. Heinzen; Ann L. Oberg; Yajue Huang; Xiaonan Hou; S. John Weroha; Scott H. Kaufmann; Reuben S. Harris
OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models
Myriam Fabre; Cristina Ferrer; Saioa Domínguez-Hormaetxe; Bruno Bockorny; Laura Murias; Oliver Seifert; Stephan A. Eisler; Roland E. Kontermann; Klaus Pfizenmaier; So Young Lee; María dM. Vivanco; Pedro P. López-Casas; Sofia Perea; Muhammad Abbas; Wolfgang Richter; Laureano Simon; Manuel Hidalgo
Author Choice
Generation of Genetically Engineered Mouse Lung Organoid Models for Squamous Cell Lung Cancers Allows for the Study of Combinatorial Immunotherapy
Josephine Hai; Hua Zhang; Jin Zhou; Zhong Wu; Ting Chen; Eleni Papadopoulos; Catríona M. Dowling; Val Pyon; Yuanwang Pan; Jie Bin Liu; Roderick T. Bronson; Heather Silver; Patrick H. Lizotte; Jiehui Deng; Joshua D. Campbell; Lynette M. Sholl; Christine Ng; Ming-Sound Tsao; Cassandra Thakurdin; Adam J. Bass; Kwok-Kin Wong
Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma
Nouf Alrasheed; Lydia Lee; Ehsan Ghorani; Jake Y. Henry; Lucia Conde; Melody Chin; Daria Galas-Filipowicz; Andrew J.S. Furness; Selina J. Chavda; Huw Richards; Dunnya De-Silva; Oliver C. Cohen; Dominic Patel; Anthony Brooks; Manuel Rodriguez-Justo; Martin Pule; Javier Herrero; Sergio A. Quezada; Kwee L. Yong
A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer
Vinata B. Lokeshwar; Daley S. Morera; Sarrah L. Hasanali; Travis J. Yates; Marie C. Hupe; Judith Knapp; Soum D. Lokeshwar; Jiaojiao Wang; Martin J.P. Hennig; Rohitha Baskar; Diogo O. Escudero; Ronny R. Racine; Neetika Dhir; Andre R. Jordan; Kelly Hoye; Ijeoma Azih; Murugesan Manoharan; Zachary Klaassen; Sravan Kavuri; Luis E. Lopez; Santu Ghosh; Bal L. Lokeshwar
Single-Cell–Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response
Rüdiger Braun; Lena Anthuber; Daniela Hirsch; Darawalee Wangsa; Justin Lack; Nicole E. McNeil; Kerstin Heselmeyer-Haddad; Irianna Torres; Danny Wangsa; Markus A. Brown; Anthony Tubbs; Noam Auslander; E. Michael Gertz; Philip R. Brauer; Margaret C. Cam; Dan L. Sackett; Jens K. Habermann; Andre Nussenzweig; Eytan Ruppin; Zhongqiu Zhang; Daniel W. Rosenberg; Thomas Ried
Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease
Hung Nguyen; Ali Alawieh; David Bastian; Sandeepkumar Kuril; Min Dai; Anusara Daenthanasanmak; Mengmeng Zhang; Supinya Iamsawat; Steven D. Schutt; Yongxia Wu; M. Mahdi Sleiman; Akshay Shetty; Carl Atkinson; Shaoli Sun; Juan Carlos Varela; Stephen Tomlinson; Xue-Zhong Yu
Letters to the Editor
Correction
Correction: Identification of a Novel, EBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Anna E. Coghill; Ruth M. Pfeiffer; Carla Proietti; Wan-Lun Hsu; Yin-Chu Chien; Lea Lekieffre; Lutz Krause; Andy Teng; Jocelyn Pablo; Kelly J. Yu; Pei-Jen Lou; Cheng-Ping Wang; Zhiwei Liu; Chien-Jen Chen; Jaap Middeldorp; Jason Mulvenna; Jeff Bethony; Allan Hildesheim; Denise L. Doolan
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