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15 July 2019
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Cover Image
Cover Image
The cover shows a section of a skin biopsy from a patient with advanced-stage cutaneous T-cell lymphoma. Immunohistochemical staining shows strong ATP5C1 expression (red) within the tumor infiltrate in both epidermis and dermis. For details, see the article by Gaydosik and colleagues on page 4443 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Carfilzomib Weekly plus Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (IFM 2012-03): A Phase I Trial
Xavier Leleu; Guillemette Fouquet; Valentine Richez; Stéphanie Guidez; Alain Duhamel; François Machuron; Lionel Karlin; Brigitte Kolb; Mourad Tiab; Carla Araujo; Nathalie Meuleman; Jean-Valère Malfuson; Pascal Bourquard; Pascal Lenain; Murielle Roussel; Arnaud Jaccard; Marie-Odile Pétillon; Karim Belhadj-Merzoug; Gérard Lepeu; Marie-Lorraine Chrétien; Jean Fontan; Philippe Rodon; Anna Schmitt; Fritz Offner; Laurent Voillat; Sophie Cereja; Frédérique Kuhnowski; Sophie Rigaudeau; Olivier Decaux; Catherine Humbrecht-Kraut; Jamile Frayfer; Olivier Fitoussi; Damien Roos-Weil; Jean-Claude Eisenmann; Véronique Dorvaux; Eric G. Voog; Michel Attal; Philippe Moreau; Hervé Avet-Loiseau; Cyrille Hulin; Thierry Facon
A Phase I/II Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed Refractory Acute Myeloid Leukemia
Anjali S. Advani; Brenda Cooper; Valeria Visconte; Paul Elson; Ricky Chan; Jennifer Carew; Wei Wei; Sudipto Mukherjee; Aaron Gerds; Hetty Carraway; Aziz Nazha; Betty Hamilton; Ronald Sobecks; Paolo Caimi; Benjamin Tomlinson; Ehsan Malek; Jane Little; Alexander Miron; John Pink; Jaroslaw Maciejewski; Allison Unger; Matt Kalaycio; Marcos de Lima; Mikkael A. Sekeres
A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma
Ramya Ramaswami; Thomas S. Uldrick; Mark N. Polizzotto; Kathleen M. Wyvill; Priscila Goncalves; Anaida Widell; Kathryn Lurain; Seth M. Steinberg; William Douglas Figg; Giovanna Tosato; Denise Whitby; Robert Yarchoan
Clinical Trials: Immunotherapy
Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial
Elizabeth A. Mittendorf; Biao Lu; Michelle Melisko; Julie Price Hiller; Igor Bondarenko; Adrian Murray Brunt; Grybach Sergii; Katarina Petrakova; George E. Peoples
Precision Medicine and Imaging
Author Choice
Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence
Raoul Charles Coombes; Karen Page; Raheleh Salari; Robert K. Hastings; Anne Armstrong; Samreen Ahmed; Simak Ali; Susan Cleator; Laura Kenny; Justin Stebbing; Mark Rutherford; Himanshu Sethi; Anna Boydell; Ryan Swenerton; Daniel Fernandez-Garcia; Kelly L.T. Gleason; Katie Goddard; David S. Guttery; Zoe J. Assaf; Hsin-Ta Wu; Prashanthi Natarajan; David A. Moore; Lindsay Primrose; Scott Dashner; Antony S. Tin; Mustafa Balcioglu; Ramya Srinivasan; Svetlana V. Shchegrova; Alexander Olson; Dina Hafez; Paul Billings; Alexey Aleshin; Farah Rehman; Bradley J. Toghill; Allison Hills; Maggie C. Louie; Cheng-Ho Jimmy Lin; Bernhard G. Zimmermann; Jaqueline A. Shaw
Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice
Lindsey E. Roeker; Christopher P. Fox; Toby A. Eyre; Danielle M. Brander; John N. Allan; Stephen J. Schuster; Chadi Nabhan; Brian T. Hill; Nirav N. Shah; Frederick Lansigan; Maryam Yazdy; Bruce D. Cheson; Nicole Lamanna; Arun K. Singavi; Catherine C. Coombs; Paul M. Barr; Alan P. Skarbnik; Mazyar Shadman; Chaitra S. Ujjani; Hande H. Tuncer; Allison M. Winter; Joanna Rhodes; Colleen Dorsey; Hannah Morse; Charlene Kabel; John M. Pagel; Annalynn M. Williams; Ryan Jacobs; Andre Goy; Sivraj Muralikrishnan; Laurie Pearson; Andrea Sitlinger; Neil Bailey; Anna Schuh; Amy A. Kirkwood; Anthony R. Mato
Prognostic Value of Deep Learning PET/CT-Based Radiomics: Potential Role for Future Individual Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma
Hao Peng; Di Dong; Meng-Jie Fang; Lu Li; Ling-Long Tang; Lei Chen; Wen-Fei Li; Yan-Ping Mao; Wei Fan; Li-Zhi Liu; Li Tian; Ai-Hua Lin; Ying Sun; Jie Tian; Jun Ma
Ultra-sensitive EGFRT790M Detection as an Independent Prognostic Marker for Lung Cancer Patients Harboring EGFRdel19 Mutations and Treated with First-generation TKIs
Julie A. Vendrell; Julien Mazieres; Romain Senal; Isabelle Rouquette; Xavier Quantin; Jean-Louis Pujol; Benoit Roch; Abdelali Bouidioua; Sylvain Godreuil; Etienne Coyaud; Pierre Brousset; Jérôme Solassol
Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types
William S. Chen; Mohammed Alshalalfa; Shuang G. Zhao; Yang Liu; Brandon A. Mahal; David A. Quigley; Ting Wei; Elai Davicioni; Timothy R. Rebbeck; Philip W. Kantoff; Christopher A. Maher; Karen E. Knudsen; Eric J. Small; Paul L. Nguyen; Felix Y. Feng
Profiling the Mutational Landscape in Known Driver Genes and Novel Genes in African American Non–Small Cell Lung Cancer Patients
Christine M. Lusk; Donovan Watza; Greg Dyson; Douglas Craig; Valerie Ratliff; Angela S. Wenzlaff; Fulvio Lonardo; Aliccia Bollig-Fischer; Gerold Bepler; Kristen Purrington; Shirish Gadgeel; Ann G. Schwartz
High-throughput Screening of Human Tumor Antigen–specific CD4 T Cells, Including Neoantigen-reactive T Cells
Carla Costa-Nunes; Amélie Cachot; Sara Bobisse; Marion Arnaud; Raphael Genolet; Petra Baumgaertner; Daniel E. Speiser; Pedro M. Sousa Alves; Federico Sandoval; Olivier Adotévi; Walter Reith; Maria Pia Protti; George Coukos; Alexandre Harari; Pedro Romero; Camilla Jandus
EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy
Julian Puppe; Mark Opdam; Philip C. Schouten; Katarzyna Jóźwiak; Esther Lips; Tesa Severson; Marieke van de Ven; Chiara Brambillasca; Peter Bouwman; Olaf van Tellingen; René Bernards; Jelle Wesseling; Christian Eichler; Fabinshy Thangarajah; Wolfram Malter; Gaurav Kumar Pandey; Luka Ozretić; Carlos Caldas; Maarten van Lohuizen; Michael Hauptmann; Kerstin Rhiem; Eric Hahnen; H. Christian Reinhardt; Reinhard Büttner; Peter Mallmann; Birgid Schömig-Markiefka; Rita Schmutzler; Sabine Linn; Jos Jonkers
Translational Cancer Mechanisms and Therapy
Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer
Adam A. Kraya; Kara N. Maxwell; Bradley Wubbenhorst; Brandon M. Wenz; John Pluta; Andrew J. Rech; Liza M. Dorfman; Nicole Lunceford; Amanda Barrett; Nandita Mitra; Jennifer J.D. Morrissette; Michael Feldman; Anupma Nayak; Susan M. Domchek; Robert H. Vonderheide; Katherine L. Nathanson
PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors
Kensuke Tateishi; Taishi Nakamura; Tareq A. Juratli; Erik A. Williams; Yuko Matsushita; Shigeta Miyake; Mayuko Nishi; Julie J. Miller; Shilpa S. Tummala; Alexandria L. Fink; Nina Lelic; Mara V.A. Koerner; Yohei Miyake; Jo Sasame; Kenji Fujimoto; Takahiro Tanaka; Ryogo Minamimoto; Shigeo Matsunaga; Shigeo Mukaihara; Takashi Shuto; Hiroki Taguchi; Naoko Udaka; Hidetoshi Murata; Akihide Ryo; Shoji Yamanaka; William T. Curry; Dora Dias-Santagata; Tetsuya Yamamoto; Koichi Ichimura; Tracy T. Batchelor; Andrew S. Chi; A. John Iafrate; Hiroaki Wakimoto; Daniel P. Cahill
Author Choice
Mogamulizumab Treatment Elicits Autoantibodies Attacking the Skin in Patients with Adult T-Cell Leukemia-Lymphoma
Yui Suzuki; Masato Saito; Toshihiko Ishii; Itaru Urakawa; Asuka Matsumoto; Ayako Masaki; Asahi Ito; Shigeru Kusumoto; Susumu Suzuki; Masanori Hiura; Takeshi Takahashi; Akimichi Morita; Hiroshi Inagaki; Shinsuke Iida; Takashi Ishida
Effects of Age and Immune Landscape on Outcome in HER2-Positive Breast Cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) Trials
Saranya Chumsri; Daniel J. Serie; Zhuo Li; Katherine L. Pogue-Geile; Aixa E. Soyano-Muller; Afshin Mashadi-Hossein; Sarah Warren; Yanyan Lou; Gerardo Colon-Otero; Keith L. Knutson; Edith A. Perez; Alvaro Moreno-Aspitia; E. Aubrey Thompson
A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer
Robert Piskol; Ling Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Rachel Tam; Rajesh Patel; Jeremy Burton; Elicia Penuel; Xueping Qu; Hartmut Koeppen; Teiko Sumiyoshi; Frederic de Sauvage; Mark R. Lackner; Felipe de Sousa e Melo; Omar Kabbarah
Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma
Dana Prukova; Ladislav Andera; Zuzana Nahacka; Jana Karolova; Michael Svaton; Magdalena Klanova; Ondrej Havranek; Jan Soukup; Karla Svobodova; Zuzana Zemanova; Diana Tuskova; Eva Pokorna; Karel Helman; Kristina Forsterova; Mariana Pacheco-Blanco; Petra Vockova; Adela Berkova; Eva Fronkova; Marek Trneny; Pavel Klener
Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer
Natalia Guillén Díaz-Maroto; Rebeca Sanz-Pamplona; Mireia Berdiel-Acer; Francisco J. Cimas; Elena García; Samuel Gonçalves-Ribeiro; Nerea Albert; Gemma Garcia-Vicién; Gabriel Capella; Victor Moreno; Ramon Salazar; Alberto Villanueva; David G. Molleví
A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2)
Ying Z. Mazzu; Joshua Armenia; Goutam Chakraborty; Yuki Yoshikawa; Si'Ana A. Coggins; Subhiksha Nandakumar; Travis A. Gerke; Mark M. Pomerantz; Xintao Qiu; Huiyong Zhao; Mohammad Atiq; Nabeela Khan; Kazumasa Komura; Gwo-Shu Mary Lee; Samson W. Fine; Connor Bell; Edward O'Connor; Henry W. Long; Matthew L. Freedman; Baek Kim; Philip W. Kantoff
OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL
Kathryn Evans; JianXin Duan; Tara Pritchard; Connor D. Jones; Lisa McDermott; Zhaohui Gu; Cara E. Toscan; Narimanne El-Zein; Chelsea Mayoh; Stephen W. Erickson; Yuelong Guo; Fanying Meng; Donald Jung; Komal S. Rathi; Kathryn G. Roberts; Charles G. Mullighan; Chi-Sheng Shia; Tillman Pearce; Beverly A. Teicher; Malcolm A. Smith; Richard B. Lock
A Constitutional Activating MET Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases
Morad El Bouchtaoui; Marcio Do Cruzeiro; Christophe Leboeuf; Irmine Loisel-Ferreira; Carèle Fedronie; Chrystophe Ferreira; Rachida Ait El Far; Marianne Ziol; Marc Espié; Géraldine Falgarone; Bruno Cassinat; Jean-Jacques Kiladjian; Jean-Paul Feugeas; Anne Janin; Guilhem Bousquet
Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics
Deyin Xing; Gang Zheng; Aparna Pallavajjala; J. Kenneth Schoolmeester; Yuehua Liu; Lisa Haley; Yan Hu; Li Liu; Lisa Logan; Yuan Lin; Kathryn E. Pearce; Christopher A. Sattler; Ya Chea Tsai; Russell Vang; Chien-Fu Hung; T.-C. Wu; Brigitte M. Ronnett
Regorafenib Promotes Antitumor Immunity via Inhibiting PD-L1 and IDO1 Expression in Melanoma
Rui-Yan Wu; Peng-Fei Kong; Liang-Ping Xia; Yun Huang; Zhi-Ling Li; Yun-Yun Tang; Yu-Hong Chen; Xuan Li; Ravichandran Senthilkumar; Hai-Liang Zhang; Ting Sun; Xue-Lian Xu; Yan Yu; Jia Mai; Xiao-Dan Peng; Dong Yang; Li-Huan Zhou; Gong-Kan Feng; Rong Deng; Xiao-Feng Zhu
Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Eun-Jin Yun; Chun-Jung Lin; Andrew Dang; Elizabeth Hernandez; Jiaming Guo; Wei-Min Chen; Joyce Allison; Nathan Kim; Payal Kapur; James Brugarolas; Kaijie Wu; Dalin He; Chih-Ho Lai; Ho Lin; Debabrata Saha; Seung Tae Baek; Benjamin P.C. Chen; Jer-Tsong Hsieh
High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma
Sarah Wang; Elizabeth E. Hwang; Rajarshi Guha; Allison F. O'Neill; Nicole Melong; Chansey J. Veinotte; Amy Conway Saur; Kellsey Wuerthele; Min Shen; Crystal McKnight; Gabriela Alexe; Madeleine E. Lemieux; Amy Wang; Emma Hughes; Xin Xu; Matthew B. Boxer; Matthew D. Hall; Andrew Kung; Jason N. Berman; Mindy I. Davis; Kimberly Stegmaier; Brian D. Crompton
Genome-wide RNAi Screening Identifies RFC4 as a Factor That Mediates Radioresistance in Colorectal Cancer by Facilitating Nonhomologous End Joining Repair
Xue-Cen Wang; Xin Yue; Rong-Xin Zhang; Ting-Yu Liu; Zhi-Zhong Pan; Meng-Jie Yang; Zhen-Hai Lu; Zi-Yang Wang; Jian-Hong Peng; Li-Yuan Le; Gao-Yuan Wang; Qi-Hua Peng; Yuan Meng; Wenlin Huang; Ran-Yi Liu
Letter to the Editor
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