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1 January 2018
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Cover Image
Cover Image
The cover shows an image of synapses (yellow) between CS1 CAR T cells (green) and MM.1S tumor cells (blue) in coculture, as detected by immunofluorescent staining (F-actin labeled in red). For details, see the article by Wang and colleagues on page 106 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Cancer Therapy: Clinical
A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600–Mutant Solid Tumors
Clinton Yam; Xiaowei Xu; Michael A. Davies; Phyllis A. Gimotty; Jennifer J.D. Morrissette; Michael T. Tetzlaff; Khalida M. Wani; Shujing Liu; Wanleng Deng; Meghan Buckley; Jianhua Zhao; Ravi K. Amaravadi; Naomi B. Haas; Ragini R. Kudchadkar; Anna C. Pavlick; Jeffrey A. Sosman; Hussein Tawbi; Luke Walker; Lynn M. Schuchter; Giorgos C. Karakousis; Tara C. Gangadhar
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome
Jules L. Derks; Noémie Leblay; Erik Thunnissen; Robert Jan van Suylen; Michael den Bakker; Harry J.M. Groen; Egbert F. Smit; Ronald Damhuis; Esther C. van den Broek; Amélie Charbrier; Matthieu Foll; James D. McKay; PALGA-Group; Lynnette Fernandez-Cuesta; Ernst-Jan M. Speel; Anne-Marie C. Dingemans
Author Choice
Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) Plus Gemcitabine in Patients with Advanced Solid Tumors
Vivek Subbiah; Juneko E. Grilley-Olson; Austin J. Combest; Neelesh Sharma; Richard H. Tran; Iulian Bobe; Atsushi Osada; Kazuhiro Takahashi; Jaikrishna Balkissoon; Aaron Camp; Atsuhiro Masada; Dirk J. Reitsma; Lyudmila A. Bazhenova
Author Choice
Fluorescein-Guided Surgery for Resection of High-Grade Gliomas: A Multicentric Prospective Phase II Study (FLUOGLIO)
Francesco Acerbi; Morgan Broggi; Karl-Michael Schebesch; Julius Höhne; Claudio Cavallo; Camilla De Laurentis; Marica Eoli; Elena Anghileri; Maura Servida; Carlo Boffano; Bianca Pollo; Marco Schiariti; Sergio Visintini; Cristina Montomoli; Lorenzo Bosio; Emanuele La Corte; Giovanni Broggi; Alexander Brawanski; Paolo Ferroli
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals
Gulidanna Shayan; Benjamin A. Kansy; Sandra P. Gibson; Raghvendra M. Srivastava; James Kyle Bryan; Julie E. Bauman; James Ohr; Seungwon Kim; Umamaheswar Duvvuri; David A. Clump; Dwight E. Heron; Jonas T. Johnson; Robert M. Hershberg; Robert L. Ferris
Author Choice
Phase III HEAT Study Adding Lyso-Thermosensitive Liposomal Doxorubicin to Radiofrequency Ablation in Patients with Unresectable Hepatocellular Carcinoma Lesions
Won Young Tak; Shi-Ming Lin; Yijun Wang; Jiasheng Zheng; Aldo Vecchione; Soo Young Park; Min Hua Chen; Stephen Wong; Ruocai Xu; Cheng-Yuan Peng; Yi-You Chiou; Guan-Tarn Huang; Jianqiang Cai; Basri Johan Jeet Abdullah; June Sung Lee; Jae Young Lee; Jong-Young Choi; Julieta Gopez-Cervantes; Morris Sherman; Richard S. Finn; Masao Omata; Michael O'Neal; Lukas Makris; Nicholas Borys; Ronnie Poon; Riccardo Lencioni
Personalized Medicine and Imaging
Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition
Josine M. Quispel-Janssen; Jitendra Badhai; Laurel Schunselaar; Stacey Price; Jonathan Brammeld; Francesco Iorio; Krishna Kolluri; Matthew Garnett; Anton Berns; Paul Baas; Ultan McDermott; Jacques Neefjes; Constantine Alifrangis
Cancer Therapy: Preclinical
Author Choice
Regional Delivery of Chimeric Antigen Receptor–Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain
Saul J. Priceman; Dileshni Tilakawardane; Brook Jeang; Brenda Aguilar; John P. Murad; Anthony K. Park; Wen-Chung Chang; Julie R. Ostberg; Josh Neman; Rahul Jandial; Jana Portnow; Stephen J. Forman; Christine E. Brown
Author Choice
Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor–Redirected T Cells Against Multiple Myeloma
Xiuli Wang; Miriam Walter; Ryan Urak; Lihong Weng; Christian Huynh; Laura Lim; ChingLam W. Wong; Wen-Chung Chang; Sandra H. Thomas; James F. Sanchez; Lu Yang; Christine E. Brown; Flavia Pichiorri; Myo Htut; Amrita Y. Krishnan; Stephen J. Forman
PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy
Chiara Tarantelli; Eugenio Gaudio; Alberto J. Arribas; Ivo Kwee; Petra Hillmann; Andrea Rinaldi; Luciano Cascione; Filippo Spriano; Elena Bernasconi; Francesca Guidetti; Laura Carrassa; Roberta Bordone Pittau; Florent Beaufils; Reto Ritschard; Denise Rageot; Alexander Sele; Barbara Dossena; Francesca Maria Rossi; Antonella Zucchetto; Monica Taborelli; Valter Gattei; Davide Rossi; Anastasios Stathis; Georg Stussi; Massimo Broggini; Matthias P. Wymann; Andreas Wicki; Emanuele Zucca; Vladimir Cmiljanovic; Doriano Fabbro; Francesco Bertoni
Author Choice
Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation–Mediated Repression of the Hedgehog/Gli1 Pathway
Zhiqiang Zhao; Qiang Jia; Man-Si Wu; Xianbiao Xie; Yongqian Wang; Guohui Song; Chang-Ye Zou; Qinglian Tang; Jinchang Lu; Gang Huang; Jin Wang; De-Chen Lin; H. Phillip Koeffler; Jun-Qiang Yin; Jingnan Shen
Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection
Franziska Niehr; Theresa Eder; Tanja Pilz; Robert Konschak; Denise Treue; Frederick Klauschen; Michael Bockmayr; Seval Türkmen; Korinna Jöhrens; Volker Budach; Ingeborg Tinhofer
Biology of Human Tumors
Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers
Lino Möhrmann; Helen J. Huang; David S. Hong; Apostolia M. Tsimberidou; Siqing Fu; Sarina A. Piha-Paul; Vivek Subbiah; Daniel D. Karp; Aung Naing; Anne Krug; Daniel Enderle; Tina Priewasser; Mikkel Noerholm; Erez Eitan; Christine Coticchia; Georg Stoll; Lisa-Marie Jordan; Cathy Eng; E. Scott Kopetz; Johan Skog; Funda Meric-Bernstam; Filip Janku
Author Choice
Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group
Amy K. Erbe; Wei Wang; Lakeesha Carmichael; KyungMann Kim; Eneida A. Mendonça; Yiqiang Song; Dustin Hess; Patrick K. Reville; Wendy B. London; Arlene Naranjo; Jacquelyn A. Hank; Mitchell B. Diccianni; Ralph A. Reisfeld; Stephen D. Gillies; Katherine K. Matthay; Susan L. Cohn; Michael D. Hogarty; John M. Maris; Julie R. Park; M. Fevzi Ozkaynak; Andrew L. Gilman; Alice L. Yu; Paul M. Sondel
Author Choice
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Kyung-A Song; Matthew J. Niederst; Timothy L. Lochmann; Aaron N. Hata; Hidenori Kitai; Jungoh Ham; Konstantinos V. Floros; Mark A. Hicks; Haichuan Hu; Hillary E. Mulvey; Yotam Drier; Daniel A.R. Heisey; Mark T. Hughes; Neha U. Patel; Elizabeth L. Lockerman; Angel Garcia; Shawn Gillepsie; Hannah L. Archibald; Maria Gomez-Caraballo; Tara J. Nulton; Brad E. Windle; Zofia Piotrowska; Sinem E. Sahingur; Shirley M. Taylor; Mikhail Dozmorov; Lecia V. Sequist; Bradley Bernstein; Hiromichi Ebi; Jeffrey A. Engelman; Anthony C. Faber
Tumor Microvessel Density as a Prognostic Marker in High-Risk Renal Cell Carcinoma Patients Treated on ECOG-ACRIN E2805
Lucia B. Jilaveanu; Maneka Puligandla; Sarah A. Weiss; Xin Victoria Wang; Christopher Zito; Keith T. Flaherty; Marta Boeke; Veronique Neumeister; Robert L. Camp; Adebowale Adeniran; Michael Pins; Judith Manola; Robert S. DiPaola; Naomi B. Haas; Harriet M. Kluger
KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer
Neeraj Lal; Brian S. White; Ghaleb Goussous; Oliver Pickles; Mike J. Mason; Andrew D. Beggs; Philippe Taniere; Benjamin E. Willcox; Justin Guinney; Gary W. Middleton
Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation
Shivani Kapoor; Karthika Natarajan; Patrick R. Baldwin; Kshama A. Doshi; Rena G. Lapidus; Trevor J. Mathias; Mario Scarpa; Rossana Trotta; Eduardo Davila; Manfred Kraus; Dennis Huszar; Adriana E. Tron; Danilo Perrotti; Maria R. Baer
Letter to the Editor
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