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15 May 2020
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Cover Image
Cover Image
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The cover shows a fluorescent image of GBM cells showing activation of NOTCH, visualized by red NICD staining, in cells adjacent to oHSV-infected cells seen in green. The white staining is F-actin. For details, see the article by Otani and colleagues on page 2381 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Atezolizumab Plus Paclitaxel Protein-bound for the Treatment of Patients with Advanced or Metastatic TNBC Whose Tumors Express PD-L1
Preeti Narayan; Sakar Wahby; Jennifer J. Gao; Laleh Amiri-Kordestani; Amna Ibrahim; Erik Bloomquist; Shenghui Tang; Yuan Xu; Jiang Liu; Wentao Fu; Pengfei Song; Bellinda L. King-Kallimanis; Sherry Hou; Yutao Gong; Shyam Kalavar; Soma Ghosh; Reena Philip; Kirsten B. Goldberg; Marc R. Theoret; Gideon M. Blumenthal; Paul G. Kluetz; Rajeshwari Sridhara; Richard Pazdur; Julia A. Beaver
Clinical Trial Brief Report
A Phase II Basket Trial of Dual Anti–CTLA-4 and Anti–PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors
Sandip P. Patel; Megan Othus; Young Kwang Chae; Francis J. Giles; Donna E. Hansel; Preet Paul Singh; Annette Fontaine; Manisha H. Shah; Anup Kasi; Tareq Al Baghdadi; Marc Matrana; Zoran Gatalica; W. Michael Korn; Jourdain Hayward; Christine McLeod; Helen X. Chen; Elad Sharon; Edward Mayerson; Christopher W. Ryan; Melissa Plets; Charles D. Blanke; Razelle Kurzrock
Clinical Trials: Targeted Therapy
Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
Michael J. Burke; Rumen Kostadinov; Richard Sposto; Lia Gore; Shannon M. Kelley; Cara Rabik; Jane B. Trepel; Min-Jung Lee; Akira Yuno; Sunmin Lee; Deepa Bhojwani; Sima Jeha; Bill H. Chang; Maria Luisa Sulis; Michelle L. Hermiston; Paul Gaynon; Van Huynh; Anupam Verma; Rebecca Gardner; Kenneth M. Heym; Robyn M. Dennis; David S. Ziegler; Theodore W. Laetsch; Javier E. Oesterheld; Steven G. Dubois; Jessica A. Pollard; Julia Glade-Bender; Todd M. Cooper; Joel A. Kaplan; Midhat S. Farooqi; Byunggil Yoo; Erin Guest; Alan S. Wayne; Patrick A. Brown
First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma
Ravi Vij; Rajneesh Nath; Daniel E.H. Afar; María-Victoria Mateos; Jesús G. Berdeja; Marc S. Raab; Andreas Guenther; Joaquín Martínez-López; Andrzej J. Jakubowiak; Xavier Leleu; Katja Weisel; Shekman Wong; Scott Gulbranson; James P. Sheridan; Anita Reddy; Bruno Paiva; Anil Singhal; Jesús F. San-Miguel; Philippe Moreau
Clinical Trials: Immunotherapy
Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Changqing Xie; Austin G. Duffy; Gagandeep Brar; Suzanne Fioravanti; Donna Mabry-Hrones; Melissa Walker; Cecilia Monge Bonilla; Bradford J. Wood; Deborah E. Citrin; Elizabeth M. Gil Ramirez; Freddy E. Escorcia; Bernadette Redd; Jonathan M. Hernandez; Jeremy L. Davis; Billel Gasmi; David Kleiner; Seth M. Steinberg; Jennifer C. Jones; Tim F. Greten
Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma
Robert A. Figlin; Nizar M. Tannir; Robert G. Uzzo; Scott S. Tykodi; David Y.T. Chen; Viraj Master; Anil Kapoor; Daniel Vaena; William Lowrance; Gennady Bratslavsky; Mark DeBenedette; Alicia Gamble; Ana Plachco; Marcus S. Norris; Joe Horvatinovich; Irina Y. Tcherepanova; Charles A. Nicolette; Christopher G. Wood; for the ADAPT study group
Efficacy, Safety, and Biomarkers of Toripalimab in Patients with Recurrent or Metastatic Neuroendocrine Neoplasms: A Multiple-Center Phase Ib Trial
Ming Lu; Panpan Zhang; Yanqiao Zhang; Zhongwu Li; Jifang Gong; Jie Li; Jian Li; Yan Li; Xiaotian Zhang; Zhihao Lu; Xicheng Wang; Jun Zhou; Zhi Peng; Weifeng Wang; Hui Feng; Hai Wu; Sheng Yao; Lin Shen
A Phase I Study of Ruxolitinib, Lenalidomide, and Steroids for Patients with Relapsed/Refractory Multiple Myeloma
James R. Berenson; Jennifer To; Tanya M. Spektor; Daisy Martinez; Carley Turner; Armando Sanchez; Matthew Ghermezi; Benjamin M. Eades; Regina A. Swift; Gary Schwartz; Shahrooz Eshaghian; Laura Stampleman; Robert A. Moss; Stephen Lim; Robert Vescio
Precision Medicine and Imaging
Baseline Plasma Tumor Mutation Burden Predicts Response to Pembrolizumab-based Therapy in Patients with Metastatic Non–Small Cell Lung Cancer
Charu Aggarwal; Jeffrey C. Thompson; Austin L. Chien; Katie J. Quinn; Wei-Ting Hwang; Taylor A. Black; Stephanie S. Yee; Theresa E. Christensen; Michael J. LaRiviere; Benjamin A. Silva; Kimberly C. Banks; Rebecca J. Nagy; Elena Helman; Abigail T. Berman; Christine A. Ciunci; Aditi P. Singh; Jeffrey S. Wasser; Joshua M. Bauml; Corey J. Langer; Roger B. Cohen; Erica L. Carpenter
Shortened Leukocyte Telomere Length Associates with an Increased Prevalence of Chronic Health Conditions among Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort
Nan Song; Zhenghong Li; Na Qin; Carrie R. Howell; Carmen L. Wilson; John Easton; Heather L. Mulder; Michael N. Edmonson; Michael C. Rusch; Jinghui Zhang; Melissa M. Hudson; Yutaka Yasui; Leslie L. Robison; Kirsten K. Ness; Zhaoming Wang
Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non–Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy
Melissa A. Frick; Steven J. Feigenberg; Samuel R. Jean-Baptiste; Louise A. Aguarin; Amberly Mendes; Chimbu Chinniah; Sam Swisher-McClure; Abigail Berman; William Levin; Keith A. Cengel; Stephen M. Hahn; Jay F. Dorsey; Charles B. Simone, II; Gary D. Kao
Translational Cancer Mechanisms and Therapy
Oncolytic HSV–Infected Glioma Cells Activate NOTCH in Adjacent Tumor Cells Sensitizing Tumors to Gamma Secretase Inhibition
Yoshihiro Otani; Ji Young Yoo; Samantha Chao; Joseph Liu; Alena Cristina Jaime-Ramirez; Tae Jin Lee; Brian Hurwitz; Yuanqing Yan; Hongsheng Dai; Joseph C. Glorioso; Michael A. Caligiuri; Jianhua Yu; Balveen Kaur
Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non–Small Cell Lung Cancer
Elena Ivanova; Mari Kuraguchi; Man Xu; Andrew J. Portell; Luke Taus; Irmina Diala; Alshad S. Lalani; Jihyun Choi; Emily S. Chambers; Shuai Li; Shengwu Liu; Ting Chen; Thanh U. Barbie; Geoffrey R. Oxnard; Jacob J. Haworth; Kwok-Kin Wong; Suzanne E. Dahlberg; Amir A. Aref; David A. Barbie; Magda Bahcall; Cloud P. Paweletz; Pasi A. Jänne
Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning
Seiya Yokoyama; Taiji Hamada; Michiyo Higashi; Kei Matsuo; Kosei Maemura; Hiroshi Kurahara; Michiko Horinouchi; Tsubasa Hiraki; Tomoyuki Sugimoto; Toshiaki Akahane; Suguru Yonezawa; Marko Kornmann; Surinder K. Batra; Michael A. Hollingsworth; Akihide Tanimoto
BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma
Eileen M. Boyle; Cody Ashby; Ruslana G. Tytarenko; Shayu Deshpande; Hongwei Wang; Yan Wang; Adam Rosenthal; Jeffrey Sawyer; Erming Tian; Erin Flynt; Antje Hoering; Sarah K. Johnson; Michael W. Rutherford; Christopher P. Wardell; Michael A. Bauer; Charles Dumontet; Thierry Facon; Sharmilan Thanendrarajan; Carolina D. Schinke; Maurizio Zangari; Frits van Rhee; Bart Barlogie; David Cairns; Graham Jackson; Anjan Thakurta; Faith E. Davies; Gareth J. Morgan; Brian A. Walker
Letters to the Editor
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