Issues

The image shows a lung adenocarcinoma with solid growth pattern. By comprehensive nextgeneration sequencing (NGS), this tumor had an identical genomic profile to a previously resected adenocarcinoma with entirely different, better-differentiated histologic features. This illustrates histologic progression of lung adenocarcinoma during metastasis, and the utility of NGS in clinical practice for confirming clonally related tumors despite histologic differences. For details, see the article by Chang and colleagues on page 7113 of this issue.