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15 May 2019
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The cover shows a section of a non–small-cell lung cancer. Immunohistochemical staining demonstrates strong positivity for HLA-F. For details, see the article by Trefny and colleagues on page 3026 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Pertuzumab for Adjuvant Treatment of HER2-Positive Early Breast Cancer
Lynn J. Howie; Nancy S. Scher; Laleh Amiri-Kordestani; Lijun Zhang; Bellinda L. King-Kallimanis; Yasmin Choudhry; Jason Schroeder; Kirsten B. Goldberg; Paul G. Kluetz; Amna Ibrahim; Rajeshwari Sridhara; Gideon M. Blumenthal; Richard Pazdur; Julia A. Beaver
Review
Perspectives
Special Report
Clinical Trials: Targeted Therapy
Author Choice
A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer (NEO-ORB)
Ingrid A. Mayer; Aleix Prat; Daniel Egle; Sibel Blau; J. Alejandro Pérez Fidalgo; Michael Gnant; Peter A. Fasching; Marco Colleoni; Antonio C. Wolff; Eric P. Winer; Christian F. Singer; Sara Hurvitz; Laura García Estévez; Peter A. van Dam; Sherko Kümmel; Christoph Mundhenke; Frankie Holmes; Naveen Babbar; Laure Charbonnier; Ivan Diaz-Padilla; Florian D. Vogl; Dalila Sellami; Carlos L. Arteaga
MAVERICC, a Randomized, Biomarker-stratified, Phase II Study of mFOLFOX6-Bevacizumab versus FOLFIRI-Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer
Aparna R. Parikh; Fa-Chyi Lee; Linda Yau; Han Koh; James Knost; Edith P. Mitchell; Ivan Bosanac; Nicholas Choong; Frank Scappaticci; Christoph Mancao; Heinz-Josef Lenz
Precision Medicine and Imaging
Application of Artificial Intelligence for Preoperative Diagnostic and Prognostic Prediction in Epithelial Ovarian Cancer Based on Blood Biomarkers
Eiryo Kawakami; Junya Tabata; Nozomu Yanaihara; Tetsuo Ishikawa; Keita Koseki; Yasushi Iida; Misato Saito; Hiromi Komazaki; Jason S. Shapiro; Chihiro Goto; Yuka Akiyama; Ryosuke Saito; Motoaki Saito; Hirokuni Takano; Kyosuke Yamada; Aikou Okamoto
Large-scale Circulating microRNA Profiling for the Liquid Biopsy of Prostate Cancer
Fumihiko Urabe; Juntaro Matsuzaki; Yusuke Yamamoto; Takahiro Kimura; Tomohiko Hara; Makiko Ichikawa; Satoko Takizawa; Yoshiaki Aoki; Shumpei Niida; Hiromi Sakamoto; Ken Kato; Shin Egawa; Hiroyuki Fujimoto; Takahiro Ochiya
A Variant of a Killer Cell Immunoglobulin-like Receptor Is Associated with Resistance to PD-1 Blockade in Lung Cancer
Marcel P. Trefny; Sacha I. Rothschild; Franziska Uhlenbrock; Dietmar Rieder; Benjamin Kasenda; Michal A. Stanczak; Fiamma Berner; Abhishek S. Kashyap; Monika Kaiser; Petra Herzig; Severin Poechtrager; Daniela S. Thommen; Florian Geier; Spasenija Savic; Philip Jermann; Ilaria Alborelli; Stefan Schaub; Frank Stenner; Martin Früh; Zlatko Trajanoski; Lukas Flatz; Kirsten D. Mertz; Alfred Zippelius; Heinz Läubli
Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma
Yusheng Lin; Hongmei Dong; Weilun Deng; Wan Lin; Kai Li; Xiao Xiong; Yi Guo; Fuyou Zhou; Changchun Ma; Yuping Chen; Hongzheng Ren; Haijun Yang; Ningtao Dai; Lang Ma; Stephen J. Meltzer; Sai-Ching J. Yeung; Hao Zhang
Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
Daniel E. Carvajal-Hausdorf; Jonathan Patsenker; Kelly P. Stanton; Franz Villarroel-Espindola; Amanda Esch; Ruth R. Montgomery; Amanda Psyrri; Konstantine T. Kalogeras; Vassiliki Kotoula; George Foutzilas; Kurt A. Schalper; Yuval Kluger; David L. Rimm
Translational Cancer Mechanisms and Therapy
Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer
Ryuma Tokunaga; Joanne Xiu; Curtis Johnston; Richard M. Goldberg; Philip A. Philip; Andreas Seeber; Madiha Naseem; Jae Ho Lo; Hiroyuki Arai; Francesca Battaglin; Alberto Puccini; Martin D. Berger; Shivani Soni; Wu Zhang; Jimmy J. Hwang; Anthony F. Shields; John L. Marshall; Hideo Baba; W. Michael Korn; Heinz-Josef Lenz
Author Choice
Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma
Vineesh Indira Chandran; Charlotte Welinder; Ann-Sofie Månsson; Svenja Offer; Eva Freyhult; Maria Pernemalm; Sigrid M. Lund; Shona Pedersen; Janne Lehtiö; Gyorgy Marko-Varga; Maria C. Johansson; Elisabet Englund; Pia C. Sundgren; Mattias Belting
Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies
Iñigo Landa; Nikita Pozdeyev; Christopher Korch; Laura A. Marlow; Robert C. Smallridge; John A. Copland; Ying C. Henderson; Stephen Y. Lai; Gary L. Clayman; Naoyoshi Onoda; Aik Choon Tan; Maria E.R. Garcia-Rendueles; Jeffrey A. Knauf; Bryan R. Haugen; James A. Fagin; Rebecca E. Schweppe
The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity
David Digomann; Ina Kurth; Anna Tyutyunnykova; Oleg Chen; Steffen Löck; Ielizaveta Gorodetska; Claudia Peitzsch; Ira-Ida Skvortsova; Giulia Negro; Bertram Aschenbrenner; Graeme Eisenhofer; Susan Richter; Stephan Heiden; Joseph Porrmann; Barbara Klink; Christian Schwager; Adam A. Dowle; Linda Hein; Leoni A. Kunz-Schughart; Amir Abdollahi; Fabian Lohaus; Mechthild Krause; Michael Baumann; Annett Linge; Anna Dubrovska
Author Choice
Capmatinib (INC280) Is Active Against Models of Non–Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation
Sabrina Baltschukat; Barbara Schacher Engstler; Alan Huang; Huai-Xiang Hao; Angela Tam; Hui Qin Wang; Jinsheng Liang; Matthew T. DiMare; Hyo-Eun Carrie Bhang; Youzhen Wang; Pascal Furet; William R. Sellers; Francesco Hofmann; Joseph Schoepfer; Ralph Tiedt
The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma
Laura Moreno; Cristina Perez; Aintzane Zabaleta; Irene Manrique; Diego Alignani; Daniel Ajona; Laura Blanco; Marta Lasa; Patricia Maiso; Idoia Rodriguez; Sonia Garate; Tomas Jelinek; Victor Segura; Cristina Moreno; Juana Merino; Paula Rodriguez-Otero; Carlos Panizo; Felipe Prosper; Jesus F. San-Miguel; Bruno Paiva
Letters to the Editor
Corrections
Correction: Efficacy and Safety of the Biosimilar ABP 215 Compared with Bevacizumab in Patients with Advanced Nonsquamous Non–small Cell Lung Cancer (MAPLE): A Randomized, Double-blind, Phase III Study
Nicholas Thatcher; Jerome H. Goldschmidt; Michael Thomas; Michael Schenker; Zhiying Pan; Luis Paz-Ares Rodriguez; Valery Breder; Gyula Ostoros; Vladimir Hanes
Correction: Focal Adhesion Kinase Targeting Using In vivo Short Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy
Jyotsnabaran Halder; Aparna A. Kamat; Charles N. Landen, Jr; Liz Y. Han; Susan K. Lutgendorf; Yvonne G. Lin; William M. Merritt; Nicholas B. Jennings; Arturo Chavez-Reyes; Robert L. Coleman; David M. Gershenson; Rosemarie Schmandt; Steven W. Cole; Gabriel Lopez-Berestein; Anil K. Sood
Editor’s Notes
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