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15 October 2018
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Cover Image
Cover Image
The cover shows a section of a gastrointestinal biopsy from a patient with Kaposi sarcoma. Immunohistochemical staining shows mast cell degranulation and high levels of tryptase in lesions. For details see the article by Ayers and colleagues on page 5085 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Statistics in CCR
Review
Clinical Trial Brief Report
Therapeutic Immune Modulation against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial
Chrisann Kyi; Vladimir Roudko; Rachel Sabado; Yvonne Saenger; William Loging; John Mandeli; Tin Htwe Thin; Deborah Lehrer; Michael Donovan; Marshall Posner; Krzysztof Misiukiewicz; Benjamin Greenbaum; Andres Salazar; Philip Friedlander; Nina Bhardwaj
Clinical Trials: Targeted Therapy
Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer
Sana D. Karam; Krishna Reddy; Patrick J. Blatchford; Tim Waxweiler; Alicia M. DeLouize; Ayman Oweida; Hilary Somerset; Carrie Marshall; Christian Young; Kurtis D. Davies; Madeleine Kane; Aik Choo Tan; Xiao Jing Wang; Antonio Jimeno; Dara L. Aisner; Daniel W. Bowles; David Raben
Precision Medicine and Imaging
Author Choice
Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab
Richard W. Joseph; Jeroen Elassaiss-Schaap; Richard Kefford; Wen-Jen Hwu; Jedd D. Wolchok; Anthony M. Joshua; Antoni Ribas; F. Stephen Hodi; Omid Hamid; Caroline Robert; Adil Daud; Roxana Dronca; Peter Hersey; Jeffrey S. Weber; Amita Patnaik; Dinesh P. de Alwis; Andrea Perrone; Jin Zhang; S. Peter Kang; Scot Ebbinghaus; Keaven M. Anderson; Tara C. Gangadhar
Molecular Imaging of Radiolabeled Bispecific T-Cell Engager 89Zr-AMG211 Targeting CEA-Positive Tumors
Stijn J.H. Waaijer; Frank J. Warnders; Sabine Stienen; Matthias Friedrich; Alexander Sternjak; H. Kam Cheung; Anton G.T. Terwisscha van Scheltinga; Carolien P. Schröder; Elisabeth G.E. de Vries; Marjolijn N. Lub-de Hooge
Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative
Michael J. Pishvaian; Robert J. Bender; David Halverson; Lola Rahib; Andrew E. Hendifar; Sameh Mikhail; Vincent Chung; Vincent J. Picozzi; Davendra Sohal; Edik M. Blais; Kimberly Mason; Emily E. Lyons; Lynn M. Matrisian; Jonathan R. Brody; Subha Madhavan; Emanuel F. Petricoin, III
The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study
Basile Stamatopoulos; Thomas Smith; Emerence Crompot; Karlien Pieters; Ruth Clifford; Marek Mraz; Pauline Robbe; Adam Burns; Adele Timbs; David Bruce; Peter Hillmen; Nathalie Meuleman; Philippe Mineur; Radu Firescu; Marie Maerevoet; Virginie De Wilde; André Efira; Jan Philippé; Bruno Verhasselt; Fritz Offner; David Sims; Andreas Heger; Hélène Dreau; Anna Schuh
Translational Cancer Mechanisms and Therapy
Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy
Ariel E. Marciscano; Ali Ghasemzadeh; Thomas R. Nirschl; Debebe Theodros; Christina M. Kochel; Brian J. Francica; Yuki Muroyama; Robert A. Anders; Andrew B. Sharabi; Esteban Velarde; Wendy Mao; Kunal R. Chaudhary; Matthew G. Chaimowitz; John Wong; Mark J. Selby; Kent B. Thudium; Alan J. Korman; David Ulmert; Daniel L.J. Thorek; Theodore L. DeWeese; Charles G. Drake
Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability
Hailing Yang; Weiqun Mao; Cristian Rodriguez-Aguayo; Lingegowda S. Mangala; Geoffrey Bartholomeusz; Lakesla R. Iles; Nicholas B. Jennings; Ahmed Ashour Ahmed; Anil K. Sood; Gabriel Lopez-Berestein; Zhen Lu; Robert C. Bast, Jr.
Author Choice
Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer
Anthony Cheung; James Opzoomer; Kristina M. Ilieva; Patrycja Gazinska; Ricarda M. Hoffmann; Hasan Mirza; Rebecca Marlow; Erika Francesch-Domenech; Matthew Fittall; Diana Dominguez Rodriguez; Angela Clifford; Luned Badder; Nirmesh Patel; Silvia Mele; Giulia Pellizzari; Heather J. Bax; Silvia Crescioli; Gyula Petranyi; Daniel Larcombe-Young; Debra H. Josephs; Silvana Canevari; Mariangela Figini; Sarah Pinder; Frank O. Nestle; Cheryl Gillett; James F. Spicer; Anita Grigoriadis; Andrew N.J. Tutt; Sophia N. Karagiannis
Author Choice
Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant
Chao Liu; Theresa Guo; Guorong Xu; Akihiro Sakai; Shuling Ren; Takahito Fukusumi; Mizuo Ando; Sayed Sadat; Yuki Saito; Zubair Khan; Kathleen M. Fisch; Joseph Califano
Author Choice
Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease–Associated Colorectal Cancers
Shahida Din; Kim Wong; Mike F. Mueller; Anca Oniscu; James Hewinson; Catherine J. Black; Martin L. Miller; Alejandro Jiménez-Sánchez; Roy Rabbie; Mamunar Rashid; Jack Satsangi; David J. Adams; Mark J. Arends
The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer
Alice Lallo; Kristopher K. Frese; Christopher J. Morrow; Robert Sloane; Sakshi Gulati; Maximillian W. Schenk; Francesca Trapani; Nicole Simms; Melanie Galvin; Stewart Brown; Cassandra L. Hodgkinson; Lynsey Priest; Adina Hughes; Zhongwu Lai; Elaine Cadogan; Garima Khandelwal; Kathryn L. Simpson; Crispin Miller; Fiona Blackhall; Mark J. O'Connor; Caroline Dive
Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors
Alison M. Nagle; Kevin M. Levine; Nilgun Tasdemir; Julie A. Scott; Kara Burlbaugh; Justin Kehm; Tiffany A. Katz; David N. Boone; Britta M. Jacobsen; Jennifer M. Atkinson; Steffi Oesterreich; Adrian V. Lee
A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer
Paul Ponath; Daniel Menezes; Chin Pan; Bing Chen; Miho Oyasu; Debbie Strachan; Heidi LeBlanc; Huadong Sun; Xi-Tao Wang; Vangipuram S. Rangan; Shrikant Deshpande; Sandra Cristea; Kwon-Sik Park; Julien Sage; Pina M. Cardarelli
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