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1 April 2018
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Cover Image
Cover Image
The cover depicts multiplexed immunofluorescence showing expression of VISTA (red channel) in cytokeratin-positive lung squamous carcinoma cells (green channel) and in cytokeratin-negative stromal cells. Nuclei are highlighted with 4′,6-diamidino-2-phenylindole (DAPI, blue channel). For details, see the article by Villarroel-Espindola and colleagues on page 1562 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Cancer Therapy: Clinical
A First-in-Human Phase I Study of Subcutaneous Outpatient Recombinant Human IL15 (rhIL15) in Adults with Advanced Solid Tumors
Jeffrey S. Miller; Chihiro Morishima; Douglas G. McNeel; Manish R. Patel; Holbrook E.K. Kohrt; John A. Thompson; Paul M. Sondel; Heather A. Wakelee; Mary L. Disis; Judith C. Kaiser; Martin A. Cheever; Howard Streicher; Steven P. Creekmore; Thomas A. Waldmann; Kevin C. Conlon
First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors
Manuel Hidalgo; Maria Martinez-Garcia; Christophe Le Tourneau; Christophe Massard; Elena Garralda; Valentina Boni; Alvaro Taus; Joan Albanell; Marie-Paule Sablin; Marie Alt; Ratislav Bahleda; Andrea Varga; Christophe Boetsch; Izolda Franjkovic; Florian Heil; Angelika Lahr; Katharina Lechner; Anthony Morel; Tapan Nayak; Simona Rossomanno; Kevin Smart; Kay Stubenrauch; Oliver Krieter
Author Choice
Genomic Correlates of Response to Everolimus in Aggressive Radioiodine-refractory Thyroid Cancer: A Phase II Study
Glenn J. Hanna; Naifa L. Busaidy; Nicole G. Chau; Lori J. Wirth; Justine A. Barletta; Antonio Calles; Robert I. Haddad; Stefan Kraft; Maria E. Cabanillas; Guilherme Rabinowits; Anne O'Neill; Sewanti A. Limaye; Erik K. Alexander; Francis D. Moore, Jr; Krystof Misiwkeiwicz; Tom Thomas; Matthew Nehs; Ellen Marqusee; Stephanie L. Lee; Pasi A. Jänne; Jochen H. Lorch
Immune Biomarkers Predictive for Disease-Free Survival with Adjuvant Sunitinib in High-Risk Locoregional Renal Cell Carcinoma: From Randomized Phase III S-TRAC Study
Daniel J. George; Jean-François Martini; Michael Staehler; Robert J. Motzer; Ahmed Magheli; Bernard Escudier; Paola Gerletti; Sherry Li; Michelle Casey; Brigitte Laguerre; Hardev S. Pandha; Allan J. Pantuck; Anup Patel; Maria J. Lechuga; Alain Ravaud
Personalized Medicine and Imaging
Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non–Small Cell Lung Cancer
Franz Villarroel-Espindola; Xiaoqing Yu; Ila Datar; Nikita Mani; Miguel Sanmamed; Vamsidhar Velcheti; Konstantinos Syrigos; Maria Toki; Hongyu Zhao; Lieping Chen; Roy S. Herbst; Kurt A. Schalper
Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Kim E.M. van Kessel; Kirstin A. van der Keur; Lars Dyrskjøt; Ferran Algaba; Naeromy Y.C. Welvaart; Willemien Beukers; Ulrika Segersten; Bastian Keck; Tobias Maurer; Tatjana Simic; Marcus Horstmann; Marc-Oliver Grimm; Gregers G. Hermann; Karin Mogensen; Arndt Hartmann; Niels Harving; Astrid C. Petersen; Jørgen B. Jensen; Kerstin Junker; Joost L. Boormans; Francisco X. Real; Núria Malats; Per-Uno Malmström; Torben F. Ørntoft; Ellen C. Zwarthoff
High Yield of Pathogenic Germline Mutations Causative or Likely Causative of the Cancer Phenotype in Selected Children with Cancer
Illja J. Diets; Esmé Waanders; Marjolijn J. Ligtenberg; Diede A.G. van Bladel; Eveline J. Kamping; Peter M. Hoogerbrugge; Saskia Hopman; Maran J. Olderode-Berends; Erica H. Gerkes; David A. Koolen; Carlo Marcelis; Gijs W. Santen; Martine J. van Belzen; Dylan Mordaunt; Lesley McGregor; Elizabeth Thompson; Antonis Kattamis; Agata Pastorczak; Wojciech Mlynarski; Denisa Ilencikova; Anneke Vulto- van Silfhout; Thatjana Gardeitchik; Eveline S. de Bont; Jan Loeffen; Anja Wagner; Arjen R. Mensenkamp; Roland P. Kuiper; Nicoline Hoogerbrugge; Marjolijn C. Jongmans
Cancer Therapy: Preclinical
Flt-3L Expansion of Recipient CD8α+ Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD
Kate A. Markey; Rachel D. Kuns; Daniel J. Browne; Kate H. Gartlan; Renee J. Robb; J. Paulo Martins; Andrea S. Henden; Simone A. Minnie; Melody Cheong; Motoko Koyama; Mark J. Smyth; Raymond J. Steptoe; Gabrielle T. Belz; Thomas Brocker; Mariapia A. Degli-Esposti; Steven W. Lane; Geoffrey R. Hill
Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer
Tamara Muliaditan; James W. Opzoomer; Jonathan Caron; Mary Okesola; Paris Kosti; Sharanpreet Lall; Mieke Van Hemelrijck; Francesco Dazzi; Andrew Tutt; Anita Grigoriadis; Cheryl E. Gillett; Stephen F. Madden; Joy M. Burchell; Shahram Kordasti; Sandra S. Diebold; James F. Spicer; James N. Arnold
RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells
Xiaosong Yang; You Pan; Zhaojun Qiu; Zhanwen Du; Yao Zhang; Pengyan Fa; Shashank Gorityala; Shanhuai Ma; Shunqiang Li; Ceshi Chen; Hongbing Wang; Yan Xu; Chunhong Yan; Keri Ruth; Zhefu Ma; Junran Zhang
Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury
Chontida Yarana; Dustin Carroll; Jing Chen; Luksana Chaiswing; Yanming Zhao; Teresa Noel; Michael Alstott; Younsoo Bae; Emily V. Dressler; Jeffrey A. Moscow; D. Allan Butterfield; Haining Zhu; Daret K. St. Clair
Establishing a Preclinical Multidisciplinary Board for Brain Tumors
Birgit V. Nimmervoll; Nidal Boulos; Brandon Bianski; Jason Dapper; Michael DeCuypere; Anang Shelat; Sabrina Terranova; Hope E. Terhune; Amar Gajjar; Yogesh T. Patel; Burgess B. Freeman; Arzu Onar-Thomas; Clinton F. Stewart; Martine F. Roussel; R. Kipling Guy; Thomas E. Merchant; Christopher Calabrese; Karen D. Wright; Richard J. Gilbertson
Development and Preclinical Validation of a Cysteine Knottin Peptide Targeting Integrin αvβ6 for Near-infrared Fluorescent-guided Surgery in Pancreatic Cancer
Willemieke S. Tummers; Richard H. Kimura; Lotfi Abou-Elkacem; C. Beinat; Alexander L. Vahrmeijer; Rutger-Jan Swijnenburg; Juergen K. Willmann; Sanjiv S. Gambhir
Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2α-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression
Ki Cheong Park; Seung Won Kim; Jeong Yong Jeon; A. Ra Jo; Hye Ji Choi; Jungmin Kim; Hyun Gyu Lee; Yonjung Kim; Gordon B. Mills; Sung Hoon Noh; Min Goo Lee; Eun Sung Park; Jae-Ho Cheong
Biology of Human Tumors
Author Choice
IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors
Remco J. Molenaar; Tomas Radivoyevitch; Yasunobu Nagata; Mohammed Khurshed; Bartolomiej Przychodzen; Hideki Makishima; Mingjiang Xu; Fonnet E. Bleeker; Johanna W. Wilmink; Hetty E. Carraway; Sudipto Mukherjee; Mikkael A. Sekeres; Cornelis J.F. van Noorden; Jaroslaw P. Maciejewski
Author Choice
Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients
Philipp A. Greif; Luise Hartmann; Sebastian Vosberg; Sophie M. Stief; Raphael Mattes; Ines Hellmann; Klaus H. Metzeler; Tobias Herold; Stefanos A. Bamopoulos; Paul Kerbs; Vindi Jurinovic; Daniela Schumacher; Friederike Pastore; Kathrin Bräundl; Evelyn Zellmeier; Bianka Ksienzyk; Nikola P. Konstandin; Stephanie Schneider; Alexander Graf; Stefan Krebs; Helmut Blum; Martin Neumann; Claudia D. Baldus; Stefan K. Bohlander; Stephan Wolf; Dennis Görlich; Wolfgang E. Berdel; Bernhard J. Wörmann; Wolfgang Hiddemann; Karsten Spiekermann
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