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1 January 2020
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Cover Image
Cover Image
The cover shows a section of the tumor core of a patient with pancreatic cancer. Immunofluorescence staining with ki67 shows the proliferating cells within the tumor on primarly resected patients. For details, see the article by Mota Reyes and colleagues on page 220 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Clinical Trials: Targeted Therapy
Clinical Assessment of 5-Fluorouracil/Leucovorin, Nab-Paclitaxel, and Irinotecan (FOLFIRABRAX) in Untreated Patients with Gastrointestinal Cancer Using UGT1A1 Genotype–Guided Dosing
Smita S. Joshi; Daniel V.T. Catenacci; Theodore G. Karrison; Jaclyn D. Peterson; Mark M. Zalupski; Amikar Sehdev; James Wade; Ahad Sadiq; Vincent J. Picozzi; Andrea Amico; Robert Marsh; Mark F. Kozloff; Blase N. Polite; Hedy L. Kindler; Manish R. Sharma
Selective Progesterone Receptor Modulators in Early-Stage Breast Cancer: A Randomized, Placebo-Controlled Phase II Window-of-Opportunity Trial Using Telapristone Acetate
Oukseub Lee; Megan E. Sullivan; Yanfei Xu; Chiara Rogers; Miguel Muzzio; Irene Helenowski; Ali Shidfar; Zexian Zeng; Hari Singhal; Borko Jovanovic; Nora Hansen; Kevin P. Bethke; Peter H. Gann; William Gradishar; J. Julie Kim; Susan E. Clare; Seema A. Khan
Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer
Miguel Quintela-Fandino; Serafín Morales; Alfonso Cortés-Salgado; Luis Manso; Juan V. Apala; Manuel Muñoz; Ariadna Gasol Cudos; Joel Salla Fortuny; María Gion; Antonio Lopez-Alonso; Javier Cortés; Juan Guerra; Diego Malón; Eduardo Caleiras; Francisca Mulero; Silvana Mouron
Author Choice
Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma
Antoni Ribas; Adil Daud; Anna C. Pavlick; Rene Gonzalez; Karl D. Lewis; Omid Hamid; Thomas F. Gajewski; Igor Puzanov; Matthew Wongchenko; Isabelle Rooney; Jessie J. Hsu; Yibing Yan; Erica Park; Grant A. McArthur
Phase I Clinical Trial of Selinexor in Combination with Daunorubicin and Cytarabine in Previously Untreated Poor-Risk Acute Myeloid Leukemia
Kendra Sweet; Rami Komrokji; Eric Padron; Christopher L. Cubitt; Joel G. Turner; Junmin Zhou; Alan F. List; David A. Sallman; Jana L. Dawson; Daniel M. Sullivan; Julio Chavez; Bijal D. Shah; Jeffrey E. Lancet
Clinical Trials: Immunotherapy
Author Choice
Efficacy and Tolerability of Tremelimumab in Locally Advanced or Metastatic Urothelial Carcinoma Patients Who Have Failed First-Line Platinum-Based Chemotherapy
Padmanee Sharma; Joohyuk Sohn; Sang Joon Shin; Do-Youn Oh; Bhumsuk Keam; Hyo Jin Lee; Marco Gizzi; Ewa Kalinka; Filip Y.F.L. de Vos; Dario Ruscica; Salvatore Ferro; Feng Xiao; Paul Baverel; Cecil Chi-Keung Chen; Kobby Asubonteng; Nassim Morsli; Luc Dirix
Author Choice
Pembrolizumab in Combination with the Oncolytic Virus Pelareorep and Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma: A Phase Ib Study
Devalingam Mahalingam; Grey A. Wilkinson; Kevin H. Eng; Paul Fields; Patrick Raber; Jennifer L. Moseley; Karol Cheetham; Matt Coffey; Gerard Nuovo; Pawel Kalinski; Bin Zhang; Sukeshi Patel Arora; Christos Fountzilas
Precision Medicine and Imaging
Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer
Naim U. Rashid; Xianlu L. Peng; Chong Jin; Richard A. Moffitt; Keith E. Volmar; Brian A. Belt; Roheena Z. Panni; Timothy M. Nywening; Silvia G. Herrera; Kristin J. Moore; Sarah G. Hennessey; Ashley B. Morrison; Ryan Kawalerski; Apoorve Nayyar; Audrey E. Chang; Benjamin Schmidt; Hong Jin Kim; David C. Linehan; Jen Jen Yeh
DNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas
Marije E. Weidema; Ellen van de Geer; Christian Koelsche; Ingrid M.E. Desar; Patrick Kemmeren; Melissa H.S. Hillebrandt-Roeffen; Vincent K.Y. Ho; Winette T.A. van der Graaf; Yvonne M.H. Versleijen-Jonkers; Andreas von Deimling; Uta E. Flucke; PALGA Group
Author Choice
Biomarker Analyses of Response to Cyclin-Dependent Kinase 4/6 Inhibition and Endocrine Therapy in Women with Treatment-Naïve Metastatic Breast Cancer
Richard S. Finn; Yuan Liu; Zhou Zhu; Miguel Martin; Hope S. Rugo; Véronique Diéras; Seock-Ah Im; Karen A. Gelmon; Nadia Harbeck; Dongrui R. Lu; Eric Gauthier; Cynthia Huang Bartlett; Dennis J. Slamon
Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers
Swathi Merugu; Lindi Chen; Elizabeth Gavens; Hany Gabra; Mark Brougham; Guy Makin; Antony Ng; Dermot Murphy; Alem S. Gabriel; Michael L. Robinson; Jennifer H. Wright; Susan A. Burchill; Angharad Humphreys; Nick Bown; David Jamieson; Deborah A. Tweddle
Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer
Joanna M. Karasinska; James T. Topham; Steve E. Kalloger; Gun Ho Jang; Robert E. Denroche; Luka Culibrk; Laura M. Williamson; Hui-Li Wong; Michael K.C. Lee; Grainne M. O'Kane; Richard A. Moore; Andrew J. Mungall; Malcolm J. Moore; Cassia Warren; Andrew Metcalfe; Faiyaz Notta; Jennifer J. Knox; Steven Gallinger; Janessa Laskin; Marco A. Marra; Steven J.M. Jones; Daniel J. Renouf; David F. Schaeffer
Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model
Rupa Juthani; Brian Madajewski; Barney Yoo; Li Zhang; Pei-Ming Chen; Feng Chen; Melik Z. Turker; Kai Ma; Michael Overholtzer; Valerie A. Longo; Sean Carlin; Virginia Aragon-Sanabria; Jason Huse; Mithat Gonen; Pat Zanzonico; Charles M. Rudin; Ulrich Wiesner; Michelle S. Bradbury; Cameron W. Brennan
A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition
Kevin Shee; Jason D. Wells; Matthew Ung; Riley A. Hampsch; Nicole A. Traphagen; Wei Yang; Stephanie C. Liu; Megan A. Zeldenrust; Liewei Wang; Krishna R. Kalari; Jia Yu; Judy C. Boughey; Eugene Demidenko; Arminja N. Kettenbach; Chao Cheng; Matthew P. Goetz; Todd W. Miller
Author Choice
Comprehensive Transcriptomic Profiling Identifies Breast Cancer Patients Who May Be Spared Adjuvant Systemic Therapy
Martin Sjöström; S. Laura Chang; Nick Fishbane; Elai Davicioni; Linda Hartman; Erik Holmberg; Felix Y. Feng; Corey W. Speers; Lori J. Pierce; Per Malmström; Mårten Fernö; Per Karlsson
MRI Tumor Regression Grade and Circulating Tumor DNA as Complementary Tools to Assess Response and Guide Therapy Adaptation in Rectal Cancer
Shelize Khakoo; Paul David Carter; Gina Brown; Nicola Valeri; Simona Picchia; Maria Antonietta Bali; Ridwan Shaikh; Thomas Jones; Ruwaida Begum; Isma Rana; Andrew Wotherspoon; Monica Terlizzo; Katharina von Loga; Eleftheria Kalaitzaki; Claire Saffery; David Watkins; Diana Tait; Ian Chau; Naureen Starling; Michael Hubank; David Cunningham
Author Choice
Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals RB1 Signaling as a Novel Mediator and Biomarker
Carolina A. Parada; Joshua W. Osbun; Tina Busald; Yigit Karasozen; Sumanpreet Kaur; Min Shi; Jason Barber; Widya Adidharma; Patrick J. Cimino; Catherine Pan; Luis F. Gonzalez-Cuyar; Robert Rostomily; Donald E. Born; Jing Zhang; Manuel Ferreira, Jr
Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma
Elizabeth R. Gerstner; Kyrre E. Emblem; Ken Chang; Bella Vakulenko-Lagun; Yi-Fen Yen; Andrew L. Beers; Jorg Dietrich; Scott R. Plotkin; Ciprian Catana; Jacob M. Hooker; Dan G. Duda; Bruce Rosen; Jayashree Kalpathy-Cramer; Rakesh K. Jain; Tracy Batchelor
Dilution of Molecular–Pathologic Gene Signatures by Medically Associated Factors Might Prevent Prediction of Resection Status After Debulking Surgery in Patients With Advanced Ovarian Cancer
Florian Heitz; Stefan Kommoss; Roshan Tourani; Anthony Grandelis; Locke Uppendahl; Constantin Aliferis; Alexander Burges; Chen Wang; Ulrich Canzler; Jinhua Wang; Antje Belau; Sonia Prader; Lars Hanker; Sisi Ma; Beyhan Ataseven; Felix Hilpert; Stephanie Schneider; Jalid Sehouli; Rainer Kimmig; Christian Kurzeder; Barbara Schmalfeldt; Elena I. Braicu; Philipp Harter; Sean C. Dowdy; Boris J. Winterhoff; Jacobus Pfisterer; Andreas du Bois
Translational Cancer Mechanisms and Therapy
Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer
Gonzalo Recondo; Laura Mezquita; Francesco Facchinetti; David Planchard; Anas Gazzah; Ludovic Bigot; Ahsan Z. Rizvi; Rosa L. Frias; Jean Paul Thiery; Jean-Yves Scoazec; Tony Sourisseau; Karen Howarth; Olivier Deas; Dariia Samofalova; Justine Galissant; Pauline Tesson; Floriane Braye; Charles Naltet; Pernelle Lavaud; Linda Mahjoubi; Aurélie Abou Lovergne; Gilles Vassal; Rastilav Bahleda; Antoine Hollebecque; Claudio Nicotra; Maud Ngo-Camus; Stefan Michiels; Ludovic Lacroix; Catherine Richon; Nathalie Auger; Thierry De Baere; Lambros Tselikas; Eric Solary; Eric Angevin; Alexander M. Eggermont; Fabrice Andre; Christophe Massard; Ken A. Olaussen; Jean-Charles Soria; Benjamin Besse; Luc Friboulet
A Validation Study on IDO Immune Biomarkers for Survival Prediction in Non–Small Cell Lung Cancer: Radiation Dose Fractionation Effect in Early-Stage Disease
Weili Wang; Lei Huang; Jian-Yue Jin; Wenhu Pi; Susannah G. Ellsworth; Shruti Jolly; Andrew L. Mellor; Mitchell Machtay; Feng-Ming (Spring) Kong
Editor’s Note
Acknowledgment to Reviewers
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