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1 March 2019
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Cover Image
Cover Image
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The cover shows how intratumoral oncolytic virus treatment induces dramatic remodeling of tumor microenvironment by facilitating the accumulation of CD8+ T cells. Left panel: pretreatment; right panel: post-treatment. For details, see the article by Chon and colleagues on page 1612 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Clinical Development of Novel Drug–Radiotherapy Combinations
Saif S. Ahmad; Marka R. Crittenden; Phuoc T. Tran; Paul G. Kluetz; Gideon M. Blumenthal; Helen Bulbeck; Richard D. Baird; Kaye J. Williams; Tim Illidge; Stephen M. Hahn; Theodore S. Lawrence; Patricia A. Spears; Amanda J. Walker; Ricky A. Sharma
Review
Clinical Trials: Targeted Therapy
Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
Sarah P. Blagden; Anne L. Hamilton; Linda Mileshkin; Shirley Wong; Agnieszka Michael; Marcia Hall; Jeffrey C. Goh; Alla S. Lisyanskaya; Michelle DeSilvio; Eleni Frangou; Euan A. Stronach; Prashanth Gopalakrishna; Tarek M. Meniawy; Hani Gabra
Author Choice
Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials
Olivier Mir; Nathan Touati; Michela Lia; Saskia Litière; Axel Le Cesne; Stefan Sleijfer; Jean-Yves Blay; Michael Leahy; Robin Young; Ron H.J. Mathijssen; Nielka P. Van Erp; Hans Gelderblom; Winette T. Van der Graaf; Alessandro Gronchi
Clinical Trials: Immunotherapy
A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus–associated Epithelial Cancers
Sanja Stevanović; Sarah R. Helman; John R. Wunderlich; Michelle M. Langhan; Stacey L. Doran; Mei Li M. Kwong; Robert P.T. Somerville; Christopher A. Klebanoff; Udai S. Kammula; Richard M. Sherry; James C. Yang; Steven A. Rosenberg; Christian S. Hinrichs
Author Choice
Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study
Guoliang Qiao; Xiaoli Wang; Lei Zhou; Xinna Zhou; Yuguang Song; Shuo Wang; Lei Zhao; Michael A. Morse; Amy Hobeika; Jin Song; Xin Yi; Xuefeng Xia; Jun Ren; Herbert Kim Lyerly
Precision Medicine and Imaging
A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection
Julia Hess; Kristian Unger; Cornelius Maihoefer; Lars Schüttrumpf; Ludmila Wintergerst; Theresa Heider; Peter Weber; Sebastian Marschner; Herbert Braselmann; Daniel Samaga; Sebastian Kuger; Ulrike Pflugradt; Philipp Baumeister; Axel Walch; Christine Woischke; Thomas Kirchner; Martin Werner; Kristin Werner; Michael Baumann; Volker Budach; Stephanie E. Combs; Jürgen Debus; Anca-Ligia Grosu; Mechthild Krause; Annett Linge; Claus Rödel; Martin Stuschke; Daniel Zips; Horst Zitzelsberger; Ute Ganswindt; Michael Henke; Claus Belka
Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non–Small Cell Lung Cancer
Germán Corredor; Xiangxue Wang; Yu Zhou; Cheng Lu; Pingfu Fu; Konstantinos Syrigos; David L. Rimm; Michael Yang; Eduardo Romero; Kurt A. Schalper; Vamsidhar Velcheti; Anant Madabhushi
NK Cell Infiltrates and HLA Class I Expression in Primary HER2+ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival
Aura Muntasell; Federico Rojo; Sonia Servitja; Carlota Rubio-Perez; Mariona Cabo; David Tamborero; Marcel Costa-García; María Martínez-Garcia; Sílvia Menéndez; Ivonne Vazquez; Ana Lluch; Abel Gonzalez-Perez; Ana Rovira; Miguel López-Botet; Joan Albanell
Author Choice
Development and Validation of a Novel Signature to Predict Overall Survival in “Driver Gene–negative” Lung Adenocarcinoma (LUAD): Results of a Multicenter Study
Yongmei Cui; Wenfeng Fang; Chaofeng Li; Kejing Tang; Jian Zhang; Yiyan Lei; Weiling He; Sui Peng; Ming Kuang; Hui Zhang; Lili Chen; Di Xu; Cuilan Tang; Wenhui Zhang; Yuxin Zhu; Wenting Jiang; Neng Jiang; Yu Sun; Yangshan Chen; Han Wang; Yingrong Lai; Shuhua Li; Qiong He; Jianwen Zhou; Yang Zhang; Millicent Lin; Honglei Chen; Chenzhi Zhou; Chunlin Wang; Jianhong Wang; Xuenong Zou; Liantang Wang; Zunfu Ke
Translational Cancer Mechanisms and Therapy
Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1–Based Immunotherapy
Su Y. Lim; Jenny H. Lee; Tuba N. Gide; Alexander M. Menzies; Alexander Guminski; Matteo S. Carlino; Edmond J. Breen; Jean Y.H. Yang; Shila Ghazanfar; Richard F. Kefford; Richard A. Scolyer; Georgina V. Long; Helen Rizos
AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival
Emilio Cosimo; Anuradha Tarafdar; Michael W. Moles; Ailsa K. Holroyd; Natasha Malik; Mark A. Catherwood; Jodie Hay; Karen M. Dunn; Alan M. Macdonald; Sylvie M. Guichard; Declan O'Rourke; Michael T. Leach; Owen J. Sansom; Sabina C. Cosulich; Alison M. McCaig; Alison M. Michie
Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2–p53 Interaction in Mucoepidermoid Carcinoma
April Andrews; Kristy Warner; Christie Rodriguez-Ramirez; Alexander T. Pearson; Felipe Nör; Zhaocheng Zhang; Samuel Kerk; Aditi Kulkarni; Joseph I. Helman; J. Chad Brenner; Max S. Wicha; Shaomeng Wang; Jacques E. Nör
NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer
Valentina Gambardella; Francisco Gimeno-Valiente; Noelia Tarazona; Carolina Martinez Ciarpaglini; Desamparados Roda; Tania Fleitas; Pablo Tolosa; Juan Miguel Cejalvo; Marisol Huerta; Susana Roselló; Josefa Castillo; Andrés Cervantes
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity
Daniel A.R. Heisey; Timothy L. Lochmann; Konstantinos V. Floros; Colin M. Coon; Krista M. Powell; Sheeba Jacob; Marissa L. Calbert; Maninderjit S. Ghotra; Giovanna T. Stein; Yuki Kato Maves; Steven C. Smith; Cyril H. Benes; Joel D. Leverson; Andrew J. Souers; Sosipatros A. Boikos; Anthony C. Faber
Author Choice
Anagrelide for Gastrointestinal Stromal Tumor
Olli-Pekka Pulkka; Yemarshet K. Gebreyohannes; Agnieszka Wozniak; John-Patrick Mpindi; Olli Tynninen; Katherine Icay; Alejandra Cervera; Salla Keskitalo; Astrid Murumägi; Evgeny Kulesskiy; Maria Laaksonen; Krister Wennerberg; Markku Varjosalo; Pirjo Laakkonen; Rainer Lehtonen; Sampsa Hautaniemi; Olli Kallioniemi; Patrick Schöffski; Harri Sihto; Heikki Joensuu
Letters to the Editor
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies—Response
Andrew J. Bauer; Douglas R. Stewart; Junne Kamihara; Anne K. Harris; Joyce Turner; Rachana Shah; Kami Wolfe Schneider; Katherine Schneider; Ann Garrity Carr; Laura A. Harney; A. Lindsay Frazier; Daniel Orbach; Dominik T. Schneider; David Malkin; Louis P. Dehner; Yoav H. Messinger; D. Ashley Hill; Kris Ann P. Schultz
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