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1 January 2019
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Cover Image
The cover shows patient-derived organoids from a liver biopsy of a patient with neuroendocrine prostate cancer. For details, see manuscript by Beltran and colleagues on page 43 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trial Brief Report
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients
Marie-Catherine Vozenin; Pauline De Fornel; Kristoffer Petersson; Vincent Favaudon; Maud Jaccard; Jean-François Germond; Benoit Petit; Marco Burki; Gisèle Ferrand; David Patin; Hanan Bouchaab; Mahmut Ozsahin; François Bochud; Claude Bailat; Patrick Devauchelle; Jean Bourhis
Clinical Trials: Targeted Therapy
A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers
Himisha Beltran; Clara Oromendia; Daniel C. Danila; Bruce Montgomery; Christopher Hoimes; Russell Z. Szmulewitz; Ulka Vaishampayan; Andrew J. Armstrong; Mark Stein; Jacek Pinski; Juan M. Mosquera; Verena Sailer; Rohan Bareja; Alessandro Romanel; Naveen Gumpeni; Andrea Sboner; Etienne Dardenne; Loredana Puca; Davide Prandi; Mark A. Rubin; Howard I. Scher; David S. Rickman; Francesca Demichelis; David M. Nanus; Karla V. Ballman; Scott T. Tagawa
Trastuzumab Emtansine (T-DM1) in Patients with Previously Treated HER2-Overexpressing Metastatic Non–Small Cell Lung Cancer: Efficacy, Safety, and Biomarkers
Solange Peters; Rolf Stahel; Lukas Bubendorf; Philip Bonomi; Augusto Villegas; Dariusz M. Kowalski; Christina S. Baik; Dolores Isla; Javier De Castro Carpeno; Pilar Garrido; Achim Rittmeyer; Marcello Tiseo; Christoph Meyenberg; Sanne de Haas; Lisa H. Lam; Michael W. Lu; Thomas E. Stinchcombe
Phase II Study of Iniparib with Concurrent Chemoradiation in Patients with Newly Diagnosed Glioblastoma
Jaishri O. Blakeley; Stuart A. Grossman; Andrew S. Chi; Tom Mikkelsen; Myrna R. Rosenfeld; Manmeet S. Ahluwalia; L. Burt Nabors; April Eichler; Ignacio Garcia Ribas; Serena Desideri; Xiaobu Ye; on behalf of the Adult Brain Tumor Consortium
A Phase II and Biomarker Study of Sorafenib Combined with Modified FOLFOX in Patients with Advanced Hepatocellular Carcinoma
Lipika Goyal; Hui Zheng; Thomas A. Abrams; Rebecca Miksad; Andrea J. Bullock; Jill N. Allen; Matthew B. Yurgelun; Jeffrey W. Clark; Avinash Kambadakone; Alona Muzikansky; Michelle Knowles; Aralee Galway; Anthony J. Afflitto; Caroline F. Dinicola; Eileen Regan; Tai Hato; Emilie Mamessier; Kohei Shigeta; Rakesh K. Jain; Dan G. Duda; Andrew X. Zhu
Clinical Trials: Immunotherapy
First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors
Julius Strauss; Christopher R. Heery; Joseph W. Kim; Caroline Jochems; Renee N. Donahue; Agnes S. Montgomery; Sheri McMahon; Elizabeth Lamping; Jennifer L. Marté; Ravi A. Madan; Marijo Bilusic; Matthew R. Silver; Elisa Bertotti; Jeffrey Schlom; James L. Gulley
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer
Charu Aggarwal; Roger B. Cohen; Matthew P. Morrow; Kimberly A. Kraynyak; Albert J. Sylvester; Dawson M. Knoblock; Joshua M. Bauml; Gregory S. Weinstein; Alexander Lin; Jean Boyer; Lindsay Sakata; Sophie Tan; Aubrey Anton; Kelsie Dickerson; Drishty Mangrolia; Russell Vang; Michael Dallas; Sandra Oyola; Susan Duff; Mark Esser; Rakesh Kumar; David Weiner; Ildiko Csiki; Mark L. Bagarazzi
Precision Medicine and Imaging
Intertumoral Heterogeneity of CD3+ and CD8+ T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis
Harry H. Yoon; Qian Shi; Erica N. Heying; Andrea Muranyi; Joerg Bredno; Faith Ough; Azita Djalilvand; June Clements; Rebecca Bowermaster; Wen-Wei Liu; Michael Barnes; Steven R. Alberts; Kandavel Shanmugam; Frank A. Sinicrope
Author Choice
Validation of miR-31-3p Expression to Predict Cetuximab Efficacy When Used as First-Line Treatment in RAS Wild-Type Metastatic Colorectal Cancer
Pierre Laurent-Puig; Marie-Lise Grisoni; Volker Heinemann; François Liebaert; Daniel Neureiter; Andreas Jung; François Montestruc; Yann Gaston-Mathe; Raphaële Thiébaut; Sebastian Stintzing
Author Choice
A Noninvasive Blood-based Combinatorial Proteomic Biomarker Assay to Detect Breast Cancer in Women over age 50 with BI-RADS 3, 4, or 5 Assessment
Meredith C. Henderson; Michael Silver; Quynh Tran; Elias E. Letsios; Rao Mulpuri; David E. Reese; Ana P. Lourenco; Joshua LaBaer; Karen S. Anderson; Josie Alpers; Carrie Costantini; Nitin Rohatgi; Haythem Ali; Karen Baker; Donald W. Northfelt; Karthik Ghosh; Stephen R. Grobmyer; Winnie Polen; Judith K. Wolf
Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer
Yang Xie; Wei Lu; Shidan Wang; Ximing Tang; Hao Tang; Yunyun Zhou; Cesar Moran; Carmen Behrens; Jack A. Roth; Qinghua Zhou; David H. Johnson; Stephen G. Swisher; John V. Heymach; Vassiliki A. Papadimitrakopoulou; Guanghua Xiao; John D. Minna; Ignacio I. Wistuba
Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer
Ibiayi Dagogo-Jack; Pablo Martinez; Beow Y. Yeap; Chiara Ambrogio; Lorin A. Ferris; Christine Lydon; Tom Nguyen; Nicholas A. Jessop; A. John Iafrate; Bruce E. Johnson; Jochen K. Lennerz; Alice T. Shaw; Mark M. Awad
Near-Infrared Dye-Labeled Anti-Prostate Stem Cell Antigen Minibody Enables Real-Time Fluorescence Imaging and Targeted Surgery in Translational Mouse Models
Mo Zhang; Naoko Kobayashi; Kirstin A. Zettlitz; Evelyn A. Kono; Joyce M. Yamashiro; Wen-Ting K. Tsai; Ziyue K. Jiang; Chau P. Tran; Chung Wang; Johnny Guan; Anna M. Wu; Robert E. Reiter
Translational Cancer Mechanisms and Therapy
Transcriptomic and Protein Analysis of Small-cell Bladder Cancer (SCBC) Identifies Prognostic Biomarkers and DLL3 as a Relevant Therapeutic Target
Vadim S. Koshkin; Jorge A. Garcia; Jordan Reynolds; Paul Elson; Cristina Magi-Galluzzi; Jesse K. McKenney; Kumiko Isse; Evan Bishop; Laura R. Saunders; Aysegul Balyimez; Summya Rashid; Ming Hu; Andrew J. Stephenson; Amr F. Fergany; Byron H. Lee; Georges-Pascal Haber; Afshin Dowlati; Timothy Gilligan; Moshe C. Ornstein; Brian I. Rini; Mohamed E. Abazeed; Omar Y. Mian; Petros Grivas
Author Choice
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia
Qi Jin; Carlos A. Martinez; Kelly M. Arcipowski; Yixing Zhu; Blanca T. Gutierrez-Diaz; Kenneth K. Wang; Megan R. Johnson; Andrew G. Volk; Feng Wang; Jian Wu; Charles Grove; Hui Wang; Ivan Sokirniy; Paul M. Thomas; Young Ah Goo; Nebiyu A. Abshiru; Nobuko Hijiya; Sofie Peirs; Niels Vandamme; Geert Berx; Steven Goosens; Stacy A. Marshall; Emily J. Rendleman; Yoh-hei Takahashi; Lu Wang; Radhika Rawat; Elizabeth T. Bartom; Clayton K. Collings; Pieter Van Vlierberghe; Alexandros Strikoudis; Stephen Kelly; Beatrix Ueberheide; Christine Mantis; Irawati Kandela; Jean-Pierre Bourquin; Beat Bornhauser; Valentina Serafin; Silvia Bresolin; Maddalena Paganin; Benedetta Accordi; Giuseppe Basso; Neil L. Kelleher; Joseph Weinstock; Suresh Kumar; John D. Crispino; Ali Shilatifard; Panagiotis Ntziachristos
Author Choice
The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Saskia J. Santegoets; Vanessa J. van Ham; Ilina Ehsan; Pornpimol Charoentong; Chantal L. Duurland; Vincent van Unen; Thomas Höllt; Lilly-Ann van der Velden; Sylvia L. van Egmond; Kim E. Kortekaas; Peggy J. de Vos van Steenwijk; Mariëtte I.E. van Poelgeest; Marij J.P. Welters; Sjoerd H. van der Burg
Targeting Resistance against the MDM2 Inhibitor RG7388 in Glioblastoma Cells by the MEK Inhibitor Trametinib
Anne Berberich; Tobias Kessler; Carina M. Thomé; Stefan Pusch; Thomas Hielscher; Felix Sahm; Iris Oezen; Lara-Marie Schmitt; Sara Ciprut; Nanina Hucke; Petra Ruebmann; Manuel Fischer; Dieter Lemke; Michael O. Breckwoldt; Andreas von Deimling; Martin Bendszus; Michael Platten; Wolfgang Wick
Author Choice
Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients
Daniela Osti; Massimiliano Del Bene; Germana Rappa; Mark Santos; Vittoria Matafora; Cristina Richichi; Stefania Faletti; Galina V. Beznoussenko; Alexandre Mironov; Angela Bachi; Lorenzo Fornasari; Daniele Bongetta; Paolo Gaetani; Francesco DiMeco; Aurelio Lorico; Giuliana Pelicci
Combined Blockade of Activating ERBB2 Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
Sarah Croessmann; Luigi Formisano; Lisa N. Kinch; Paula I. Gonzalez-Ericsson; Dhivya R. Sudhan; Rebecca J. Nagy; Aju Mathew; Eric H. Bernicker; Massimo Cristofanilli; Jie He; Richard E. Cutler, Jr; Alshad S. Lalani; Vincent A. Miller; Richard B. Lanman; Nick V. Grishin; Carlos L. Arteaga
Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy
Carmela Passaro; Quazim Alayo; Isabel DeLaura; John McNulty; Korneel Grauwet; Hirotaka Ito; Vivek Bhaskaran; Marco Mineo; Sean E. Lawler; Khalid Shah; Maria C. Speranza; William Goins; Eric McLaughlin; Soledad Fernandez; David A. Reardon; Gordon J. Freeman; E. Antonio Chiocca; Hiroshi Nakashima
Author Choice
The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies
Matthew C. Stubbs; Timothy C. Burn; Richard Sparks; Thomas Maduskuie; Sharon Diamond; Mark Rupar; Xiaoming Wen; Alla Volgina; Nina Zolotarjova; Paul Waeltz; Margaret Favata; Ravi Jalluri; Huiqing Liu; Xuesong Mike Liu; Jun Li; Robert Collins; Nikoo Falahatpisheh; Padmaja Polam; Darlise DiMatteo; Patricia Feldman; Valerie Dostalik; Pramod Thekkat; Christine Gardiner; Xin He; Yanlong Li; Maryanne Covington; Richard Wynn; Bruce Ruggeri; Swamy Yeleswaram; Chu-Biao Xue; Wenqing Yao; Andrew P. Combs; Reid Huber; Gregory Hollis; Peggy Scherle; Phillip C.C. Liu
Author Choice
NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263
Anahita Dastur; AHyun Choi; Carlotta Costa; Xunqin Yin; August Williams; Joseph McClanaghan; Max Greenberg; Justine Roderick; Neha U. Patel; Jessica Boisvert; Ultan McDermott; Mathew J. Garnett; Jorge Almenara; Steven Grant; Kathryn Rizzo; Jeffrey A. Engelman; Michelle Kelliher; Anthony C. Faber; Cyril H. Benes
Activated Natural Killer Cells in Combination with Anti-GD2 Antibody Dinutuximab Improve Survival of Mice after Surgical Resection of Primary Neuroblastoma
Wesley E. Barry; Jeremy R. Jackson; Grace E. Asuelime; Hong-Wei Wu; Jianping Sun; Zesheng Wan; Jemily Malvar; Michael A. Sheard; Larry Wang; Robert C. Seeger; Eugene S. Kim
PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma
Frederik Holst; Henrica M.J. Werner; Siv Mjøs; Erling A. Hoivik; Kanthida Kusonmano; Elisabeth Wik; Anna Berg; Even Birkeland; William J. Gibson; Mari K. Halle; Jone Trovik; Andrew D. Cherniack; Karl-Henning Kalland; Gordon B. Mills; Christian F. Singer; Camilla Krakstad; Rameen Beroukhim; Helga B. Salvesen
Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers
Carl M. Gay; Pan Tong; Robert J. Cardnell; Triparna Sen; Xiao Su; Jun Ma; Rasha O. Bara; Faye M. Johnson; Chris Wakefield; John V. Heymach; Jing Wang; Lauren A. Byers
Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts
Carter M. Suryadevara; Rupen Desai; S. Harrison Farber; Bryan D. Choi; Adam M. Swartz; Steven H. Shen; Patrick C. Gedeon; David J. Snyder; James E. Herndon, II; Patrick Healy; Elizabeth A. Reap; Gary E. Archer; Peter E. Fecci; John H. Sampson; Luis Sanchez-Perez
Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia
Na Li; Michael A. Lopez; Maria Linares; Subodh Kumar; Stefania Oliva; Joaquin Martinez-Lopez; Lian Xu; Yan Xu; Tommaso Perini; William Senapedis; Erkan Baloglu; Masood A. Shammas; Zachary Hunter; Kenneth C. Anderson; Steven P. Treon; Nikhil C. Munshi; Mariateresa Fulciniti
Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers
Kazuhito Sato; Masahito Kawazu; Yoko Yamamoto; Toshihide Ueno; Shinya Kojima; Genta Nagae; Hiroyuki Abe; Manabu Soda; Takafumi Oga; Shinji Kohsaka; Eirin Sai; Yoshihiro Yamashita; Hisae Iinuma; Masashi Fukayama; Hiroyuki Aburatani; Toshiaki Watanabe; Hiroyuki Mano
CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
Carolina Rubio; Mónica Martínez-Fernández; Cristina Segovia; Iris Lodewijk; Cristian Suarez-Cabrera; Carmen Segrelles; Fernando López-Calderón; Ester Munera-Maravilla; Mirentxu Santos; Alejandra Bernardini; Ramón García-Escudero; Corina Lorz; Maria José Gómez-Rodriguez; Guillermo de Velasco; Irene Otero; Felipe Villacampa; Felix Guerrero-Ramos; Sergio Ruiz; Federico de la Rosa; Sara Domínguez-Rodríguez; Francisco X. Real; Núria Malats; Daniel Castellano; Marta Dueñas; Jesus M. Paramio
Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma
Xinhua Song; Xianqiong Liu; Haichuan Wang; Jingxiao Wang; Yu Qiao; Antonio Cigliano; Kirsten Utpatel; Silvia Ribback; Maria G. Pilo; Marina Serra; John D. Gordan; Li Che; Shanshan Zhang; Antonio Cossu; Alberto Porcu; Rosa M. Pascale; Frank Dombrowski; Hongbo Hu; Diego F. Calvisi; Matthias Evert; Xin Chen
Author Choice
Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer
Elahe A. Mostaghel; Ailin Zhang; Susana Hernandez; Brett T. Marck; Xiaotun Zhang; Daniel Tamae; Heather E. Biehl; Maria Tretiakova; Jon Bartlett; John Burns; Ruth Dumpit; Lisa Ang; Alvin M. Matsumoto; Trevor M. Penning; Steven P. Balk; Colm Morrissey; Eva Corey; Lawrence D. True; Peter S. Nelson
Acknowledgment to Reviewers
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