Skip Nav Destination
Issues
1 July 2019
-
Cover Image
Cover Image
Immunofluorescence staining from a case of castration-resistant prostate cancer for the expression of leukemia inhibitory factor (LIF) with neuroendocrine (NE) marker chromogranin A (CgA). LIF expression partially colocalizes with CgA expression, demonstrating that it is produced by NE tumor cells. For details, see the article by Liu and colleagues on page 4128 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
Review
Clinical Trial Brief Report
Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Siltuximab in High-Risk Smoldering Multiple Myeloma
Timothy A. Brighton; Amit Khot; Simon J. Harrison; David Ghez; Brendan M. Weiss; Andres Kirsch; Hila Magen; Mercedes Gironella; Albert Oriol; Matthew Streetly; Britte Kranenburg; Xiang Qin; Rajesh Bandekar; Peter Hu; Mary Guilfoyle; Ming Qi; Sepideh Nemat; Hartmut Goldschmidt
Clinical Trials: Targeted Therapy
A Phase I/II Trial of Carfilzomib, Pegylated Liposomal Doxorubicin, and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma
Mark A. Schroeder; Mark A. Fiala; Eric Huselton; Michael H. Cardone; Savina Jaeger; Sae Rin Jean; Kathryn Shea; Armin Ghobadi; Tanya Wildes; Keith E. Stockerl-Goldstein; Ravi Vij
Phase I Study of Intermittent High-Dose Lapatinib Alternating with Capecitabine for HER2-Positive Breast Cancer Patients with Central Nervous System Metastases
Aki Morikawa; Elisa de Stanchina; Elena Pentsova; Margaret M. Kemeny; Bob T. Li; Kendrick Tang; Sujata Patil; Martin Fleisher; Catherine Van Poznak; Larry Norton; Andrew D. Seidman
Safety and Feasibility of Repeated and Transient Blood–Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma
Ahmed Idbaih; Michael Canney; Lisa Belin; Carole Desseaux; Alexandre Vignot; Guillaume Bouchoux; Nicolas Asquier; Bruno Law-Ye; Delphine Leclercq; Anne Bissery; Yann De Rycke; Clementine Trosch; Laurent Capelle; Marc Sanson; Khe Hoang-Xuan; Caroline Dehais; Caroline Houillier; Florence Laigle-Donadey; Bertrand Mathon; Arthur André; Cyril Lafon; Jean-Yves Chapelon; Jean-Yves Delattre; Alexandre Carpentier
Author Choice
Alpha Particle Radium 223 Dichloride in High-risk Osteosarcoma: A Phase I Dose Escalation Trial
Vivek Subbiah; Pete M. Anderson; Kalevi Kairemo; Kenneth Hess; Winston W. Huh; Vinod Ravi; Najat C. Daw; Neeta Somaiah; Joseph A. Ludwig; Robert S. Benjamin; Sant Chawla; David S. Hong; Funda Meric-Bernstam; Gregory Ravizzini; Eugenie Kleinerman; Homer Macapinlac; Eric Rohren
Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer
Elizabeth Won; Azfar Basunia; Walid K. Chatila; Jaclyn F. Hechtman; Joanne F. Chou; Geoffrey Y. Ku; Sree B. Chalasani; Michelle S. Boyar; Zoe Goldberg; Avni M. Desai; Yaelle Tuvy; Michael F. Berger; Laura Tang; David P. Kelsen; Mark Schattner; David H. Ilson; Marinela Capanu; David B. Solit; Nikolaus Schultz; Yelena Y. Janjigian
Precision Medicine and Imaging
Author Choice
Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer
Ahmed Salem; Ross A. Little; Ayşe Latif; Adam K. Featherstone; Muhammad Babur; Isabel Peset; Susan Cheung; Yvonne Watson; Victoria Tessyman; Hitesh Mistry; Garry Ashton; Caron Behan; Julian C. Matthews; Marie-Claude Asselin; Robert G. Bristow; Alan Jackson; Geoff J.M. Parker; Corinne Faivre-Finn; Kaye J. Williams; James P.B. O'Connor
Author Choice
miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial
Gayathri Anandappa; Andrea Lampis; David Cunningham; Khurum H. Khan; Kyriakos Kouvelakis; Georgios Vlachogiannis; Somaieh Hedayat; Nina Tunariu; Sheela Rao; David Watkins; Naureen Starling; Chiara Braconi; Mahnaz Darvish-Damavandi; Hazel Lote; Janet Thomas; Clare Peckitt; Ria Kalaitzaki; Nasir Khan; Nicos Fotiadis; Massimo Rugge; Ruwaida Begum; Isma Rana; Annette Bryant; Jens C. Hahne; Ian Chau; Matteo Fassan; Nicola Valeri
Association of Systemic Inflammation Index and Body Mass Index with Survival in Patients with Renal Cell Cancer Treated with Nivolumab
Ugo De Giorgi; Giuseppe Procopio; Diana Giannarelli; Roberto Sabbatini; Alessandra Bearz; Sebastiano Buti; Umberto Basso; Manfred Mitterer; Cinzia Ortega; Paolo Bidoli; Francesco Ferraù; Lucio Crinò; Antonio Frassoldati; Paolo Marchetti; Enrico Mini; Alessandro Scoppola; Claudio Verusio; Giuseppe Fornarini; Giacomo Cartenì; Claudia Caserta; Cora N. Sternberg
Author Choice
Comparative Analysis of AR Variant AR-V567es mRNA Detection Systems Reveals Eminent Variability and Questions the Role as a Clinical Biomarker in Prostate Cancer
Christof Bernemann; Verena Humberg; Barbara Thielen; Julie Steinestel; Xin Chen; Stefan Duensing; Andres J. Schrader; Martin Boegemann
Author Choice
Prediction of Distant Recurrence Using EndoPredict Among Women with ER+, HER2− Node-Positive and Node-Negative Breast Cancer Treated with Endocrine Therapy Only
Martin Filipits; Peter Dubsky; Margaretha Rudas; Richard Greil; Marija Balic; Zsuzsanna Bago-Horvath; Christian F. Singer; Dominik Hlauschek; Krystal Brown; Ryan Bernhisel; Ralf Kronenwett; Johnathan M. Lancaster; Florian Fitzal; Michael Gnant
Breast Phyllodes Tumors Recruit and Repolarize Tumor-Associated Macrophages via Secreting CCL5 to Promote Malignant Progression, Which Can Be Inhibited by CCR5 Inhibition Therapy
Yan Nie; Hongyan Huang; Mingyan Guo; Jiewen Chen; Wei Wu; Wende Li; Xiaoding Xu; Xiaorong Lin; Wenkui Fu; Yandan Yao; Fang Zheng; Man-Li Luo; Phei Er Saw; Herui Yao; Erwei Song; Hai Hu
Author Choice
Plasma miRNA Levels for Predicting Therapeutic Response to Neoadjuvant Treatment in HER2-positive Breast Cancer: Results from the NeoALTTO Trial
Serena Di Cosimo; Valentina Appierto; Sara Pizzamiglio; Paola Tiberio; Marilena V. Iorio; Florentine Hilbers; Evandro de Azambuja; Lorena de la Peña; Miguel Izquierdo; Jens Huober; José Baselga; Martine Piccart; Filippo G. de Braud; Giovanni Apolone; Paolo Verderio; Maria Grazia Daidone
Molecular Characterization of Neuroendocrine-like Bladder Cancer
José Batista da Costa; Ewan A. Gibb; Trinity J. Bivalacqua; Yang Liu; Htoo Zarni Oo; David T. Miyamoto; Mohammed Alshalalfa; Elai Davicioni; Jonathan Wright; Marc A. Dall’Era; James Douglas; Joost L. Boormans; Michiel S. Van der Heijden; Chin-Lee Wu; Bas W.G. van Rhijn; Shilpa Gupta; Petros Grivas; Kent W. Mouw; Paari Murugan; Ladan Fazli; Seong Ra; Badrinath R. Konety; Roland Seiler; Siamak Daneshmand; Omar Y. Mian; Jason A. Efstathiou; Yair Lotan; Peter C. Black
Translational Cancer Mechanisms and Therapy
Author Choice
Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell–recruiting Antibody Optimized for Cytotoxicity and Cytokine Release
Christina L. Zuch de Zafra; Flordeliza Fajardo; Wendy Zhong; Matthew J. Bernett; Umesh S. Muchhal; Gregory L. Moore; Jennitte Stevens; Ryan Case; Joshua T. Pearson; Siyuan Liu; Patricia L. McElroy; Jude Canon; John R. Desjarlais; Angela Coxon; Mercedesz Balazs; Olivier Nolan-Stevaux
Mobilization of CD8+ T Cells via CXCR4 Blockade Facilitates PD-1 Checkpoint Therapy in Human Pancreatic Cancer
Yongwoo David Seo; Xiuyun Jiang; Kevin M. Sullivan; Florencia G. Jalikis; Kimberly S. Smythe; Arezou Abbasi; Marissa Vignali; James O. Park; Sara K. Daniel; Seth M. Pollack; Teresa S. Kim; Raymond Yeung; Ian Nicholas Crispe; Robert H. Pierce; Harlan Robins; Venu G. Pillarisetty
Combination of Trastuzumab Emtansine and Stereotactic Radiosurgery Results in High Rates of Clinically Significant Radionecrosis and Dysregulation of Aquaporin-4
Priscilla K. Stumpf; Diana M. Cittelly; Tyler P. Robin; Julie A. Carlson; Kelly A. Stuhr; Maria Jose Contreras-Zarate; Steven Lai; D. Ryan Ormond; Chad G. Rusthoven; Laurie E. Gaspar; Rachel Rabinovitch; Brian D. Kavanagh; Arthur Liu; Jennifer R. Diamond; Peter Kabos; Christine M. Fisher
Class 1, 2, and 3 BRAF-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Marta Schirripa; Paola Biason; Sara Lonardi; Nicoletta Pella; Maria Simona Pino; Federica Urbano; Carlotta Antoniotti; Chiara Cremolini; Salvatore Corallo; Filippo Pietrantonio; Fabio Gelsomino; Stefano Cascinu; Armando Orlandi; Giada Munari; Umberto Malapelle; Serena Saggio; Gabriella Fontanini; Massimo Rugge; Claudia Mescoli; Stefano Lazzi; Luca Reggiani Bonetti; Giovanni Lanza; Angelo Paolo Dei Tos; Giovanna De Maglio; Maurizio Martini; Francesca Bergamo; Vittorina Zagonel; Fotios Loupakis; Matteo Fassan
Survival Following Chemotherapy in Ovarian Clear Cell Carcinoma Is Not Associated with Pathological Misclassification of Tumor Histotype
Masataka Takenaka; Martin Köbel; Dale W. Garsed; Sian Fereday; Ahwan Pandey; Dariush Etemadmoghadam; Joy Hendley; Ayako Kawabata; Daito Noguchi; Nozomu Yanaihara; Hiroyuki Takahashi; Takako Kiyokawa; Masahiro Ikegami; Hirokuni Takano; Seiji Isonishi; Kazuhiko Ochiai; Nadia Traficante; Sreeja Gadipally; Timothy Semple; Dane Vassiliadis; Kausyalya Amarasinghe; Jason Li; Gisela Mir Arnau; Aikou Okamoto; Michael Friedlander; David D. L. Bowtell; for the Australian Ovarian Cancer Study Group
Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia
Alak Manna; Sonikpreet Aulakh; Prachi Jani; Salman Ahmed; Sharoon Akhtar; Marie Coignet; Michael Heckman; Zahara Meghji; Kirtipal Bhatia; Aarushi Sharma; Taimur Sher; Victoria Alegria; Fabio Malavasi; Eduardo N. Chini; Asher Chanan-Khan; Sikander Ailawadhi; Aneel Paulus
Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial
Sibylle Loibl; Denise Treue; Jan Budczies; Karsten Weber; Albrecht Stenzinger; Wolfgang D. Schmitt; Wilko Weichert; Paul Jank; Jenny Furlanetto; Frederick Klauschen; Thomas Karn; Nicole Pfarr; Gunter von Minckwitz; Markus Möbs; Christian Jackisch; Christine Sers; Andreas Schneeweiss; Peter A. Fasching; Christian Schem; Michael Hummel; Marion van Mackelenbergh; Valentina Nekljudova; Michael Untch; Carsten Denkert
Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer
Nicole M. Kettner; Smruthi Vijayaraghavan; Merih Guray Durak; Tuyen Bui; Mehrnoosh Kohansal; Min Jin Ha; Bin Liu; Xiayu Rao; Jing Wang; Min Yi; Jason P.W. Carey; Xian Chen; T. Kris Eckols; Akshara S. Raghavendra; Nuhad K. Ibrahim; Meghan Sri Karuturi; Stephanie S. Watowich; Aysegul Sahin; David J. Tweardy; Kelly K. Hunt; Debu Tripathy; Khandan Keyomarsi
Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells
Esther Drent; Renée Poels; Ruud Ruiter; Niels W.C.J. van de Donk; Sonja Zweegman; Huipin Yuan; Joost de Bruijn; Michel Sadelain; Henk M. Lokhorst; Richard W.J. Groen; Tuna Mutis; Maria Themeli
Author Choice
Functional and Mechanistic Interrogation of BET Bromodomain Degraders for the Treatment of Metastatic Castration-resistant Prostate Cancer
Steven Kregel; Rohit Malik; Irfan A. Asangani; Kari Wilder-Romans; Thekkelnaycke Rajendiran; Lanbo Xiao; Josh N. Vo; Tanu Soni; Marcin Cieslik; Ester Fernadez-Salas; Bing Zhou; Xuhong Cao; Corey Speers; Shaomeng Wang; Arul M. Chinnaiyan
Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction
Sofía Carbajosa; María Florencia Pansa; Natalia S. Paviolo; Andrés M. Castellaro; Diego L. Andino; Ayelén D. Nigra; Iris Alejandra García; Ana C. Racca; Lucía Rodriguez-Berdini; Virginia Angiolini; Laura Guantay; Florencia Villafañez; María Belén Federico; María Celeste Rodríguez-Baili; Beatriz L. Caputto; Gerard Drewes; Kevin P. Madauss; Israel Gloger; Elmer Fernandez; Germán A. Gil; José Luis Bocco; Vanesa Gottifredi; Gastón Soria
Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms
Omar El Charif; Brandon Mapes; Matthew R. Trendowski; Heather E. Wheeler; Claudia Wing; Paul C. Dinh, Jr; Robert D. Frisina; Darren R. Feldman; Robert J. Hamilton; David J. Vaughn; Chunkit Fung; Christian Kollmannsberger; Taisei Mushiroda; Michiaki Kubo; Eric R. Gamazon; Nancy J. Cox; Robert Huddart; Shirin Ardeshir-Rouhani-Fard; Patrick Monahan; Sophie D. Fossa; Lawrence H. Einhorn; Lois B. Travis; M. Eileen Dolan
Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK
Annmarie Ramkissoon; Katherine E. Chaney; David Milewski; Kyle B. Williams; Rory L. Williams; Kwangmin Choi; Adam Miller; Tanya V. Kalin; Joseph G. Pressey; Sara Szabo; Mohammad Azam; David A. Largaespada; Nancy Ratner
Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46
Yen-Nien Liu; Shaoxi Niu; Wei-Yu Chen; Qingfu Zhang; Yulei Tao; Wei-Hao Chen; Kuo-Ching Jiang; Xufeng Chen; Huaiyin Shi; Aijun Liu; Jinhang Li; Yanjing Li; Yi-Chao Lee; Xu Zhang; Jiaoti Huang
L-Type Cav 1.2 Calcium Channel-α-1C Regulates Response to Rituximab in Diffuse Large B-Cell Lymphoma
Jiu-Yang Zhang; Pei-Pei Zhang; Wen-Ping Zhou; Jia-Yu Yu; Zhi-Hua Yao; Jun-Feng Chu; Shu-Na Yao; Cheng Wang; Waseem Lone; Qing-Xin Xia; Jie Ma; Shu-Jun Yang; Kang-Dong Liu; Zi-Gang Dong; Yong-Jun Guo; Lynette M. Smith; Timothy W. McKeithan; Wing C. Chan; Javeed Iqbal; Yan-Yan Liu
Author Choice
Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Anna A. Kiseleva; Vladislav A. Korobeynikov; Anna S. Nikonova; Peishan Zhang; Petr Makhov; Alexander Y. Deneka; Margret B. Einarson; Ilya G. Serebriiskii; Hanqing Liu; Jeffrey R. Peterson; Erica A. Golemis
Editor’s Note
Editor's Note: Cotreatment with STI-571 Enhances Tumor Necrosis Factor α-related Apoptosis-inducing Ligand (TRAIL or Apo-2L)–induced Apoptosis of Bcr-Abl–positive Human Acute Leukemia Cells
Ramadevi Nimmanapalli; Mercedes Porosnicu; Diep Nguyen; Elizabeth Worthington; Erica O’Bryan; Charles Perkins; Kapil Bhalla
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds