Skip to Main Content

Advertisement

Umbrella Alt Text
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 24, Issue 6
15 March 2018
Issue Cover
All Issues
  • Cover Image

    Cover Image

    issue cover
    The cover shows a section of a normal cerebellar lobe (left) and adjacent medulloblastoma tissue (right) in a mouse brain. Immunohistochemical staining shows that tumor cells highly express SREBP2 (sterol regulatory element-binding protein 2), a protein involved in the regulation of cholesterol homeostasis. For details, see the article by Gordon and colleagues on page 1375 of this issue.
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
Open the PDF for in another window

CCR Translations

RASA1/NF1-Mutant Lung Cancer: Racing to the Clinic?
Shunsuke Kitajima; David A. Barbie
View articletitled, <em>RASA1</em>/<em>NF1</em>-Mutant Lung Cancer: Racing to the Clinic?
Open the PDF for in another window
CART Targeting of Solid Tumors: More Pieces to the Puzzle
Michael Kalos
View articletitled, CART Targeting of Solid Tumors: More Pieces to the Puzzle
Open the PDF for in another window

Statistics in CCR

Author Choice
Deep Learning–Based Multi-Omics Integration Robustly Predicts Survival in Liver Cancer
Kumardeep Chaudhary; Olivier B. Poirion; Liangqun Lu; Lana X. Garmire
View articletitled, Deep Learning–Based Multi-Omics Integration Robustly Predicts Survival in Liver Cancer
Supplementary data
Open the PDF for in another window

Review

Primary and Acquired Resistance to Immune Checkpoint Inhibitors in Metastatic Melanoma
Tuba N. Gide; James S. Wilmott; Richard A. Scolyer; Georgina V. Long
View articletitled, Primary and Acquired Resistance to Immune Checkpoint Inhibitors in Metastatic Melanoma
Supplementary data
Open the PDF for in another window

Perspective

Beyond Concurrent Chemoradiation: The Emerging Role of PD-1/PD-L1 Inhibitors in Stage III Lung Cancer
Neal S. McCall; Adam P. Dicker; Bo Lu
View articletitled, Beyond Concurrent Chemoradiation: The Emerging Role of PD-1/PD-L1 Inhibitors in Stage III Lung Cancer
Open the PDF for in another window

Cancer Therapy: Clinical

Phase I Study of Chimeric Antigen Receptor–Modified T Cells in Patients with EGFR-Positive Advanced Biliary Tract Cancers
Yelei Guo; Kaichao Feng; Yang Liu; Zhiqiang Wu; Hanren Dai; Qingming Yang; Yao Wang; Hejin Jia; Weidong Han
View articletitled, Phase I Study of Chimeric Antigen Receptor–Modified T Cells in Patients with EGFR-Positive Advanced Biliary Tract Cancers
Supplementary data
Open the PDF for in another window
Author Choice
Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
Julius Strauss; Christopher R. Heery; Jeffrey Schlom; Ravi A. Madan; Liang Cao; Zhigang Kang; Elizabeth Lamping; Jennifer L. Marté; Renee N. Donahue; Italia Grenga; Lisa Cordes; Olaf Christensen; Lisa Mahnke; Christoph Helwig; James L. Gulley
View articletitled, Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
Supplementary data
Open the PDF for in another window
Safety, Activity, and Biomarkers of SHR-1210, an Anti-PD-1 Antibody, for Patients with Advanced Esophageal Carcinoma
Jing Huang; Binghe Xu; Hongnan Mo; Weilong Zhang; Xuelian Chen; Dawei Wu; Dong Qu; Xingyuan Wang; Bo Lan; Beibei Yang; Pei Wang; Hongtu Zhang; Qing Yang; Yuchen Jiao
View articletitled, Safety, Activity, and Biomarkers of SHR-1210, an Anti-PD-1 Antibody, for Patients with Advanced Esophageal Carcinoma
Supplementary data
Open the PDF for in another window
Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Anna E. Coghill; Ruth M. Pfeiffer; Carla Proietti; Wan-Lun Hsu; Yin-Chu Chien; Lea Lekieffre; Lutz Krause; Andy Teng; Jocelyn Pablo; Kelly J. Yu, PhD; Pei-Jen Lou, MD; Cheng-Ping Wang; Zhiwei Liu; Chien-Jen Chen; Jaap Middeldorp; Jason Mulvenna; Jeff Bethony; Allan Hildesheim; Denise L. Doolan
View articletitled, Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Supplementary data
Open the PDF for in another window
p53-Reactive T Cells Are Associated with Clinical Benefit in Patients with Platinum-Resistant Epithelial Ovarian Cancer After Treatment with a p53 Vaccine and Gemcitabine Chemotherapy
Nicola R. Hardwick; Paul Frankel; Christopher Ruel; Julie Kilpatrick; Weimin Tsai; Ferdynand Kos; Teodora Kaltcheva; Lucille Leong; Robert Morgan; Vincent Chung; Raechelle Tinsley; Melissa Eng; Sharon Wilczynski; Joshua D.I. Ellenhorn; Don J. Diamond; Mihaela Cristea
View articletitled, p53-Reactive T Cells Are Associated with Clinical Benefit in Patients with Platinum-Resistant Epithelial Ovarian Cancer After Treatment with a p53 Vaccine and Gemcitabine Chemotherapy
Supplementary data
Open the PDF for in another window
Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
Zishuo I. Hu; Jinru Shia; Zsofia K. Stadler; Anna M. Varghese; Marinela Capanu; Erin Salo-Mullen; Maeve A. Lowery; Luis A. Diaz, Jr; Diana Mandelker; Kenneth H. Yu; Alice Zervoudakis; David P. Kelsen; Christine A. Iacobuzio-Donahue; David S. Klimstra; Leonard B. Saltz; Ibrahim H. Sahin; Eileen M. O'Reilly
View articletitled, Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
Open the PDF for in another window

Personalized Medicine and Imaging

Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients
Dennis Plenker; Miriam Bertrand; Adrianus J. de Langen; Richard Riedel; Carina Lorenz; Andreas H. Scheel; Judith Müller; Johannes Brägelmann; Juliane Daßler-Plenker; Carsten Kobe; Thorsten Persigehl; Alexander Kluge; Thomas Wurdinger; Pepijn Schellen; Gunther Hartmann; Tobias Zacherle; Roopika Menon; Erik Thunnissen; Reinhard Büttner; Frank Griesinger; Jürgen Wolf; Lukas Heukamp; Martin L. Sos; Johannes M. Heuckmann
View articletitled, Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients
Supplementary data
Open the PDF for in another window
Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
Kyaw L. Aung; Sandra E. Fischer; Robert E. Denroche; Gun-Ho Jang; Anna Dodd; Sean Creighton; Bernadette Southwood; Sheng-Ben Liang; Dianne Chadwick; Amy Zhang; Grainne M. O'Kane; Hamzeh Albaba; Shari Moura; Robert C. Grant; Jessica K. Miller; Faridah Mbabaali; Danielle Pasternack; Ilinca M. Lungu; John M.S. Bartlett; Sangeet Ghai; Mathieu Lemire; Spring Holter; Ashton A. Connor; Richard A. Moffitt; Jen Jen Yeh; Lee Timms; Paul M. Krzyzanowski; Neesha Dhani; David Hedley; Faiyaz Notta; Julie M. Wilson; Malcolm J. Moore; Steven Gallinger; Jennifer J. Knox
View articletitled, Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
Supplementary data
Open the PDF for in another window
A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma
Soledad Gómez; Alícia Garrido-Garcia; Laura Garcia-Gerique; Isadora Lemos; Mariona Suñol; Carmen de Torres; Marta Kulis; Sara Pérez-Jaume; Ángel M. Carcaboso; Betty Luu; Mark W. Kieran; Nada Jabado; Alexey Kozlenkov; Stella Dracheva; Vijay Ramaswamy; Volker Hovestadt; Pascal Johann; David T.W. Jones; Stefan M. Pfister; Andrés Morales La Madrid; Ofelia Cruz; Michael D. Taylor; Jose-Ignacio Martin-Subero; Jaume Mora; Cinzia Lavarino
View articletitled, A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma
Supplementary data
Open the PDF for in another window
Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy
Stefan Schmidt; Annett Linge; Alex Zwanenburg; Stefan Leger; Fabian Lohaus; Constanze Krenn; Steffen Appold; Volker Gudziol; Alexander Nowak; Cläre von Neubeck; Inge Tinhofer; Volker Budach; Ali Sak; Martin Stuschke; Panagiotis Balermpas; Claus Rödel; Hatice Bunea; Anca-Ligia Grosu; Amir Abdollahi; Jürgen Debus; Ute Ganswindt; Claus Belka; Steffi Pigorsch; Stephanie E. Combs; David Mönnich; Daniel Zips; Gustavo B. Baretton; Frank Buchholz; Michael Baumann; Mechthild Krause; Steffen Löck; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG; for the DKTK-ROG
View articletitled, Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy
Supplementary data
Open the PDF for in another window

Cancer Therapy: Preclinical

Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Renata E. Gordon; Li Zhang; Suraj Peri; Yin-Ming Kuo; Fang Du; Brian L. Egleston; Jessica M. Y. Ng; Andrew J. Andrews; Igor Astsaturov; Tom Curran; Zeng-Jie Yang
View articletitled, Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Supplementary data
Open the PDF for in another window
Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer
Douglass W. Tucker; Christopher R. Getchell; Eric T. McCarthy; Anders W. Ohman; Naoko Sasamoto; Shuyun Xu; Joo Yeon Ko; Mamta Gupta; Amy Shafrir; Jamie E. Medina; Jonathan J. Lee; Lauren A. MacDonald; Ammara Malik; Kathleen T Hasselblatt; Wenjing Li; Hong Zhang; Samuel J. Kaplan; George F. Murphy; Michelle S. Hirsch; Joyce F. Liu; Ursula A. Matulonis; Kathryn L. Terry; Christine G. Lian; Daniela M. Dinulescu
View articletitled, Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer
Supplementary data
Open the PDF for in another window
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non–Small Cell Lung Cancer
Chellappagounder Thangavel; Ettickan Boopathi; Yi Liu; Christopher McNair; Alex Haber; Maryna Perepelyuk; Anshul Bhardwaj; Sankar Addya; Adam Ertel; Sunday Shoyele; Ruth Birbe; Joseph M. Salvino; Adam P. Dicker; Karen E. Knudsen; Robert B. Den
View articletitled, Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non–Small Cell Lung Cancer
Supplementary data
Open the PDF for in another window
CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer
Alex D. Michaels; Timothy E. Newhook; Sara J. Adair; Sho Morioka; Bernadette J. Goudreau; Sarbajeet Nagdas; Matthew G. Mullen; Jesse B. Persily; Timothy N. J. Bullock; Craig L. Slingluff, Jr; Kodi S. Ravichandran; J. Thomas Parsons; Todd W. Bauer
View articletitled, CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer
Supplementary data
Open the PDF for in another window

Biology of Human Tumors

Author Choice
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors
Sarah Croessmann; Jonathan H. Sheehan; Kyung-min Lee; Gregory Sliwoski; Jie He; Rebecca Nagy; David Riddle; Ingrid A. Mayer; Justin M. Balko; Richard Lanman; Vincent A. Miller; Lewis C. Cantley; Jens Meiler; Carlos L. Arteaga
View articletitled, <em>PIK3CA</em> C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3K<strong>α</strong> Inhibitors
Supplementary data
Open the PDF for in another window
RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non–Small Cell Lung Carcinomas Sensitive to MEK Inhibition
Takuo Hayashi; Patrice Desmeules; Roger S. Smith; Alexander Drilon; Romel Somwar; Marc Ladanyi
View articletitled, <em>RASA1</em> and <em>NF1</em> are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non–Small Cell Lung Carcinomas Sensitive to MEK Inhibition
Supplementary data
Open the PDF for in another window
Loss-of-Function Mutations in Calcitonin Receptor (CALCR) Identify Highly Aggressive Glioblastoma with Poor Outcome
Jagriti Pal; Vikas Patil; Anupam Kumar; Kavneet Kaur; Chitra Sarkar; Kumaravel Somasundaram
View articletitled, Loss-of-Function Mutations in Calcitonin Receptor (<em>CALCR</em>) Identify Highly Aggressive Glioblastoma with Poor Outcome
Supplementary data
Open the PDF for in another window
Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer
Liang Yu; Di Wu; Hugh Gao; Jesse J. Balic; Anna Tsykin; Tae-Su Han; You Dong Liu; Catherine L. Kennedy; Ji Kun Li; Jie Qi Mao; Patrick Tan; Masanobu Oshima; Gregory J. Goodall; Brendan J. Jenkins
View articletitled, Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer
Supplementary data
Open the PDF for in another window
RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Qian Liang; Dan Ma; Xiaoqiang Zhu; Zhenhua Wang; Tian-Tian Sun; Chaoqin Shen; Tingting Yan; Xianglong Tian; TaChung Yu; Fangfang Guo; JiaYin Tang; Yanwei Lin; Huimin Chen; Chao Zhou; Zhizheng Ge; Ming Zhong; Jinxian Chen; Qiang Liu; Zheng Wang; Jing-Yuan Fang; Haoyan Chen; Jie Hong
View articletitled, RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Supplementary data
Open the PDF for in another window
Expanded Genomic Profiling of Circulating Tumor Cells in Metastatic Breast Cancer Patients to Assess Biomarker Status and Biology Over Time (CALGB 40502 and CALGB 40503, Alliance)
Mark Jesus M. Magbanua; Hope S. Rugo; Denise M. Wolf; Louai Hauranieh; Ritu Roy; Praveen Pendyala; Eduardo V. Sosa; Janet H. Scott; Jin Sun Lee; Brandelyn Pitcher; Terry Hyslop; William T. Barry; Steven J. Isakoff; Maura Dickler; Laura van't Veer; John W. Park
View articletitled, Expanded Genomic Profiling of Circulating Tumor Cells in Metastatic Breast Cancer Patients to Assess Biomarker Status and Biology Over Time (CALGB 40502 and CALGB 40503, Alliance)
Supplementary data
Open the PDF for in another window
ESR1 Methylation: A Liquid Biopsy–Based Epigenetic Assay for the Follow-up of Patients with Metastatic Breast Cancer Receiving Endocrine Treatment
Sophia Mastoraki; Areti Strati; Eleni Tzanikou; Maria Chimonidou; Eleni Politaki; Alexandra Voutsina; Amanda Psyrri; Vassilis Georgoulias; Evi Lianidou
View articletitled, <em>ESR1</em> Methylation: A Liquid Biopsy–Based Epigenetic Assay for the Follow-up of Patients with Metastatic Breast Cancer Receiving Endocrine Treatment
Supplementary data
Open the PDF for in another window

Advertisement

Breaking
Breast Cancer Incidence Up by Half in AAPI Women
Genentech Buys Regor’s CDK Inhibitors for $850 Million
Massive Lawsuit Against BMS Dismissed
View more recent articles
Latest News
MicroRNAs, Focus of Nobel Prize, Highlight Untapped Potential
COVID-19 Vaccines Linked to Improved Survival in ICI-Treated Cancers
Immigration Systems Hampering Global Research
View more recent articles
Research Watch
Type 2 Immune Factors Enhance T Cell–Driven Antitumor Immune Responses
Pan-KRAS Degraders Effectively Target KRAS-Mutant Cancers
Coagulation Factor X Directly Fuels the Growth of Prostate Cancer
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

AACR Journals

 

 

  • Copyright © 2023 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept