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1 May 2017
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Cover Image
Cover Image
The cover shows fluorescence images of ABY-029 (green), 5-ALA-induced PpIX (blue), and IRDye680RD-CX (red) tissue distribution acquired on ex vivo brain tissue sections bearing large F98 EGFR-positive tumors. The distribution of these imaging agents, which were acquired 3 hours following coinjection, represent markers of EGFR expression, protoporphyrin metabolism, and perfusion, respectively, which enable optically guided tumor identification. For details, see the article by Elliott and colleagues on page 2203 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Drug Updates
Molecular Pathways
Review
Clinical Trial Brief Report
Cancer Therapy: Clinical
FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma
Amy K. Erbe; Wei Wang; Jacob Goldberg; Mikayla Gallenberger; KyungMann Kim; Lakeesha Carmichael; Dustin Hess; Eneida A. Mendonca; Yiqiang Song; Jacquelyn A. Hank; Su-Chun Cheng; Sabina Signoretti; Michael Atkins; Alexander Carlson; James W. Mier; David J. Panka; David F. McDermott; Paul M. Sondel
Author Choice
Neoadjuvant Enzalutamide Prior to Prostatectomy
Bruce Montgomery; Maria S. Tretiakova; Anthony M. Joshua; Martin E. Gleave; Neil Fleshner; Glenn J. Bubley; Elahe A. Mostaghel; Kim N. Chi; Daniel W. Lin; Martin Sanda; William Novotny; Kenneth Wu; Philip W. Kantoff; Brett T. Marck; Stephen Plymate; Steven P. Balk; Peter S. Nelson; Alvin M. Matsumoto; Rosina T. Lis; Adam Kibel; Gabriel P. Haas; Andrew Krivoshik; Alison Hannah; Mary-Ellen Taplin
Biomarker and Tumor Responses of Oral Cavity Squamous Cell Carcinoma to Trametinib: A Phase II Neoadjuvant Window-of-Opportunity Clinical Trial
Ravindra Uppaluri; Ashley E. Winkler; Tianxiang Lin; Jonathan H. Law; Bruce H. Haughey; Brian Nussenbaum; Randal C. Paniello; Jason T. Rich; Jason A. Diaz; Loren P. Michel; Tanya Wildes; Gavin P. Dunn; Paul Zolkind; Dorina Kallogjeri; Jay F. Piccirillo; Farrokh Dehdashti; Barry A. Siegel; Rebecca D. Chernock; James S. Lewis, Jr.; Douglas R. Adkins
Impact of TP53 Mutations on Outcome in EGFR-Mutated Patients Treated with First-Line Tyrosine Kinase Inhibitors
Matteo Canale; Elisabetta Petracci; Angelo Delmonte; Elisa Chiadini; Claudio Dazzi; Maximilian Papi; Laura Capelli; Claudia Casanova; Nicoletta De Luigi; Marita Mariotti; Alessandro Gamboni; Rita Chiari; Chiara Bennati; Daniele Calistri; Vienna Ludovini; Lucio Crinò; Dino Amadori; Paola Ulivi
Personalized Medicine and Imaging
Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma
Jonathan T. Elliott; Kayla Marra; Linton T. Evans; Scott C. Davis; Kimberley S. Samkoe; Joachim Feldwisch; Keith D. Paulsen; David W. Roberts; Brian W. Pogue
Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer
James M. Flanagan; Angela Wilson; Chail Koo; Nahal Masrour; John Gallon; Erick Loomis; Kirsty Flower; Charlotte Wilhelm-Benartzi; Alexander Hergovich; Paula Cunnea; Hani Gabra; Elena Ioana Braicu; Jalid Sehouli; Silvia Darb-Esfahani; Adriaan Vanderstichele; Ignace Vergote; Caroline Kreuzinger; Dan Cacsire Castillo-Tong; G. Bea A. Wisman; Els MJJ Berns; Nadeem Siddiqui; James Paul; Robert Brown
Chromosomal Instability in Cell-Free DNA as a Highly Specific Biomarker for Detection of Ovarian Cancer in Women with Adnexal Masses
Adriaan Vanderstichele; Pieter Busschaert; Dominiek Smeets; Chiara Landolfo; Els Van Nieuwenhuysen; Karin Leunen; Patrick Neven; Frédéric Amant; Sven Mahner; Elena Ioana Braicu; Robert Zeilinger; An Coosemans; Dirk Timmerman; Diether Lambrechts; Ignace Vergote
Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases
Sydney Dubois; Pierre-Julien Viailly; Elodie Bohers; Philippe Bertrand; Philippe Ruminy; Vinciane Marchand; Catherine Maingonnat; Sylvain Mareschal; Jean-Michel Picquenot; Dominique Penther; Jean-Philippe Jais; Bruno Tesson; Pauline Peyrouze; Martin Figeac; Fabienne Desmots; Thierry Fest; Corinne Haioun; Thierry Lamy; Christiane Copie-Bergman; Bettina Fabiani; Richard Delarue; Frédéric Peyrade; Marc André; Nicolas Ketterer; Karen Leroy; Gilles Salles; Thierry J. Molina; Hervé Tilly; Fabrice Jardin
Cancer Therapy: Preclinical
Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells
Loretta Gammaitoni; Lidia Giraudo; Marco Macagno; Valeria Leuci; Giulia Mesiano; Ramona Rotolo; Francesco Sassi; Martina Sanlorenzo; Alessandro Zaccagna; Alberto Pisacane; Rebecca Senetta; Michela Cangemi; Giulia Cattaneo; Valentina Martin; Valentina Coha; Susanna Gallo; Ymera Pignochino; Anna Sapino; Giovanni Grignani; Fabrizio Carnevale-Schianca; Massimo Aglietta; Dario Sangiolo
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor–Sensitive and -Resistant Chronic Myeloid Leukemia
Isabel Ben-Batalla; Robert Erdmann; Heather Jørgensen; Rebecca Mitchell; Thomas Ernst; Gunhild von Amsberg; Philippe Schafhausen; Janna L. Velthaus; Stephen Rankin; Richard E. Clark; Steffen Koschmieder; Alexander Schultze; Subir Mitra; Peter Vandenberghe; Tim H. Brümmendorf; Peter Carmeliet; Andreas Hochhaus; Klaus Pantel; Carsten Bokemeyer; G. Vignir Helgason; Tessa L. Holyoake; Sonja Loges
Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts
Hung-Ming Lam; Ryan McMullin; Holly M. Nguyen; Ilsa Coleman; Michael Gormley; Roman Gulati; Lisha G. Brown; Sarah K. Holt; Weimin Li; Deborah S. Ricci; Karin Verstraeten; Shibu Thomas; Elahe A. Mostaghel; Peter S. Nelson; Robert L. Vessella; Eva Corey
The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia
Matthew D. Blunt; Stefan Koehrer; Rachel C. Dobson; Marta Larrayoz; Sarah Wilmore; Alice Hayman; Jack Parnell; Lindsay D. Smith; Andrew Davies; Peter W.M. Johnson; Pamela B. Conley; Anjali Pandey; Jonathan C. Strefford; Freda K. Stevenson; Graham Packham; Francesco Forconi; Greg P. Coffey; Jan A. Burger; Andrew J. Steele
Biology of Human Tumors
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis
Hong-Tai Tzeng; Chung-Han Tsai; Yi-Ting Yen; Hung-Chi Cheng; Yi-Chieh Chen; Shih-Wen Pu; Yu-Shiuan Wang; Yan-Shen Shan; Yau-Lin Tseng; Wu-Chou Su; Wu-Wei Lai; Li-Wha Wu; Yi-Ching Wang
Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α
Yana G. Najjar; Patricia Rayman; Xuefei Jia; Paul G. Pavicic, Jr; Brian I. Rini; Charles Tannenbaum; Jennifer Ko; Samuel Haywood; Peter Cohen; Thomas Hamilton; C. Marcela Diaz-Montero; James Finke
lncRNAs as Novel Indicators of Patients' Prognosis in Stage I Epithelial Ovarian Cancer: A Retrospective and Multicentric Study
Paolo Martini; Lara Paracchini; Giulia Caratti; Maurizia Mello-Grand; Robert Fruscio; Luca Beltrame; Enrica Calura; Gabriele Sales; Antonella Ravaggi; Eliana Bignotti; Franco E. Odicino; Enrico Sartori; Patrizia Perego; Dionyssios Katsaros; Ilaria Craparotta; Giovanna Chiorino; Stefano Cagnin; Laura Mannarino; Lorenzo Ceppi; Costantino Mangioni; Chiara Ghimenti; Maurizio D'Incalci; Sergio Marchini; Chiara Romualdi
Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer
William J. Gibson; Daniel T. Ruan; Vera A. Paulson; Justine A. Barletta; Glenn J. Hanna; Stefan Kraft; Antonio Calles; Matthew A. Nehs; Francis D. Moore, Jr; Amaro Taylor-Weiner; Jeremiah A. Wala; Travis I. Zack; Thomas C. Lee; Fiona M. Fennessy; Erik K. Alexander; Tom Thomas; Pasi A. Janne; Levi A. Garraway; Scott L. Carter; Rameen Beroukhim; Jochen H. Lorch; Eliezer M. Van Allen
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