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1 September 2018
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Cover Image
Cover Image
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The cover shows a section of a tumor biopsy from a child with teleangiectatic osteosarcoma. Immunohistochemical CD68 macrophage stain (brown) shows tumor-associated macrophages along septae in the tumor. For details, see article by Aghighi, Theruvath, and colleagues on page 4110.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy
Gwynn Ison; Lynn J. Howie; Laleh Amiri-Kordestani; Lijun Zhang; Shenghui Tang; Rajeshwari Sridhara; Vadryn Pierre; Rosane Charlab; Anuradha Ramamoorthy; Pengfei Song; Fang Li; Jingyu Yu; Wimolnut Manheng; Todd R. Palmby; Soma Ghosh; Hisani N. Horne; Eunice Y. Lee; Reena Philip; Kaushalkumar Dave; Xiao Hong Chen; Sharon L. Kelly; Kumar G. Janoria; Anamitro Banerjee; Okponanabofa Eradiri; Jeannette Dinin; Kirsten B. Goldberg; William F. Pierce; Amna Ibrahim; Paul G. Kluetz; Gideon M. Blumenthal; Julia A. Beaver; Richard Pazdur
Clinical Trials: Targeted Therapy
Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors
Daniel D. Von Hoff; Drew W. Rasco; Elisabeth I. Heath; Pamela N. Munster; Jan H.M. Schellens; Nicolas Isambert; Christophe Le Tourneau; Bert O'Neil; Ron H.J. Mathijssen; Jose A. Lopez-Martin; W. Jeff Edenfield; Miguel Martin; Patricia M. LoRusso; Gordon L. Bray; Jorge DiMartino; Aaron Nguyen; Kejian Liu; Eric Laille; Johanna C. Bendell
Radium-223 Dichloride in Combination with Vascular Endothelial Growth Factor–Targeting Therapy in Advanced Renal Cell Carcinoma with Bone Metastases
Rana R. McKay; Dominick Bossé; Kathryn P. Gray; M. Dror Michaelson; Katherine Krajewski; Heather A. Jacene; Meghara Walsh; Joaquim Bellmunt; Mark Pomerantz; Lauren C. Harshman; Toni K. Choueiri
Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Tadashi Akiba; Toshiaki Morikawa; Makoto Odaka; Takeo Nakada; Noriki Kamiya; Makoto Yamashita; Mitsuo Yabe; Takuya Inagaki; Hisatoshi Asano; Shohei Mori; Yo Tsukamoto; Mitsuyoshi Urashima
Clinical Trials: Immunotherapy
Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation
Jeff K. Davies; Lisa L. Brennan; John R. Wingard; Christopher R. Cogle; Neena Kapoor; Ami J. Shah; Bimalangshu R. Dey; Thomas R. Spitzer; Marcos de Lima; Laurence J. Cooper; Peter F. Thall; Richard E. Champlin; Lee M. Nadler; Eva C. Guinan
Precision Medicine and Imaging
Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation
Maryam Aghighi; Ashok J. Theruvath; Anuj Pareek; Laura L. Pisani; Raphael Alford; Anne M. Muehe; Tarsheen K. Sethi; Samantha J. Holdsworth; Florette K. Hazard; Dita Gratzinger; Sandra Luna-Fineman; Ranjana Advani; Sheri L. Spunt; Heike E. Daldrup-Link
Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma
Vladimir Bezrookove; Mehdi Nosrati; James R. Miller, III; David De Semir; Altaf A. Dar; Elham Vosoughi; Edith Vaquero; Antje Sucker; Alexander J. Lazar; Jeffrey E. Gershenwald; Michael A. Davies; Dirk Schadendorf; Mohammed Kashani-Sabet
The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes
Matthew P. Salomon; Xiaowen Wang; Diego M. Marzese; Sandy C. Hsu; Nellie Nelson; Xin Zhang; Chikako Matsuba; Yuki Takasumi; Carmen Ballesteros-Merino; Bernard A. Fox; Garni Barkhoudarian; Daniel F. Kelly; Dave S.B. Hoon
STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non–Muscle-Invasive Bladder Cancer
Alana Lelo; Frederik Prip; Brent T. Harris; David Solomon; Deborah L. Berry; Krysta Chaldekas; Anagha Kumar; Jeffry Simko; Jørgen Bjerggaard Jensen; Pritish Bhattacharyya; Ciaran Mannion; Jung-Sik Kim; George Philips; Lars Dyrskjøt; Todd Waldman
Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention
Maeve A. Lowery; Ryan Ptashkin; Emmet Jordan; Michael F. Berger; Ahmet Zehir; Marinela Capanu; Nancy E. Kemeny; Eileen M. O'Reilly; Imane El-Dika; William R. Jarnagin; James J. Harding; Michael I. D'Angelica; Andrea Cercek; Jaclyn F. Hechtman; David B. Solit; Nikolaus Schultz; David M. Hyman; David S. Klimstra; Leonard B. Saltz; Ghassan K. Abou-Alfa
Translational Cancer Mechanisms and Therapy
Author Choice
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
Karolina Woroniecka; Pakawat Chongsathidkiet; Kristen Rhodin; Hanna Kemeny; Cosette Dechant; S. Harrison Farber; Aladine A. Elsamadicy; Xiuyu Cui; Shohei Koyama; Christina Jackson; Landon J. Hansen; Tanner M. Johanns; Luis Sanchez-Perez; Vidyalakshmi Chandramohan; Yen-Rei Andrea Yu; Darell D. Bigner; Amber Giles; Patrick Healy; Glenn Dranoff; Kent J. Weinhold; Gavin P. Dunn; Peter E. Fecci
Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
Malte Mohme; Simon Schliffke; Cecile L. Maire; Alessandra Rünger; Laura Glau; Klaus C. Mende; Jakob Matschke; Christina Gehbauer; Nuray Akyüz; Svenja Zapf; Mareike Holz; Miriam Schaper; Tobias Martens; Nils O. Schmidt; Sven Peine; Manfred Westphal; Mascha Binder; Eva Tolosa; Katrin Lamszus
MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer
Renée de Leeuw; Christopher McNair; Matthew J. Schiewer; Neermala Poudel Neupane; Lucas J. Brand; Michael A. Augello; Zhen Li; Larry C. Cheng; Akihiro Yoshida; Sean M. Courtney; E. Starr Hazard; Gary Hardiman; Maha H. Hussain; J. Alan Diehl; Justin M. Drake; Wm. Kevin Kelly; Karen E. Knudsen
Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies
Hanni Uusi-Kerttula; James A. Davies; Jill M. Thompson; Phonphimon Wongthida; Laura Evgin; Kevin G. Shim; Angela Bradshaw; Alexander T. Baker; Pierre J. Rizkallah; Rachel Jones; Louise Hanna; Emma Hudson; Richard G. Vile; John D. Chester; Alan L. Parker
Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion
Recep Bayraktar; Cristina Ivan; Emine Bayraktar; Pinar Kanlikilicer; Nashwa N. Kabil; Nermin Kahraman; Hamada A. Mokhlis; Didem Karakas; Cristian Rodriguez-Aguayo; Ahmet Arslan; Jianting Sheng; Stephen Wong; Gabriel Lopez-Berestein; George A. Calin; Bulent Ozpolat
Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine
Yee Sun Tan; Kanokwan Sansanaphongpricha; Yuying Xie; Christopher R. Donnelly; Xiaobo Luo; Blake R. Heath; Xinyi Zhao; Emily Bellile; Hongxiang Hu; Hongwei Chen; Peter J. Polverini; Qianming Chen; Simon Young; Thomas E. Carey; Jacques E. Nör; Robert L. Ferris; Gregory T. Wolf; Duxin Sun; Yu L. Lei
Author Choice
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity
Tara L. Peters; Joseph Tillotson; Alison M. Yeomans; Sarah Wilmore; Elizabeth Lemm; Carlos Jiménez-Romero; Luis A. Amador; Lingxiao Li; Amit D. Amin; Praechompoo Pongtornpipat; Christopher J. Zerio; Andrew J. Ambrose; Gillian Paine-Murrieta; Patricia Greninger; Francisco Vega; Cyril H. Benes; Graham Packham; Abimael D. Rodríguez; Eli Chapman; Jonathan H. Schatz
The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma
Javier Vaquero; Cindy Lobe; Sylvana Tahraoui; Audrey Clapéron; Martine Mergey; Fatiha Merabtene; Dominique Wendum; Cédric Coulouarn; Chantal Housset; Christèle Desbois-Mouthon; Françoise Praz; Laura Fouassier
Author Choice
Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors
Tinya Abrams; Anu Connor; Christie Fanton; Steven B. Cohen; Thomas Huber; Kathy Miller; E. Erica Hong; Xiaohong Niu; Janine Kline; Marjorie Ison-Dugenny; Sarah Harris; Dana Walker; Klaus Krauser; Francesco Galimi; Zhen Wang; Majid Ghoddusi; Keith Mansfield; Si Tuen Lee-Hoeflich; Jocelyn Holash; Nancy Pryer; William Kluwe; Seth A. Ettenberg; William R. Sellers; Emma Lees; Paul Kwon; Judith A. Abraham; Siew C. Schleyer
High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling
Takuji Hayashi; Kazutoshi Fujita; Satoshi Nojima; Yujiro Hayashi; Kosuke Nakano; Yu Ishizuya; Cong Wang; Yoshiyuki Yamamoto; Toshiro Kinouchi; Kyosuke Matsuzaki; Kentaro Jingushi; Taigo Kato; Atsunari Kawashima; Akira Nagahara; Takeshi Ujike; Motohide Uemura; Maria Del Carmen Rodriguez Pena; Jennifer B. Gordetsky; Eiichi Morii; Kazutake Tsujikawa; George J. Netto; Norio Nonomura
A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening
Michael L. Beshiri; Caitlin M. Tice; Crystal Tran; Holly M. Nguyen; Adam G. Sowalsky; Supreet Agarwal; Keith H. Jansson; Qi Yang; Kerry M. McGowen; JuanJuan Yin; Aian Neil Alilin; Fatima H. Karzai; William L. Dahut; Eva Corey; Kathleen Kelly
Editor’s Notes
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