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15 September 2019
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Cover Image
Cover Image
The cover shows the compartment selection by NanoString Digital Spatial Profiling (DSP) in a melanoma tissue microarray spot. Immunofluorescence staining shows melanocyte (green), CD68+ (blue), and CD45+ (purple) compartments. For details, see the article by Toki and colleagues on page 5503 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
Special Report
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir
Vincent A. de Weger; Frederik E. Stuurman; Stijn L.W. Koolen; Johannes J. Moes; Jeroen J.M.A. Hendrikx; Emilia Sawicki; Bas Thijssen; Marianne Keessen; Hilde Rosing; Marja Mergui-Roelvink; Alwin D.R. Huitema; Bastiaan Nuijen; Jos H. Beijnen; Jan H.M. Schellens; Serena Marchetti
A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers
Razelle Kurzrock; Douglas W. Ball; Marianna L. Zahurak; Barry D. Nelkin; Vivek Subbiah; Shabina Ahmed; Ashley O'Connor; Enusha Karunsena; Rose M. Parkinson; Justin A. Bishop; Yoonji Ha; Rajni Sharma; Christopher D. Gocke; Ralph Zinner; Michelle A. Rudek; Steven I. Sherman; Nilofer S. Azad
Clinical Trials: Immunotherapy
Author Choice
Clinical Efficacy and Safety of Nivolumab: Results of a Multicenter, Open-label, Single-arm, Japanese Phase II study in Malignant Pleural Mesothelioma (MERIT)
Morihito Okada; Takashi Kijima; Keisuke Aoe; Terufumi Kato; Nobukazu Fujimoto; Kazuhiko Nakagawa; Yuichiro Takeda; Toyoaki Hida; Kuninobu Kanai; Fumio Imamura; Satoshi Oizumi; Toshiaki Takahashi; Mitsuhiro Takenoyama; Hiroshi Tanaka; Jun Hirano; Yoshinobu Namba; Yuichiro Ohe
Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)
Dung T. Le; Vincent J. Picozzi; Andrew H. Ko; Zev A. Wainberg; Hedy Kindler; Andrea Wang-Gillam; Paul Oberstein; Michael A. Morse; Herbert J. Zeh, III; Colin Weekes; Tony Reid; Erkut Borazanci; Todd Crocenzi; Noelle K. LoConte; Benjamin Musher; Dan Laheru; Aimee Murphy; Chan Whiting; Nitya Nair; Amanda Enstrom; Sandy Ferber; Dirk G. Brockstedt; Elizabeth M. Jaffee
Precision Medicine and Imaging
Evolutionary Routes in Metastatic Uveal Melanomas Depend on MBD4 Alterations
Manuel Rodrigues; Lenha Mobuchon; Alexandre Houy; Samar Alsafadi; Sylvain Baulande; Odette Mariani; Benjamin Marande; Khadija Ait Rais; Monique K. Van der Kooij; Ellen Kapiteijn; Sieta Gassama; Sophie Gardrat; Raymond L. Barnhill; Vincent Servois; Rémi Dendale; Marc Putterman; Sarah Tick; Sophie Piperno-Neumann; Nathalie Cassoux; Gaëlle Pierron; Joshua J. Waterfall; Sergio Roman-Roman; Pascale Mariani; Marc-Henri Stern
Genetic Polymorphisms Predisposing the Interleukin 6–Induced APOBEC3B-UNG Imbalance Increase HCC Risk via Promoting the Generation of APOBEC-Signature HBV Mutations
Wenbin Liu; Jianfeng Wu; Fan Yang; Longteng Ma; Chong Ni; Xiaomei Hou; Ling Wang; Aijing Xu; Jiahui Song; Yang Deng; Linfeng Xian; Zixiong Li; Shuo Wang; Xi Chen; Jianhua Yin; Xue Han; Chengzhong Li; Jun Zhao; Guangwen Cao
Translational Cancer Mechanisms and Therapy
Author Choice
Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas
Philip Jonsson; Andrew L. Lin; Robert J. Young; Natalie M. DiStefano; David M. Hyman; Bob T. Li; Michael F. Berger; Ahmet Zehir; Marc Ladanyi; David B. Solit; Angela G. Arnold; Zsofia K. Stadler; Diana Mandelker; Michael E. Goldberg; Juliann Chmielecki; Maryam Pourmaleki; Shahiba Q. Ogilvie; Shweta S. Chavan; Andrew T. McKeown; Malbora Manne; Allison Hyde; Kathryn Beal; T. Jonathan Yang; Craig P. Nolan; Elena Pentsova; Antonio Omuro; Igor T. Gavrilovic; Thomas J. Kaley; Eli L. Diamond; Jacqueline B. Stone; Christian Grommes; Adrienne Boire; Mariza Daras; Anna F. Piotrowski; Alexandra M. Miller; Philip H. Gutin; Timothy A. Chan; Viviane S. Tabar; Cameron W. Brennan; Marc Rosenblum; Lisa M. DeAngelis; Ingo K. Mellinghoff; Barry S. Taylor
Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
Jaime A. Eberle-Singh; Irina Sagalovskiy; H. Carlo Maurer; Stephen A. Sastra; Carmine F. Palermo; Amanda R. Decker; Min Jung Kim; Josephine Sheedy; Anna Mollin; Liangxian Cao; Jianhua Hu; Arthur Branstrom; Marla Weetall; Kenneth P. Olive
Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer
Sophia C. Kamran; Jochen K. Lennerz; Claire A. Margolis; David Liu; Brendan Reardon; Stephanie A. Wankowicz; Emily E. Van Seventer; Adam Tracy; Jennifer Y. Wo; Scott L. Carter; Henning Willers; Ryan B. Corcoran; Theodore S. Hong; Eliezer M. Van Allen
Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma
Hiroaki Katagi; Nundia Louis; Dusten Unruh; Takahiro Sasaki; Xingyao He; Ali Zhang; Quanhong Ma; Andrea Piunti; Yosuke Shimazu; Jonathan B. Lamano; Angel M. Carcaboso; Xiao Tian; Andrei Seluanov; Vera Gorbunova; Kathryn L. Laurie; Akihide Kondo; Nitin R. Wadhwani; Rishi Lulla; Stewart Goldman; Sriram Venneti; Oren J. Becher; Lihua Zou; Ali Shilatifard; Rintaro Hashizume
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Youngran Park; M. Herman Chui; Yohan Suryo Rahmanto; Zheng-Cheng Yu; Raghavendra A. Shamanna; Marina A. Bellani; Stephanie Gaillard; Ayse Ayhan; Akila Viswanathan; Michael M. Seidman; Sonia Franco; Anthony K.L. Leung; Vilhelm A. Bohr; Ie-Ming Shih; Tian-Li Wang
Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies
Yu Zhao; Zhongfeng Liu; Xuan Wang; Huantong Wu; Jianping Zhang; Junfang Yang; Fayou Zhang; Lining Liu; Jiafu Long; Peihua Lu; Zhiguo Chen
DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway
Vishal Kothari; Jonathan F. Goodwin; Shuang G. Zhao; Justin M. Drake; Yi Yin; S. Laura Chang; Joseph R. Evans; Kari Wilder-Romans; Kristina Gabbara; Emanuela Dylgjeri; Jonathan Chou; Grace Sun; Scott A. Tomlins; Rohit Mehra; Kristen Hege; Ellen H. Filvaroff; Edward M. Schaeffer; R. Jeffrey Karnes; David A. Quigley; Dana E. Rathkopf; Housheng H. He; Corey Speers; Daniel E. Spratt; Luke A. Gilbert; Alan Ashworth; Arul M. Chinnaiyan; Ganesh V. Raj; Karen E. Knudsen; Felix Y. Feng
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies
Emanuela Dylgjeri; Christopher McNair; Jonathan F. Goodwin; Heather K. Raymon; Peter A. McCue; Ayesha A. Shafi; Benjamin E. Leiby; Renée de Leeuw; Vishal Kothari; Jennifer J. McCann; Amy C. Mandigo; Saswati N. Chand; Matthew J. Schiewer; Lucas J. Brand; Irina Vasilevskaya; Nicolas Gordon; Talya S. Laufer; Leonard G. Gomella; Costas D. Lallas; Edouard J. Trabulsi; Felix Y. Feng; Ellen H. Filvaroff; Kristin Hege; Dana Rathkopf; Karen E. Knudsen
Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks
Sriram Sundaravel; Wen-Liang Kuo; Jong Jin Jeong; Gaurav S. Choudhary; Shanisha Gordon-Mitchell; Hui Liu; Tushar D. Bhagat; Kathy L. McGraw; Sandeep Gurbuxani; Alan F. List; Amit Verma; Amittha Wickrema
Author Choice
COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms
Antje Lindemann; Ameeta A. Patel; Natalie L. Silver; Lin Tang; Zhiyi Liu; Li Wang; Noriaki Tanaka; Xiayu Rao; Hideaki Takahashi; Nakachi K. Maduka; Mei Zhao; Tseng-Cheng Chen; WeiWei Liu; Meng Gao; Jing Wang; Steven J. Frank; Walter N. Hittelman; Gordon B. Mills; Jeffrey N. Myers; Abdullah A. Osman
VEGFR1+ Metastasis–Associated Macrophages Contribute to Metastatic Angiogenesis and Influence Colorectal Cancer Patient Outcome
Aida Freire Valls; Karl Knipper; Evangelia Giannakouri; Víctor Sarachaga; Sascha Hinterkopf; Michael Wuehrl; Ying Shen; Praveenkumar Radhakrishnan; Johannes Klose; Alexis Ulrich; Martin Schneider; Hellmut G. Augustin; Carmen Ruiz de Almodovar; Thomas Schmidt
HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma
Fernanda Faião-Flores; Michael F. Emmons; Michael A. Durante; Fumi Kinose; Biswarup Saha; Bin Fang; John M. Koomen; Srikumar P. Chellappan; Silvya Stuchi Maria-Engler; Uwe Rix; Jonathan D. Licht; J. William Harbour; Keiran S.M. Smalley
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers
Hailing Yang; Zhang Shu; Yongying Jiang; Weiqun Mao; Lan Pang; Abena Redwood; Sabrina L. Jeter-Jones; Nicholas B. Jennings; Argentina Ornelas; Jinhua Zhou; Cristian Rodriguez-Aguayo; Geoffrey Bartholomeusz; LaKesla R. Iles; Niki M. Zacharias; Steven W. Millward; Gabriel Lopez-Berestein; Xiao-Feng Le; Ahmed A. Ahmed; Helen Piwnica-Worms; Anil K. Sood; Robert C. Bast; Zhen Lu
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