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15 January 2018
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Cover Image
Cover Image
The cover shows a section of the lung from a patient affected by adenocarcinoma. Double immunofluorescence staining illustrating cytotoxic tumor-infiltrating lymphocytes (TIL) carrying granzyme B (green) to hinder the invasion of the bronchial lumen by cytokeratin positive (red) cancer cells. For details, see the article by Mazzaschi and colleagues on page 407 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Cancer Therapy: Clinical
Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Matthew P. Morrow; Kimberly A. Kraynyak; Albert J. Sylvester; Michael Dallas; Dawson Knoblock; Jean D. Boyer; Jian Yan; Russell Vang; Amir S. Khan; Laurent Humeau; Niranjan Y. Sardesai; J. Joseph Kim; Stanley Plotkin; David B. Weiner; Cornelia L. Trimble; Mark L. Bagarazzi
Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma
Sara A. Byron; Nhan L. Tran; Rebecca F. Halperin; Joanna J. Phillips; John G. Kuhn; John F. de Groot; Howard Colman; Keith L. Ligon; Patrick Y. Wen; Timothy F. Cloughesy; Ingo K. Mellinghoff; Nicholas A. Butowski; Jennie W. Taylor; Jennifer L. Clarke; Susan M. Chang; Mitchel S. Berger; Annette M. Molinaro; Gerald M. Maggiora; Sen Peng; Sara Nasser; Winnie S. Liang; Jeffrey M. Trent; Michael E. Berens; John D. Carpten; David W. Craig; Michael D. Prados
Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial
Channing J. Paller; Xian C. Zhou; Elisabeth I. Heath; Mary-Ellen Taplin; Tina Mayer; Mark N. Stein; Glenn J. Bubley; Roberto Pili; Tamaro Hudson; Radhika Kakarla; Muneer M. Abbas; Nicole M. Anders; Donna Dowling; Serina King; Ashley B. Bruns; William D. Wagner; Charles G. Drake; Emmanuel S. Antonarakis; Mario A. Eisenberger; Samuel R. Denmeade; Michelle A. Rudek; Gary L. Rosner; Michael A. Carducci
A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer
Axel Grothey; Jonathan R. Strosberg; Lindsay A. Renfro; Herbert I. Hurwitz; John L. Marshall; Howard Safran; Michael J. Guarino; George P. Kim; J.R. Hecht; Susan C. Weil; John Heyburn; Wenquan Wang; Charles Schweizer; Daniel J. O'Shannessy; Luis Alberto Diaz, Jr
Personalized Medicine and Imaging
Location of Mutation in BRCA2 Gene and Survival in Patients with Ovarian Cancer
S. Intidhar Labidi-Galy; Timothée Olivier; Manuel Rodrigues; Domenico Ferraioli; Olfa Derbel; Alexandre Bodmer; Patrick Petignat; Beata Rak; Nicolas Chopin; Olivier Tredan; Pierre-Etienne Heudel; Sarah Stuckelberger; Pierre Meeus; Patrick Meraldi; Valeria Viassolo; Aurélie Ayme; Pierre O. Chappuis; Marc-Henri Stern; Claude Houdayer; Dominique Stoppa-Lyonnet; Adrien Buisson; Lisa Golmard; Valérie Bonadona; Isabelle Ray-Coquard
Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non–Small Cell Lung Cancer
Kathryn C. Arbour; Emmett Jordan; Hyunjae Ryan Kim; Jordan Dienstag; Helena A. Yu; Francisco Sanchez-Vega; Piro Lito; Michael Berger; David B. Solit; Matthew Hellmann; Mark G. Kris; Charles M. Rudin; Ai Ni; Maria Arcila; Marc Ladanyi; Gregory J. Riely
RAD50 Expression Is Associated with Poor Clinical Outcomes after Radiotherapy for Resected Non–small Cell Lung Cancer
Yifan Wang; Jayanthi Gudikote; Uma Giri; Jun Yan; Weiye Deng; Rui Ye; Wen Jiang; Nan Li; Brian P. Hobbs; Jing Wang; Stephen G. Swisher; Junya Fujimoto; Ignacio I. Wistuba; Ritsuko Komaki; John V. Heymach; Steven H. Lin
Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response
Alexander Muckenhuber; Anne Katrin Berger; Anna Melissa Schlitter; Katja Steiger; Björn Konukiewitz; Andreas Trumpp; Roland Eils; Jens Werner; Helmut Friess; Irene Esposito; Günter Klöppel; Güralp O. Ceyhan; Moritz Jesinghaus; Carsten Denkert; Marcus Bahra; Albrecht Stenzinger; Martin R. Sprick; Dirk Jäger; Christoph Springfeld; Wilko Weichert
Cancer Therapy: Preclinical
Author Choice
Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression
Timothy L. Lochmann; Konstantinos V. Floros; Mitra Naseri; Krista M. Powell; Wade Cook; Ryan J. March; Giovanna T. Stein; Patricia Greninger; Yuki Kato Maves; Laura R. Saunders; Scott J. Dylla; Carlotta Costa; Sosipatros A. Boikos; Joel D. Leverson; Andrew J. Souers; Geoffrey W. Krystal; Hisashi Harada; Cyril H. Benes; Anthony C. Faber
Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
JongBok Lee; Mark D. Minden; Weihsu C. Chen; Elena Streck; Branson Chen; Hyeonjeong Kang; Andrea Arruda; Dalam Ly; Sandy D. Der; Sohyeong Kang; Paulina Achita; Cheryl D'Souza; Yueyang Li; Richard W. Childs; John E. Dick; Li Zhang
Author Choice
Dual mTOR Kinase Inhibitor MLN0128 Sensitizes HR+/HER2+ Breast Cancer Patient-Derived Xenografts to Trastuzumab or Fulvestrant
Pei-Yin Hsu; Victoria Shang Wu; Noriko Kanaya; Karineh Petrossian; Hang-Kai Hsu; Duc Nguyen; Daniel Schmolze; Masaya Kai; Chun-Yu Liu; Hannah Lu; Peiguo Chu; Courtney A. Vito; Laura Kruper; Joanne Mortimer; Shiuan Chen
Biology of Human Tumors
Author Choice
Low PD-1 Expression in Cytotoxic CD8+ Tumor-Infiltrating Lymphocytes Confers an Immune-Privileged Tissue Microenvironment in NSCLC with a Prognostic and Predictive Value
Giulia Mazzaschi; Denise Madeddu; Angela Falco; Giovanni Bocchialini; Matteo Goldoni; Francesco Sogni; Giovanna Armani; Costanza Annamaria Lagrasta; Bruno Lorusso; Chiara Mangiaracina; Rocchina Vilella; Caterina Frati; Roberta Alfieri; Luca Ampollini; Michele Veneziani; Enrico Maria Silini; Andrea Ardizzoni; Konrad Urbanek; Franco Aversa; Federico Quaini; Marcello Tiseo
Author Choice
Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell–Cancer-Associated Fibroblast Interactions during Collective Invasion
Alessandra M. Richardson; Lauren S. Havel; Allyson E. Koyen; Jessica M. Konen; John Shupe; W.G. Wiles, IV; W. David Martin; Hans E. Grossniklaus; Gabriel Sica; Melissa Gilbert-Ross; Adam I. Marcus
Inhibition of REDD1 Sensitizes Bladder Urothelial Carcinoma to Paclitaxel by Inhibiting Autophagy
Qinghai Zeng; Jianye Liu; Peiguo Cao; Jingjing Li; Xiaoming Liu; Xiaojun Fan; Ling Liu; Yan Cheng; Wei Xiong; Jigang Li; Hao Bo; Yuxing Zhu; Fei Yang; Jun Hu; Ming Zhou; Yanhong Zhou; Qiong Zou; Jianda Zhou; Ke Cao
Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma
Ling Tang; Jun Zeng; Pengyu Geng; Chengnan Fang; Yang Wang; Mingju Sun; Changsong Wang; Jiao Wang; Peiyuan Yin; Chunxiu Hu; Lei Guo; Jane Yu; Peng Gao; Enyou Li; Zhengping Zhuang; Guowang Xu; Yang Liu
Corrections
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