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1 May 2019
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Cover Image
Cover Image
H&E-stained photomicrograph showing the growth plate from the tibia of a BALB/c nude mouse 32 days after injection of breast cancer cells. Breast cancer cells expressing low concentrations of IL-1B do not induce metastases in bone. For details, see the article by Tulotta and colleagues on page 2769 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: (Daunorubicin and Cytarabine) Liposome for Injection for the Treatment of Adults with High-Risk Acute Myeloid Leukemia
Aviva C. Krauss; Xin Gao; Liang Li; Michael L. Manning; Paresma Patel; Wentao Fu; Kumar G. Janoria; Gerlie Gieser; David A. Bateman; Donna Przepiorka; Yuan Li Shen; Stacy S. Shord; Christopher M. Sheth; Anamitro Banerjee; Jiang Liu; Kirsten B. Goldberg; Ann T. Farrell; Gideon M. Blumenthal; Richard Pazdur
Review
Clinical Trials: Targeted Therapy
Author Choice
A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations
Martin H. Voss; Cinta Hierro; Rebecca S. Heist; James M. Cleary; Funda Meric-Bernstam; Josep Tabernero; Filip Janku; Leena Gandhi; A. John Iafrate; Darrell R. Borger; Nobuya Ishii; Youyou Hu; Yulia Kirpicheva; Valerie Nicolas-Metral; Anna Pokorska-Bocci; Anne Vaslin Chessex; Claudio Zanna; Keith T. Flaherty; Jose Baselga
Author Choice
A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Peter E. Hall; Rachel Lewis; Nelofer Syed; Richard Shaffer; Jane Evanson; Stephen Ellis; Matthew Williams; Xiaoxing Feng; Amanda Johnston; Jim A. Thomson; Fiona P. Harris; Raj Jena; Tomasz Matys; Sarah Jefferies; Kate Smith; Bor-Wen Wu; John S. Bomalaski; Timothy Crook; Kevin O'Neill; Dimitris Paraskevopoulos; Ramsay S. Khadeir; Michael Sheaff; Simon Pacey; Piers N. Plowman; Peter W. Szlosarek
Author Choice
A Phase II Study of Talazoparib after Platinum or Cytotoxic Nonplatinum Regimens in Patients with Advanced Breast Cancer and Germline BRCA1/2 Mutations (ABRAZO)
Nicholas C. Turner; Melinda L. Telli; Hope S. Rugo; Audrey Mailliez; Johannes Ettl; Eva-Maria Grischke; Lida A. Mina; Judith Balmaña; Peter A. Fasching; Sara A. Hurvitz; Andrew M. Wardley; Colombe Chappey; Alison L. Hannah; Mark E. Robson; on behalf of the ABRAZO Study Group
Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study
Erika J. Crosby; William Gwin; Kimberly Blackwell; Paul K. Marcom; Serena Chang; Holden T. Maecker; Gloria Broadwater; Terry Hyslop; Sungjin Kim; Andre Rogatko; Veronica Lubkov; Joshua C. Snyder; Takuya Osada; Amy C. Hobeika; Michael A. Morse; H. Kim Lyerly; Zachary C. Hartman
Precision Medicine and Imaging
Continued Endocrine Therapy Is Associated with Improved Survival in Patients with Breast Cancer Brain Metastases
Elisabeth S. Bergen; Anna S. Berghoff; Mela Medjedovic; Margaretha Rudas; Florian Fitzal; Zsuzsanna Bago-Horvath; Karin Dieckmann; Robert M. Mader; Ruth Exner; Michael Gnant; Christoph C. Zielinski; Guenther G. Steger; Matthias Preusser; Rupert Bartsch
Author Choice
The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis
Ben Staal; Ying Liu; Daniel Barnett; Peter Hsueh; Zonglin He; ChongFeng Gao; Katie Partyka; Mark W. Hurd; Aatur D. Singhi; Richard R. Drake; Ying Huang; Anirban Maitra; Randall E. Brand; Brian B. Haab
Translational Cancer Mechanisms and Therapy
Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment
Claudia Tulotta; Diane V. Lefley; Katy Freeman; Walter M. Gregory; Andrew M. Hanby; Paul R. Heath; Faith Nutter; J. Mark Wilkinson; Amy R. Spicer-Hadlington; Xinming Liu; Steven M.J. Bradbury; Lisa Hambley; Victoria Cookson; Gloria Allocca; Marianna Kruithof de Julio; Robert E. Coleman; Janet E. Brown; Ingunn Holen; Penelope D. Ottewell
BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells
Cigdem Atay; Taekyoung Kwak; Sergio Lavilla-Alonso; Laxminarasimha Donthireddy; Allison Richards; Valerie Moberg; Shari Pilon-Thomas; Michael Schell; Jane L. Messina; Vito W. Rebecca; Min Xiao; Jiufeng Tan; Gao Zhang; Jeffrey S. Weber; Meenhard Herlyn; Amod A. Sarnaik; Dmitry I. Gabrilovich
Unstable Genome and Transcriptome Dynamics during Tumor Metastasis Contribute to Therapeutic Heterogeneity in Colorectal Cancers
Sung-Yup Cho; Jeesoo Chae; Deukchae Na; Wonyoung Kang; Ahra Lee; Seoyeon Min; Jinjoo Kang; Boram Choi; Jieun Lee; Chang Ohk Sung; Jeffrey H. Chuang; Charles Lee; Won-Suk Lee; Hansoo Park; Jong-Il Kim
Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer
Anthony D. Saleh; Hui Cheng; Scott E. Martin; Han Si; Pinar Ormanoglu; Sophie Carlson; Paul E. Clavijo; Xinping Yang; Rita Das; Shaleeka Cornelius; Jamie Couper; Douglas Chepeha; Ludmila Danilova; Thomas M. Harris; Michael B. Prystowsky; Geoffrey J. Childs; Richard V. Smith; A. Gordon Robertson; Steven J. M. Jones; Andrew D. Cherniack; Sang S. Kim; Antonina Rait; Kathleen F. Pirollo; Esther H. Chang; Zhong Chen; Carter Van Waes
L-Carnitine–Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme
Matthias A. Fink; Heiko Paland; Susann Herzog; Markus Grube; Silke Vogelgesang; Kerstin Weitmann; Angela Bialke; Wolfgang Hoffmann; Bernhard H. Rauch; Henry W.S. Schroeder; Sandra Bien-Möller
Corrections
Correction: Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects
Titia G. Meijer; Nicole S. Verkaik; Anieta M. Sieuwerts; Job van Riet; Kishan A.T. Naipal; Carolien H.M. van Deurzen; Michael A. den Bakker; Hein F.B.M. Sleddens; Hendrikus-Jan Dubbink; T. Dorine den Toom; Winand N.M. Dinjens; Esther Lips; Petra M. Nederlof; Marcel Smid; Harmen J.G. van de Werken; Roland Kanaar; John W.M. Martens; Agnes Jager; Dik C. van Gent
Correction: Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth
Ming Li; Laszlo Radvanyi; Bingnan Yin; Kiera Rycaj; Jia Li; Raghavender Chivukula; Kevin Lin; Yue Lu; JianJun Shen; David Z. Chang; Donghui Li; Gary L. Johanning; Feng Wang-Johanning
Correction: Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma
Claire Fabre; Naoya Mimura; Kathryn Bobb; Sun-Young Kong; Güllü Gorgun; Diana Cirstea; Yiguo Hu; Jiro Minami; Hiroto Ohguchi; Jie Zhang; Jeffrey Meshulam; Ruben D. Carrasco; Yu-Tzu Tai; Paul G. Richardson; Teru Hideshima; Kenneth C. Anderson
Correction: Durable Carcinoembryonic Antigen (CEA)-Specific Humoral and Cellular Immune Responses in Colorectal Carcinoma Patients Vaccinated with Recombinant CEA and Granulocyte/Macrophage Colony-Stimulating Factor
Gustav J. Ullenhag; Jan-Erik Frödin; Mahmood Jeddi-Tehrani; Niklas Lidströmer; Karin Strigård; Emma Eriksson; Ali Samanci; Aniruddha Choudhury; Bo Nilsson; Eva D. Rossmann; Szilvia Mosolits; Håkan Mellstedt
Retraction
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