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1 October 2019
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The cover shows a section of a tumor biopsy from a patient with malignant mesothelioma. Multiplex immunohistochemical staining reveals different immune cell populations infiltrating the tumor. For details, see the article by Hassan and colleagues on page 5787 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients
Umamaheswar Duvvuri; Jonathan George; Seungwon Kim; Diego Alvarado; Veronique M. Neumeister; Ahmed Chenna; Richard Gedrich; Thomas Hawthorne; Theresa LaVallee; Jennifer R. Grandis; Julie E. Bauman
Health-Related Quality of Life Impact from Adding Bevacizumab to Cisplatin-Pemetrexed in Malignant Pleural Mesothelioma in the MAPS IFCT-GFPC-0701 Phase III Trial
Guillaume Eberst; Amélie Anota; Arnaud Scherpereel; Julien Mazieres; Jacques Margery; Laurent Greillier; Clarisse Audigier-Valette; Denis Moro-Sibilot; Olivier Molinier; Hervé Léna; Frédéric Rivière; Isabelle Monnet; Valérie Gounant; Henri Janicot; Radj Gervais; Chrystelle Locher; Emilie Charton; Franck Morin; Gérard Zalcman; Virginie Westeel; on behalf of the French Cooperative Thoracic Intergroup (IFCT)
Clinical Trials: Immunotherapy
Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma
Raffit Hassan; Evan Alley; Hedy Kindler; Scott Antonia; Thierry Jahan; Somayeh Honarmand; Nitya Nair; Chan C. Whiting; Amanda Enstrom; Ed Lemmens; Takahiro Tsujikawa; Sushil Kumar; Gina Choe; Anish Thomas; Katherine McDougall; Aimee L. Murphy; Elizabeth Jaffee; Lisa M. Coussens; Dirk G. Brockstedt
A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma
Patrick Y. Wen; David A. Reardon; Terri S. Armstrong; Surasak Phuphanich; Robert D. Aiken; Joseph C. Landolfi; William T. Curry; Jay-Jiguang Zhu; Michael Glantz; David M. Peereboom; James M. Markert; Renato LaRocca; Donald M. O'Rourke; Karen Fink; Lyndon Kim; Michael Gruber; Glenn J. Lesser; Edward Pan; Santosh Kesari; Alona Muzikansky; Clemencia Pinilla; Radleigh G. Santos; John S. Yu
Author Choice
First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1
Neeta Somaiah; Matthew S. Block; Joseph W. Kim; Geoffrey I. Shapiro; Khanh T. Do; Patrick Hwu; Joseph P. Eder; Robin L. Jones; Hailing Lu; Jan H. ter Meulen; Chet Bohac; Michael Chen; Frank J. Hsu; Sacha Gnjatic; Seth M. Pollack
Phase I Trial of an ICAM-1-Targeted Immunotherapeutic-Coxsackievirus A21 (CVA21) as an Oncolytic Agent Against Non Muscle-Invasive Bladder Cancer
Nicola E. Annels; David Mansfield; Mehreen Arif; Carmen Ballesteros-Merino; Guy R. Simpson; Mick Denyer; Sarbjinder S. Sandhu; Alan A. Melcher; Kevin J. Harrington; Bronwyn Davies; Gough Au; Mark Grose; Izhar Bagwan; Bernard Fox; Richard Vile; Hugh Mostafid; Darren Shafren; Hardev S. Pandha
Precision Medicine and Imaging
Author Choice
Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations
Thereasa A. Rich; Karen L. Reckamp; Young Kwang Chae; Robert C. Doebele; Wade T. Iams; Michael Oh; Victoria M. Raymond; Richard B. Lanman; Jonathan W. Riess; Thomas E. Stinchcombe; Vivek Subbiah; David R. Trevarthen; Stephen Fairclough; Jennifer Yen; Oliver Gautschi
Mutation Status of RAS, TP53, and SMAD4 is Superior to Mutation Status of RAS Alone for Predicting Prognosis after Resection of Colorectal Liver Metastases
Yoshikuni Kawaguchi; Scott Kopetz; Timothy E. Newhook; Mario De Bellis; Yun Shin Chun; Ching-Wei D. Tzeng; Thomas A. Aloia; Jean-Nicolas Vauthey
Author Choice
Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer
Christopher H. Lieu; Erica A. Golemis; Ilya G. Serebriiskii; Justin Newberg; Amanda Hemmerich; Caitlin Connelly; Wells A. Messersmith; Cathy Eng; S. Gail Eckhardt; Garrett Frampton; Matthew Cooke; Joshua E. Meyer
ESM1 as a Marker of Macrotrabecular-Massive Hepatocellular Carcinoma
Julien Calderaro; Léa Meunier; Cong Trung Nguyen; Marouane Boubaya; Stefano Caruso; Alain Luciani; Giuliana Amaddeo; Hélène Regnault; Jean-Charles Nault; Justine Cohen; Frédéric Oberti; Sophie Michalak; Mohamed Bouattour; Valérie Vilgrain; Georges Philippe Pageaux; Jeanne Ramos; Nathalie Barget; Boris Guiu; Valérie Paradis; Christophe Aubé; Alexis Laurent; Jean-Michel Pawlotsky; Nathalie Ganne-Carrié; Jessica Zucman-Rossi; Olivier Seror; Marianne Ziol
Translational Cancer Mechanisms and Therapy
Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma
Gwendolen Lorch; Karthigayini Sivaprakasam; Victoria Zismann; Nieves Perdigones; Tania Contente-Cuomo; Alexandra Nazareno; Salvatore Facista; Shukmei Wong; Kevin Drenner; Winnie S. Liang; Joseph M. Amann; Sara L. Sinicropi-Yao; Michael J. Koenig; Krista La Perle; Timothy G. Whitsett; Muhammed Murtaza; Jeffrey M. Trent; David P. Carbone; William P.D. Hendricks
Author Choice
Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343
Marlon J. Hinner; Rachida Siham Bel Aiba; Thomas J. Jaquin; Sven Berger; Manuela Carola Dürr; Corinna Schlosser; Andrea Allersdorfer; Alexander Wiedenmann; Gabriele Matschiner; Julia Schüler; Ulrich Moebius; Christine Rothe; Louis Matis; Shane Anthony Olwill
Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy
Clara H. Karches; Mohamed-Reda Benmebarek; Moritz L. Schmidbauer; Mathias Kurzay; Richard Klaus; Martina Geiger; Felicitas Rataj; Bruno L. Cadilha; Stefanie Lesch; Constanze Heise; Ramona Murr; Johannes vom Berg; Martin Jastroch; Daniel Lamp; Jian Ding; Peter Duewell; Gerhard Niederfellner; Claudio Sustmann; Stefan Endres; Christian Klein; Sebastian Kobold
Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo
Brittany Woods; Wei Chen; Sophia Chiu; Christian Marinaccio; Chunling Fu; Lilly Gu; Marinka Bulic; Qiong Yang; Anouar Zouak; Shengxian Jia; Praveen Kumar Suraneni; Kailin Xu; Ross L. Levine; John D. Crispino; Qiang Jeremy Wen
Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy
Matthew R. Trendowski; Omar El-Charif; Mark J. Ratain; Patrick Monahan; Zepeng Mu; Heather E. Wheeler; Paul C. Dinh, Jr; Darren R. Feldman; Shirin Ardeshir-Rouhani-Fard; Robert J. Hamilton; David J. Vaughn; Chunkit Fung; Christian Kollmannsberger; Taisei Mushiroda; Michiaki Kubo; Robyn Hannigan; Frederick Strathmann; Lawrence H. Einhorn; Sophie D. Fossa; Lois B. Travis; M. Eileen Dolan
Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine
Sabrina Z. Wang; Brad Poore; Jesse Alt; Antoinette Price; Sariah J. Allen; Allison R. Hanaford; Harpreet Kaur; Brent A. Orr; Barbara S. Slusher; Charles G. Eberhart; Eric H. Raabe; Jeffrey A. Rubens
Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity
Clara Bodelon; J. Keith Killian; Joshua N. Sampson; William F. Anderson; Rayna Matsuno; Louise A. Brinton; Jolanta Lissowska; Michael S. Anglesio; David D.L. Bowtell; Jennifer A. Doherty; Susan J. Ramus; Aline Talhouk; Mark E. Sherman; Nicolas Wentzensen
ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer
Zhuqing Li; Wei Zhou; Yi Zhang; Wei Sun; Mingo M.H. Yung; Jing Sun; Jing Li; Chi-Wei Chen; Zongzhu Li; Yunxiao Meng; Jie Chai; Yuan Zhou; Stephanie S. Liu; Annie N.Y. Cheung; Hextan Y.S. Ngan; David W. Chan; Wei Zheng; Wenge Zhu
Author Choice
The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy
Todd C. Knepper; Meagan Montesion; Jeffery S. Russell; Ethan S. Sokol; Garrett M. Frampton; Vincent A. Miller; Lee A. Albacker; Howard L. McLeod; Zeynep Eroglu; Nikhil I. Khushalani; Vernon K. Sondak; Jane L. Messina; Michael J. Schell; James A. DeCaprio; Kenneth Y. Tsai; Andrew S. Brohl
Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors
Aslamuzzaman Kazi; Shengyan Xiang; Hua Yang; Liwei Chen; Perry Kennedy; Muhammad Ayaz; Steven Fletcher; Christopher Cummings; Harshani R. Lawrence; Francisca Beato; Ya'an Kang; Michael P. Kim; Andrea Delitto; Patrick W. Underwood; Jason B. Fleming; Jose G. Trevino; Andrew D. Hamilton; Said M. Sebti
Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy
Christina Schug; Carolin Kitzberger; Wolfgang Sievert; Rebekka Spellerberg; Mariella Tutter; Kathrin A. Schmohl; Bernadette Eberlein; Tilo Biedermann; Katja Steiger; Christian Zach; Markus Schwaiger; Gabriele Multhoff; Ernst Wagner; Peter J. Nelson; Christine Spitzweg
Letters to the Editor
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