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15 May 2018
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Cover Image
Cover Image
The cover shows hematoxylin- and eosin-stained lung section of a nude mouse with STK33-overexpressed gastric cancer cells injected in the tail vein. For details, see the article by Kong and colleagues on page 2440 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies
Kris Ann P. Schultz; Gretchen M. Williams; Junne Kamihara; Douglas R. Stewart; Anne K. Harris; Andrew J. Bauer; Joyce Turner; Rachana Shah; Katherine Schneider; Kami Wolfe Schneider; Ann Garrity Carr; Laura A. Harney; Shari Baldinger; A. Lindsay Frazier; Daniel Orbach; Dominik T. Schneider; David Malkin; Louis P. Dehner; Yoav H. Messinger; D. Ashley Hill
Cancer Therapy: Clinical
Phase II Study of the Dual EGFR/HER3 Inhibitor Duligotuzumab (MEHD7945A) versus Cetuximab in Combination with FOLFIRI in Second-Line RAS Wild-Type Metastatic Colorectal Cancer
Andrew G. Hill; Michael P. Findlay; Matthew E. Burge; Christopher Jackson; Pilar Garcia Alfonso; Leslie Samuel; Vinod Ganju; Meinolf Karthaus; Alessio Amatu; Mark Jeffery; Maria Di Bartolomeo; John Bridgewater; Andrew L. Coveler; Manuel Hidalgo; Amy V. Kapp; Roxana I. Sufan; Bruce B. McCall; William D. Hanley; Elicia M. Penuel; Andrea Pirzkall; Josep Tabernero
Author Choice
A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses
Daniela Matei; Sharad Ghamande; Lynda Roman; Angeles Alvarez Secord; John Nemunaitis; Merry Jennifer Markham; Kenneth P. Nephew; Simone Jueliger; Aram Oganesian; Sue Naim; Xiang Yao Su; Harold Keer; Mohammad Azab; Gini F. Fleming
Author Choice
Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS
Michael R. Savona; Daniel A. Pollyea; Wendy Stock; Vivian G. Oehler; Mark A. Schroeder; Jeffrey Lancet; James McCloskey; Hagop M. Kantarjian; Weidong Wendy Ma; M. Naveed Shaik; A. Douglas Laird; Mirjana Zeremski; Ashleigh O'Connell; Geoffrey Chan; Jorge E. Cortes
Updated Results of Rituximab Pre- and Post-BEAM with or without 90Yttrium Ibritumomab Tiuxetan during Autologous Transplant for Diffuse Large B-cell Lymphoma
Jad Chahoud; Dawen Sui; William D. Erwin; Alison M. Gulbis; Martin Korbling; Mingzhi Zhang; Sairah Ahmed; Gheath Alatrash; Paolo Anderlini; Stefan O. Ciurea; Betul Oran; Luis E. Fayad; Roland L. Bassett, Jr; Elias J. Jabbour; L. Jeffrey Medeiros; Homer A. Macapinlac; Ken H. Young; Issa F. Khouri
Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial
Patrick Neven; Lynn Jongen; Anneleen Lintermans; Kathleen Van Asten; Chantal Blomme; Diether Lambrechts; An Poppe; Hans Wildiers; Anne-Sophie Dieudonné; Olivier Brouckaert; Jan Decloedt; Patrick Berteloot; Didier Verhoeven; Markus Joerger; Peter Vuylsteke; Wim Wynendaele; Minne Casteels; Sabine Van Huffel; Willem Lybaert; Johan Van Ginderachter; Robert Paridaens; Ignace Vergote; Vincent Olaf Dezentjé; Ben Van Calster; Henk-Jan Guchelaar
Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile
Nan Xie; Nicholas Matigian; Tharindu Vithanage; Kye Gregory; Zeyad D. Nassar; Peter J. Cabot; Paul N. Shaw; Carl M.J. Kirkpatrick; Kim-Anh Lê Cao; David Sturgess; Marie-Odile Parat
Author Choice
The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome
Carmela Ricciardelli; Tina Bianco-Miotto; Shalini Jindal; Lisa M. Butler; Samuel Leung; Catriona M. McNeil; Sandra A. O'Toole; Esmaeil Ebrahimie; Ewan K.A. Millar; Andrew J. Sakko; Alexandra I. Ruiz; Sarah L. Vowler; David G. Huntsman; Stephen N. Birrell; Robert L. Sutherland; Carlo Palmieri; Theresa E. Hickey; Wayne D. Tilley
Personalized Medicine and Imaging
Author Choice
Molecular Lymph Node Status for Prognostic Stratification of Prostate Cancer Patients Undergoing Radical Prostatectomy with Extended Pelvic Lymph Node Dissection
Matthias M. Heck; Margitta Retz; Miriam Bandur; Marc Souchay; Elisabeth Vitzthum; Gregor Weirich; Tibor Schuster; Michael Autenrieth; Hubert Kübler; Tobias Maurer; Mark Thalgott; Kathleen Herkommer; Jürgen E. Gschwend; Roman Nawroth
A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma
Xiaoyan Liu; Jesse J. Swen; Meta H.M. Diekstra; Epie Boven; Daniel Castellano; Hans Gelderblom; Ron H.J. Mathijssen; Sita H. Vermeulen; Egbert Oosterwijk; Kerstin Junker; Max Roessler; Kristin Alexiusdottir; Asgerdur Sverrisdottir; Marius T. Radu; Valentin Ambert; Tim Eisen; Anne Warren; Cristina Rodríguez-Antona; Jesus García-Donas; Stefan Böhringer; Karel K.M. Koudijs; Lambertus A.L.M. Kiemeney; Brian I. Rini; Henk-Jan Guchelaar
Cancer Therapy: Preclinical
Author Choice
Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion–Positive Tumor Cells in a Brain Metastasis Model
Akihiro Nishiyama; Tadaaki Yamada; Kenji Kita; Rong Wang; Sachiko Arai; Koji Fukuda; Azusa Tanimoto; Shinji Takeuchi; Shoichiro Tange; Atsushi Tajima; Noritaka Furuya; Takayoshi Kinoshita; Seiji Yano
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell–Driven Antitumor Immunity
Sarah L. Buchan; Mohannad Fallatah; Stephen M. Thirdborough; Vadim Y. Taraban; Anne Rogel; Lawrence J. Thomas; Christine A. Penfold; Li-Zhen He; Michael A. Curran; Tibor Keler; Aymen Al-Shamkhani
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
Jacqueline H.L. Fok; Somaieh Hedayat; Lei Zhang; Lauren I. Aronson; Fabio Mirabella; Charlotte Pawlyn; Michael D. Bright; Christopher P. Wardell; Jonathan J. Keats; Emmanuel De Billy; Carl S. Rye; Nicola E.A. Chessum; Keith Jones; Gareth J. Morgan; Suzanne A. Eccles; Paul Workman; Faith E. Davies
Author Choice
Androgen Deprivation Therapy Potentiates the Efficacy of Vascular Targeted Photodynamic Therapy of Prostate Cancer Xenografts
Kwanghee Kim; Philip A. Watson; Souhil Lebdai; Sylvia Jebiwott; Alexander J. Somma; Stephen La Rosa; Dipti Mehta; Katie S. Murray; Hans Lilja; David Ulmert; Sebastien Monette; Avigdor Scherz; Jonathan A. Coleman
Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia
Xuejie Jiang; Po Yee Mak; Hong Mu; Wenjing Tao; Duncan H. Mak; Steven Kornblau; Qi Zhang; Peter Ruvolo; Jared K. Burks; Weiguo Zhang; Teresa McQueen; Rongqing Pan; Hongsheng Zhou; Marina Konopleva; Jorge Cortes; Qifa Liu; Michael Andreeff; Bing Z. Carter
Biology of Human Tumors
Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation
Satoshi Takagi; Shokichi Tsukamoto; Jihye Park; Kelly E. Johnson; Yawara Kawano; Michele Moschetta; Chia-Jen Liu; Yuji Mishima; Katsutoshi Kokubun; Salomon Manier; Karma Z. Salem; Daisy Huynh; Antonio Sacco; Jodi Forward; Aldo M. Roccaro; Elisabeth M. Battinelli; Irene M. Ghobrial
Author Choice
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
Luke Piggott; Andreia Silva; Timothy Robinson; Angelica Santiago-Gómez; Bruno M. Simões; Michael Becker; Iduna Fichtner; Ladislav Andera; Philippa Young; Christine Morris; Peter Barrett-Lee; Fouad Alchami; Marco Piva; Maria dM. Vivanco; Robert B. Clarke; Julia Gee; Richard Clarkson
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