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15 December 2018
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Cover Image
Cover Image
The cover shows an invasive front of a breast tumor derived from an orthotropic xenograft of the MDA231i cells. The image shows how HMGA1 expression (green) is enriched in the invasive front of the tumor. Cytokeratin (red) is used to stain human epithelial cells, and Hoechst to counterstain the nuclei. For details, see the article by Méndez and colleagues on page 6367 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Clinical Trials: Targeted Therapy
Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma
Steven G. DuBois; Yael P. Mosse; Elizabeth Fox; Rachel A. Kudgus; Joel M. Reid; Renee McGovern; Susan Groshen; Rochelle Bagatell; John M. Maris; Clare J. Twist; Kelly Goldsmith; M. Meaghan Granger; Brian Weiss; Julie R. Park; Margaret E. Macy; Susan L. Cohn; Greg Yanik; Lars M. Wagner; Randall Hawkins; Jesse Courtier; Hollie Lai; Fariba Goodarzian; Hiroyuki Shimada; Najee Boucher; Scarlett Czarnecki; Chunqiao Luo; Denice Tsao-Wei; Katherine K. Matthay; Araz Marachelian
Author Choice
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/Vincristine in Relapsed/Refractory Aggressive B-cell Lymphoma
Kevin R. Kelly; Jonathan W. Friedberg; Steven I. Park; Kevin McDonagh; John Hayslip; Daniel Persky; Jia Ruan; Soham Puvvada; Peter Rosen; Swaminathan Padmanabhan Iyer; Alexandra Stefanovic; Steven H. Bernstein; Steven Weitman; Anand Karnad; Gregory Monohan; Ari VanderWalde; Raul Mena; Monika Schmelz; Catherine Spier; Susan Groshen; Karthik Venkatakrishnan; Xiaofei Zhou; Emily Sheldon-Waniga; E. Jane Leonard; Daruka Mahadevan
A Phase I Trial of a Guadecitabine (SGI-110) and Irinotecan in Metastatic Colorectal Cancer Patients Previously Exposed to Irinotecan
Valerie Lee; Judy Wang; Marianna Zahurak; Elske Gootjes; Henk M. Verheul; Rose Parkinson; Zachary Kerner; Anup Sharma; Gary Rosner; Ana De Jesus-Acosta; Daniel Laheru; Dung T. Le; Aram Oganesian; Ellen Lilly; Thomas Brown; Peter Jones; Stephen Baylin; Nita Ahuja; Nilofer Azad
Author Choice
A Clinical and Molecular Phase II Trial of Oral ENMD-2076 in Ovarian Clear Cell Carcinoma (OCCC): A Study of the Princess Margaret Phase II Consortium
Stephanie Lheureux; Anna Tinker; Blaise Clarke; Prafull Ghatage; Stephen Welch; Johanne I. Weberpals; Neesha C. Dhani; Marcus O. Butler; Katia Tonkin; Qian Tan; David S.P. Tan; Kelly Brooks; Janelle Ramsahai; Lisa Wang; Nhu-An Pham; Patricia A. Shaw; Ming S. Tsao; Swati Garg; Tracey Stockley; Amit M. Oza
Clinical Trials: Immunotherapy
Author Choice
Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia
Karen Thudium Mueller; Edward Waldron; Stephan A. Grupp; John E. Levine; Theodore W. Laetsch; Michael A. Pulsipher; Michael W. Boyer; Keith J. August; Jason Hamilton; Rakesh Awasthi; Andrew M. Stein; Denise Sickert; Abhijit Chakraborty; Bruce L. Levine; Carl H. June; Lori Tomassian; Sweta S. Shah; Mimi Leung; Tetiana Taran; Patricia A. Wood; Shannon L. Maude
Author Choice
A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia
Gunilla Enblad; Hannah Karlsson; Gustav Gammelgård; Jessica Wenthe; Tanja Lövgren; Rose Marie Amini; Kristina I. Wikstrom; Magnus Essand; Barbara Savoldo; Helene Hallböök; Martin Höglund; Gianpietro Dotti; Malcolm K. Brenner; Hans Hagberg; Angelica Loskog
Precision Medicine and Imaging
Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in EGFR-Mutant NSCLC
Xiuning Le; Sonam Puri; Marcelo V. Negrao; Monique B. Nilsson; Jacqulyne Robichaux; Theresa Boyle; J. Kevin Hicks; Katherine L. Lovinger; Emily Roarty; Waree Rinsurongkawong; Ming Tang; Huiying Sun; Yasir Elamin; Lara C. Lacerda; Jeff Lewis; Jack A. Roth; Stephen G. Swisher; J. Jack Lee; William N. William, Jr; Bonnie S. Glisson; Jianjun Zhang; Vassiliki A. Papadimitrakopoulou; Jhanelle E. Gray; John V. Heymach
Polygenic Determinants for Subsequent Breast Cancer Risk in Survivors of Childhood Cancer: The St Jude Lifetime Cohort Study (SJLIFE)
Zhaoming Wang; Qi Liu; Carmen L. Wilson; John Easton; Heather Mulder; Ti-Cheng Chang; Michael C. Rusch; Michael N. Edmonson; Stephen V. Rice; Matthew J. Ehrhardt; Rebecca M. Howell; Chimene A. Kesserwan; Gang Wu; Kim E. Nichols; James R. Downing; Melissa M. Hudson; Jinghui Zhang; Yutaka Yasui; Leslie L. Robison
Author Choice
Analysis of Circulating Tumor DNA and Clinical Correlates in Patients with Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
Shumei Kato; Ryosuke Okamura; Joel M. Baumgartner; Hitendra Patel; Lawrence Leichman; Kaitlyn Kelly; Jason K. Sicklick; Paul T. Fanta; Scott M. Lippman; Razelle Kurzrock
Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects
Titia G. Meijer; Nicole S. Verkaik; Anieta M. Sieuwerts; Job van Riet; Kishan A.T. Naipal; Carolien H.M. van Deurzen; Michael A. den Bakker; Hein F.B.M. Sleddens; Hendrikus-Jan Dubbink; T. Dorine den Toom; Winand N.M. Dinjens; Esther Lips; Petra M. Nederlof; Marcel Smid; Harmen J.G. van de Werken; Roland Kanaar; John W.M. Martens; Agnes Jager; Dik C. van Gent
Author Choice
A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models
Pascal O. Zinn; Sanjay K. Singh; Aikaterini Kotrotsou; Islam Hassan; Ginu Thomas; Markus M. Luedi; Ahmed Elakkad; Nabil Elshafeey; Tagwa Idris; Jennifer Mosley; Joy Gumin; Gregory N. Fuller; John F. de Groot; Veera Baladandayuthapani; Erik P. Sulman; Ashok J. Kumar; Raymond Sawaya; Frederick F. Lang; David Piwnica-Worms; Rivka R. Colen
PSMA Ligand PET/MRI for Primary Prostate Cancer: Staging Performance and Clinical Impact
Bernhard Grubmüller; Pascal Baltzer; Sabrina Hartenbach; David D’Andrea; Thomas H. Helbich; Alexander R. Haug; Gregor M. Goldner; Wolfgang Wadsak; Sarah Pfaff; Markus Mitterhauser; Theresa Balber; Neydher Berroteran-Infante; Marko Grahovac; John Babich; Christian Seitz; Gero Kramer; Martin Susani; Peter Mazal; Lukas Kenner; Shahrokh F. Shariat; Marcus Hacker; Markus Hartenbach
Translational Cancer Mechanisms and Therapy
Author Choice
PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial–Mesenchymal Transition
Xin Chen; Ri-Xin Chen; Wen-Su Wei; Yong-Hong Li; Zi-Hao Feng; Lei Tan; Jie-Wei Chen; Gang-Jun Yuan; Si-Liang Chen; Sheng-Jie Guo; Kang-Hua Xiao; Zhuo-Wei Liu; Jun-Hang Luo; Fang-Jian Zhou; Dan Xie
Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis
Madelon Paauwe; Mark J.A. Schoonderwoerd; Roxan F.C.P. Helderman; Tom J. Harryvan; Arwin Groenewoud; Gabi W. van Pelt; Rosalie Bor; Danielle M. Hemmer; Henri H. Versteeg; B. Ewa Snaar-Jagalska; Charles P. Theuer; James C.H. Hardwick; Cornelis F.M. Sier; Peter ten Dijke; Lukas J.A.C. Hawinkels
Author Choice
Gemcitabine Synergizes with Immune Checkpoint Inhibitors and Overcomes Resistance in a Preclinical Model and Mesothelioma Patients
Paulino Tallón de Lara; Virginia Cecconi; Stefanie Hiltbrunner; Hideo Yagita; Martina Friess; Beata Bode; Isabelle Opitz; Bart Vrugt; Walter Weder; Paul Stolzmann; Emanuela Felley-Bosco; Rolf A. Stahel; Verena Tischler; Christian Britschgi; Davide Soldini; Maries van den Broek; Alessandra Curioni-Fontecedro
Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling
Thai H. Tran; Fransiscus E. Utama; Takahiro Sato; Amy R. Peck; John F. Langenheim; Sameer S. Udhane; Yunguang Sun; Chengbao Liu; Melanie A. Girondo; Albert J. Kovatich; Jeffrey A. Hooke; Craig D. Shriver; Hai Hu; Juan P. Palazzo; Marluce Bibbo; Paul W. Auer; Michael J. Flister; Terry Hyslop; Edith P. Mitchell; Inna Chervoneva; Hallgeir Rui
Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer
Olga Méndez; Vicente Peg; Cándida Salvans; Mireia Pujals; Yolanda Fernández; Ibane Abasolo; José Pérez; Ana Matres; Marta Valeri; Josep Gregori; Laura Villarreal; Simó Schwartz, Jr; Santiago Ramon y Cajal; Josep Tabernero; Javier Cortés; Joaquín Arribas; Josep Villanueva
Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy
Ashley Orillion; Nur P. Damayanti; Li Shen; Remi Adelaiye-Ogala; Hayley Affronti; May Elbanna; Sreenivasulu Chintala; Michael Ciesielski; Luigi Fontana; Chinghai Kao; Bennett D. Elzey; Timothy L. Ratliff; David E. Nelson; Dominic Smiraglia; Scott I. Abrams; Roberto Pili
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors
Cheryl A. London; Jaime Acquaviva; Donald L. Smith; Manuel Sequeira; Luisa Shin Ogawa; Heather L. Gardner; Louis Feo Bernabe; Misty D. Bear; Sandra A. Bechtel; David A. Proia
Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191
Haiwen Ni; Fazal Shirazi; Veerabhadran Baladandayuthapani; Heather Lin; Isere Kuiatse; Hua Wang; Richard J. Jones; Zuzana Berkova; Yasumichi Hitoshi; Stephen M. Ansell; Steven P. Treon; Sheeba K. Thomas; Hans C. Lee; Zhiqiang Wang; R. Eric Davis; Robert Z. Orlowski
BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models
Arsheed A. Ganaie; Firdous H. Beigh; Matteo Astone; Marina G. Ferrari; Raihana Maqbool; Syed Umbreen; Aijaz S. Parray; Hifzur R. Siddique; Tabish Hussain; Paari Murugan; Colm Morrissey; Shahriar Koochekpour; Yibin Deng; Badrinath R. Konety; Luke H. Hoeppner; Mohammad Saleem
Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer
Sandeep Shelar; Eun-Hee Shim; Garrett J. Brinkley; Anirban Kundu; Francesca Carobbio; Tyler Poston; Jubilee Tan; Vishwas Parekh; Daniel Benson; David K. Crossman; Phillip J. Buckhaults; Dinesh Rakheja; Richard Kirkman; Yusuke Sato; Seishi Ogawa; Shilpa Dutta; Sadanandan E. Velu; Ethan Emberley; Alison Pan; Jason Chen; Tony Huang; Devin Absher; Anja Becker; Conrad Kunick; Sunil Sudarshan
IFNγ-induced Chemokines Are Required for CXCR3-mediated T-Cell Recruitment and Antitumor Efficacy of Anti-HER2/CD3 Bispecific Antibody
Ji Li; Ryan Ybarra; Judy Mak; Aurelie Herault; Patricia De Almeida; Alfonso Arrazate; James Ziai; Klara Totpal; Melissa R. Junttila; Kevin B. Walsh; Teemu T. Junttila
Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma
Monika A. Davare; Jacob J. Henderson; Anupriya Agarwal; Jacob P. Wagner; Sudarshan R. Iyer; Nameeta Shah; Randy Woltjer; Romel Somwar; Stephen W. Gilheeney; Ana DeCarvalo; Tom Mikkelson; Erwin G. Van Meir; Marc Ladanyi; Brian J. Druker
Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset of Class II BRAF Mutant Melanomas
Matthew Dankner; Mathieu Lajoie; Dan Moldoveanu; Tan-Trieu Nguyen; Paul Savage; Shivshankari Rajkumar; Xiu Huang; Maria Lvova; Alexei Protopopov; Dana Vuzman; David Hogg; Morag Park; Marie-Christine Guiot; Kevin Petrecca; Catalin Mihalcioiu; Ian R. Watson; Peter M. Siegel; April A.N. Rose
Author Choice
Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer
Rayna Rosati; Lisa Polin; Charles Ducker; Jing Li; Xun Bao; Dakshnamurthy Selvakumar; Seongho Kim; Besa Xhabija; Martha Larsen; Thomas McFall; Yanfang Huang; Benjamin L. Kidder; Andrew Fribley; Janice Saxton; Hiroki Kakuta; Peter Shaw; Manohar Ratnam
Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions
Thomas R. Pisanic, II; Leslie M. Cope; Shiou-Fu Lin; Ting-Tai Yen; Pornpat Athamanolap; Ryoichi Asaka; Kentaro Nakayama; Amanda N. Fader; Tza-Huei Wang; Ie-Ming Shih; Tian-Li Wang
EGFR Exon 20 Insertion Mutations Display Sensitivity to Hsp90 Inhibition in Preclinical Models and Lung Adenocarcinomas
Susan E. Jorge; Antonio R. Lucena-Araujo; Hiroyuki Yasuda; Zofia Piotrowska; Geoffrey R. Oxnard; Deepa Rangachari; Mark S. Huberman; Lecia V. Sequist; Susumu S. Kobayashi; Daniel B. Costa
RETRACTED: KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition
Soo-Jeong Cho; Changhwan Yoon; Jun Ho Lee; Kevin K. Chang; Jian-xian Lin; Young-Ho Kim; Myeong-Cherl Kook; Bülent Arman Aksoy; Do Joong Park; Hassan Ashktorab; Duane T. Smoot; Nikolaus Schultz; Sam S. Yoon
SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads
Krista Kinneer; John Meekin; Arnaud C. Tiberghien; Yu-Tzu Tai; Sandrina Phipps; Christine Mione Kiefer; Marlon C. Rebelatto; Nazzareno Dimasi; Alyssa Moriarty; Kyriakos P. Papadopoulos; Sriram Sridhar; Stephen J. Gregson; Michael J. Wick; Luke Masterson; Kenneth C. Anderson; Ronald Herbst; Philip W. Howard; David A. Tice
Author Choice
Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction
Peter W. Nagle; Nynke A. Hosper; Lara Barazzuol; Anne L. Jellema; Mirjam Baanstra; Marc-Jan van Goethem; Sytze Brandenburg; Ulrich Giesen; Johannes A. Langendijk; Peter van Luijk; Rob P. Coppes
Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition
Xian Chen; Kwang-Huei Low; Angela Alexander; Yufeng Jiang; Cansu Karakas; Kenneth R. Hess; Jason P.W. Carey; Tuyen N. Bui; Smruthi Vijayaraghavan; Kurt W. Evans; Min Yi; D. Christian Ellis; Kwok-Leung Cheung; Ian O. Ellis; Siqing Fu; Funda Meric-Bernstam; Kelly K. Hunt; Khandan Keyomarsi
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