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1 November 2019
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Cover Image
Cover Image
The cover shows a fluorescence in situ hybridization assay that was performed on tumor tissue from a patient with metastatic breast cancer, revealing amplification of the FGFR1 gene. This patient was treated with mTOR inhibitor-based combination therapy and achieved a prolonged radiological response. For details, see the article by Drago and colleagues on page 6443 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor
John Glod; Fernanda I. Arnaldez; Lori Wiener; Melissa Spencer; J. Keith Killian; Paul Meltzer; Eva Dombi; Claudia Derse-Anthony; Joanne Derdak; Ramaprasad Srinivasan; W. Marston Linehan; Markku Miettinen; Seth M. Steinberg; Lee Helman; Brigitte C. Widemann
Author Choice
First-in-Human Study of Mivebresib (ABBV-075), an Oral Pan-Inhibitor of Bromodomain and Extra Terminal Proteins, in Patients with Relapsed/Refractory Solid Tumors
Sarina A. Piha-Paul; Jasgit C. Sachdev; Minal Barve; Patricia LoRusso; Russell Szmulewitz; Sapna Pradyuman Patel; Primo N. Lara, Jr; Xiaotian Chen; Beibei Hu; Kevin J. Freise; Dimple Modi; Anjla Sood; Jessica E. Hutti; Johannes Wolff; Bert H. O'Neil
Clinical Trials: Immunotherapy
A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma
Wayne L. Furman; Sara M. Federico; Mary Beth McCarville; Barry L. Shulkin; Andrew M. Davidoff; Matthew J. Krasin; Natasha Sahr; April Sykes; Jianrong Wu; Rachel C. Brennan; Michael William Bishop; Sara Helmig; Elizabeth Stewart; Fariba Navid; Brandon Triplett; Victor M. Santana; Armita Bahrami; Gwendolyn Anthony; Alice L. Yu; Jacquelyn Hank; Stephen D. Gillies; Paul M. Sondel; Wing H. Leung; Alberto S. Pappo
Precision Medicine and Imaging
AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography
Ronald M. Juarez-Chambi; Carmen Kut; Jose J. Rico-Jimenez; Kaisorn L. Chaichana; Jiefeng Xi; Daniel U. Campos-Delgado; Fausto J. Rodriguez; Alfredo Quinones-Hinojosa; Xingde Li; Javier A. Jo
Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations
Yoshiyuki Suehara; Deepu Alex; Anita Bowman; Sumit Middha; Ahmet Zehir; Debyani Chakravarty; Lu Wang; George Jour; Khedoudja Nafa; Takuo Hayashi; Achim A. Jungbluth; Denise Frosina; Emily Slotkin; Neerav Shukla; Paul Meyers; John H. Healey; Meera Hameed; Marc Ladanyi
DNA Methylation Markers for Breast Cancer Detection in the Developing World
Bradley M. Downs; Claudia Mercado-Rodriguez; Ashley Cimino-Mathews; Chuang Chen; Jing-Ping Yuan; Eunice Van Den Berg; Leslie M. Cope; Fernando Schmitt; Gary M. Tse; Syed Z. Ali; Danielle Meir-Levi; Rupali Sood; Juanjuan Li; Andrea L. Richardson; Marina B. Mosunjac; Monica Rizzo; Suzana Tulac; Kriszten J. Kocmond; Timothy de Guzman; Edwin W. Lai; Brian Rhees; Michael Bates; Antonio C. Wolff; Edward Gabrielson; Susan C. Harvey; Christopher B. Umbricht; Kala Visvanathan; Mary Jo Fackler; Saraswati Sukumar
Author Choice
Prediction of Lymph Node Metastasis in Breast Cancer by Gene Expression and Clinicopathological Models: Development and Validation within a Population-Based Cohort
Looket Dihge; Johan Vallon-Christersson; Cecilia Hegardt; Lao H. Saal; Jari Häkkinen; Christer Larsson; Anna Ehinger; Niklas Loman; Martin Malmberg; Pär-Ola Bendahl; Åke Borg; Johan Staaf; Lisa Rydén
Translational Cancer Mechanisms and Therapy
The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma
Anna Truini; Jacqueline H. Starrett; Tyler Stewart; Kumar Ashtekar; Zenta Walther; Anna Wurtz; David Lu; Jin H. Park; Michelle DeVeaux; Xiaoling Song; Scott Gettinger; Daniel Zelterman; Mark A. Lemmon; Sarah B. Goldberg; Katerina Politi
Author Choice
Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma
Weiyi Peng; Leila J. Williams; Chunyu Xu; Brenda Melendez; Jodi A. McKenzie; Yuan Chen; Heather L. Jackson; Kui S. Voo; Rina M. Mbofung; Sara Elizabeth Leahey; Jian Wang; Gregory Lizee; Hussein A. Tawbi; Michael A. Davies; Axel Hoos; James Smothers; Roopa Srinivasan; Elaine M. Paul; Niranjan Yanamandra; Patrick Hwu
A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma
Y.N. Vashisht Gopal; Seth Gammon; Rishika Prasad; Barbara Knighton; Federica Pisaneschi; Jason Roszik; Ningping Feng; Sarah Johnson; Snigdha Pramanik; Jessica Sudderth; Dawen Sui; Courtney Hudgens; Grant M. Fischer; Wanleng Deng; Alexandre Reuben; Weiyi Peng; Jian Wang; Jennifer L. McQuade; Michael T. Tetzlaff; Maria E. Di Francesco; Joe Marszalek; David Piwnica-Worms; Ralph J. DeBerardinis; Michael A. Davies
FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor–Positive (HR+) Breast Cancer
Joshua Z. Drago; Luigi Formisano; Dejan Juric; Andrzej Niemierko; Alberto Servetto; Seth A. Wander; Laura M. Spring; Neelima Vidula; Jerry Younger; Jeffrey Peppercorn; Megan Yuen; Giuliana Malvarosa; Dennis Sgroi; Steven J. Isakoff; Beverly Moy; Leif W. Ellisen; A. John Iafrate; Carlos L. Arteaga; Aditya Bardia
Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response
Li Ding; Vijay S. Madamsetty; Spencer Kiers; Olga Alekhina; Andrey Ugolkov; John Dube; Yu Zhang; Jin-San Zhang; Enfeng Wang; Shamit K. Dutta; Daniel M. Schmitt; Francis J. Giles; Alan P. Kozikowski; Andrew P. Mazar; Debabrata Mukhopadhyay; Daniel D. Billadeau
Author Choice
Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy
Miguel Reis Ferreira; H. Jervoise N. Andreyev; Kabir Mohammed; Lesley Truelove; Sharon M. Gowan; Jia Li; Sarah L. Gulliford; Julian R. Marchesi; David P. Dearnaley
Characterization and Comparison of GITR Expression in Solid Tumors
Luis Vence; Samantha L. Bucktrout; Irina Fernandez Curbelo; Jorge Blando; Bevin M. Smith; Ashley E. Mahne; John C. Lin; Terrence Park; Edward Pascua; Tao Sai; Javier Chaparro-Riggers; Sumit K. Subudhi; Jorge B. Scutti; Maria G. Higa; Hao Zhao; Shalini S. Yadav; Anirban Maitra; Ignacio I. Wistuba; James P. Allison; Padmanee Sharma
Author Choice
Genetic Aberrations in the CDK4 Pathway Are Associated with Innate Resistance to PD-1 Blockade in Chinese Patients with Non-Cutaneous Melanoma
Jiayi Yu; Junya Yan; Qian Guo; Zhihong Chi; Bixia Tang; Bin Zheng; Jinyu Yu; Ting Yin; Zhiyuan Cheng; Xiaowen Wu; Huan Yu; Jie Dai; Xinan Sheng; Lu Si; Chuanliang Cui; Xue Bai; Lili Mao; Bin Lian; Xuan Wang; Xieqia Yan; Siming Li; Li Zhou; Keith T. Flaherty; Jun Guo; Yan Kong
Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia
Christopher J. Walker; Jessica Kohlschmidt; Ann-Kathrin Eisfeld; Krzysztof Mrózek; Sandya Liyanarachchi; Chi Song; Deedra Nicolet; James S. Blachly; Marius Bill; Dimitrios Papaioannou; Christopher C. Oakes; Brian Giacopelli; Luke K. Genutis; Sophia E. Maharry; Shelley Orwick; Kellie J. Archer; Bayard L. Powell; Jonathan E. Kolitz; Geoffrey L. Uy; Eunice S. Wang; Andrew J. Carroll; Richard M. Stone; John C. Byrd; Albert de la Chapelle; Clara D. Bloomfield
Parallel Analyses of Somatic Mutations in Plasma Circulating Tumor DNA (ctDNA) and Matched Tumor Tissues in Early-Stage Breast Cancer
Xianyu Zhang; Weiwei Zhao; Wei Wei; Zilong You; Xiaohua Ou; Mingming Sun; Yanling Yin; Xiaoyan Tang; Zhen Zhao; Changming Hu; Feifei Liu; Junhao Deng; Linlin Mao; Danyan Zhou; Yuxia Ren; Xiaoxia Li; Shangfei Zhang; Chang Liu; Jingshu Geng; Guodong Yao; Bingbing Song; Yupeng Liu; Dalin Li; Yongdong Jiang; Yanbo Chen; Yashuang Zhao; Shihui Yu; Da Pang
Letters to the Editor
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