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1 September 2018
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Cover Image
Cover Image
The cover shows a section of a tumor biopsy from a child with teleangiectatic osteosarcoma. Immunohistochemical CD68 macrophage stain (brown) shows tumor-associated macrophages along septae in the tumor. For details, see article by Aghighi, Theruvath, and colleagues on page 4110. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy
Gwynn Ison; Lynn J. Howie; Laleh Amiri-Kordestani; Lijun Zhang; Shenghui Tang; Rajeshwari Sridhara; Vadryn Pierre; Rosane Charlab; Anuradha Ramamoorthy; Pengfei Song; Fang Li; Jingyu Yu; Wimolnut Manheng; Todd R. Palmby; Soma Ghosh; Hisani N. Horne; Eunice Y. Lee; Reena Philip; Kaushalkumar Dave; Xiao Hong Chen; Sharon L. Kelly; Kumar G. Janoria; Anamitro Banerjee; Okponanabofa Eradiri; Jeannette Dinin; Kirsten B. Goldberg; William F. Pierce; Amna Ibrahim; Paul G. Kluetz; Gideon M. Blumenthal; Julia A. Beaver; Richard Pazdur
Clinical Trials: Targeted Therapy
Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors
Daniel D. Von Hoff; Drew W. Rasco; Elisabeth I. Heath; Pamela N. Munster; Jan H.M. Schellens; Nicolas Isambert; Christophe Le Tourneau; Bert O'Neil; Ron H.J. Mathijssen; Jose A. Lopez-Martin; W. Jeff Edenfield; Miguel Martin; Patricia M. LoRusso; Gordon L. Bray; Jorge DiMartino; Aaron Nguyen; Kejian Liu; Eric Laille; Johanna C. Bendell
Radium-223 Dichloride in Combination with Vascular Endothelial Growth Factor–Targeting Therapy in Advanced Renal Cell Carcinoma with Bone Metastases
Rana R. McKay; Dominick Bossé; Kathryn P. Gray; M. Dror Michaelson; Katherine Krajewski; Heather A. Jacene; Meghara Walsh; Joaquim Bellmunt; Mark Pomerantz; Lauren C. Harshman; Toni K. Choueiri
Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Tadashi Akiba; Toshiaki Morikawa; Makoto Odaka; Takeo Nakada; Noriki Kamiya; Makoto Yamashita; Mitsuo Yabe; Takuya Inagaki; Hisatoshi Asano; Shohei Mori; Yo Tsukamoto; Mitsuyoshi Urashima
Clinical Trials: Immunotherapy
Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation
Jeff K. Davies; Lisa L. Brennan; John R. Wingard; Christopher R. Cogle; Neena Kapoor; Ami J. Shah; Bimalangshu R. Dey; Thomas R. Spitzer; Marcos de Lima; Laurence J. Cooper; Peter F. Thall; Richard E. Champlin; Lee M. Nadler; Eva C. Guinan
Precision Medicine and Imaging
Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation
Maryam Aghighi; Ashok J. Theruvath; Anuj Pareek; Laura L. Pisani; Raphael Alford; Anne M. Muehe; Tarsheen K. Sethi; Samantha J. Holdsworth; Florette K. Hazard; Dita Gratzinger; Sandra Luna-Fineman; Ranjana Advani; Sheri L. Spunt; Heike E. Daldrup-Link
Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma
Vladimir Bezrookove; Mehdi Nosrati; James R. Miller, III; David De Semir; Altaf A. Dar; Elham Vosoughi; Edith Vaquero; Antje Sucker; Alexander J. Lazar; Jeffrey E. Gershenwald; Michael A. Davies; Dirk Schadendorf; Mohammed Kashani-Sabet
The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes
Matthew P. Salomon; Xiaowen Wang; Diego M. Marzese; Sandy C. Hsu; Nellie Nelson; Xin Zhang; Chikako Matsuba; Yuki Takasumi; Carmen Ballesteros-Merino; Bernard A. Fox; Garni Barkhoudarian; Daniel F. Kelly; Dave S.B. Hoon
STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non–Muscle-Invasive Bladder Cancer
Alana Lelo; Frederik Prip; Brent T. Harris; David Solomon; Deborah L. Berry; Krysta Chaldekas; Anagha Kumar; Jeffry Simko; Jørgen Bjerggaard Jensen; Pritish Bhattacharyya; Ciaran Mannion; Jung-Sik Kim; George Philips; Lars Dyrskjøt; Todd Waldman
Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention
Maeve A. Lowery; Ryan Ptashkin; Emmet Jordan; Michael F. Berger; Ahmet Zehir; Marinela Capanu; Nancy E. Kemeny; Eileen M. O'Reilly; Imane El-Dika; William R. Jarnagin; James J. Harding; Michael I. D'Angelica; Andrea Cercek; Jaclyn F. Hechtman; David B. Solit; Nikolaus Schultz; David M. Hyman; David S. Klimstra; Leonard B. Saltz; Ghassan K. Abou-Alfa
Translational Cancer Mechanisms and Therapy
Author Choice
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
Karolina Woroniecka; Pakawat Chongsathidkiet; Kristen Rhodin; Hanna Kemeny; Cosette Dechant; S. Harrison Farber; Aladine A. Elsamadicy; Xiuyu Cui; Shohei Koyama; Christina Jackson; Landon J. Hansen; Tanner M. Johanns; Luis Sanchez-Perez; Vidyalakshmi Chandramohan; Yen-Rei Andrea Yu; Darell D. Bigner; Amber Giles; Patrick Healy; Glenn Dranoff; Kent J. Weinhold; Gavin P. Dunn; Peter E. Fecci
Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
Malte Mohme; Simon Schliffke; Cecile L. Maire; Alessandra Rünger; Laura Glau; Klaus C. Mende; Jakob Matschke; Christina Gehbauer; Nuray Akyüz; Svenja Zapf; Mareike Holz; Miriam Schaper; Tobias Martens; Nils O. Schmidt; Sven Peine; Manfred Westphal; Mascha Binder; Eva Tolosa; Katrin Lamszus
MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer
Renée de Leeuw; Christopher McNair; Matthew J. Schiewer; Neermala Poudel Neupane; Lucas J. Brand; Michael A. Augello; Zhen Li; Larry C. Cheng; Akihiro Yoshida; Sean M. Courtney; E. Starr Hazard; Gary Hardiman; Maha H. Hussain; J. Alan Diehl; Justin M. Drake; Wm. Kevin Kelly; Karen E. Knudsen
Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies
Hanni Uusi-Kerttula; James A. Davies; Jill M. Thompson; Phonphimon Wongthida; Laura Evgin; Kevin G. Shim; Angela Bradshaw; Alexander T. Baker; Pierre J. Rizkallah; Rachel Jones; Louise Hanna; Emma Hudson; Richard G. Vile; John D. Chester; Alan L. Parker
Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion
Recep Bayraktar; Cristina Ivan; Emine Bayraktar; Pinar Kanlikilicer; Nashwa N. Kabil; Nermin Kahraman; Hamada A. Mokhlis; Didem Karakas; Cristian Rodriguez-Aguayo; Ahmet Arslan; Jianting Sheng; Stephen Wong; Gabriel Lopez-Berestein; George A. Calin; Bulent Ozpolat
Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine
Yee Sun Tan; Kanokwan Sansanaphongpricha; Yuying Xie; Christopher R. Donnelly; Xiaobo Luo; Blake R. Heath; Xinyi Zhao; Emily Bellile; Hongxiang Hu; Hongwei Chen; Peter J. Polverini; Qianming Chen; Simon Young; Thomas E. Carey; Jacques E. Nör; Robert L. Ferris; Gregory T. Wolf; Duxin Sun; Yu L. Lei
Author Choice
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity
Tara L. Peters; Joseph Tillotson; Alison M. Yeomans; Sarah Wilmore; Elizabeth Lemm; Carlos Jiménez-Romero; Luis A. Amador; Lingxiao Li; Amit D. Amin; Praechompoo Pongtornpipat; Christopher J. Zerio; Andrew J. Ambrose; Gillian Paine-Murrieta; Patricia Greninger; Francisco Vega; Cyril H. Benes; Graham Packham; Abimael D. Rodríguez; Eli Chapman; Jonathan H. Schatz
The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma
Javier Vaquero; Cindy Lobe; Sylvana Tahraoui; Audrey Clapéron; Martine Mergey; Fatiha Merabtene; Dominique Wendum; Cédric Coulouarn; Chantal Housset; Christèle Desbois-Mouthon; Françoise Praz; Laura Fouassier
Author Choice
Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors
Tinya Abrams; Anu Connor; Christie Fanton; Steven B. Cohen; Thomas Huber; Kathy Miller; E. Erica Hong; Xiaohong Niu; Janine Kline; Marjorie Ison-Dugenny; Sarah Harris; Dana Walker; Klaus Krauser; Francesco Galimi; Zhen Wang; Majid Ghoddusi; Keith Mansfield; Si Tuen Lee-Hoeflich; Jocelyn Holash; Nancy Pryer; William Kluwe; Seth A. Ettenberg; William R. Sellers; Emma Lees; Paul Kwon; Judith A. Abraham; Siew C. Schleyer
High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling
Takuji Hayashi; Kazutoshi Fujita; Satoshi Nojima; Yujiro Hayashi; Kosuke Nakano; Yu Ishizuya; Cong Wang; Yoshiyuki Yamamoto; Toshiro Kinouchi; Kyosuke Matsuzaki; Kentaro Jingushi; Taigo Kato; Atsunari Kawashima; Akira Nagahara; Takeshi Ujike; Motohide Uemura; Maria Del Carmen Rodriguez Pena; Jennifer B. Gordetsky; Eiichi Morii; Kazutake Tsujikawa; George J. Netto; Norio Nonomura
A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening
Michael L. Beshiri; Caitlin M. Tice; Crystal Tran; Holly M. Nguyen; Adam G. Sowalsky; Supreet Agarwal; Keith H. Jansson; Qi Yang; Kerry M. McGowen; JuanJuan Yin; Aian Neil Alilin; Fatima H. Karzai; William L. Dahut; Eva Corey; Kathleen Kelly
Editor’s Notes
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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