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15 April 2018
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The cover shows a mixed urothelial and small cell carcinoma from a single patient. Deep sequencing of macrodissected urothelial and small-cell components revealed truncal mutations clonal in both components, indicating a common ancestral origin. Other driver mutations were clonal exclusively in one component. For details, see the article by Chang and colleagues on page 1965 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
Editorial
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Use of PRO Measures to Inform Tolerability in Oncology Trials: Implications for Clinical Review, IND Safety Reporting, and Clinical Site Inspections
Janice Kim; Harpreet Singh; Kassa Ayalew; Kristina Borror; Michelle Campbell; Laura Lee Johnson; Alyson Karesh; Ni A. Khin; Joanne R. Less; Jerry Menikoff; Lori Minasian; Sandra A. Mitchell; Elektra J. Papadopoulos; Richard L. Piekarz; Kevin A. Prohaska; Susan Thompson; Rajeshwari Sridhara; Richard Pazdur; Paul G. Kluetz
Review
Perspectives
Cancer Therapy: Clinical
Pembrolizumab Plus Pegylated Interferon alfa-2b or Ipilimumab for Advanced Melanoma or Renal Cell Carcinoma: Dose-Finding Results from the Phase Ib KEYNOTE-029 Study
Michael B. Atkins; F. Stephen Hodi; John A. Thompson; David F. McDermott; Wen-Jen Hwu; Donald P. Lawrence; Nancy A. Dawson; Deborah J. Wong; Shailender Bhatia; Marihella James; Lokesh Jain; Seth Robey; Xinxin Shu; Blanca Homet Moreno; Rodolfo F. Perini; Toni K. Choueiri; Antoni Ribas
Author Choice
Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer
Neil H. Segal; Aiwu R. He; Toshihiko Doi; Ronald Levy; Shailender Bhatia; Michael J. Pishvaian; Rossano Cesari; Ying Chen; Craig B. Davis; Bo Huang; Aron D. Thall; Ajay K. Gopal
Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials
Yu-Pei Chen; Ling-Long Tang; Qi Yang; Sharon-Shuxian Poh; Edwin P. Hui; Anthony T.C. Chan; Whee-Sze Ong; Terence Tan; Joseph Wee; Wen-Fei Li; Lei Chen; Brigette B.Y. Ma; Macy Tong; Sze-Huey Tan; Shie-Lee Cheah; Kam-Weng Fong; Kiattisa Sommat; Yoke Lim Soong; Ying Guo; Ai-Hua Lin; Ying Sun; Ming-Huang Hong; Su-Mei Cao; Ming-Yuan Chen; Jun Ma
Author Choice
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Andreas T. Björklund; Mattias Carlsten; Ebba Sohlberg; Lisa L. Liu; Trevor Clancy; Mohsen Karimi; Sarah Cooley; Jeffrey S. Miller; Monika Klimkowska; Marie Schaffer; Emma Watz; Kristina Wikström; Pontus Blomberg; Björn Engelbrekt Wahlin; Marzia Palma; Lotta Hansson; Per Ljungman; Eva Hellström-Lindberg; Hans-Gustaf Ljunggren; Karl-Johan Malmberg
Pathological Response in a Triple-Negative Breast Cancer Cohort Treated with Neoadjuvant Carboplatin and Docetaxel According to Lehmann's Refined Classification
Isabel Echavarria; Sara López-Tarruella; Antoni Picornell; Jose Ángel García-Saenz; Yolanda Jerez; Katherine Hoadley; Henry L. Gómez; Fernando Moreno; María Del Monte-Millan; Iván Márquez-Rodas; Enrique Alvarez; Rocío Ramos-Medina; Javier Gayarre; Tatiana Massarrah; Inmaculada Ocaña; María Cebollero; Hugo Fuentes; Agusti Barnadas; Ana Isabel Ballesteros; Uriel Bohn; Charles M. Perou; Miguel Martin
Personalized Medicine and Imaging
Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients
Britt I. Drögemöller; Beth Brooks; Carol Critchley; José G. Monzon; Galen E.B. Wright; Geoffrey Liu; Daniel J. Renouf; Christian K. Kollmannsberger; Philippe L. Bedard; Michael R. Hayden; Karen A. Gelmon; Bruce C. Carleton; Colin J.D. Ross
Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA
Sarah B. Goldberg; Azeet Narayan; Adam J. Kole; Roy H. Decker; Jimmitti Teysir; Nicholas J. Carriero; Angela Lee; Roxanne Nemati; Sameer K. Nath; Shrikant M. Mane; Yanhong Deng; Nitin Sukumar; Daniel Zelterman; Daniel J. Boffa; Katerina Politi; Scott N. Gettinger; Lynn D. Wilson; Roy S. Herbst; Abhijit A. Patel
Author Choice
Hybrid Capture–Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus
Alexa B. Schrock; Dean Pavlick; Samuel J. Klempner; Jon H. Chung; Brady Forcier; Allison Welsh; Lauren Young; Bryan Leyland-Jones; Rodolfo Bordoni; Richard D. Carvajal; Joseph Chao; Razelle Kurzrock; Jason K. Sicklick; Jeffrey S. Ross; Philip J. Stephens; Craig Devoe; Fadi Braiteh; Siraj M. Ali; Vincent A. Miller
Cancer Therapy: Preclinical
Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function
Andrew Stiff; Prashant Trikha; Bethany Mundy-Bosse; Elizabeth McMichael; Thomas A. Mace; Brooke Benner; Kari Kendra; Amanda Campbell; Shalini Gautam; David Abood; Ian Landi; Vincent Hsu; Megan Duggan; Robert Wesolowski; Matthew Old; John Harrison Howard; Lianbo Yu; Nancy Stasik; Thomas Olencki; Natarajan Muthusamy; Susheela Tridandapani; John C. Byrd; Michael Caligiuri; William E. Carson
Author Choice
STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair
Cristina Maranto; Vindhya Udhane; David T. Hoang; Lei Gu; Vitali Alexeev; Kareem Malas; Karmel Cardenas; Jonathan R. Brody; Ulrich Rodeck; Carmen Bergom; Ken A. Iczkowski; Ken Jacobsohn; William See; Sara M. Schmitt; Marja T. Nevalainen
Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition
Jessica D. Lang; William P.D. Hendricks; Krystal A. Orlando; Hongwei Yin; Jeffrey Kiefer; Pilar Ramos; Ritin Sharma; Patrick Pirrotte; Elizabeth A. Raupach; Chris Sereduk; Nanyun Tang; Winnie S. Liang; Megan Washington; Salvatore J. Facista; Victoria L. Zismann; Emily M. Cousins; Michael B. Major; Yemin Wang; Anthony N. Karnezis; Aleksandar Sekulic; Ralf Hass; Barbara C. Vanderhyden; Praveen Nair; Bernard E. Weissman; David G. Huntsman; Jeffrey M. Trent
Biology of Human Tumors
Author Choice
Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis
Matthew T. Chang; Alexander Penson; Neil B. Desai; Nicholas D. Socci; Ronglai Shen; Venkatraman E. Seshan; Ritika Kundra; Adam Abeshouse; Agnes Viale; Eugene K. Cha; Xueli Hao; Victor E. Reuter; Charles M. Rudin; Bernard H. Bochner; Jonathan E. Rosenberg; Dean F. Bajorin; Nikolaus Schultz; Michael F. Berger; Gopa Iyer; David B. Solit; Hikmat A. Al-Ahmadie; Barry S. Taylor
Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer
Rasmi R. Mishra; Nevin Belder; Suhail A. Ansari; Merve Kayhan; Hilal Bal; Umar Raza; Pelin G. Ersan; Ünal M. Tokat; Erol Eyüpoğlu; Özge Saatci; Pouria Jandaghi; Stefan Wiemann; Ayşegül Üner; Caglar Cekic; Yasser Riazalhosseini; Özgür Şahin
REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer
Qingwei Wang; Xiao Gao; Tong Yu; Lei Yuan; Jie Dai; Weicang Wang; Geng Chen; Chan Jiao; Wang Zhou; Quan Huang; Long Cui; Pei Zhang; Robb E. Moses; Jianhua Yang; Fengyuan Chen; Junjiang Fu; Jianru Xiao; Lei Li; Yongyan Dang; Xiaotao Li
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