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15 January 2019
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Cover Image
Cover Image
The cover shows a section of a 3-dimensional-reconstructed pseudocrypt derived from a small bowel adenocarcinoma cell line. For details, see the article by Adam and colleagues on page 641 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in CCR
CCR Drug Updates
FDA Approval: Blinatumomab for Patients with B-cell Precursor Acute Lymphoblastic Leukemia in Morphologic Remission with Minimal Residual Disease
Emily Y. Jen; Qing Xu; Aaron Schetter; Donna Przepiorka; Yuan Li Shen; Donna Roscoe; Rajeshwari Sridhara; Albert Deisseroth; Reena Philip; Ann T. Farrell; Richard Pazdur
Clinical Trials: Targeted Therapy
A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma
Jacob P. Laubach; Chia-Jen Liu; Noopur S. Raje; Andrew J. Yee; Philippe Armand; Robert L. Schlossman; Jacalyn Rosenblatt; Jacquelyn Hedlund; Michael Martin; Craig Reynolds; Kenneth H. Shain; Ira Zackon; Laura Stampleman; Patrick Henrick; Bradley Rivotto; Kalvis T.V. Hornburg; Henry J. Dumke; Stacey Chuma; Alexandra Savell; Damian R. Handisides; Stew Kroll; Kenneth C. Anderson; Paul G. Richardson; Irene M. Ghobrial
Author Choice
Patritumab with Cetuximab plus Platinum-Containing Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: An Open-Label, Phase Ib Study
Magnus T. Dillon; Lorna Grove; Kate L. Newbold; Heather Shaw; Nicholas F. Brown; Jeanne Mendell; Shuquan Chen; Robert A. Beckman; Anne Jennings; Marivic Ricamara; Jonathan Greenberg; Martin Forster; Kevin J. Harrington
Author Choice
A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors
Florence Atrafi; Harry J.M. Groen; Lauren A. Byers; Elena Garralda; Martijn P. Lolkema; Randeep S. Sangha; Santiago Viteri; Young Kwang Chae; D. Ross Camidge; Nashat Y. Gabrail; Beibei Hu; Tian Tian; Silpa Nuthalapati; Elizabeth Hoening; Lei He; Philip Komarnitsky; Antonio Calles
Author Choice
PTEN Expression, Not Mutation Status in TSC1, TSC2, or mTOR, Correlates with the Outcome on Everolimus in Patients with Renal Cell Carcinoma Treated on the Randomized RECORD-3 Trial
Martin H. Voss; David Chen; Albert Reising; Mahtab Marker; Jiayuan Shi; Jianning Xu; Irina Ostrovnaya; Venkatraman E. Seshan; Almedina Redzematovic; Ying-Bei Chen; Parul Patel; Xia Han; James J. Hsieh; A. Ari Hakimi; Robert J. Motzer
Clinical Trials: Immunotherapy
Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study
Jianming Xu; Yun Zhang; Ru Jia; Chunyan Yue; Lianpeng Chang; Rongrui Liu; Gairong Zhang; Chuanhua Zhao; Yaoyue Zhang; Chunxia Chen; Yan Wang; Xin Yi; Zhiyuan Hu; Jianjun Zou; Quanren Wang
E3611—A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-α2b in Advanced Melanoma
Ahmad A. Tarhini; Sandra J. Lee; Xiaoxue Li; Uma N.M. Rao; Arun Nagarajan; Mark R. Albertini; Jerry W. Mitchell, Jr; Stuart J. Wong; Mark A. Taylor; Noel Laudi; Phu V. Truong; Robert M. Conry; John M. Kirkwood
Precision Medicine and Imaging
Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics
John H. Yim; Audrey H. Choi; Arthur X. Li; Hanjun Qin; Sue Chang; Sun-Wing T. Tong; Peiguo Chu; Byung-Wook Kim; Daniel Schmolze; Ryan Lew; Yasmine Ibrahim; Valeriy A. Poroyko; Sylvana Salvatierra; Alysha Baker; Jinhui Wang; Xiwei Wu; Gerd P. Pfeifer; Yuman Fong; Maria A. Hahn
Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy
Shanshan Jiang; Charles G. Eberhart; Michael Lim; Hye-Young Heo; Yi Zhang; Lindsay Blair; Zhibo Wen; Matthias Holdhoff; Doris Lin; Peng Huang; Huamin Qin; Alfredo Quinones-Hinojosa; Jon D. Weingart; Peter B. Barker; Martin G. Pomper; John Laterra; Peter C.M. van Zijl; Jaishri O. Blakeley; Jinyuan Zhou
Association of CD4+ Radiation-Induced Lymphocyte Apoptosis with Fibrosis and Telangiectasia after Radiotherapy in 272 Breast Cancer Patients with >10-Year Follow-up
Marlon R. Veldwijk; Petra Seibold; Akke Botma; Irmgard Helmbold; Elena Sperk; Frank A. Giordano; Nicole Gürth; Anne Kirchner; Sabine Behrens; Frederik Wenz; Jenny Chang-Claude; Carsten Herskind
Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer
Amilcar Flores-Morales; Tobias B. Bergmann; Charlotte Lavallee; Tanveer S. Batth; Dong Lin; Mads Lerdrup; Stine Friis; Anette Bartels; Gitte Kristensen; Agnieszka Krzyzanowska; Hui Xue; Ladan Fazli; Klaus H. Hansen; Martin A. Røder; Klaus Brasso; José M. Moreira; Anders Bjartell; Yuzhuo Wang; Jesper V. Olsen; Colin C. Collins; Diego Iglesias-Gato
Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors
Yemarshet K. Gebreyohannes; Agnieszka Wozniak; Madalina-Elena Zhai; Jasmien Wellens; Jasmien Cornillie; Ulla Vanleeuw; Erica Evans; Alexandra K. Gardino; Christoph Lengauer; Maria Debiec-Rychter; Raf Sciot; Patrick Schöffski
Translational Cancer Mechanisms and Therapy
Serum Nardilysin, a Surrogate Marker for Epithelial–Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection
Tomoaki Yoh; Etsuro Hatano; Yosuke Kasai; Hiroaki Fuji; Kiyoto Nishi; Kan Toriguchi; Hideaki Sueoka; Mikiko Ohno; Satoru Seo; Keiko Iwaisako; Kojiro Taura; Rina Yamaguchi; Masato Kurokawa; Jiro Fujimoto; Takeshi Kimura; Shinji Uemoto; Eiichiro Nishi
DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway
Liana Adam; F. Anthony San Lucas; Richard Fowler; Yao Yu; Wenhui Wu; Yulun Liu; Huamin Wang; David Menter; Michael T. Tetzlaff; Joe Ensor, Jr; Ganiraju Manyam; Stefan T. Arold; Chad Huff; Scott Kopetz; Paul Scheet; Michael J. Overman
Biomarkers and Bone Imaging Dynamics Associated with Clinical Outcomes of Oral Cabozantinib Therapy in Metastatic Castrate-Resistant Prostate Cancer
Ulka N. Vaishampayan; Izabela Podgorski; Lance K. Heilbrun; Jawana M. Lawhorn-Crews; Kimberlee C. Dobson; Julie Boerner; Karri Stark; Daryn W. Smith; Elisabeth I. Heath; Joseph A. Fontana; Anthony F. Shields
Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma
Nichola Cruickshanks; Ying Zhang; Sarah Hine; Myron Gibert; Fang Yuan; Madison Oxford; Cassandra Grello; Mary Pahuski; Collin Dube; Fadila Guessous; Baomin Wang; Ciana Deveau; Karim Saoud; Isela Gallagher; Julia Wulfkuhle; David Schiff; See Phan; Emanuel Petricoin; Roger Abounader
Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma
Ju Youn Lee; Michail Schizas; Felipe C. Geyer; Pier Selenica; Salvatore Piscuoglio; Rita A. Sakr; Charlotte K.Y. Ng; Jose V. Scarpa Carniello; Russell Towers; Dilip D. Giri; Victor P. de Andrade; Anastasios D. Papanastasiou; Agnes Viale; Reuben S. Harris; David B. Solit; Britta Weigelt; Jorge S. Reis-Filho; Tari A. King
Author Choice
RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer
Daniel Nava Rodrigues; Nicola Casiraghi; Alessandro Romanel; Mateus Crespo; Susana Miranda; Pasquale Rescigno; Ines Figueiredo; Ruth Riisnaes; Suzanne Carreira; Semini Sumanasuriya; Paola Gasperini; Adam Sharp; Joaquin Mateo; Alan Makay; Christopher McNair; Matthew Schiewer; Karen Knudsen; Gunther Boysen; Francesca Demichelis; Johann S. de Bono
Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer
Marine F. Garrido; Nicolas J.-P. Martin; Matthieu Bertrand; Catherine Gaudin; Frédéric Commo; Nassif El Kalaany; Nader Al Nakouzi; Ladan Fazli; Elaine Del Nery; Jacques Camonis; Franck Perez; Stéphanie Lerondel; Alain Le Pape; Daniel Compagno; Martin Gleave; Yohann Loriot; Laurent Désaubry; Stéphan Vagner; Karim Fizazi; Anne Chauchereau
Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers
Avinoam Nevler; Alexander J. Muller; Erika Sutanto-Ward; James B. DuHadaway; Kei Nagatomo; Eric Londin; Kevin O'Hayer; Joseph A. Cozzitorto; Harish Lavu; Theresa P. Yeo; Mark Curtis; Tatiana Villatoro; Benjamin E. Leiby; Laura Mandik-Nayak; Jordan M. Winter; Charles J. Yeo; George C. Prendergast; Jonathan R. Brody
Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma
Fabienne Desmots; Mikaël Roussel; Céline Pangault; Francisco Llamas-Gutierrez; Cédric Pastoret; Eric Guiheneuf; Jérôme Le Priol; Valérie Camara-Clayette; Gersende Caron; Catherine Henry; Marc-Antoine Belaud-Rotureau; Pascal Godmer; Thierry Lamy; Fabrice Jardin; Karin Tarte; Vincent Ribrag; Thierry Fest
Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas
Dusten Unruh; Snezana Mirkov; Brian Wray; Michael Drumm; Jonathan Lamano; Yuping D. Li; Qazi F. Haider; Rodrigo Javier; Kathleen McCortney; Amanda Saratsis; Denise M. Scholtens; Jann N. Sarkaria; C. David James; Craig Horbinski
Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma
Sylvie Job; Irena Draskovic; Nelly Burnichon; Alexandre Buffet; Jérôme Cros; Charles Lépine; Annabelle Venisse; Estelle Robidel; Virginie Verkarre; Tchao Meatchi; Mathilde Sibony; Laurence Amar; Jérôme Bertherat; Aurélien de Reyniès; Arturo Londoño-Vallejo; Judith Favier; Luis Jaime Castro-Vega; Anne-Paule Gimenez-Roqueplo
Extended Adjuvant Therapy with Neratinib Plus Fulvestrant Blocks ER/HER2 Crosstalk and Maintains Complete Responses of ER+/HER2+ Breast Cancers: Implications to the ExteNET Trial
Dhivya R. Sudhan; Luis J. Schwarz; Angel Guerrero-Zotano; Luigi Formisano; Mellissa J. Nixon; Sarah Croessmann; Paula I. González Ericsson; Melinda Sanders; Justin M. Balko; Francesca Avogadri-Connors; Richard E. Cutler; Alshad S. Lalani; Richard Bryce; Alan Auerbach; Carlos L. Arteaga
Author Choice
KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition
Sandra Misale; Jackson P. Fatherree; Eliane Cortez; Chendi Li; Samantha Bilton; Daria Timonina; David T. Myers; Dana Lee; Maria Gomez-Caraballo; Max Greenberg; Varuna Nangia; Patricia Greninger; Regina K. Egan; Joseph McClanaghan; Giovanna T. Stein; Ellen Murchie; Patrick P. Zarrinkar; Matthew R. Janes; Lian-Sheng Li; Yi Liu; Aaron N. Hata; Cyril H. Benes
Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model
Jingjing Luo; Li Bian; Melanie A. Blevins; Dongyan Wang; Chao Liang; Danfeng Du; Fanglong Wu; Barry Holwerda; Rui Zhao; David Raben; Hongmei Zhou; Christian D. Young; Xiao-Jing Wang
Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the In Vitro Integrity of T Cells from Cancer Patients
Masato Kobayashi; Jin-Sung Chung; Muhammad Beg; Yull Arriaga; Udit Verma; Kevin Courtney; John Mansour; Barbara Haley; Saad Khan; Yutaka Horiuchi; Vijay Ramani; David Harker; Purva Gopal; Farshid Araghizadeh; Ponciano D. Cruz, Jr; Kiyoshi Ariizumi
The Number of Screening Cycles Needed to Reduce Prostate Cancer Mortality in the Finnish Section of the European Randomized Study of Prostate Cancer (ERSPC)
Tomi Pakarainen; Jaakko Nevalainen; Kirsi Talala; Kimmo Taari; Jani Raitanen; Paula Kujala; Ulf-Håkan Stenman; Teuvo L.J. Tammela; Anssi Auvinen
Author Choice
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells
Sameer Agnihotri; Sheila Mansouri; Kelly Burrell; Mira Li; Yasin Mamatjan; Jeff Liu; Romina Nejad; Sushil Kumar; Shahrzad Jalali; Sanjay K. Singh; Alenoush Vartanian; Eric Xueyu Chen; Shirin Karimi; Olivia Singh; Severa Bunda; Alireza Mansouri; Kenneth D. Aldape; Gelareh Zadeh
Enhancing Abiraterone Acetate Efficacy in Androgen Receptor–positive Triple-negative Breast Cancer: Chk1 as a Potential Target
Thomas Grellety; Celine Callens; Elodie Richard; Adrien Briaux; Valérie Vélasco; Marina Pulido; Anthony Gonçalves; Pierre Gestraud; Gaetan MacGrogan; Hervé Bonnefoi; Bruno Cardinaud
Author Choice
Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer
Daniel L.J. Thorek; Anson T. Ku; Nicholas Mitsiades; Darren Veach; Philip A. Watson; Dipti Metha; Sven-Erik Strand; Sai Kiran Sharma; Jason S. Lewis; Diane S. Abou; Hans G. Lilja; Steven M. Larson; Michael R. McDevitt; David Ulmert
Letters to the Editor
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