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1 September 2019
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Cover Image
Cover Image
The cover shows a section of lung squamous cell carcinoma from a patient stained with picrosirus red, which contains abundant tumor-associated fibrosis (orange-red collagen fiber fascicles) that often contaminates biopsy samples. Hariri and colleagues demonstrate that polarization-sensitive optical coherence tomography can accurately detect and distinguish fibrosis from tumor, which can be utilized to guide biopsy site sampling in vivo and tumor banking selection ex vivo to increase tumor yield. For details, see the article by Hariri and colleagues on page 5242 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Clinical Trials: Targeted Therapy
A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer
James J. Harding; Andrew X. Zhu; Todd M. Bauer; Toni K. Choueiri; Alexander Drilon; Martin H. Voss; Charles S. Fuchs; Ghassan K. Abou-Alfa; Sameera R. Wijayawardana; Xuejing Aimee Wang; Brian A. Moser; Arantxa Uruñuela; Volker Wacheck; Johanna C. Bendell
Author Choice
Safety, Efficacy, and Biomarker Analysis of Pyrotinib in Combination with Capecitabine in HER2-Positive Metastatic Breast Cancer Patients: A Phase I Clinical Trial
Qiao Li; Xiuwen Guan; Shanshan Chen; Zongbi Yi; Bo Lan; Puyuan Xing; Ying Fan; Jiayu Wang; Yang Luo; Peng Yuan; Ruigang Cai; Pin Zhang; Qing Li; Dafang Zhong; Yifan Zhang; Jianjun Zou; Xiaoyu Zhu; Fei Ma; Binghe Xu
Clinical Trials: Immunotherapy
Author Choice
Nivolumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use
Robert L. Ferris; Lisa Licitra; Jerome Fayette; Caroline Even; George Blumenschein, Jr; Kevin J. Harrington; Joel Guigay; Everett E. Vokes; Nabil F. Saba; Robert Haddad; Shanmugasundaram Ramkumar; Jeffery Russell; Peter Brossart; Makoto Tahara; A. Dimitrios Colevas; Fernando Concha-Benavente; Mark Lynch; Li Li; Maura L. Gillison
Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab: a Phase I Clinical Trial
M. Christina Cox; Luciano Castiello; Mauro Mattei; Laura Santodonato; Giuseppina D'Agostino; Elena Muraro; Debora Martorelli; Caterina Lapenta; Arianna Di Napoli; Francesca Di Landro; Michela Cangemi; Antonio Pavan; Paolo Castaldo; Stefan Hohaus; Simona Donati; Enrica Montefiore; Cinzia Berdini; Davide Carlei; Domenica M. Monque; Luigi Ruco; Daniela Prosperi; Agostino Tafuri; Francesca Spadaro; Paola Sestili; Massimo Spada; Riccardo Dolcetti; Stefano M. Santini; Carmela Rozera; Eleonora Aricò; Imerio Capone; Filippo Belardelli
Precision Medicine and Imaging
Author Choice
Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors
Nicolas J. Llosa; Brandon Luber; Ada J. Tam; Kellie N. Smith; Nicholas Siegel; Anas H. Awan; Hongni Fan; Teniola Oke; JiaJia Zhang; Jada Domingue; Elizabeth L. Engle; Charles A. Roberts; Bjarne R. Bartlett; Laveet K. Aulakh; Elizabeth D. Thompson; Janis M. Taube; Jennifer N. Durham; Cynthia L. Sears; Dung T. Le; Luis A. Diaz; Drew M. Pardoll; Hao Wang; Robert A. Anders; Franck Housseau
Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas
Carmen Rapp; Steffen Dettling; Fang Liu; Anna Theresa Ull; Rolf Warta; Christine Jungk; Saskia Roesch; Andreas Mock; Felix Sahm; Melissa Schmidt; Gerhard Jungwirth; Klaus Zweckberger; Katrin Lamszus; Konstaninos Gousias; Almuth F. Kessler; Niels Grabe; Mario Loehr; Ralf Ketter; Steffi Urbschat; Christian Senft; Manfred Westphal; Amir Abdollahi; Juergen Debus; Andreas von Deimling; Andreas Unterberg; Matthias Simon; Christel C. Herold-Mende
Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas
Jennifer K. Lue; Sathyen A. Prabhu; Yuxuan Liu; Yulissa Gonzalez; Akanksha Verma; Prabhjot S. Mundi; Nebiyu Abshiru; Jeannie M. Camarillo; Swasti Mehta; Emily I. Chen; Changhong Qiao; Renu Nandakumar; Serge Cremers; Neil L. Kelleher; Olivier Elemento; Jennifer E. Amengual
Comprehensive Liquid Profiling of Circulating Tumor DNA and Protein Biomarkers in Long-Term Follow-Up Patients with Hepatocellular Carcinoma
Zhixiong Cai; Geng Chen; Yongyi Zeng; Xiuqing Dong; Zhenli Li; Yanbing Huang; Fuli Xin; Liman Qiu; Haipo Xu; Wei Zhang; Xiaoping Su; Xiaolong Liu; Jingfeng Liu
Role of Chemotherapy, VEGFR Inhibitors, and mTOR Inhibitors in Advanced Perivascular Epithelioid Cell Tumors (PEComas)
Roberta Sanfilippo; Robin L. Jones; Jean-Yves Blay; Axel Le Cesne; Salvatore Provenzano; Georgios Antoniou; Olivier Mir; Giovanni Fucà; Elena Fumagalli; Rossella Bertulli; Silvia Stacchiotti; Mehdi Brahmi; Federica Grosso; Armelle Dufresne; Nadia Hindi; Marta Sbaraglia; Alessandro Gronchi; Paola Collini; Angelo P. Dei Tos; Paolo G. Casali
Author Choice
Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer
Jill M. Brooks; Albert N. Menezes; Maha Ibrahim; Lucinda Archer; Neeraj Lal; Christopher J. Bagnall; Sandra V. von Zeidler; Helen R. Valentine; Rachel J. Spruce; Nikolaos Batis; Jennifer L. Bryant; Margaret Hartley; Baksho Kaul; Gordon B. Ryan; Riyue Bao; Arun Khattri; Steven P. Lee; Kalu U.E. Ogbureke; Gary Middleton; Daniel A. Tennant; Andrew D. Beggs; Jonathan Deeks; Catharine M. L. West; Jean-Baptiste Cazier; Benjamin E. Willcox; Tanguy Y. Seiwert; Hisham Mehanna
Translational Cancer Mechanisms and Therapy
Author Choice
Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence
Sneha Ramakrishna; Steven L. Highfill; Zachary Walsh; Sang M. Nguyen; Haiyan Lei; Jack F. Shern; Haiying Qin; Ira L. Kraft; Maryalice Stetler-Stevenson; Constance M. Yuan; Jennifer D. Hwang; Yang Feng; Zhongyu Zhu; Dimiter Dimitrov; Nirali N. Shah; Terry J. Fry
Early Modeled Longitudinal CA-125 Kinetics and Survival of Ovarian Cancer Patients: A GINECO AGO MRC CTU Study
Olivier Colomban; Michel Tod; Alexandra Leary; Isabelle Ray-Coquard; Alain Lortholary; Anne Claire Hardy-Bessard; Jacobus Pfisterer; Andreas Du Bois; Christian Kurzeder; Alexander Burges; Julien Péron; Gilles Freyer; Benoit You
Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer
Alex B. Blair; Victoria M. Kim; Stephen T. Muth; May Tun Saung; Nathalie Lokker; Barbara Blouw; Todd D. Armstrong; Elizabeth M. Jaffee; Takahiro Tsujikawa; Lisa M. Coussens; Jin He; Richard A. Burkhart; Christopher L. Wolfgang; Lei Zheng
Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Cheri A. Pasch; Peter F. Favreau; Alexander E. Yueh; Christopher P. Babiarz; Amani A. Gillette; Joe T. Sharick; Mohammad Rezaul Karim; Kwangok P. Nickel; Alyssa K. DeZeeuw; Carley M. Sprackling; Philip B. Emmerich; Rebecca A. DeStefanis; Rosabella T. Pitera; Susan N. Payne; Demetra P. Korkos; Linda Clipson; Christine M. Walsh; Devon Miller; Evie H. Carchman; Mark E. Burkard; Kayla K. Lemmon; Kristina A. Matkowskyj; Michael A. Newton; Irene M. Ong; Michael F. Bassetti; Randall J. Kimple; Melissa C. Skala; Dustin A. Deming
Synchronous Detection of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow Predicts Adverse Outcome in Early Breast Cancer
Mark Jesus M. Magbanua; Christina Yau; Denise M. Wolf; Jin Sun Lee; Aheli Chattopadhyay; Janet H. Scott; Erin Bowlby-Yoder; E. Shelley Hwang; Michael Alvarado; Cheryl A. Ewing; Amy L. Delson; Laura J. van't Veer; Laura Esserman; John W. Park
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
Jennifer A. Ligibel; Deborah Dillon; Anita Giobbie-Hurder; Anne McTiernan; Elizabeth Frank; MacIntosh Cornwell; Matthew Pun; Nancy Campbell; Ryan J.O. Dowling; Martin C. Chang; Sara Tolaney; Anees B. Chagpar; Rachel L. Yung; Rachel A. Freedman; Laura S. Dominici; Mehra Golshan; Esther Rhei; Krishan Taneja; Ying Huang; Myles Brown; Eric P. Winer; Rinath Jeselsohn; Melinda L. Irwin
Author Choice
A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis
Yao Liu; Fanzheng Meng; Jiabei Wang; Mingyang Liu; Guangchao Yang; Ruipeng Song; Tongsen Zheng; Yingjian Liang; Shugeng Zhang; Dalong Yin; Jizhou Wang; Haiyan Yang; Shangha Pan; Bo Sun; Jihua Han; Jing Sun; Yaliang Lan; Yan Wang; Xirui Liu; Mingxi Zhu; Yifeng Cui; Bo Zhang; Dehai Wu; Shuhang Liang; Yufeng Liu; Xuan Song; Zhaoyang Lu; Jingxuan Yang; Min Li; Lianxin Liu
Letters to the Editor
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