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15 August 2019
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The cover shows a section of the bone marrow biopsy from a patient with primary myelofibrosis. Reticulin staining shows diffusely increased bone marrow fibrosis, a hallmark of the disease pathology. For details, see the article by Gangat and colleagues on page 4898 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Review
Clinical Trials: Targeted Therapy
Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors
Rastislav Bahleda; Antoine Italiano; Cinta Hierro; Alain Mita; Andres Cervantes; Nancy Chan; Mark Awad; Emiliano Calvo; Victor Moreno; Ramaswamy Govindan; Alexander Spira; Martha Gonzalez; Bob Zhong; Ademi Santiago-Walker; Italo Poggesi; Trilok Parekh; Hong Xie; Jeffrey Infante; Josep Tabernero
Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial
Naseema Gangat; Christian Marinaccio; Ronan Swords; Justin M. Watts; Sandeep Gurbuxani; Alfred Rademaker; Angela J. Fought; Olga Frankfurt; Jessica K. Altman; Qiang Jeremy Wen; Noushin Farnoud; Christopher A. Famulare; Akshar Patel; Roberto Tapia; Rangit R. Vallapureddy; Stephanie Barath; Amy Graf; Amy Handlogten; Darci Zblewski; Mrinal M. Patnaik; Aref Al-kali; Yvonne Trang Dinh; Kristen Englund Prahl; Shradha Patel; Juan Carlos Nobrega; Dalissa Tejera; Amber Thomassen; Juehua Gao; Peng Ji; Raajit K. Rampal; Francis J. Giles; Ayalew Tefferi; Brady Stein; John D. Crispino
Histone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results
Matthew J. Wieduwilt; Nela Pawlowska; Scott Thomas; Rebecca Olin; Aaron C. Logan; Lloyd E. Damon; Thomas Martin; McNancy Kang; Peter H. Sayre; Wanda Boyer; Karin M.L. Gaensler; Kirsten Anderson; Pamela N. Munster; Charalambos Andreadis
First-in-Human Phase I Study of the Selective MET Inhibitor, Savolitinib, in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Antitumor Activity
Hui K. Gan; Michael Millward; Ye Hua; Chuan Qi; Yang Sai; Weiguo Su; Jian Wang; Lilin Zhang; Melanie M. Frigault; Shethah Morgan; Liu Yang; Jason D. Lickliter
Clinical Trials: Immunotherapy
A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules
Margaret E. Gatti-Mays; Julius Strauss; Renee N. Donahue; Claudia Palena; Jaydira Del Rivero; Jason M. Redman; Ravi A. Madan; Jennifer L. Marté; Lisa M. Cordes; Elizabeth Lamping; Alanvin Orpia; Andrea Burmeister; Eva Wagner; Cesar Pico Navarro; Christopher R. Heery; Jeffrey Schlom; James L. Gulley
IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion
Kevin C. Conlon; E. Lake Potter; Stefania Pittaluga; Chyi-Chia Richard Lee; Milos D. Miljkovic; Thomas A. Fleisher; Sigrid Dubois; Bonita R. Bryant; Michael Petrus; Liyanage P. Perera; Jennifer Hsu; William D. Figg; Cody J. Peer; Joanna H. Shih; Jason L. Yovandich; Stephen P. Creekmore; Mario Roederer; Thomas A. Waldmann
A Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Head and Neck Squamous Cell Carcinoma
Elizabeth L. McMichael; Brooke Benner; Lakhvir S. Atwal; Nicholas B. Courtney; Xiaokui Mo; Melanie E. Davis; Amanda R. Campbell; Megan C. Duggan; Kallan Williams; Kyle Martin; Kala Levine; Gonzalo N. Olaverria Salavaggione; Tiffany Noel; Akaansha Ganju; Sarvani Uppati; Bonnie Paul; Thomas Olencki; Theodoros N. Teknos; Panos Savvides; Susheela Tridandapani; John C. Byrd; Michael A. Caligiuri; Stephen V. Liu; William E. Carson, III
Precision Medicine and Imaging
Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer
Vincent P. Groot; Stacy Mosier; Ammar A. Javed; Jonathan A. Teinor; Georgios Gemenetzis; Ding Ding; Lisa M. Haley; Jun Yu; Richard A. Burkhart; Alina Hasanain; Marija Debeljak; Hirohiko Kamiyama; Amol Narang; Daniel A. Laheru; Lei Zheng; Ming-Tseh Lin; Christopher D. Gocke; Elliot K. Fishman; Ralph H. Hruban; Michael G. Goggins; I. Quintus Molenaar; John L. Cameron; Matthew J. Weiss; Victor E. Velculescu; Jin He; Christopher L. Wolfgang; James R. Eshleman
Prognostic Value of Residual Disease after Neoadjuvant Therapy in HER2-Positive Breast Cancer Evaluated by Residual Cancer Burden, Neoadjuvant Response Index, and Neo-Bioscore
Tessa G. Steenbruggen; Maartje van Seijen; Liselore M. Janssen; Mette S. van Ramshorst; Erik van Werkhoven; Marie-Jeanne T.D.F. Vrancken Peeters; Jelle Wesseling; Esther H. Lips; Gabe S. Sonke
Author Choice
Multi-Omics Profiling Reveals Distinct Microenvironment Characterization and Suggests Immune Escape Mechanisms of Triple-Negative Breast Cancer
Yi Xiao; Ding Ma; Shen Zhao; Chen Suo; Jinxiu Shi; Meng-Zhu Xue; Miao Ruan; Hai Wang; Jingjing Zhao; Qin Li; Peng Wang; Leming Shi; Wen-Tao Yang; Wei Huang; Xin Hu; Ke-Da Yu; Shenglin Huang; François Bertucci; Yi-Zhou Jiang; Zhi-Ming Shao; on behalf of AME Breast Cancer Collaborative Group
Comprehensive Genomic Profiling Identifies Novel Genetic Predictors of Response to Anti–PD-(L)1 Therapies in Non–Small Cell Lung Cancer
Wenfeng Fang; Yuxiang Ma; Jiani C. Yin; Shaodong Hong; Huaqiang Zhou; Ao Wang; Fufeng Wang; Hua Bao; Xue Wu; Yunpeng Yang; Yan Huang; Hongyun Zhao; Yang W. Shao; Li Zhang
Voxel Forecast for Precision Oncology: Predicting Spatially Variant and Multiscale Cancer Therapy Response on Longitudinal Quantitative Molecular Imaging
Stephen R. Bowen; Daniel S. Hippe; W. Art Chaovalitwongse; Chunyan Duan; Phawis Thammasorn; Xiao Liu; Robert S. Miyaoka; Hubert J. Vesselle; Paul E. Kinahan; Ramesh Rengan; Jing Zeng
Functional Properties of KIT Mutations Are Associated with Differential Clinical Outcomes and Response to Targeted Therapeutics in CBF Acute Myeloid Leukemia
Katherine Tarlock; Todd A. Alonzo; Yi-Cheng Wang; Robert B. Gerbing; Rhonda Ries; Michael R. Loken; Laura Pardo; Tiffany Hylkema; Jason Joaquin; Leela Sarukkai; Susana C. Raimondi; Betsy Hirsch; Lillian Sung; Richard Aplenc; Irwin Bernstein; Alan S. Gamis; Soheil Meshinchi; Jessica A. Pollard
Translational Cancer Mechanisms and Therapy
Inferring the Evolution and Progression of Small-Cell Lung Cancer by Single-Cell Sequencing of Circulating Tumor Cells
Zhe Su; Zhijie Wang; Xiaohui Ni; Jianchun Duan; Yan Gao; Minglei Zhuo; Ruoyan Li; Jun Zhao; Qi Ma; Hua Bai; Hengyu Chen; Shuhang Wang; Xixi Chen; Tongtong An; Yuyan Wang; Yanhua Tian; Jiangyong Yu; Di Wang; Xiaoliang Sunney Xie; Fan Bai; Jie Wang
Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non–Small Cell Lung Cancer
Siwen Hu-Lieskovan; Aaron Lisberg; Jesse M. Zaretsky; Tristan R. Grogan; Hira Rizvi; Daniel K. Wells; James Carroll; Amy Cummings; John Madrigal; Benjamin Jones; Jacklin Gukasyan; I. Peter Shintaku; Dennis Slamon; Steven Dubinett; Jonathan W. Goldman; David Elashoff; Matthew D. Hellmann; Antoni Ribas; Edward B. Garon
Author Choice
A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERRγ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer
Thoudam Debraj Singh; Jaeyoung Song; Jina Kim; Jungwook Chin; Hyun Dong Ji; Jae-Eon Lee; Sang Bong Lee; Heeseok Yoon; Ji Hoon Yu; Sang Kyoon Kim; Ghil Suk Yoon; Hayoung Hwang; Ho Won Lee; Ji Min Oh; Sang-Woo Lee; Jaetae Lee; Hueng-Sik Choi; Soon-Young Na; Won-Il Choi; Young Joo Park; Young Shin Song; Young A. Kim; In-Kyu Lee; Sung Jin Cho; Yong Hyun Jeon
Divergent Biological Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer
Roland Seiler; Ewan A. Gibb; Natalie Q. Wang; Htoo Zarni Oo; Hung-Ming Lam; Kim E. van Kessel; Charlotte S. Voskuilen; Brian Winters; Nicholas Erho; Mandeep M. Takhar; James Douglas; Funda Vakar-Lopez; Simon J. Crabb; Bas W.G. van Rhijn; Elisabeth E. Fransen van de Putte; Ellen C. Zwarthoff; George N. Thalmann; Elai Davicioni; Joost L. Boormans; Marc Dall'Era; Michiel S. van der Heijden; Jonathan L. Wright; Peter C. Black
Author Choice
Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste
Stuart J. Smith; Betty M. Tyler; Toby Gould; Gareth J. Veal; Noah Gorelick; Jonathan Rowlinson; Riccardo Serra; Alison Ritchie; Phillip Berry; Annette Otto; John Choi; Nicolas Skuli; Maria Estevez-Cebrero; Kevin M. Shakesheff; Henry Brem; Richard G. Grundy; Ruman Rahman
Author Choice
MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion
Milind D. Chalishazar; Sarah J. Wait; Fang Huang; Abbie S. Ireland; Anandaroop Mukhopadhyay; Younjee Lee; Sophia S. Schuman; Matthew R. Guthrie; Kristofer C. Berrett; Jeffery M. Vahrenkamp; Zeping Hu; Marek Kudla; Katarzyna Modzelewska; Guoying Wang; Nicholas T. Ingolia; Jason Gertz; David H. Lum; Sabina C. Cosulich; John S. Bomalaski; Ralph J. DeBerardinis; Trudy G. Oliver
Genomic Evolutionary Patterns of Leiomyosarcoma and Liposarcoma
Ali Amin-Mansour; Suzanne George; Stefano Sioletic; Scott L. Carter; Mara Rosenberg; Amaro Taylor-Weiner; Chip Stewart; Aaron Chevalier; Sara Seepo; Adam Tracy; Gad Getz; Jason L. Hornick; Marisa R. Nucci; Bradley Quade; George D. Demetri; Chandrajit P. Raut; Levi A. Garraway; Eliezer M. Van Allen; Andrew J. Wagner
Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients: Center for International Blood and Marrow Transplant Research Report
Haesook T. Kim; Kwang Woo Ahn; Zhen-Huan Hu; Matthew S. Davids; Virginia O. Volpe; Joseph H. Antin; Mohamed L. Sorror; Mazyar Shadman; Oliver Press; Joseph Pidala; William Hogan; Robert Negrin; Steven Devine; Joseph Uberti; Edward Agura; Richard Nash; Jayesh Mehta; Joseph McGuirk; Stephen Forman; Amelia Langston; Sergio A. Giralt; Miguel-Angel Perales; Minoo Battiwalla; Gregory A. Hale; Robert Peter Gale; David I. Marks; Mehdi Hamadani; Sid Ganguly; Ulrike Bacher; Hillard Lazarus; Ran Reshef; Gerhard C. Hildebrandt; Yoshihiro Inamoto; Jean-Yves Cahn; Melhem Solh; Mohamed A. Kharfan-Dabaja; Nilanjan Ghosh; Ayman Saad; Mahmoud Aljurf; Harry C. Schouten; Brian T. Hill; Attaphol Pawarode; Tamila Kindwall-Keller; Nakhle Saba; Edward A. Copelan; Sunita Nathan; Amer Beitinjaneh; Bipin N. Savani; Jan Cerny; Michael R. Grunwald; Jean Yared; Baldeep M. Wirk; Taiga Nishihori; Saurabh Chhabra; Richard F. Olsson; Asad Bashey; Usama Gergis; Uday Popat; Ronald Sobecks; Edwin Alyea; Wael Saber; Jennifer R. Brown
The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents
Filippo Spriano; Elaine Yee Lin Chung; Eugenio Gaudio; Chiara Tarantelli; Luciano Cascione; Sara Napoli; Katti Jessen; Laura Carrassa; Valdemar Priebe; Giulio Sartori; Garrett Graham; Saravana P. Selvanathan; Andrea Cavalli; Andrea Rinaldi; Ivo Kwee; Monica Testoni; Davide Genini; B. Hilda Ye; Emanuele Zucca; Anastasios Stathis; Brian Lannutti; Jeffrey A. Toretsky; Francesco Bertoni
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