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15 June 2018
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Cover Image
Cover Image
The cover shows a section of a human cervical tumor from a patient treated with chemotherapy. Immunohistochemical staining shows cytoplasmic and nuclear localization of Smad2. For details, see the article by Zhu and colleagues on page 2780 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
Precision Oncology Decision Support: Current Approaches and Strategies for the Future
Katherine C. Kurnit; Ecaterina E. Ileana Dumbrava; Beate Litzenburger; Yekaterina B. Khotskaya; Amber M. Johnson; Timothy A. Yap; Jordi Rodon; Jia Zeng; Md Abu Shufean; Ann M. Bailey; Nora S. Sánchez; Vijaykumar Holla; John Mendelsohn; Kenna Mills Shaw; Elmer V. Bernstam; Gordon B. Mills; Funda Meric-Bernstam
Clinical Trial Brief Report
Anaplastic Lymphoma Kinase Mutation (ALK F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib
Benedito A. Carneiro; Sahithi Pamarthy; Ami N. Shah; Vinay Sagar; Kenji Unno; HuiYing Han; Ximing J. Yang; Rubens B. Costa; Rebecca J. Nagy; Richard B. Lanman; Timothy M. Kuzel; Jeffrey S. Ross; Laurie Gay; Julia A. Elvin; Siraj M. Ali; Massimo Cristofanilli; Young K. Chae; Francis J. Giles; Sarki A. Abdulkadir
Clinical Trials: Targeted Therapy
Author Choice
A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma
Eduardo Méndez; Cristina P. Rodriguez; Michael C. Kao; Sharat Raju; Ahmed Diab; R. Alex Harbison; Eric Q. Konnick; Ganesh M. Mugundu; Rafael Santana-Davila; Renato Martins; Neal D. Futran; Laura Q.M. Chow
Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors
David M. Hyman; Naiyer Rizvi; Ronald Natale; Deborah K. Armstrong; Michael Birrer; Lawrence Recht; Efrat Dotan; Vicky Makker; Thomas Kaley; Denison Kuruvilla; Matthew Gribbin; Jennifer McDevitt; Dominic W. Lai; Mohammed Dar
Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
Caroline E. McCoach; Collin M. Blakely; Kimberly C. Banks; Benjamin Levy; Ben M. Chue; Victoria M. Raymond; Anh T. Le; Christine E. Lee; Joseph Diaz; Saiama N. Waqar; William T. Purcell; Dara L. Aisner; Kurtis D. Davies; Richard B. Lanman; Alice T. Shaw; Robert C. Doebele
Ensartinib (X-396) in ALK-Positive Non–Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study
Leora Horn; Jeffrey R. Infante; Karen L. Reckamp; George R. Blumenschein; Ticiana A. Leal; Saiama N. Waqar; Barbara J. Gitlitz; Rachel E. Sanborn; Jennifer G. Whisenant; Liping Du; Joel W. Neal; Jon P. Gockerman; Gary Dukart; Kimberly Harrow; Chris Liang; James J. Gibbons; Allison Holzhausen; Christine M. Lovly; Heather A. Wakelee
Clinical Trials: Immunotherapy
Impact of Donor Type in Patients with AML Given Allogeneic Hematopoietic Cell Transplantation After Low-Dose TBI-Based Regimen
Frédéric Baron; Myriam Labopin; Annalisa Ruggeri; Jan J. Cornelissen; Ellen Meijer; Henrik Sengeloev; Dietger Niederwieser; Marco R. De Groot; Harry C. Schouten; Noel Milpied; Didier Blaise; Bipin N. Savani; Eliane Gluckman; Mohamad Mohty; Arnon Nagler
Safety and Antitumor Activity of Pembrolizumab in Patients with Estrogen Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer
Hope S. Rugo; Jean-Pierre Delord; Seock-Ah Im; Patrick A. Ott; Sarina A. Piha-Paul; Philippe L. Bedard; Jasgit Sachdev; Christophe Le Tourneau; Emilie M.J. van Brummelen; Andrea Varga; Roberto Salgado; Sherene Loi; Sanatan Saraf; Dina Pietrangelo; Vassiliki Karantza; Antoinette R. Tan
Precision Medicine and Imaging
Author Choice
Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid
Francisco Martínez-Ricarte; Regina Mayor; Elena Martínez-Sáez; Carlota Rubio-Pérez; Estela Pineda; Esteban Cordero; Marta Cicuéndez; Maria A. Poca; Nuria López-Bigas; Santiago Ramon y Cajal; María Vieito; Joan Carles; Josep Tabernero; Ana Vivancos; Soledad Gallego; Francesc Graus; Juan Sahuquillo; Joan Seoane
TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer
Oscar Murcia; Rodrigo Jover; Cecilia Egoavil; Lucia Perez-Carbonell; Miriam Juárez; Eva Hernández-Illán; Estefania Rojas; Cristina Alenda; Francesc Balaguer; Montserrat Andreu; Xavier Llor; Antoni Castells; C. Richard Boland; Ajay Goel
Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer
Chang Xu; Olga Nikolova; Ryan S. Basom; Ryan M. Mitchell; Reid Shaw; Russell D. Moser; Heuijoon Park; Kay E. Gurley; Michael C. Kao; Carlos L. Green; Franz X. Schaub; Robert L. Diaz; Hallie A. Swan; In S. Jang; Justin Guinney; Vijayakrishna K. Gadi; Adam A. Margolin; Carla Grandori; Christopher J. Kemp; Eduardo Méndez
Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer
Anosheh Afghahi; Natasha Purington; Summer S. Han; Manisha Desai; Emma Pierson; Maya B. Mathur; Tina Seto; Caroline A. Thompson; Joseph Rigdon; Melinda L. Telli; Sunil S. Badve; Christina N. Curtis; Robert B. West; Kathleen Horst; Scarlett L. Gomez; James M. Ford; George W. Sledge; Allison W. Kurian
Translational Cancer Mechanisms and Therapy
Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Swati Khanna; Suzanne Graef; Francis Mussai; Anish Thomas; Neha Wali; Bahar Guliz Yenidunya; Constance Yuan; Betsy Morrow; Jingli Zhang; Firouzeh Korangy; Tim F. Greten; Seth M. Steinberg; Maryalice Stetler-Stevenson; Gary Middleton; Carmela De Santo; Raffit Hassan
Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer
Adam J. Camblin; Emily A. Pace; Sharlene Adams; Michael D. Curley; Victoria Rimkunas; Lin Nie; Gege Tan; Troy Bloom; Sergio Iadevaia; Jason Baum; Charlene Minx; Akos Czibere; Chrystal U. Louis; Daryl C. Drummond; Ulrik B. Nielsen; Birgit Schoeberl; J. Marc Pipas; Robert M. Straubinger; Vasileios Askoxylakis; Alexey A. Lugovskoy
Author Choice
RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Vincenzo Carafa; Angela Nebbioso; Francesca Cuomo; Dante Rotili; Gilda Cobellis; Paola Bontempo; Alfonso Baldi; Enrico P. Spugnini; Gennaro Citro; Angela Chambery; Rosita Russo; Menotti Ruvo; Paolo Ciana; Luca Maravigna; Jani Shaik; Enrico Radaelli; Pasquale De Antonellis; Domenico Tarantino; Adele Pirolli; Rino Ragno; Massimo Zollo; Hendrik G. Stunnenberg; Antonello Mai; Lucia Altucci
Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo
Zay Yar Oo; Alexander J. Stevenson; Martina Proctor; Sheena M. Daignault; Sebastian Walpole; Catherine Lanagan; James Chen; Dubravka Škalamera; Loredana Spoerri; Stephen A. Ainger; Richard A. Sturm; Nikolas K. Haass; Brian Gabrielli
The Pattern of Mesenchymal Stem Cell Expression Is an Independent Marker of Outcome in Multiple Myeloma
Carolina Schinke; Pingping Qu; Syed J. Mehdi; Antje Hoering; Joshua Epstein; Sarah K. Johnson; Frits van Rhee; Maurizio Zangari; Sharmilan Thanendrarajan; Bart Barlogie; Faith E. Davies; Shmuel Yaccoby; Gareth J. Morgan
Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression
Stephen B. Keysar; Justin R. Eagles; Bettina Miller; Brian C. Jackson; Farshad N. Chowdhury; Julie Reisinger; Tugs-Saikhan Chimed; Phuong N. Le; John J. Morton; Hilary L. Somerset; Marileila Varella-Garcia; Aik-Choon Tan; John I. Song; Daniel W. Bowles; Mary E. Reyland; Antonio Jimeno
Author Choice
Exosome-Based Detection of EGFR T790M in Plasma from Non–Small Cell Lung Cancer Patients
Elena Castellanos-Rizaldos; Dominik G. Grimm; Vasisht Tadigotla; James Hurley; John Healy; Patricia L. Neal; Mia Sher; Raajdeep Venkatesan; Chris Karlovich; Mitch Raponi; Anne Krug; Mikkel Noerholm; Jihane Tannous; Bakhos A. Tannous; Luis E. Raez; Johan K. Skog
Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma
Steffen Dettling; Slava Stamova; Rolf Warta; Martina Schnölzer; Carmen Rapp; Anchana Rathinasamy; David Reuss; Kolja Pocha; Saskia Roesch; Christine Jungk; Uwe Warnken; Volker Eckstein; Niels Grabe; Christoph Schramm; Markus A. Weigand; Andreas von Deimling; Andreas Unterberg; Philipp Beckhove; Christel Herold-Mende
Pancreatic Juice Mutation Concentrations Can Help Predict the Grade of Dysplasia in Patients Undergoing Pancreatic Surveillance
Masaya Suenaga; Jun Yu; Koji Shindo; Koji Tamura; Jose Alejandro Almario; Christopher Zaykoski; P. Dane Witmer; Shahriar Fesharakizadeh; Michael Borges; Anne-Marie Lennon; Eun-Ji Shin; Marcia Irene Canto; Michael Goggins
Obituary
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