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15 April 2017
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Cover Image
Cover Image
The cover shows a section of a primary tumor from mice harboring activated Braf and inactivated Pten in melanocytes that developed a genetically induced melanoma tumor. The staining shows aggressive tumor growth in animals treated with vehicle (as opposed to those treated with novel recombinant sIFN-I interferon). For details, see the article by Zhang and colleagues on page 2038 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
CCR Drug Updates
Molecular Pathways
Cancer Therapy: Clinical
Author Choice
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination
Kristen A. Batich; Elizabeth A. Reap; Gary E. Archer; Luis Sanchez-Perez; Smita K. Nair; Robert J. Schmittling; Pam Norberg; Weihua Xie; James E. Herndon, II; Patrick Healy; Roger E. McLendon; Allan H. Friedman; Henry S. Friedman; Darell Bigner; Gordana Vlahovic; Duane A. Mitchell; John H. Sampson
Author Choice
A First-in-Human Phase I Study of a Bivalent MET Antibody, Emibetuzumab (LY2875358), as Monotherapy and in Combination with Erlotinib in Advanced Cancer
Lee S. Rosen; Jonathan W. Goldman; Alain P. Algazi; P. Kellie Turner; Brian Moser; Tianle Hu; Xuejing Aimee Wang; Jay Tuttle; Volker Wacheck; James E. Wooldridge; Michaela Banck
Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1
Stéphane Champiat; Laurent Dercle; Samy Ammari; Christophe Massard; Antoine Hollebecque; Sophie Postel-Vinay; Nathalie Chaput; Alexander Eggermont; Aurélien Marabelle; Jean-Charles Soria; Charles Ferté
Author Choice
Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody
Neil H. Segal; Theodore F. Logan; F. Stephen Hodi; David McDermott; Ignacio Melero; Omid Hamid; Henrik Schmidt; Caroline Robert; Vanna Chiarion-Sileni; Paolo A. Ascierto; Michele Maio; Walter J. Urba; Tara C. Gangadhar; Satyendra Suryawanshi; Jaclyn Neely; Maria Jure-Kunkel; Suba Krishnan; Holbrook Kohrt; Mario Sznol; Ronald Levy
Author Choice
Randomized, Placebo-Controlled, Phase II Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non–Small Cell Lung Cancer
Suresh S. Ramalingam; Normand Blais; Julien Mazieres; Martin Reck; C. Michael Jones; Erzsebet Juhasz; Laszlo Urban; Sergey Orlov; Fabrice Barlesi; Ebenezer Kio; Ulrich Keiholz; Qin Qin; Jiang Qian; Caroline Nickner; Juliann Dziubinski; Hao Xiong; Peter Ansell; Mark McKee; Vincent Giranda; Vera Gorbunova
A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel
Jinhua Zhou; Albandri Alfraidi; Shu Zhang; Janice M. Santiago-O'Farrill; Venkata Krishna Yerramreddy Reddy; Abdulkhaliq Alsaadi; Ahmed A. Ahmed; Hailing Yang; Jinsong Liu; Weiqun Mao; Yan Wang; Hiroshi Takemori; Hariprasad Vankayalapati; Zhen Lu; Robert C. Bast, Jr
Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy
Bradley J. Monk; Andrea Facciabene; William E. Brady; Carol A. Aghajanian; Paula M. Fracasso; Joan L. Walker; Heather A. Lankes; Kristi L. Manjarrez; Gwenn-äel H. Danet-Desnoyers; Katherine M. Bell-McGuinn; Carolyn K. McCourt; Alexander Malykhin; Robert M. Hershberg; George Coukos
A Phase II, Randomized, Open-Label Study of Neoadjuvant Degarelix versus LHRH Agonist in Prostate Cancer Patients Prior to Radical Prostatectomy
Rashid K. Sayyid; Andrew Evans; Karen Hersey; Ranjena Maloni; Antonio Hurtado-Coll; Girish Kulkarni; Antonio Finelli; Alexandre R. Zlotta; Robert Hamilton; Martin Gleave; Neil E. Fleshner
Personalized Medicine and Imaging
Author Choice
Assessment of Total Lesion Glycolysis by 18F FDG PET/CT Significantly Improves Prognostic Value of GEP and ISS in Myeloma
James E. McDonald; Marcus M. Kessler; Michael W. Gardner; Amy F. Buros; James A. Ntambi; Sarah Waheed; Frits van Rhee; Maurizio Zangari; Christoph J. Heuck; Nathan Petty; Carolina Schinke; Sharmilan Thanendrarajan; Alan Mitchell; Antje Hoering; Bart Barlogie; Gareth J. Morgan; Faith E. Davies
Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum
Alicia Hulbert; Ignacio Jusue-Torres; Alejandro Stark; Chen Chen; Kristen Rodgers; Beverly Lee; Candace Griffin; Andrew Yang; Peng Huang; John Wrangle; Steven A. Belinsky; Tza-Huei Wang; Stephen C. Yang; Stephen B. Baylin; Malcolm V. Brock; James G. Herman
A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients
Iris J.H. van Vlodrop; Sophie C. Joosten; Tim De Meyer; Kim M. Smits; Leander Van Neste; Veerle Melotte; Marcella M.L.L. Baldewijns; Leo J. Schouten; Piet A. van den Brandt; Jana Jeschke; Joo Mi Yi; Kornel E. Schuebel; Nita Ahuja; James G. Herman; Maureen J. Aarts; Fred T. Bosman; Wim Van Criekinge; Manon van Engeland
Author Choice
Significant Effect of Polymorphisms in CYP2D6 on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study
Hitoshi Zembutsu; Seigo Nakamura; Sadako Akashi-Tanaka; Takashi Kuwayama; Chie Watanabe; Tomoko Takamaru; Hiroyuki Takei; Takashi Ishikawa; Kana Miyahara; Hiroshi Matsumoto; Yoshie Hasegawa; Goro Kutomi; Hiroaki Shima; Fukino Satomi; Minoru Okazaki; Hisamitsu Zaha; Mai Onomura; Ayami Matsukata; Yasuaki Sagara; Shinichi Baba; Akimitsu Yamada; Kazuhiro Shimada; Daisuke Shimizu; Koichiro Tsugawa; Arata Shimo; Ern Yu Tan; Mikael Hartman; Ching-Wan Chan; Soo Chin Lee; Yusuke Nakamura
Cancer Therapy: Preclinical
A Potent In Vivo Antitumor Efficacy of Novel Recombinant Type I Interferon
Kang-Jian Zhang; Xiao-Fei Yin; Yuan-Qin Yang; Hui-Ling Li; Yan-Ni Xu; Lie-Yang Chen; Xi-Jun Liu; Su-Jing Yuan; Xian-Long Fang; Jing Xiao; Shuai Wu; Hai-Neng Xu; Liang Chu; Kanstantsin V. Katlinski; Yuliya V. Katlinskaya; Rong-Bing Guo; Guang-Wen Wei; Da-Cheng Wang; Xin-Yuan Liu; Serge Y. Fuchs
Biology of Human Tumors
Author Choice
Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer
Qiaoyi Liang; Jonathan Chiu; Yingxuan Chen; Yanqin Huang; Akira Higashimori; Jingyuan Fang; Hassan Brim; Hassan Ashktorab; Siew Chien Ng; Simon Siu Man Ng; Shu Zheng; Francis Ka Leung Chan; Joseph Jao Yiu Sung; Jun Yu
A Positive Feedback Loop of lncRNA-PVT1 and FOXM1 Facilitates Gastric Cancer Growth and Invasion
Mi-die Xu; Yiqin Wang; Weiwei Weng; Ping Wei; Peng Qi; Qiongyan Zhang; Cong Tan; Shu-juan Ni; Lei Dong; Yusi Yang; Wanrun Lin; Qinghua Xu; Dan Huang; Zhaohui Huang; Yuqing Ma; Wei Zhang; Weiqi Sheng; Xiang Du
Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases
Priyadharsini Nagarajan; Jonathan L. Curry; Jing Ning; Jin Piao; Carlos A. Torres-Cabala; Phyu P. Aung; Doina Ivan; Merrick I. Ross; Charles F. Levenback; Michael Frumovitz; Jeffrey E. Gershenwald; Michael A. Davies; Anais Malpica; Victor G. Prieto; Michael T. Tetzlaff
Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against Cancer
Hamza Mameri; Ivan Bièche; Didier Meseure; Elisabetta Marangoni; Géraldine Buhagiar-Labarchède; André Nicolas; Sophie Vacher; Rosine Onclercq-Delic; Vinodh Rajapakse; Sudhir Varma; William C. Reinhold; Yves Pommier; Mounira Amor-Guéret
Correction
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