Skip Nav Destination
Issues
1 February 2019
-
Cover Image
Cover Image
The cover shows an immunofluorescence panel from prototypical hyperprogressive disease infiltrates in non-small cell lung cancer patients treated with immune checkpoint inhibitor, showing the colocalization of CD33 and PD-L1 in clustered macrophages with epithelioid morphology. For details, see the article by Lo Russo and colleagues on page 989 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Author Choice
Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss
Johann S. de Bono; Ugo De Giorgi; Daniel Nava Rodrigues; Christophe Massard; Sergio Bracarda; Albert Font; Jose Angel Arranz Arija; Kent C. Shih; George Daniel Radavoi; Na Xu; Wai Y. Chan; Han Ma; Steven Gendreau; Ruth Riisnaes; Premal H. Patel; Daniel J. Maslyar; Viorel Jinga
Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers
Maeve A. Lowery; Mikaela Bradley; Joanne F. Chou; Marinela Capanu; Scott Gerst; James J. Harding; Imane El Dika; Michael Berger; Ahmet Zehir; Ryan Ptashkin; Philip Wong; Teresa Rasalan-Ho; Kenneth H. Yu; Andrea Cercek; Ezra Morgono; Erica Salehi; Emily Valentino; Ellen Hollywood; Eileen M. O'Reilly; Ghassan K. Abou-Alfa
Clinical Trials: Immunotherapy
Long-Term Survival in Patients Responding to Anti–PD-1/PD-L1 Therapy and Disease Outcome upon Treatment Discontinuation
Marie-Léa Gauci; Emilie Lanoy; Stéphane Champiat; Caroline Caramella; Samy Ammari; Sandrine Aspeslagh; Andrea Varga; Capucine Baldini; Rastilav Bahleda; Anas Gazzah; Jean-Marie Michot; Sophie Postel-Vinay; Eric Angevin; Vincent Ribrag; Antoine Hollebecque; Jean-Charles Soria; Caroline Robert; Christophe Massard; Aurélien Marabelle
Precision Medicine and Imaging
Author Choice
Exome Analysis Reveals Genomic Markers Associated with Better Efficacy of Nivolumab in Lung Cancer Patients
Corentin Richard; Jean-David Fumet; Sandy Chevrier; Valentin Derangère; Fanny Ledys; Aurélie Lagrange; Laure Favier; Bruno Coudert; Laurent Arnould; Caroline Truntzer; Romain Boidot; François Ghiringhelli
Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma
François Audenet; Sumit Isharwal; Eugene K. Cha; Mark T.A. Donoghue; Esther N. Drill; Irina Ostrovnaya; Eugene J. Pietzak; John P. Sfakianos; Aditya Bagrodia; Paari Murugan; Guido Dalbagni; Timothy F. Donahue; Jonathan E. Rosenberg; Dean F. Bajorin; Maria E. Arcila; Jaclyn F. Hechtman; Michael F. Berger; Barry S. Taylor; Hikmat Al-Ahmadie; Gopa Iyer; Bernard H. Bochner; Jonathan A. Coleman; David B. Solit
ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer
Qiang Li; Alexis W. Damish; Zoë Frazier; David Liu; Elizaveta Reznichenko; Atanas Kamburov; Andrew Bell; Huiyong Zhao; Emmet J. Jordan; S. Paul Gao; Jennifer Ma; Philip H. Abbosh; Joaquim Bellmunt; Elizabeth R. Plimack; Jean-Bernard Lazaro; David B. Solit; Dean Bajorin; Jonathan E. Rosenberg; Alan D. D'Andrea; Nadeem Riaz; Eliezer M. Van Allen; Gopa Iyer; Kent W. Mouw
Translational Cancer Mechanisms and Therapy
Author Choice
Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
Giuseppe Lo Russo; Massimo Moro; Michele Sommariva; Valeria Cancila; Mattia Boeri; Giovanni Centonze; Simona Ferro; Monica Ganzinelli; Patrizia Gasparini; Veronica Huber; Massimo Milione; Luca Porcu; Claudia Proto; Giancarlo Pruneri; Diego Signorelli; Sabina Sangaletti; Lucia Sfondrini; Chiara Storti; Elena Tassi; Alberto Bardelli; Silvia Marsoni; Valter Torri; Claudio Tripodo; Mario Paolo Colombo; Andrea Anichini; Licia Rivoltini; Andrea Balsari; Gabriella Sozzi; Marina Chiara Garassino
IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System
Cristina Puig-Saus; Giulia Parisi; Angel Garcia-Diaz; Paige E. Krystofinski; Salemiz Sandoval; Ruixue Zhang; Ameya S. Champhekar; James McCabe; Gardenia C. Cheung-Lau; Nhat A. Truong; Agustin Vega-Crespo; Marie Desiles S. Komenan; Jia Pang; Mignonette H. Macabali; Justin D. Saco; Jeffrey L. Goodwin; Brad Bolon; Christopher S. Seet; Amelie Montel-Hagen; Gay M. Crooks; Roger P. Hollis; Beatriz Campo-Fernandez; Daniela Bischof; Kenneth Cornetta; Eric H. Gschweng; Celia Adelson; Alexander Nguyen; Lili Yang; Owen N. Witte; David Baltimore; Begonya Comin-Anduix; Donald B. Kohn; Xiaoyan Wang; Paula Cabrera; Paula J. Kaplan-Lefko; Beata Berent-Maoz; Antoni Ribas
Author Choice
Peripheral Stem Cell Apheresis is Feasible Post 131Iodine-Metaiodobenzylguanidine-Therapy in High-Risk Neuroblastoma, but Results in Delayed Platelet Reconstitution
Kathelijne C.J.M. Kraal; Ilse Timmerman; Hannah M. Kansen; Cor van den Bos; Jozsef Zsiros; Henk van den Berg; Sebastiaan Somers; Eric Braakman; Annemarie M.L. Peek; Max M. van Noesel; C. Ellen van der Schoot; Marta Fiocco; Huib N. Caron; Carlijn Voermans; Godelieve A.M. Tytgat
Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response
Shilpak Chatterjee; Paramita Chakraborty; Anusara Daenthanasanmak; Supinya Iamsawat; Gabriela Andrejeva; Libia A. Luevano; Melissa Wolf; Uday Baliga; Carsten Krieg; Craig C. Beeson; Meenal Mehrotra; Elizabeth G. Hill; Jeffery C. Rathmell; Xue-Zhong Yu; Andrew S. Kraft; Shikhar Mehrotra
Author Choice
Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A
Shuye Lin; Xiaoyue Wang; Yuanming Pan; Rongmeng Tian; Bonan Lin; Guosheng Jiang; Keqiang Chen; Yuqi He; Lulu Zhang; Wanli Zhai; Peng Jin; Lang Yang; Guoqiang Li; Yun Wu; Jiang Hu; Wanghua Gong; Zhijie Chang; Jian-qiu Sheng; Youyong Lu; Ji Ming Wang; Jiaqiang Huang
Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers
Michael Offin; Hira Rizvi; Megan Tenet; Andy Ni; Francisco Sanchez-Vega; Bob T. Li; Alexander Drilon; Mark G. Kris; Charles M. Rudin; Nikolaus Schultz; Maria E. Arcila; Marc Ladanyi; Gregory J. Riely; Helena Yu; Matthew D. Hellmann
Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer
Kai-Jian Wang; Chao Wang; Li-He Dai; Jun Yang; Hai Huang; Xiao-Jing Ma; Zhe Zhou; Ze-Yu Yang; Wei-Dong Xu; Mei-Mian Hua; Xin Lu; Shu-Xiong Zeng; Hui-Qing Wang; Zhen-Sheng Zhang; Yan-Qiong Cheng; Dan Liu; Qin-Qin Tian; Ying-Hao Sun; Chuan-Liang Xu
Author Choice
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas
Marthe M. de Jonge; Aurélie Auguste; Lise M. van Wijk; Philip C. Schouten; Matty Meijers; Natalja T. ter Haar; Vincent T.H.B.M. Smit; Remi A. Nout; Mark A. Glaire; David N. Church; Harry Vrieling; Bastien Job; Yannick Boursin; Cor D. de Kroon; Etienne Rouleau; Alexandra Leary; Maaike P.G. Vreeswijk; Tjalling Bosse
Targeting Cancer Cells and Tumor Microenvironment in Preclinical and Clinical Models of Hodgkin Lymphoma Using the Dual PI3Kδ/γ Inhibitor RP6530
Silvia L. Locatelli; Giuseppa Careddu; Simone Serio; Francesca M. Consonni; Akihiro Maeda; Srikant Viswanadha; Swaroop Vakkalanka; Luca Castagna; Armando Santoro; Paola Allavena; Antonio Sica; Carmelo Carlo-Stella
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds