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15 April 2019
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Cover Image
Cover Image
The cover shows sections of epidermis from H1975-bearing BALB/c nude mice treated with YH25448. A lower H&E staining intensity was observed in the epidermis of YH25448-treated mice, suggesting that YH25448 induced less skin inflammation than osimertinib. For details, see the article by Yun and colleagues on page 2575 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors
David S. Hong; Patricia LoRusso; Omid Hamid; Filip Janku; Muaiad Kittaneh; Daniel V.T. Catenacci; Emily Chan; Tanios Bekaii-Saab; Shirish M. Gadgeel; Robert D. Loberg; Benny M. Amore; Yuying C. Hwang; Rui Tang; Gataree Ngarmchamnanrith; Eunice L. Kwak
A Multicenter Phase II Study of AMG 337 in Patients with MET-Amplified Gastric/Gastroesophageal Junction/Esophageal Adenocarcinoma and Other MET-Amplified Solid Tumors
Eric Van Cutsem; Boguslawa Karaszewska; Yoon-Koo Kang; Hyun Cheol Chung; Veena Shankaran; Salvatore Siena; Ning F. Go; Hui Yang; Marco Schupp; David Cunningham
Author Choice
PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial
Sarah J. Kitson; Zoe Maskell; Vanitha N. Sivalingam; Jennifer L. Allen; Saad Ali; Sean Burns; Kyle Gilmour; Rahamatulla Latheef; Richard J. Slade; Philip W. Pemberton; Joseph Shaw; W. David Ryder; Henry C. Kitchener; Emma J. Crosbie
Precision Medicine and Imaging
Author Choice
Central Nervous System Metastasis in Patients with HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival from SystHERs
Sara A. Hurvitz; Joyce O'Shaughnessy; Ginny Mason; Denise A. Yardley; Mohammad Jahanzeb; Adam Brufsky; Hope S. Rugo; Sandra M. Swain; Peter A. Kaufman; Debu Tripathy; Laura Chu; Haocheng Li; Vincent Antao; Melody Cobleigh
Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas
Shuang G. Zhao; William S. Chen; Rajdeep Das; S. Laura Chang; Scott A. Tomlins; Jonathan Chou; David A. Quigley; Ha X. Dang; Travis J. Barnard; Brandon A. Mahal; Ewan A. Gibb; Yang Liu; Elai Davicioni; Linda R. Duska; Edwin M. Posadas; Shruti Jolly; Daniel E. Spratt; Paul L. Nguyen; Christopher A. Maher; Eric J. Small; Felix Y. Feng
Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography
Hannah E. Greenwood; Patrick N. McCormick; Thibault Gendron; Matthias Glaser; Raul Pereira; Oliver D. K. Maddocks; Kerstin Sander; Tong Zhang; Norman Koglin; Mark F. Lythgoe; Erik Årstad; Daniel Hochhauser; Timothy H. Witney
Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL
Aurore Touzart; Etienne Lengliné; Mehdi Latiri; Mohamed Belhocine; Charlotte Smith; Xavier Thomas; Salvatore Spicuglia; Denis Puthier; Françoise Pflumio; Thibaut Leguay; Carlos Graux; Yves Chalandon; Françoise Huguet; Stéphane Leprêtre; Norbert Ifrah; Hervé Dombret; Elizabeth Macintyre; Mathilde Hunault; Nicolas Boissel; Vahid Asnafi
Validation of Melanoma Immune Profile (MIP), a Prognostic Immune Gene Prediction Score for Stage II–III Melanoma
Robyn D. Gartrell; Douglas K. Marks; Emanuelle M. Rizk; Margaret Bogardus; Camille L. Gérard; Luke W. Barker; Yichun Fu; Camden L. Esancy; Gen Li; Jiayi Ji; Shumin Rui; Marc S. Ernstoff; Bret Taback; Sarabjot Pabla; Rui Chang; Sandra J. Lee; John J. Krolewski; Carl Morrison; Basil A. Horst; Yvonne M. Saenger
Translational Cancer Mechanisms and Therapy
Immune Checkpoint Inhibitor-induced Reinvigoration of Tumor-infiltrating CD8+ T Cells is Determined by Their Differentiation Status in Glioblastoma
Junsik Park; Minsuk Kwon; Kyung Hwan Kim; Tae-Shin Kim; Seon-Hui Hong; Chang Gon Kim; Seok-Gu Kang; Ju Hyung Moon; Eui Hyun Kim; Su-Hyung Park; Jong Hee Chang; Eui-Cheol Shin
CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
Robbie G. Majzner; Johanna L. Theruvath; Anandani Nellan; Sabine Heitzeneder; Yongzhi Cui; Christopher W. Mount; Skyler P. Rietberg; Miles H. Linde; Peng Xu; Christopher Rota; Elena Sotillo; Louai Labanieh; Daniel W. Lee; Rimas J. Orentas; Dimiter S. Dimitrov; Zhongyu Zhu; Brad St Croix; Alberto Delaidelli; Alla Sekunova; Ezio Bonvini; Siddhartha S. Mitra; Martha M. Quezado; Ravindra Majeti; Michelle Monje; Poul H.B. Sorensen; John M. Maris; Crystal L. Mackall
Author Choice
YH25448, an Irreversible EGFR-TKI with Potent Intracranial Activity in EGFR Mutant Non–Small Cell Lung Cancer
Jiyeon Yun; Min Hee Hong; Seok-Young Kim; Chae-Won Park; Soyoung Kim; Mi Ran Yun; Han Na Kang; Kyoung-Ho Pyo; Sung Sook Lee; Jong Sung Koh; Ho-Juhn Song; Dong Kyun Kim; Young-Sung Lee; Se-Woong Oh; Soongyu Choi; Hye Ryun Kim; Byoung Chul Cho
Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study
Shin-Ae Kang; Jye Swei Guan; Hock Jin Tan; Tinghine Chu; Aye Aye Thike; Cristina Bernadó; Joaquín Arribas; Chow Yin Wong; Puay Hoon Tan; Mihir Gudi; Thomas Choudary Putti; Joohyuk Sohn; Swee Ho Lim; Soo Chin Lee; Yoon Pin Lim
Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-Specific Cytotoxic T Lymphocytes
Gheath Alatrash; Na Qiao; Mao Zhang; Madhushree Zope; Alexander A. Perakis; Pariya Sukhumalchandra; Anne V. Philips; Haven R. Garber; Celine Kerros; Lisa S. St. John; Maria R. Khouri; Hiep Khong; Karen Clise-Dwyer; Leonard P. Miller; Steve Wolpe; Willem W. Overwijk; Jeffrey J. Molldrem; Qing Ma; Elizabeth J. Shpall; Elizabeth A. Mittendorf
Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs)
Lei Cai; Theodoros Michelakos; Vikram Deshpande; Kshitij S. Arora; Teppei Yamada; David T. Ting; Marty S. Taylor; Carlos Fernandez-del Castillo; Andrew L. Warshaw; Keith D. Lillemoe; Soldano Ferrone; Cristina R. Ferrone
Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG
Chandrajit P. Raut; Dario Callegaro; Rosalba Miceli; Francesco Barretta; Piotr Rutkowski; Jean-Yves Blay; Guy Lahat; Dirk C. Strauss; Ricardo Gonzalez; Nita Ahuja; Giovanni Grignani; Vittorio Quagliuolo; Eberhard Stoeckle; Antonino De Paoli; Venu G. Pillarisetty; Carolyn Nessim; Carol J. Swallow; Sanjay Bagaria; Robert Canter; John Mullen; Hans J. Gelderblom; Elisabetta Pennacchioli; Frits van Coevorden; Kenneth Cardona; Marco Fiore; Mark Fairweather; Alessandro Gronchi
Corrections
Correction: Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer
Anna C. Ferrari; Joshi J. Alumkal; Mark N. Stein; Mary-Ellen Taplin; James Babb; Ethan S. Barnett; Alejandro Gomez-Pinillos; Xiaomei Liu; Dirk Moore; Robert DiPaola; Tomasz M. Beer
Retraction
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