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1 May 2018
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Cover Image
Cover Image
The cover shows a tissue section of a colorectal cancer patient-derived tumor xenograft that was treated with 5-fluorouracil chemotherapy. Immunofluorescence staining has been performed using an antibody to pimonidazole (shown in green), which accumulates in hypoxic cells, and DAPI counterstain (blue) to show cell nuclei. For details, see the article by Haynes and colleagues on page 2116 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Perspective
Cancer Therapy: Clinical
Author Choice
A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA-Mutated Breast and Gynecologic Cancers
Udai Banerji; Emma J. Dean; J. Alejandro Pérez-Fidalgo; Gerald Batist; Philippe L. Bedard; Benoit You; Shannon N. Westin; Peter Kabos; Michelle D. Garrett; Mathew Tall; Helen Ambrose; J. Carl Barrett; T. Hedley Carr; S.Y. Amy Cheung; Claire Corcoran; Marie Cullberg; Barry R. Davies; Elza C. de Bruin; Paul Elvin; Andrew Foxley; Peter Lawrence; Justin P.O. Lindemann; Rhiannon Maudsley; Martin Pass; Vicky Rowlands; Paul Rugman; Gaia Schiavon; James Yates; Jan H.M. Schellens
A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia
Timothy S. Pardee; Rebecca G. Anderson; Kristin M. Pladna; Scott Isom; Lais P. Ghiraldeli; Lance D. Miller; Jeff W. Chou; Guangxu Jin; Wei Zhang; Leslie R. Ellis; Dmitriy Berenzon; Dianna S. Howard; David D. Hurd; Megan Manuel; Sarah Dralle; Susan Lyerly; Bayard L. Powell
Author Choice
Adjuvant Transarterial Chemoembolization for HBV-Related Hepatocellular Carcinoma After Resection: A Randomized Controlled Study
Zheng Wang; Zhenggang Ren; Yi Chen; Jie Hu; Guohuan Yang; Lei Yu; Xinrong Yang; Ao Huang; Xin Zhang; Shaolai Zhou; Huichuan Sun; Yanhong Wang; Ningling Ge; Xiaoyu Xu; Zhaoyou Tang; Wanyee Lau; Jia Fan; Jiping Wang; Jian Zhou
Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma
Johanna Bendell; Valerie Andre; Alan Ho; Ragini Kudchadkar; Michael Migden; Jeffrey Infante; Ramon V. Tiu; Celine Pitou; Trevor Tucker; Les Brail; Daniel Von Hoff
Personalized Medicine and Imaging
Author Choice
Prediction of Chemotherapeutic Efficacy in Non–Small Cell Lung Cancer by Serum Metabolomic Profiling
Yanhua Tian; Zhijie Wang; Xiaohui Liu; Jianchun Duan; Guoshuang Feng; Yuxin Yin; Jin Gu; Zhaoli Chen; Shugeng Gao; Hua Bai; Rui Wan; Jun Jiang; Jia Liu; Cong Zhang; Di Wang; Jiefei Han; Xue Zhang; Liangliang Cai; Jie He; Jie Wang
Cancer Therapy: Preclinical
Author Choice
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer
Jennifer Haynes; Trevor D. McKee; Andrew Haller; Yadong Wang; Cherry Leung; Deena M.A. Gendoo; Evelyne Lima-Fernandes; Antonija Kreso; Robin Wolman; Eva Szentgyorgyi; Douglass C. Vines; Benjamin Haibe-Kains; Bradly G. Wouters; Ur Metser; David A. Jaffray; Myles Smith; Catherine A. O'Brien
Author Choice
Mechanistic Exploration of Cancer Stem Cell Marker Voltage-Dependent Calcium Channel α2δ1 Subunit-mediated Chemotherapy Resistance in Small-Cell Lung Cancer
Jiangyong Yu; Shuhang Wang; Wei Zhao; Jianchun Duan; Zhijie Wang; Hanxiao Chen; Yanhua Tian; Di Wang; Jun Zhao; Tongtong An; Hua Bai; Meina Wu; Jie Wang
Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models
Mari Kogiso; Lin Qi; Frank K. Braun; Sarah G. Injac; Linna Zhang; Yuchen Du; Huiyuan Zhang; Frank Y. Lin; Sibo Zhao; Holly Lindsay; Jack M. Su; Patricia A. Baxter; Adekunle M. Adesina; Debra Liao; Mark G. Qian; Stacey Berg; Jodi A. Muscal; Xiao-Nan Li
Targeting Tumor Vasculature with TNF Leads Effector T Cells to the Tumor and Enhances Therapeutic Efficacy of Immune Checkpoint Blockers in Combination with Adoptive Cell Therapy
Angela Rita Elia; Matteo Grioni; Veronica Basso; Flavio Curnis; Massimo Freschi; Angelo Corti; Anna Mondino; Matteo Bellone
Biology of Human Tumors
Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women
Megan A. Clarke; Ana Gradissimo; Mark Schiffman; Jessica Lam; Christopher C. Sollecito; Barbara Fetterman; Thomas Lorey; Nancy Poitras; Tina R. Raine-Bennett; Philip E. Castle; Nicolas Wentzensen; Robert D. Burk
Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma
Wei Guo; Yun-Fan Sun; Min-Na Shen; Xiao-Lu Ma; Jiong Wu; Chun-Yan Zhang; Yan Zhou; Yang Xu; Bo Hu; Min Zhang; Gang Wang; Wei-Qin Chen; Lin Guo; Ren-Quan Lu; Chao-Hui Zhou; Xin Zhang; Ying-Hong Shi; Shuang-jian Qiu; Bai-shen Pan; Ya Cao; Jian Zhou; Xin-Rong Yang; Jia Fan
Correction
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