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15 March 2019
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Cover Image
Cover Image
The cover shows immunohistochemical staining of folate receptor alpha expression within the ciliary body epithelia of the normal human eye. For details, see article by Matulonis and colleagues on page 1727 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Review
Clinical Trials: Targeted Therapy
Author Choice
Brentuximab Vedotin plus Chemotherapy in North American Subjects with Newly Diagnosed Stage III or IV Hodgkin Lymphoma
Radhakrishnan Ramchandren; Ranjana H. Advani; Stephen M. Ansell; Nancy L. Bartlett; Robert Chen; Joseph M. Connors; Tatyana Feldman; Andres Forero-Torres; Jonathan W. Friedberg; Ajay K. Gopal; Leo I. Gordon; John Kuruvilla; Kerry J. Savage; Anas Younes; Gerald Engley; Thomas J. Manley; Keenan Fenton; David J. Straus
Author Choice
Evaluation of Prophylactic Corticosteroid Eye Drop Use in the Management of Corneal Abnormalities Induced by the Antibody–Drug Conjugate Mirvetuximab Soravtansine
Ursula A. Matulonis; Michael J. Birrer; David M. O'Malley; Kathleen N. Moore; Jason Konner; Lucy Gilbert; Lainie P. Martin; Todd M. Bauer; Amit M. Oza; Karim Malek; Jan Pinkas; Stella K. Kim
Clinical Trials: Immunotherapy
Myeloablative Haploidentical Transplantation Is Superior to Chemotherapy for Patients with Intermediate-risk Acute Myelogenous Leukemia in First Complete Remission
Meng Lv; Yu Wang; Ying-Jun Chang; Xiao-Hui Zhang; Lan-Ping Xu; Qian Jiang; Hao Jiang; Jin Lu; Huan Chen; Wei Han; Feng-Rong Wang; Jing-Zhi Wang; Yao Chen; Chen-Hua Yan; Yuan-Yuan Zhang; Yu-Qian Sun; Xiao-Dong Mo; Hong-Hu Zhu; Jin-Song Jia; Ting Zhao; Jing Wang; Kai-Yan Liu; Xiao-Jun Huang
Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells
Ping Zhang; Jyothy Raju; Md Ashik Ullah; Raymond Au; Antiopi Varelias; Kate H. Gartlan; Stuart D. Olver; Luke D. Samson; Elise Sturgeon; Nienke Zomerdijk; Judy Avery; Tessa Gargett; Michael P. Brown; Lachlan J. Coin; Devika Ganesamoorthy; Cheryl Hutchins; Gary R. Pratt; Glen A. Kennedy; A. James Morton; Cameron I. Curley; Geoffrey R. Hill; Siok-Keen Tey
Precision Medicine and Imaging
Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702)
Habib Rahbar; Zheng Zhang; Thomas L. Chenevert; Justin Romanoff; Averi E. Kitsch; Lucy G. Hanna; Sara M. Harvey; Linda Moy; Wendy B. DeMartini; Basak Dogan; Wei T. Yang; Lilian C. Wang; Bonnie N. Joe; Karen Y. Oh; Colleen H. Neal; Elizabeth S. McDonald; Mitchell D. Schnall; Constance D. Lehman; Christopher E. Comstock; Savannah C. Partridge
TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Abiraterone or Enzalutamide Outcome in Metastatic Castration-Resistant Prostate Cancer
Bram De Laere; Steffi Oeyen; Markus Mayrhofer; Tom Whitington; Pieter-Jan van Dam; Peter Van Oyen; Christophe Ghysel; Jozef Ampe; Piet Ost; Wim Demey; Lucien Hoekx; Dirk Schrijvers; Barbara Brouwers; Willem Lybaert; Els G. Everaert; Daan De Maeseneer; Michiel Strijbos; Alain Bols; Karen Fransis; Nick Beije; Inge E. de Kruijff; Valerie van Dam; Anja Brouwer; Dirk Goossens; Lien Heyrman; Gert G. Van den Eynden; Annemie Rutten; Jurgen Del Favero; Mattias Rantalainen; Prabhakar Rajan; Stefan Sleijfer; Anders Ullén; Jeffrey Yachnin; Henrik Grönberg; Steven J. Van Laere; Johan Lindberg; Luc Y. Dirix
Author Choice
Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers
Rodrigo Santa Cruz Guindalini; Yonglan Zheng; Hiroyuki Abe; Kristen Whitaker; Toshio F. Yoshimatsu; Tom Walsh; David Schacht; Kirti Kulkarni; Deepa Sheth; Marion S. Verp; Angela R. Bradbury; Jane Churpek; Elias Obeid; Jeffrey Mueller; Galina Khramtsova; Fang Liu; Akila Raoul; Hongyuan Cao; Iris L. Romero; Susan Hong; Robert Livingston; Nora Jaskowiak; Xiaoming Wang; Marcio Debiasi; Colin C. Pritchard; Mary-Claire King; Gregory Karczmar; Gillian M. Newstead; Dezheng Huo; Olufunmilayo I. Olopade
MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical Trials
Monika E. Hegi; Els Genbrugge; Thierry Gorlia; Roger Stupp; Mark R. Gilbert; Olivier L. Chinot; L. Burt Nabors; Greg Jones; Wim Van Criekinge; Josef Straub; Michael Weller
Genetic, Epigenetic, and Immunologic Profiling of MMR-Deficient Relapsed Glioblastoma
Stefano Indraccolo; Giuseppe Lombardi; Matteo Fassan; Lorenza Pasqualini; Silvia Giunco; Raffaella Marcato; Alessandra Gasparini; Cinzia Candiotto; Silvia Nalio; Pasquale Fiduccia; Giuseppe Nicolò Fanelli; Ardi Pambuku; Alessandro Della Puppa; Domenico D'Avella; Laura Bonaldi; Marina Paola Gardiman; Roberta Bertorelle; Anita De Rossi; Vittorina Zagonel
Translational Cancer Mechanisms and Therapy
Expression of MT4-MMP, EGFR, and RB in Triple-Negative Breast Cancer Strongly Sensitizes Tumors to Erlotinib and Palbociclib Combination Therapy
Pierre Foidart; Cassandre Yip; Jean Radermacher; Silvia Blacher; Mehdi Lienard; Laetitia Montero-Ruiz; Erik Maquoi; Elodie Montaudon; Sophie Château-Joubert; Joëlle Collignon; Michel Coibion; Véronique Jossa; Elisabetta Marangoni; Agnès Noël; Nor Eddine Sounni; Guy Jerusalem
The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma
Juliane L. Buhl; Florian Selt; Thomas Hielscher; Romain Guiho; Jonas Ecker; Felix Sahm; Johannes Ridinger; Dennis Riehl; Diren Usta; Britta Ismer; Alexander C. Sommerkamp; J.P. Martinez-Barbera; Annika K. Wefers; Marc Remke; Daniel Picard; Stefan Pusch; Jan Gronych; Ina Oehme; Cornelis M. van Tilburg; Marcel Kool; Daniela Kuhn; David Capper; Andreas von Deimling; Martin U. Schuhmann; Christel Herold-Mende; Andrey Korshunov; Tilman Brummer; Stefan M. Pfister; David T.W. Jones; Olaf Witt; Till Milde
Author Choice
Expression of AR-V7 and ARv567es in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY
Scott T. Tagawa; Emmanuel S. Antonarakis; Ada Gjyrezi; Giuseppe Galletti; Seaho Kim; Daniel Worroll; John Stewart; Atef Zaher; Ted P. Szatrowski; Karla V. Ballman; Katsuhiro Kita; Shinsuke Tasaki; Yang Bai; Luigi Portella; Brian J. Kirby; Fred Saad; Mario A. Eisenberger; David M. Nanus; Paraskevi Giannakakou
Author Choice
BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation
Daniela Asslaber; Nathalie Wacht; Michael Leisch; Yuan Qi; Nicole Maeding; Clemens Hufnagl; Bettina Jansko; Nadja Zaborsky; Andreas Villunger; Tanja N. Hartmann; Richard Greil; Alexander Egle
Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation
Tom B. Davidson; Alexander Lee; Melody Hsu; Shaina Sedighim; Joey Orpilla; Janet Treger; Max Mastall; Saskia Roesch; Carmen Rapp; Mildred Galvez; Aaron Mochizuki; Joseph Antonios; Alejandro Garcia; Nikesh Kotecha; Nicholas Bayless; David Nathanson; Anthony Wang; Richard Everson; William H. Yong; Timothy F. Cloughesy; Linda M. Liau; Christel Herold-Mende; Robert M. Prins
CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy
Hirokazu Kimura; Hideki Yamamoto; Takeshi Harada; Katsumi Fumoto; Yoshihito Osugi; Ryota Sada; Natsumi Maehara; Hayato Hikita; Soichiro Mori; Hidetoshi Eguchi; Masahito Ikawa; Tetsuo Takehara; Akira Kikuchi
SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance
Isaac Wasserman; Lik Hang Lee; Shuji Ogino; Michael R. Marco; Chao Wu; Xi Chen; Jashodeep Datta; Eran Sadot; Bryan Szeglin; Jose G. Guillem; Philip B. Paty; Martin R. Weiser; Garrett M. Nash; Leonard Saltz; Afsar Barlas; Katia Manova-Todorova; Srijaya Prakash Babu Uppada; Arthur E. Elghouayel; Peter Ntiamoah; Jonathan N. Glickman; Tsuyoshi Hamada; Keisuke Kosumi; Kentaro Inamura; Andrew T. Chan; Reiko Nishihara; Andrea Cercek; Karuna Ganesh; Nancy E. Kemeny; Punita Dhawan; Rona Yaeger; Charles L. Sawyers; Julio Garcia-Aguilar; Marios Giannakis; Jinru Shia; J. Joshua Smith
TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner
Tanveer Sharif; Cathleen Dai; Emma Martell; Mohammad Saleh Ghassemi-Rad; Mark Robert Hanes; Patrick J. Murphy; Barry E. Kennedy; Chitra Venugopal; Minomi Subapanditha; Carman A. Giacomantonio; Paola Marcato; Sheila K. Singh; Shashi Gujar
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