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1 April 2019
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Cover Image
Cover Image
The cover shows a color-segmented Masson trichrome stained image obtained from a human BxPC-3 xenograft tumor. Quantitative image analysis shows elevated collagen deposition and reduced drug uptake in the stiffer BxPC-3 xenograft tumors. For details, see the article by Wang and colleagues on page 2136 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Clinical Trial Brief Reports
Postprogression Outcomes for Osimertinib versus Standard-of-Care EGFR-TKI in Patients with Previously Untreated EGFR-mutated Advanced Non–Small Cell Lung Cancer
David Planchard; Michael J. Boyer; Jong-Seok Lee; Arunee Dechaphunkul; Parneet K. Cheema; Toshiaki Takahashi; Jhanelle E. Gray; Marcello Tiseo; Suresh S. Ramalingam; Alexander Todd; Astrid McKeown; Yuri Rukazenkov; Yuichiro Ohe
Clinical Trials: Targeted Therapy
Combination Paclitaxel and Palbociclib: Results of a Phase I Trial in Advanced Breast Cancer
Amy S. Clark; Nicholas P. McAndrew; Andrea Troxel; Michael Feldman; Priti Lal; Mark Rosen; Jessica Burrell; Colleen Redlinger; Maryann Gallagher; Angela R. Bradbury; Susan M. Domchek; Kevin R. Fox; Peter J. O'Dwyer; Angela M. DeMichele
Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma
Naomi B. Haas; Leonard J. Appleman; Mark Stein; Maryann Redlinger; Melissa Wilks; Xiaowei Xu; Angelique Onorati; Anusha Kalavacharla; Taehyong Kim; Chao Jie Zhen; Sabah Kadri; Jeremy P. Segal; Phyllis A. Gimotty; Lisa E. Davis; Ravi K. Amaravadi
Clinical Trials: Immunotherapy
Author Choice
Efficacy and Safety of the Biosimilar ABP 215 Compared with Bevacizumab in Patients with Advanced Nonsquamous Non–small Cell Lung Cancer (MAPLE): A Randomized, Double-blind, Phase III Study
Nicholas Thatcher; Jerome H. Goldschmidt; Michael Thomas; Michael Schenker; Zhiying Pan; Luis Paz-Ares Rodriguez; Valery Breder; Gyula Ostoros; Vladimir Hanes
A Pilot Trial of the Combination of Transgenic NY-ESO-1–reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab
Theodore S. Nowicki; Beata Berent-Maoz; Gardenia Cheung-Lau; Rong Rong Huang; Xiaoyan Wang; Jennifer Tsoi; Paula Kaplan-Lefko; Paula Cabrera; Justin Tran; Jia Pang; Mignonette Macabali; Ivan Perez Garcilazo; Ignacio Baselga Carretero; Anusha Kalbasi; Alistair J. Cochran; Catherine S. Grasso; Siwen Hu-Lieskovan; Bartosz Chmielowski; Begoña Comin-Anduix; Arun Singh; Antoni Ribas
Precision Medicine and Imaging
Clinical Validity of HPV Circulating Tumor DNA in Advanced Anal Carcinoma: An Ancillary Study to the Epitopes-HPV02 Trial
Alice Bernard-Tessier; Emmanuelle Jeannot; David Guenat; Alice Debernardi; Marc Michel; Charlotte Proudhon; Anne Vincent-Salomon; Ivan Bièche; Jean-Yves Pierga; Bruno Buecher; Aurélia Meurisse; Éric François; Romain Cohen; Marine Jary; Véronique Vendrely; Emmanuelle Samalin; Farid El Hajbi; Nabil Baba-Hamed; Christophe Borg; François-Clément Bidard; Stefano Kim
Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies
James J. Harding; Subhiksha Nandakumar; Joshua Armenia; Danny N. Khalil; Melanie Albano; Michele Ly; Jinru Shia; Jaclyn F. Hechtman; Ritika Kundra; Imane El Dika; Richard K. Do; Yichao Sun; T. Peter Kingham; Michael I. D'Angelica; Michael F. Berger; David M. Hyman; William Jarnagin; David S. Klimstra; Yelena Y. Janjigian; David B. Solit; Nikolaus Schultz; Ghassan K. Abou-Alfa
Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study
Zhixiong Wang; Swetha Kambhampati; Yulan Cheng; Ke Ma; Cem Simsek; Alan H. Tieu; John M. Abraham; Xi Liu; Vishnu Prasath; Mark Duncan; Alejandro Stark; Alexander Trick; Hua-Ling Tsai; Hao Wang; Yulong He; Mouen A. Khashab; Saowanee Ngamruengphong; Eun J. Shin; Tza-Huei Wang; Stephen J. Meltzer
The First-week Proliferative Response of Peripheral Blood PD-1+CD8+ T Cells Predicts the Response to Anti-PD-1 Therapy in Solid Tumors
Kyung Hwan Kim; Jinhyun Cho; Bo Mi Ku; Jiae Koh; Jong-Mu Sun; Se-Hoon Lee; Jin Seok Ahn; Jaekyung Cheon; Young Joo Min; Su-Hyung Park; Keunchil Park; Myung-Ju Ahn; Eui-Cheol Shin
Author Choice
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes
Amrei Binzer-Panchal; Elin Hardell; Björn Viklund; Mehran Ghaderi; Tjalling Bosse; Marisa R. Nucci; Cheng-Han Lee; Nina Hollfelder; Pádraic Corcoran; Jordi Gonzalez-Molina; Lidia Moyano-Galceran; Debra A. Bell; John K. Schoolmeester; Anna Måsbäck; Gunnar B. Kristensen; Ben Davidson; Kaisa Lehti; Anders Isaksson; Joseph W. Carlson
Circulating miRNAs and PD-L1 Tumor Expression Are Associated with Survival in Advanced NSCLC Patients Treated with Immunotherapy: a Prospective Study
Mattia Boeri; Massimo Milione; Claudia Proto; Diego Signorelli; Giuseppe Lo Russo; Carlotta Galeone; Carla Verri; Mavis Mensah; Giovanni Centonze; Antonia Martinetti; Elisa Sottotetti; Ugo Pastorino; Marina Chiara Garassino; Gabriella Sozzi
irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial
Jean-Christophe Pignon; Opeyemi Jegede; Sachet A. Shukla; David A. Braun; Christine E. Horak; Megan Wind-Rotolo; Yuko Ishii; Paul J. Catalano; Jonian Grosha; Abdallah Flaifel; Jesse S. Novak; Kathleen M. Mahoney; Gordon J. Freeman; Arlene H. Sharpe; F. Stephen Hodi; Robert J. Motzer; Toni K. Choueiri; Catherine J. Wu; Michael B. Atkins; David F. McDermott; Sabina Signoretti
Translational Cancer Mechanisms and Therapy
Author Choice
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression
Vincent Bernard; Alexander Semaan; Jonathan Huang; F. Anthony San Lucas; Feven C. Mulu; Bret M. Stephens; Paola A. Guerrero; Yanqing Huang; Jun Zhao; Nabiollah Kamyabi; Subrata Sen; Paul A. Scheet; Cullen M. Taniguchi; Michael P. Kim; Ching-Wei Tzeng; Matthew H. Katz; Aatur D. Singhi; Anirban Maitra; Hector A. Alvarez
Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma
Lei Dong; Shuo You; Qing Zhang; Satoru Osuka; Narra S. Devi; Stefan Kaluz; Jalisa H. Ferguson; Hua Yang; Guoliang Chen; Binghe Wang; Hans E. Grossniklaus; Erwin G. Van Meir
Induction of Peripheral Effector CD8 T-cell Proliferation by Combination of Paclitaxel, Carboplatin, and Bevacizumab in Non–small Cell Lung Cancer Patients
Pauline L. de Goeje; Myrthe Poncin; Koen Bezemer; Margaretha E.H. Kaijen-Lambers; Harry J.M. Groen; Egbert F. Smit; Anne-Marie C. Dingemans; André Kunert; Rudi W. Hendriks; Joachim G.J.V. Aerts
Preclinical Efficacy of Endoglin-Targeting Antibody–Drug Conjugates for the Treatment of Ewing Sarcoma
Pilar Puerto-Camacho; Ana Teresa Amaral; Salah-Eddine Lamhamedi-Cherradi; Brian A. Menegaz; Helena Castillo-Ecija; José Luis Ordóñez; Saioa Domínguez; Carmen Jordan-Perez; Juan Diaz-Martin; Laura Romero-Pérez; Maria Lopez-Alvarez; Gema Civantos-Jubera; María José Robles-Frías; Michele Biscuola; Cristina Ferrer; Jaume Mora; Branko Cuglievan; Keri Schadler; Oliver Seifert; Roland Kontermann; Klaus Pfizenmaier; Laureano Simón; Myriam Fabre; Ángel M. Carcaboso; Joseph A. Ludwig; Enrique de Álava
Author Choice
Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort
Xiaoji Chen; Ching-Wei Chang; Jill M. Spoerke; Kathryn E. Yoh; Vidushi Kapoor; Charles Baudo; Junko Aimi; Mamie Yu; May M.Y. Liang-Chu; Rebecca Suttmann; Ling-Yuh Huw; Steven Gendreau; Craig Cummings; Mark R. Lackner
YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Fan Li; Yan Xu; Bovey Liu; Pankaj Kumar Singh; Wei Zhao; Jiankang Jin; Guangchun Han; Ailing W. Scott; Xiaochuan Dong; Longfei Huo; Lang Ma; Melissa Pool Pizzi; Ying Wang; Yuan Li; Kazuto Harada; Min Xie; Heath D. Skinner; Sheng Ding; Linghua Wang; Sunil Krishnan; Randy L. Johnson; Shumei Song; Jaffer A. Ajani
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Caitlin D. Lowery; Michele Dowless; Matthew Renschler; Wayne Blosser; Alle B. VanWye; Jennifer R. Stephens; Philip W. Iversen; Aimee Bence Lin; Richard P. Beckmann; Kateryna Krytska; Kristina A. Cole; John M. Maris; Douglas S. Hawkins; Brian P. Rubin; Raushan T. Kurmasheva; Peter J. Houghton; Richard Gorlick; E. Anders Kolb; Min H. Kang; C. Patrick Reynolds; Stephen W. Erickson; Beverly A. Teicher; Malcolm A. Smith; Louis F. Stancato
Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism
Varun V. Prabhu; Neel S. Madhukar; Coryandar Gilvary; C. Leah B. Kline; Sophie Oster; Wafik S. El-Deiry; Olivier Elemento; Faye Doherty; Alexander VanEngelenburg; Jessica Durrant; Rohinton S. Tarapore; Sean Deacon; Neil Charter; Jinkyu Jung; Deric M. Park; Mark R. Gilbert; Jessica Rusert; Robert Wechsler-Reya; Isabel Arrillaga-Romany; Tracy T. Batchelor; Patrick Y. Wen; Wolfgang Oster; Joshua E. Allen
Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis
Dongqing Yan; Anthony D. Pomicter; Srinivas Tantravahi; Clinton C. Mason; Anna V. Senina; Jonathan M. Ahmann; Qiang Wang; Hein Than; Ami B. Patel; William L. Heaton; Anna M. Eiring; Phillip M. Clair; Kevin C. Gantz; Hannah M. Redwine; Sabina I. Swierczek; Brayden J. Halverson; Erkan Baloglu; Sharon Shacham; Jamshid S. Khorashad; Todd W. Kelley; Mohamed E. Salama; Rodney R. Miles; Kenneth M. Boucher; Josef T. Prchal; Thomas O'Hare; Michael W. Deininger
Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator–activated Receptor Signaling as Driver of Cancer-induced Muscle Fatigue
Hannah E. Wilson; Kacey K. Rhodes; Daniel Rodriguez; Ikttesh Chahal; David A. Stanton; Joseph Bohlen; Mary Davis; Aniello M. Infante; Hannah Hazard-Jenkins; David J. Klinke; Elena N. Pugacheva; Emidio E. Pistilli
An Epithelial-to-Mesenchymal Transcriptional Switch Triggers Evolution of Pulmonary Sarcomatoid Carcinoma (PSC) and Identifies Dasatinib as New Therapeutic Option
Gloria Manzotti; Federica Torricelli; Donati Benedetta; Filippo Lococo; Valentina Sancisi; Giulio Rossi; Simonetta Piana; Alessia Ciarrocchi
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