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Issues

Volume 24, Issue 13
1 July 2018
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  • Cover Image

    Cover Image

    issue cover
    The cover shows a section of Panc-1 cells after treatment with irradiation. Immunofluorescent staining shows colocalization of γ-H2AX foci (red) and SMAD4 (green) in the nuclei. For details, see the article by Wang and colleagues on page 3176 of this issue.
  • PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265

Highlights

Highlights of This Issue
View articletitled, Highlights of This Issue
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CCR Translations

Goldilocks Dosing of TKIs: A Dose that Is Just Right Leads to Optimal Outcomes
Brian I. Rini
View articletitled, Goldilocks Dosing of TKIs: A Dose that Is Just Right Leads to Optimal Outcomes
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Cycling Toward Progress: Ribociclib, a CDK 4/6 Inhibitor for Breast Cancer
Laura Spring; Aditya Bardia
View articletitled, Cycling Toward Progress: Ribociclib, a CDK 4/6 Inhibitor for Breast Cancer
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Review

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection
Ehab Billatos; Jessica L. Vick; Marc E. Lenburg; Avrum E. Spira
View articletitled, The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection
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Perspective

Report of the 14th International Conference on Malignant Lymphoma (ICML) Closed Workshop on Future Design of Clinical Trials in Lymphomas
Anastasios Stathis; Alexia Iasonos; John F. Seymour; Catherine Thieblemont; Vincent Ribrag; Emanuele Zucca; Anas Younes
View articletitled, Report of the 14th International Conference on Malignant Lymphoma (ICML) Closed Workshop on Future Design of Clinical Trials in Lymphomas
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CCR Drug Updates

FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor–Positive, HER2-Negative Advanced or Metastatic Breast Cancer
Anand Shah; Erik Bloomquist; Shenghui Tang; Wentao Fu; Youwei Bi; Qi Liu; Jingyu Yu; Ping Zhao; Todd R. Palmby; Kirsten B. Goldberg; C.J. George Chang; Paresma Patel; Elleni Alebachew; Amy Tilley; William F. Pierce; Amna Ibrahim; Gideon M. Blumenthal; Rajeshwari Sridhara; Julia A. Beaver; Richard Pazdur
View articletitled, FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor–Positive, HER2-Negative Advanced or Metastatic Breast Cancer
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Clinical Trials: Targeted Therapy

Author Choice
Pazopanib Exposure Relationship with Clinical Efficacy and Safety in the Adjuvant Treatment of Advanced Renal Cell Carcinoma
Cora N. Sternberg; Frede Donskov; Naomi B. Haas; Christian Doehn; Paul Russo; Mohamed Elmeliegy; Guillaume Baneyx; Hiya Banerjee; Paola Aimone; Robert J. Motzer
View articletitled, Pazopanib Exposure Relationship with Clinical Efficacy and Safety in the Adjuvant Treatment of Advanced Renal Cell Carcinoma
Supplementary data
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Author Choice
Folate Receptor Alpha Peptide Vaccine Generates Immunity in Breast and Ovarian Cancer Patients
Kimberly R. Kalli; Matthew S. Block; Pashtoon M. Kasi; Courtney L. Erskine; Timothy J. Hobday; Allan Dietz; Douglas Padley; Michael P. Gustafson; Barath Shreeder; Danell Puglisi-Knutson; Dan W. Visscher; Toni K. Mangskau; Glynn Wilson; Keith L. Knutson
View articletitled, Folate Receptor Alpha Peptide Vaccine Generates Immunity in Breast and Ovarian Cancer Patients
Supplementary data
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5-Fluorouracil Enhances Protoporphyrin IX Accumulation and Lesion Clearance during Photodynamic Therapy of Actinic Keratoses: A Mechanism-Based Clinical Trial
Edward V. Maytin; Sanjay Anand; Margo Riha; Sara Lohser; Alejandra Tellez; Rim Ishak; Lauren Karpinski; Janine Sot; Bo Hu; Anton Denisyuk; Scott C. Davis; Angela Kyei; Allison Vidimos
View articletitled, 5-Fluorouracil Enhances Protoporphyrin IX Accumulation and Lesion Clearance during Photodynamic Therapy of Actinic Keratoses: A Mechanism-Based Clinical Trial
Supplementary data
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Clinical Trials: Immunotherapy

CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment
Jarem Edwards; James S. Wilmott; Jason Madore; Tuba Nur Gide; Camelia Quek; Annie Tasker; Angela Ferguson; Jinbiao Chen; Rehana Hewavisenti; Peter Hersey; Thomas Gebhardt; Wolfgang Weninger; Warwick J. Britton; Robyn P.M. Saw; John F. Thompson; Alexander M. Menzies; Georgina V. Long; Richard A. Scolyer; Umaimainthan Palendira
View articletitled, CD103<sup>+</sup> Tumor-Resident CD8<sup>+</sup> T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment
Supplementary data
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Precision Medicine and Imaging

Author Choice
p95HER2 Methionine 611 Carboxy-Terminal Fragment Is Predictive of Trastuzumab Adjuvant Treatment Benefit in the FinHer Trial
Jeff Sperinde; Weidong Huang; Aki Vehtari; Ahmed Chenna; Pirkko-Liisa Kellokumpu-Lehtinen; John Winslow; Petri Bono; Yolanda S. Lie; Christos J. Petropoulos; Jodi Weidler; Heikki Joensuu
View articletitled, p95HER2 Methionine 611 Carboxy-Terminal Fragment Is Predictive of Trastuzumab Adjuvant Treatment Benefit in the FinHer Trial
Supplementary data
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High p95HER2/HER2 Ratio Associated With Poor Outcome in Trastuzumab-Treated HER2-Positive Metastatic Breast Cancer NCCTG N0337 and NCCTG 98-32-52 (Alliance)
Saranya Chumsri; Jeff Sperinde; Heshan Liu; Joseph Gligorov; Jean-Philippe Spano; Martine Antoine; Alvaro Moreno Aspitia; Winston Tan; John Winslow; Christos J. Petropoulos; Ahmed Chenna; Michael Bates; Jodi Marie Weidler; Weidong Huang; Amylou Dueck; Edith A. Perez
View articletitled, High p95HER2/HER2 Ratio Associated With Poor Outcome in Trastuzumab-Treated HER2-Positive Metastatic Breast Cancer NCCTG N0337 and NCCTG 98-32-52 (Alliance)
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Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers
Nikita Pozdeyev; Laurie M. Gay; Ethan S. Sokol; Ryan Hartmaier; Kelsi E. Deaver; Stephanie Davis; Jena D. French; Pierre Vanden Borre; Daniel V. LaBarbera; Aik-Choon Tan; Rebecca E. Schweppe; Lauren Fishbein; Jeffrey S. Ross; Bryan R. Haugen; Daniel W. Bowles
View articletitled, Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers
Supplementary data
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Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer
Hangcheng Fu; Yu Zhu; Yiwei Wang; Zheng Liu; Junyu Zhang; Huyang Xie; Qiang Fu; Bo Dai; Dingwei Ye; Jiejie Xu
View articletitled, Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer
Supplementary data
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Association of p27 and Cyclin D1 Expression and Benefit from Adjuvant Trastuzumab Treatment in HER2-Positive Early Breast Cancer: A TransHERA Study
Martin Filipits; Urania Dafni; Michael Gnant; Varvara Polydoropoulou; Margaret Hills; Astrid Kiermaier; Evandro de Azambuja; Denis Larsimont; Federico Rojo; Giuseppe Viale; Masakazu Toi; Nadia Harbeck; Kathleen I. Prichard; Richard D. Gelber; Phuong Dinh; Dimitrios Zardavas; Brian Leyland-Jones; Martine J. Piccart-Gebhart; Mitch Dowsett; on behalf of the TransHERA investigators
View articletitled, Association of p27 and Cyclin D1 Expression and Benefit from Adjuvant Trastuzumab Treatment in HER2-Positive Early Breast Cancer: A TransHERA Study
Supplementary data
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Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non–Small Cell Lung Carcinoma (NSCLC)
Rieke Frank; Matthias Scheffler; Sabine Merkelbach-Bruse; Michaela A. Ihle; Anna Kron; Michael Rauer; Frank Ueckeroth; Katharina König; Sebastian Michels; Rieke Fischer; Anna Eisert; Jana Fassunke; Carina Heydt; Monika Serke; Yon-Dschun Ko; Ulrich Gerigk; Thomas Geist; Britta Kaminsky; Lukas C. Heukamp; Mathieu Clement-Ziza; Reinhard Büttner; Jürgen Wolf
View articletitled, Clinical and Pathological Characteristics of <em>KEAP1</em>- and <em>NFE2L2</em>-Mutated Non–Small Cell Lung Carcinoma (NSCLC)
Supplementary data
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Author Choice
Investigating Novel Resistance Mechanisms to Third-Generation EGFR Tyrosine Kinase Inhibitor Osimertinib in Non–Small Cell Lung Cancer Patients
Zhe Yang; Nong Yang; Qiuxiang Ou; Yi Xiang; Tao Jiang; Xue Wu; Hua Bao; Xiaoling Tong; Xiaonan Wang; Yang W. Shao; Yunpeng Liu; Yan Wang; Caicun Zhou
View articletitled, Investigating Novel Resistance Mechanisms to Third-Generation EGFR Tyrosine Kinase Inhibitor Osimertinib in Non–Small Cell Lung Cancer Patients
Supplementary data
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Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance
Helena A. Yu; Ken Suzawa; Emmet Jordan; Ahmet Zehir; Ai Ni; Ryan Kim; Mark G. Kris; Matthew D. Hellmann; Bob T. Li; Romel Somwar; David B. Solit; Michael F. Berger; Maria Arcila; Gregory J. Riely; Marc Ladanyi
View articletitled, Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance
Supplementary data
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Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer
Saro H. Armenian; Derek Rinderknecht; Kaylene Au; Lanie Lindenfeld; George Mills; Aida Siyahian; Claudia Herrera; Karla Wilson; Kalyanasundaram Venkataraman; Kristen Mascarenhas; Peyman Tavallali; Marianne Razavi; Niema Pahlevan; Jon Detterich; Smita Bhatia; Morteza Gharib
View articletitled, Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer
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Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non–Small Cell Lung Cancer Detected by 18F-fluorothymidine
Francesca Iommelli; Viviana De Rosa; Cristina Terlizzi; Marcello Monti; Mariarosaria Panico; Rosa Fonti; Silvana Del Vecchio
View articletitled, Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non–Small Cell Lung Cancer Detected by <sup>18</sup>F-fluorothymidine
Supplementary data
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Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect
Bradley T. Scroggins; Masayuki Matsuo; Ayla O. White; Keita Saito; Jeeva P. Munasinghe; Carole Sourbier; Kazutoshi Yamamoto; Vivian Diaz; Yoichi Takakusagi; Kazuhiro Ichikawa; James B. Mitchell; Murali C. Krishna; Deborah E. Citrin
View articletitled, Hyperpolarized [1-<sup>13</sup>C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer <em>In Vivo</em> Predicts Efficacy of Targeting the Warburg Effect
Supplementary data
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Translational Cancer Mechanisms and Therapy

Author Choice
Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)
Jonathan Welti; Adam Sharp; Wei Yuan; David Dolling; Daniel Nava Rodrigues; Ines Figueiredo; Veronica Gil; Antje Neeb; Matthew Clarke; George Seed; Mateus Crespo; Semini Sumanasuriya; Jian Ning; Eleanor Knight; Jeffrey C. Francis; Ashley Hughes; Wendy S. Halsey; Alec Paschalis; Ram S. Mani; Ganesh V. Raj; Stephen R. Plymate; Suzanne Carreira; Gunther Boysen; Arul M. Chinnaiyan; Amanda Swain; Johann S. de Bono; International SU2C/PCF Prostate Cancer Dream Team
View articletitled, Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)
Supplementary data
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Author Choice
An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations
Nicholas Pulliam; Fang Fang; Ali R. Ozes; Jessica Tang; Adeoluwa Adewuyi; Harold Keer; John Lyons; Stephen B. Baylin; Daniela Matei; Harikrishna Nakshatri; Feyruz V. Rassool; Kathy D. Miller; Kenneth P. Nephew
View articletitled, An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations
Supplementary data
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SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy
Feng Wang; Xiaojun Xia; Chunying Yang; Jianliang Shen; Junhua Mai; Han-Cheon Kim; Dickson Kirui; Ya'an Kang; Jason B. Fleming; Eugene J. Koay; Sankar Mitra; Mauro Ferrari; Haifa Shen
View articletitled, <em>SMAD4</em> Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy
Supplementary data
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Author Choice
ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism
Mingyang Liu; Jingxuan Yang; Yuqing Zhang; Zhijun Zhou; Xiaobo Cui; Liyang Zhang; Kar-Ming Fung; Wei Zheng; Felicia D. Allard; Eric U. Yee; Kai Ding; Huanwen Wu; Zhiyong Liang; Lei Zheng; Martin E. Fernandez-Zapico; Yi-Ping Li; Michael S. Bronze; Katherine T. Morris; Russell G. Postier; Courtney W. Houchen; Jing Yang; Min Li
View articletitled, ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism
Supplementary data
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Adjuvant Treatment for POLE Proofreading Domain–Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues
Inge C. Van Gool; Emily Rayner; Elisabeth M. Osse; Remi A. Nout; Carien L. Creutzberg; Ian P.M. Tomlinson; David N. Church; Vincent T.H.B.M. Smit; Niels de Wind; Tjalling Bosse; Mark Drost
View articletitled, Adjuvant Treatment for <em>POLE</em> Proofreading Domain–Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues
Supplementary data
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Author Choice
COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment
Xiao-Feng Dong; Tian-Qi Liu; Xu-Ting Zhi; Jie Zou; Jing-Tao Zhong; Tao Li; Xiang-Lan Mo; Wei Zhou; Wen-Wen Guo; Xia Liu; Yuan-Yuan Chen; Meng-Yang Li; Xiao-Gang Zhong; Ya-Min Han; Zhong-Hao Wang; Zhao-Ru Dong
View articletitled, COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment
Supplementary data
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Vitamin D–Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt Pathway and Vitamin D Receptor Transcription
Yu-Fang Huang; Yi-Hui Wu; Wen-Fang Cheng; Shu-Ling Peng; Wan-Lin Shen; Cheng-Yang Chou
View articletitled, Vitamin D–Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt Pathway and Vitamin D Receptor Transcription
Supplementary data
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Correction

Correction: Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo
View articletitled, Correction: Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells <em>In Vitro</em> and <em>In Vivo</em>
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