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15 December 2019
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Cover Image
Cover Image
The cover shows a patient-derived neuroblastoma xenograft sphere infiltrated by human IL-15–activated NK cells. For details, see the article by Nguyen and colleagues on page 7554 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Perspectives
Clinical Trials: Targeted Therapy
Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors
César Serrano; Alessandro Leal; Yanan Kuang; Jeffrey A. Morgan; Constance M. Barysauskas; Jillian Phallen; Olivia Triplett; Adrián Mariño-Enríquez; Andrew J. Wagner; George D. Demetri; Victor E. Velculescu; Cloud P. Paweletz; Jonathan A. Fletcher; Suzanne George
A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors
Mark W. Kieran; Birgit Geoerger; Ira J. Dunkel; Alberto Broniscer; Darren Hargrave; Pooja Hingorani; Isabelle Aerts; Anne-Isabelle Bertozzi; Kenneth J. Cohen; Trent R. Hummel; Violet Shen; Eric Bouffet; Christine A. Pratilas; Andrew D.J. Pearson; Lillian Tseng; Noelia Nebot; Steven Green; Mark W. Russo; James A. Whitlock
Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
Darren R. Hargrave; Eric Bouffet; Uri Tabori; Alberto Broniscer; Kenneth J. Cohen; Jordan R. Hansford; Birgit Geoerger; Pooja Hingorani; Ira J. Dunkel; Mark W. Russo; Lillian Tseng; Kohinoor Dasgupta; Eduard Gasal; James A. Whitlock; Mark W. Kieran
Author Choice
Crizotinib in MET-Deregulated or ROS1-Rearranged Pretreated Non–Small Cell Lung Cancer (METROS): A Phase II, Prospective, Multicenter, Two-Arms Trial
Lorenza Landi; Rita Chiari; Marcello Tiseo; Federica D'Incà; Claudio Dazzi; Antonio Chella; Angelo Delmonte; Laura Bonanno; Diana Giannarelli; Diego Luigi Cortinovis; Filippo de Marinis; Gloria Borra; Alessandro Morabito; Cesare Gridelli; Domenico Galetta; Fausto Barbieri; Francesco Grossi; Enrica Capelletto; Gabriele Minuti; Francesca Mazzoni; Claudio Verusio; Emilio Bria; Greta Alì; Rossella Bruno; Agnese Proietti; Gabriella Fontanini; Lucio Crinò; Federico Cappuzzo
Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies
Hiroto Inaba; John C. Panetta; Stanley B. Pounds; Lei Wang; Lie Li; Fariba Navid; Sara M. Federico; Eric D. Eisenmann; Aksana Vasilyeva; Yong-Dong Wang; Sheila Shurtleff; Ching-Hon Pui; Tanja A. Gruber; Raul C. Ribeiro; Jeffrey E. Rubnitz; Sharyn D. Baker
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors
Timothy A. Yap; Jane N. Winter; Lisa Giulino-Roth; Jemma Longley; Juanita Lopez; Jean-Marie Michot; John P. Leonard; Vincent Ribrag; Michael T. McCabe; Caretha L. Creasy; Melissa Stern; Teodora Pene Dumitrescu; Xiaowei Wang; Steve Frey; Jennifer Carver; Thierry Horner; Choon Oh; Ahmed Khaled; Arindam Dhar; Peter W.M. Johnson
Clinical Trials: Immunotherapy
T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor–Expressing T Cells
Natalia Lapteva; Margaret Gilbert; Iulia Diaconu; Lisa A. Rollins; Mina Al-Sabbagh; Swati Naik; Robert A. Krance; Tamara Tripic; Manasa Hiregange; Darshana Raghavan; Olga Dakhova; Rayne H. Rouce; Hao Liu; Bilal Omer; Barbara Savoldo; Gianpietro Dotti; Conrad Russel Cruz; Keli Sharpe; Melissa Gates; Aaron Orozco; April Durett; Elizabeth Pacheco; Adrian P. Gee; Carlos A. Ramos; Helen E. Heslop; Malcolm K. Brenner; Cliona M. Rooney
Author Choice
Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial
Anna Maria Di Giacomo; Alessia Covre; Francesca Finotello; Dietmar Rieder; Riccardo Danielli; Luca Sigalotti; Diana Giannarelli; Florent Petitprez; Laetitia Lacroix; Monica Valente; Ornella Cutaia; Carolina Fazio; Giovanni Amato; Andrea Lazzeri; Santa Monterisi; Clelia Miracco; Sandra Coral; Andrea Anichini; Christoph Bock; Amelie Nemc; Aram Oganesian; James Lowder; Mohammad Azab; Wolf H. Fridman; Catherine Sautès-Fridman; Zlatko Trajanoski; Michele Maio
A Single-Arm, Multicenter, Phase II Study of Camrelizumab in Relapsed or Refractory Classical Hodgkin Lymphoma
Yuqin Song; Jianqiu Wu; Xinchuan Chen; Tongyu Lin; Junning Cao; Yanyan Liu; Yaozhong Zhao; Jie Jin; Haiwen Huang; Jianda Hu; Jun Luo; Liling Zhang; Hongwei Xue; Qingyuan Zhang; Weiwei Wang; Chunxia Chen; Jifeng Feng; Jun Zhu
Precision Medicine and Imaging
Impact of FDG PET Imaging for Expanding Patient Eligibility and Measuring Treatment Response in a Genome-Driven Basket Trial of the Pan-HER Kinase Inhibitor, Neratinib
Gary A. Ulaner; Cristina Saura; Sarina A. Piha-Paul; Ingrid Mayer; David Quinn; Komal Jhaveri; Ben Stone; Seta Shahin; Grace Mann; Melanie Dujka; Richard Bryce; Funda Meric-Bernstam; David B. Solit; David M. Hyman
Discovery, Validation, and Application of Novel Methylated DNA Markers for Detection of Esophageal Cancer in Plasma
Yi Qin; Chung W. Wu; William R. Taylor; Tarek Sawas; Kelli N. Burger; Douglas W. Mahoney; Zhifu Sun; Tracy C. Yab; Graham P. Lidgard; Hatim T. Allawi; Navtej S. Buttar; Thomas C. Smyrk; Prasad G. Iyer; David A. Katzka; David A. Ahlquist; John B. Kisiel
Antibody Responses to Cancer Antigens Identify Patients with a Poor Prognosis among HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma Patients
Simon Laban; Dominik S. Gangkofner; Dana Holzinger; Lea Schroeder; Stefan B. Eichmüller; Inka Zörnig; Dirk Jäger; Gunnar Wichmann; Andreas Dietz; Martina A. Broglie; Christel C. Herold-Mende; Gerhard Dyckhoff; Paolo Boscolo-Rizzo; Jasmin Ezić; Ralf Marienfeld; Peter Möller; Johann M. Kraus; Gunnar Völkel; Hans A. Kestler; Cornelia Brunner; Patrick J. Schuler; Marlene C. Wigand; Marie-Nicole Theodoraki; Johannes Doescher; Thomas K. Hoffmann; Michael Pawlita; Tim Waterboer; Julia Butt
Author Choice
Transcriptomic Analysis Reveals Prognostic Molecular Signatures of Stage I Melanoma
Rohit Thakur; Jonathan P. Laye; Martin Lauss; Joey Mark S. Diaz; Sally Jane O'Shea; Joanna Poźniak; Anastasia Filia; Mark Harland; Joanne Gascoyne; Juliette A. Randerson-Moor; May Chan; Tracey Mell; Göran Jönsson; D. Timothy Bishop; Julia Newton-Bishop; Jennifer H. Barrett; Jérémie Nsengimana
Prostate-Specific Membrane Antigen Ligand Positron Emission Tomography in Men with Nonmetastatic Castration-Resistant Prostate Cancer
Wolfgang P. Fendler; Manuel Weber; Amir Iravani; Michael S. Hofman; Jérémie Calais; Johannes Czernin; Harun Ilhan; Fred Saad; Eric J. Small; Matthew R. Smith; Paola M. Perez; Thomas A. Hope; Isabel Rauscher; Anil Londhe; Angela Lopez-Gitlitz; Shinta Cheng; Tobias Maurer; Ken Herrmann; Matthias Eiber; Boris Hadaschik
Author Choice
Predicting the 1p/19q Codeletion Status of Presumed Low-Grade Glioma with an Externally Validated Machine Learning Algorithm
Sebastian R. van der Voort; Fatih Incekara; Maarten M.J. Wijnenga; Georgios Kapas; Mayke Gardeniers; Joost W. Schouten; Martijn P.A. Starmans; Rishie Nandoe Tewarie; Geert J. Lycklama; Pim J. French; Hendrikus J. Dubbink; Martin J. van den Bent; Arnaud J.P.E. Vincent; Wiro J. Niessen; Stefan Klein; Marion Smits
ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
Sargur Madabushi Srideshikan; Jamison Brooks; Darren Zuro; Bijender Kumar; James Sanchez; Liliana Echavarria Parra; Marvin Orellana; Paresh Vishwasrao; Indu Nair; Junie Chea; Kofi Poku; Nicole Bowles; Aaron Miller; Todd Ebner; Justin Molnar; Joseph Rosenthal; Daniel A. Vallera; Jeffrey Y.C. Wong; Anthony S. Stein; David Colcher; John E. Shively; Paul J. Yazaki; Susanta K. Hui
Translational Cancer Mechanisms and Therapy
Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma
Jian Zhou; Francisco Sanchez-Vega; Raul Caso; Kay See Tan; Whitney S. Brandt; Gregory D. Jones; Shi Yan; Prasad S. Adusumilli; Matthew Bott; James Huang; James M. Isbell; Smita Sihag; Daniela Molena; Valerie W. Rusch; Walid K. Chatila; Natasha Rekhtman; Fan Yang; Marc Ladanyi; David B. Solit; Michael F. Berger; Nikolaus Schultz; David R. Jones
Author Choice
Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors
Mariana Ferreira Leal; Ben P. Haynes; Eugene Schuster; Belinda Yeo; Maria Afentakis; Lila Zabaglo; Vera Martins; Richard Buus; Andrew Dodson; Maggie C.U. Cheang; Ian E. Smith; Lesley-Ann Martin; Mitch Dowsett
Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)
Chen Yuan; Kaori Sato; Bruce W. Hollis; Sui Zhang; Donna Niedzwiecki; Fang-Shu Ou; I-Wen Chang; Bert H. O'Neil; Federico Innocenti; Heinz-Josef Lenz; Charles D. Blanke; Richard M. Goldberg; Alan P. Venook; Robert J. Mayer; Charles S. Fuchs; Jeffrey A. Meyerhardt; Kimmie Ng
Author Choice
Germline BRCA-Associated Endometrial Carcinoma Is a Distinct Clinicopathologic Entity
Marthe M. de Jonge; Lauren L. Ritterhouse; Cornelis D. de Kroon; Maaike P.G. Vreeswijk; Jeremy P. Segal; Rutika Puranik; Harry Hollema; Matti A. Rookus; Christi J. van Asperen; Flora E. van Leeuwen; Vincent T.H.B.M. Smit; Brooke E. Howitt; Tjalling Bosse; for the HEBON Group
Author Choice
Purinostat Mesylate Is a Uniquely Potent and Selective Inhibitor of HDACs for the Treatment of BCR-ABL–Induced B-Cell Acute Lymphoblastic Leukemia
Linyu Yang; Qiang Qiu; Minghai Tang; Fang Wang; Yuyao Yi; Dongni Yi; Zhuang Yang; Zejiang Zhu; Shoujun Zheng; Jianhong Yang; Heying Pei; Li Zheng; Yong Chen; Liping Gou; Liya Luo; Xing Deng; Haoyu Ye; Yiguo Hu; Ting Niu; Lijuan Chen
Author Choice
Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia
Beatrice Del Papa; Stefano Baldoni; Erica Dorillo; Filomena De Falco; Chiara Rompietti; Debora Cecchini; Maria Grazia Cantelmi; Daniele Sorcini; Manuel Nogarotto; Francesco Maria Adamo; Federica Mezzasoma; Estevão Carlos Silva Barcelos; Elisa Albi; Roberta Iacucci Ostini; Ambra Di Tommaso; Andrea Marra; Guido Montanaro; Maria Paola Martelli; Franca Falzetti; Mauro Di Ianni; Emanuela Rosati; Paolo Sportoletti
Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas
Roberta Frapolli; Ezia Bello; Marianna Ponzo; Ilaria Craparotta; Laura Mannarino; Sara Ballabio; Sergio Marchini; Laura Carrassa; Paolo Ubezio; Luca Porcu; Silvia Brich; Roberta Sanfilippo; Paolo Giovanni Casali; Alessandro Gronchi; Silvana Pilotti; Maurizio D'Incalci
Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
Mauricio S. Caetano; Ahmed I. Younes; Hampartsoum B. Barsoumian; Michael Quigley; Hari Menon; Chan Gao; Thomas Spires; Timothy P. Reilly; Alexandra P. Cadena; Taylor R. Cushman; Jonathan E. Schoenhals; Ailin Li; Quynh-Nhu Nguyen; Maria Angelica Cortez; James W. Welsh
Correlation of Tumor Burden in Sentinel Lymph Nodes with Tumor Burden in Nonsentinel Lymph Nodes and Survival in Cutaneous Melanoma
Kenjiro Namikawa; Phyu P. Aung; Denái R. Milton; Michael T. Tetzlaff; Carlos A. Torres-Cabala; Jonathan L. Curry; Priyadharsini Nagarajan; Doina Ivan; Merrick Ross; Jeffrey E. Gershenwald; Victor G. Prieto
Mechanisms and Antitumor Activity of a Binary EGFR/DNA–Targeting Strategy Overcomes Resistance of Glioblastoma Stem Cells to Temozolomide
Zeinab Sharifi; Bassam Abdulkarim; Brian Meehan; Janusz Rak; Paul Daniel; Julie Schmitt; Nidia Lauzon; Kolja Eppert; Heather M. Duncan; Kevin Petrecca; Marie-Christine Guiot; Bertrand Jean-Claude; Siham Sabri
Letter to the Editor
Correction
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