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15 February 2018
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The cover shows a branched blood vessel in a tissue section from a patient with glioblastoma. Immunohistochemical staining reveals accumulation of the matrix protein fibulin-3, forming long perivascular fibers. For details, see the article by Nandhu and colleagues on page 821 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in CCR
Review
Author Choice
Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE
Brian M. Alexander; Sujuan Ba; Mitchel S. Berger; Donald A. Berry; Webster K. Cavenee; Susan M. Chang; Timothy F. Cloughesy; Tao Jiang; Mustafa Khasraw; Wenbin Li; Robert Mittman; George H. Poste; Patrick Y. Wen; W.K. Alfred Yung; Anna D. Barker; on behalf of the GBM AGILE Network
Cancer Therapy: Clinical
A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors
Andrea E. Wahner Hendrickson; Michael E. Menefee; Lynn C. Hartmann; Harry J. Long; Donald W. Northfelt; Joel M. Reid; Felix Boakye-Agyeman; Olumide Kayode; Karen S. Flatten; Maria I. Harrell; Elizabeth M. Swisher; Guy G. Poirier; Daniel Satele; Jake Allred; Janet L. Lensing; Alice Chen; Jiuping Ji; Yiping Zang; Charles Erlichman; Paul Haluska; Scott H. Kaufmann
Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib
Ira L. Kraft; Srivandana Akshintala; Yuelin Zhu; Haiyan Lei; Claudia Derse-Anthony; Eva Dombi; Seth M. Steinberg; Maya Lodish; Steven G. Waguespack; Oxana Kapustina; Elizabeth Fox; Frank M. Balis; Maria J. Merino; Paul S. Meltzer; John W. Glod; Jack F. Shern; Brigitte C. Widemann
Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human
Joachim G.J.V. Aerts; Pauline L. de Goeje; Robin Cornelissen; Margaretha E.H. Kaijen-Lambers; Koen Bezemer; Cor H. van der Leest; Niken M. Mahaweni; André Kunert; Ferry A.L.M. Eskens; Cynthia Waasdorp; Eric Braakman; Bronno van der Holt; Arnold G. Vulto; Rudi W. Hendriks; Joost P.J.J. Hegmans; Henk C. Hoogsteden
Personalized Medicine and Imaging
Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study
Barbara M. Norquist; Mark F. Brady; Maria I. Harrell; Tom Walsh; Ming K. Lee; Suleyman Gulsuner; Sarah S. Bernards; Silvia Casadei; Robert A. Burger; Krishnansu S. Tewari; Floor Backes; Robert S. Mannel; Gretchen Glaser; Cheryl Bailey; Stephen Rubin; John Soper; Heather A. Lankes; Nilsa C. Ramirez; Mary Claire King; Michael J. Birrer; Elizabeth M. Swisher
A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab
Martin D. Berger; Sebastian Stintzing; Volker Heinemann; Shu Cao; Dongyun Yang; Yu Sunakawa; Satoshi Matsusaka; Yan Ning; Satoshi Okazaki; Yuji Miyamoto; Mitsukuni Suenaga; Marta Schirripa; Diana L. Hanna; Shivani Soni; Alberto Puccini; Wu Zhang; Chiara Cremolini; Alfredo Falcone; Fotios Loupakis; Heinz-Josef Lenz
Author Choice
Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
Anita Sveen; Jarle Bruun; Peter W. Eide; Ina A. Eilertsen; Lorena Ramirez; Astrid Murumägi; Mariliina Arjama; Stine A. Danielsen; Kushtrim Kryeziu; Elena Elez; Josep Tabernero; Justin Guinney; Hector G. Palmer; Arild Nesbakken; Olli Kallioniemi; Rodrigo Dienstmann; Ragnhild A. Lothe
Cancer Therapy: Preclinical
A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy
Paolo Luraghi; Viola Bigatto; Elia Cipriano; Gigliola Reato; Francesca Orzan; Francesco Sassi; Francesca De Bacco; Claudio Isella; Sara E. Bellomo; Enzo Medico; Paolo M. Comoglio; Andrea Bertotti; Livio Trusolino; Carla Boccaccio
Author Choice
PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer
Yinhui Yang; Yang Bai; Yundong He; Yu Zhao; Jiaxiang Chen; Linlin Ma; Yunqian Pan; Michael Hinten; Jun Zhang; R. Jeffrey Karnes; Manish Kohli; Jennifer J. Westendorf; Benyi Li; Runzhi Zhu; Haojie Huang; Wanhai Xu
Author Choice
Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α
Caitlin D. Lowery; Wayne Blosser; Michele Dowless; Shelby Knoche; Jennifer Stephens; Huiling Li; David Surguladze; Nick Loizos; Debra Luffer-Atlas; Gerard J. Oakley, III; Qianxu Guo; Seema Iyer; Brian P. Rubin; Louis Stancato
Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin
Xu Wang; Jonathan J. Beitler; Wen Huang; Guo Chen; Guoqing Qian; Kelly Magliocca; Mihir R. Patel; Amy Y. Chen; Jun Zhang; Sreenivas Nannapaneni; Sungjin Kim; Zhengjia Chen; Xingming Deng; Nabil F. Saba; Zhuo Georgia Chen; Jack L. Arbiser; Dong M. Shin
Biology of Human Tumors
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Sarah E. Josefsson; Kanutte Huse; Arne Kolstad; Klaus Beiske; Daniela Pende; Chloé B. Steen; Else Marit Inderberg; Ole Christian Lingjærde; Bjørn Østenstad; Erlend B. Smeland; Ronald Levy; Jonathan M. Irish; June H. Myklebust
Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus–Related Hepatocellular Carcinoma
Yuanfeng Li; Yun Zhai; Qingfeng Song; Haitao Zhang; Pengbo Cao; Jie Ping; Xinyi Liu; Bingqian Guo; Guanjun Liu; Jin Song; Ying Zhang; Aiqing Yang; Hongbo Yan; Liang Yang; Ying Cui; Yilong Ma; Jinliang Xing; Xizhong Shen; Taotao Liu; Hongxin Zhang; Jiaze An; Jin-Xin Bei; Weihua Jia; Longli Kang; Lijun Liu; Dongya Yuan; Zhibin Hu; Hongbing Shen; Lei Lu; Xuan Wang; Hua Li; Fuchu He; Hongxing Zhang; Gangqiao Zhou
FAM198B Is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression
Chia-Ying Hsu; Gee-Chen Chang; Yi-Ju Chen; Yi-Chiung Hsu; Yi-Jing Hsiao; Kang-Yi Su; Hsuan-Yu Chen; Chien-Yu Lin; Jin-Shing Chen; Yu-Ju Chen; Qi-Sheng Hong; Wen-Hui Ku; Chih-Ying Wu; Bing-Ching Ho; Ching-Cheng Chiang; Pan-Chyr Yang; Sung-Liang Yu
The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy
Martin Puhr; Julia Hoefer; Andrea Eigentler; Christian Ploner; Florian Handle; Georg Schaefer; Jan Kroon; Angela Leo; Isabel Heidegger; Iris Eder; Zoran Culig; Gabri Van der Pluijm; Helmut Klocker
Author Choice
Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma
Mathieu Chicard; Leo Colmet-Daage; Nathalie Clement; Adrien Danzon; Mylène Bohec; Virginie Bernard; Sylvain Baulande; Angela Bellini; Paul Deveau; Gaëlle Pierron; Eve Lapouble; Isabelle Janoueix-Lerosey; Michel Peuchmaur; Nadège Corradini; Anne Sophie Defachelles; Dominique Valteau-Couanet; Jean Michon; Valérie Combaret; Olivier Delattre; Gudrun Schleiermacher
Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival
Natalie Vandeven; Christopher W. Lewis; Vladimir Makarov; Nadeem Riaz; Kelly G. Paulson; Daniel Hippe; Amy Bestick; Ryan Doumani; Tessa Marx; Seesha Takagishi; Timothy A. Chan; Jaehyuk Choi; Paul Nghiem
Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor
Gerardo A. Vitiello; Benjamin D. Medina; Shan Zeng; Timothy G. Bowler; Jennifer Q. Zhang; Jennifer K. Loo; Nesteene J. Param; Mengyuan Liu; Alec J. Moral; Julia N. Zhao; Ferdinand Rossi; Cristina R. Antonescu; Vinod P. Balachandran; Justin R. Cross; Ronald P. DeMatteo
Correction
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